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KR850007800A - 세팔로스포린 유도체의 에스테르 제조방법 - Google Patents

세팔로스포린 유도체의 에스테르 제조방법 Download PDF

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Publication number
KR850007800A
KR850007800A KR1019850000263A KR850000263A KR850007800A KR 850007800 A KR850007800 A KR 850007800A KR 1019850000263 A KR1019850000263 A KR 1019850000263A KR 850000263 A KR850000263 A KR 850000263A KR 850007800 A KR850007800 A KR 850007800A
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KR
South Korea
Prior art keywords
formula
alkyl
compound
group
cephalosporin derivative
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KR1019850000263A
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KR870001007B1 (ko
Inventor
빈센트 커턴(외 1) 윌리암
Original Assignee
죤 제이헤이간
아메리칸 사이아나밋드 캄파니
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Publication of KR850007800A publication Critical patent/KR850007800A/ko
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Publication of KR870001007B1 publication Critical patent/KR870001007B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

세팔로스포린 유도체의 에스테르 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 7β-〔2-(2-아미노티아졸-4-일)-(Z)-2-메톡스이미노아세트아미도〕-3-〔(1,2,3-타아디아졸-5-일)-티오메틸〕세프-3-엠-4-카르복실산을 산수용체 존재하에 하기 구조식(а)의 알킬화제와 반응시키는 단계로 구성되는, 하기 구조식(Ⅰ)화합물의 제조방법.
    상기식에서, R1은 수소 및 C1-C6알킬로 이루어지는 군에서 선택되고, R2는 C1-C6알킬, 아릴, 아다만틸 및 -OR3(R3는 C1-C6알킬)로 이루어지는 군에서 선택된다.
  2. (가) 하기 구조식(b) 화합물을 산수용체 존재하에 구조식(a)의 알킬화제와 반응시켜 구조식(c)화합물을 얻고, (나) 단계(가)의 생성물을 디시클로헥실카르보디이미드와 Ⅰ-하이드록시벤조트리아졸의 존재하에 구조식(d) 화합물과 반응시키는 단계들로 구성되는, 구조식(Ⅰ)화합물의 제조방법.
    상기식에서 R1은 수소 및 C1-C6알킬로 이루어지는 군에서 선택되고, R2는 C1-C6알킬, 아릴, 아다만틸 및 -OR3(R3는 C1-C6알킬)로 이루어지는 군에서 선택되며, 구조식(b)와 (d)의 아민기는 보호될 수 있다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850000263A 1984-04-02 1985-01-17 세팔로스포린 유도체의 에스테르 제조방법 Expired KR870001007B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US595,844 1984-04-02
US595844 1984-04-02
US06/595,844 US4914091A (en) 1984-04-02 1984-04-02 Esters of cephalosporin derivitives

Publications (2)

Publication Number Publication Date
KR850007800A true KR850007800A (ko) 1985-12-09
KR870001007B1 KR870001007B1 (ko) 1987-05-18

Family

ID=24384908

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850000263A Expired KR870001007B1 (ko) 1984-04-02 1985-01-17 세팔로스포린 유도체의 에스테르 제조방법

Country Status (15)

Country Link
US (1) US4914091A (ko)
EP (1) EP0157000A3 (ko)
JP (1) JPS60209589A (ko)
KR (1) KR870001007B1 (ko)
AU (1) AU571042B2 (ko)
DK (1) DK626984A (ko)
ES (2) ES8606873A1 (ko)
FI (1) FI851306A7 (ko)
HU (1) HU194252B (ko)
IL (1) IL73918A0 (ko)
NO (1) NO851336L (ko)
NZ (1) NZ210761A (ko)
PH (1) PH20664A (ko)
PT (1) PT80180B (ko)
ZA (1) ZA85240B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252473A3 (en) * 1986-07-08 1989-07-05 American Cyanamid Company 7 beta-(substituted) amino-3-substituted cephalosporanic acids and esters
KR20120087878A (ko) * 2009-08-10 2012-08-07 비에이치아이 리미티드 파트너쉽 1,3-프로판디설포닉 애시드의 수송을 위한 방법, 화합물 및 조성물
EP2968274B1 (en) 2013-03-15 2019-10-16 Kala Pharmaceuticals, Inc. Meropenem derivatives and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1425933A (en) * 1972-03-13 1976-02-25 Astra Laekemedel Ab Cephalosporins
DE2758000A1 (de) * 1977-12-24 1979-07-05 Hoechst Ag Verfahren zur herstellung von penicillinen und cephalosporinen
NL8003186A (nl) * 1979-06-01 1980-12-03 Sankyo Co Cefalosporine-verbindingen die geschikt zijn voor orale toediening.
US4399132A (en) * 1980-08-11 1983-08-16 American Cyanamid Company 7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)-acetamido]-3-[(1,2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C1 -C6 alkyl derivatives thereof
ES8303422A1 (es) * 1980-12-15 1983-02-01 Fujisawa Pharmaceutical Co Un procedimiento para preparar derivados del acido 7-acilaminocefalosporanico .
JPS57163386A (en) * 1981-08-13 1982-10-07 Takeda Chem Ind Ltd Cephalosporin derivative and its production
CA1215354A (en) * 1983-06-02 1986-12-16 Akio Miyake Cephalosporin esters, their production and use
JPS59225191A (ja) * 1983-06-02 1984-12-18 Takeda Chem Ind Ltd 経口用セフアロスポリン誘導体

Also Published As

Publication number Publication date
ES539367A0 (es) 1986-05-16
ES8606359A1 (es) 1986-05-01
DK626984D0 (da) 1984-12-21
EP0157000A2 (en) 1985-10-09
HU194252B (en) 1988-01-28
DK626984A (da) 1985-10-03
US4914091A (en) 1990-04-03
FI851306A0 (fi) 1985-04-01
JPS60209589A (ja) 1985-10-22
NO851336L (no) 1985-10-03
IL73918A0 (en) 1985-03-31
AU571042B2 (en) 1988-03-31
FI851306L (fi) 1985-10-03
NZ210761A (en) 1988-08-30
FI851306A7 (fi) 1985-10-03
PH20664A (en) 1987-03-23
ES8606873A1 (es) 1986-05-16
ES549294A0 (es) 1986-05-01
EP0157000A3 (en) 1986-10-22
KR870001007B1 (ko) 1987-05-18
PT80180A (en) 1985-04-01
HUT37436A (en) 1985-12-28
ZA85240B (en) 1985-09-25
PT80180B (en) 1987-02-06
AU3702184A (en) 1985-10-10

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