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ES8606359A1 - Procedimiento para preparar esteres de cefalosporinas - Google Patents

Procedimiento para preparar esteres de cefalosporinas

Info

Publication number
ES8606359A1
ES8606359A1 ES549294A ES549294A ES8606359A1 ES 8606359 A1 ES8606359 A1 ES 8606359A1 ES 549294 A ES549294 A ES 549294A ES 549294 A ES549294 A ES 549294A ES 8606359 A1 ES8606359 A1 ES 8606359A1
Authority
ES
Spain
Prior art keywords
atoms
alkyl
formula
compound
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549294A
Other languages
English (en)
Other versions
ES549294A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES549294A0 publication Critical patent/ES549294A0/es
Publication of ES8606359A1 publication Critical patent/ES8606359A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PREPARACION DE ESTERES DE CEFALOSPORINAS DE FORMULA (I) DONDE R1 ES HIDROGENO O ALQUILO DE 1 A 6 ATOMOS DE C Y R2 PUEDE REPRESENTAR: ALQUILO DE 1 A 6 ATOMOS DE C, ARILO, ADAMANTILO O -OR3 DONDE R3 ES ALQUILO DE 1 A 6 ATOMOS DE C. CONSISTE EN LA REACCION DEL COMPUESTO DE CEFALOSPORINA 7B-(2-(2-AMINOTIAZOL-4-IL)-(Z)-2-METOXI-MINOACETAMIDO)-3--((1,2,3-TIADIAZOL-5-IL)-TIOMETIL)CEF-3EM-4-CARBOXILICO CON UN AGENTE ALQUILANTE Y EN PRESENCIA DE UN ACEPTOR DE ACIDO TAL COMO UNA AMINA TERCIARIA. OBTENIENDOSE EL COMPUESTO DE FORMULA (II) DONDE R1 Y R2 TIENE EL SIGNIFICADO ANTERIOR QUE POR REACCION CON EL COMPUESTO DE FORMULA (III) DONDE EL GRUPO AMINA PUEDE ESTAR PROTEGIDO EN PRESENCIA DE DICICLOHEXILCARBODIIMIDA Y 1-HIDROXIBENZOTRIAZOL; SE OBTIENE EL PRODUCTO FINAL.
ES549294A 1984-04-02 1985-11-26 Procedimiento para preparar esteres de cefalosporinas Expired ES8606359A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/595,844 US4914091A (en) 1984-04-02 1984-04-02 Esters of cephalosporin derivitives

Publications (2)

Publication Number Publication Date
ES549294A0 ES549294A0 (es) 1986-05-01
ES8606359A1 true ES8606359A1 (es) 1986-05-01

Family

ID=24384908

Family Applications (2)

Application Number Title Priority Date Filing Date
ES539367A Expired ES8606873A1 (es) 1984-04-02 1985-01-04 Procedimiento para preparar esteres de cefalosporinas
ES549294A Expired ES8606359A1 (es) 1984-04-02 1985-11-26 Procedimiento para preparar esteres de cefalosporinas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES539367A Expired ES8606873A1 (es) 1984-04-02 1985-01-04 Procedimiento para preparar esteres de cefalosporinas

Country Status (15)

Country Link
US (1) US4914091A (es)
EP (1) EP0157000A3 (es)
JP (1) JPS60209589A (es)
KR (1) KR870001007B1 (es)
AU (1) AU571042B2 (es)
DK (1) DK626984A (es)
ES (2) ES8606873A1 (es)
FI (1) FI851306L (es)
HU (1) HU194252B (es)
IL (1) IL73918A0 (es)
NO (1) NO851336L (es)
NZ (1) NZ210761A (es)
PH (1) PH20664A (es)
PT (1) PT80180B (es)
ZA (1) ZA85240B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252473A3 (en) * 1986-07-08 1989-07-05 American Cyanamid Company 7 beta-(substituted) amino-3-substituted cephalosporanic acids and esters
BR112012002780A2 (pt) * 2009-08-10 2017-02-21 Bellus Health Inc métodos, compostos, e composições para a aplicação de ácido 1,3-propanodisulfônico
JP2016517435A (ja) 2013-03-15 2016-06-16 カラ ファーマシューティカルズ インコーポレイテッド メロペネム誘導体及びその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1425933A (en) * 1972-03-13 1976-02-25 Astra Laekemedel Ab Cephalosporins
DE2758000A1 (de) * 1977-12-24 1979-07-05 Hoechst Ag Verfahren zur herstellung von penicillinen und cephalosporinen
DE3020625A1 (de) * 1979-06-01 1980-12-04 Sankyo Co Fuer die orale verabreichung geeignete cephalosporin-derivate
US4399132A (en) * 1980-08-11 1983-08-16 American Cyanamid Company 7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)-acetamido]-3-[(1,2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C1 -C6 alkyl derivatives thereof
IT1142096B (it) * 1980-12-15 1986-10-08 Fujisawa Pharmaceutical Co Derivati dell'acido 7-acilammino cefalosporanico e procedimenti per la loro preparazione
JPS57163386A (en) * 1981-08-13 1982-10-07 Takeda Chem Ind Ltd Cephalosporin derivative and its production
JPS59225191A (ja) * 1983-06-02 1984-12-18 Takeda Chem Ind Ltd 経口用セフアロスポリン誘導体
CA1215354A (en) * 1983-06-02 1986-12-16 Akio Miyake Cephalosporin esters, their production and use

Also Published As

Publication number Publication date
ES8606873A1 (es) 1986-05-16
AU3702184A (en) 1985-10-10
FI851306A0 (fi) 1985-04-01
KR870001007B1 (ko) 1987-05-18
FI851306A7 (fi) 1985-10-03
DK626984A (da) 1985-10-03
PT80180B (en) 1987-02-06
KR850007800A (ko) 1985-12-09
AU571042B2 (en) 1988-03-31
PH20664A (en) 1987-03-23
EP0157000A3 (en) 1986-10-22
NO851336L (no) 1985-10-03
NZ210761A (en) 1988-08-30
ZA85240B (en) 1985-09-25
HUT37436A (en) 1985-12-28
ES549294A0 (es) 1986-05-01
FI851306L (fi) 1985-10-03
DK626984D0 (da) 1984-12-21
EP0157000A2 (en) 1985-10-09
US4914091A (en) 1990-04-03
JPS60209589A (ja) 1985-10-22
HU194252B (en) 1988-01-28
IL73918A0 (en) 1985-03-31
PT80180A (en) 1985-04-01
ES539367A0 (es) 1986-05-16

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