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KR830009046A - 아로일 이미다졸론의 제조방법 - Google Patents

아로일 이미다졸론의 제조방법 Download PDF

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Publication number
KR830009046A
KR830009046A KR1019820000933A KR820000933A KR830009046A KR 830009046 A KR830009046 A KR 830009046A KR 1019820000933 A KR1019820000933 A KR 1019820000933A KR 820000933 A KR820000933 A KR 820000933A KR 830009046 A KR830009046 A KR 830009046A
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South Korea
Prior art keywords
hydrogen
reacted
pyridyl
optionally
compound
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KR1019820000933A
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KR890000765B1 (ko
Inventor
리차드 시 데이지
프랭크 피 팔로폴리
리차드 에이 쉔틀러
제이ㆍ마아틴 그리사
Original Assignee
조세프 지ㆍ템플, 제이 알
메렐 다우 파마슈티칼스 인코포레이티드
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Publication of KR830009046A publication Critical patent/KR830009046A/ko
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Publication of KR890000765B1 publication Critical patent/KR890000765B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Luminescent Compositions (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

내용 없음

Description

아로일 이미다졸론의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 일반식(III)의 아미노케톤을 시아네이트 또는 티오시아네이트염과 반응시키고, 경우에 따라 T가 산소원자인 생성물을 오황화인과 반응시켜 T가 이가의 황원자인 화합물을 수득하고, 경우에 따라 R이 수소인 생성물을 아실 할라이드 또는 알킬화제와 반응시켜 R이 수소 이외의 기인 화합물을 수득하고, 경우에 따라 수득한 생성물을 금속 염기염 또는 무기 또는 유기산과 반응시켜 약제학적으로 허용할 수 있는 염을 생성시킴을 특징으로 하여 일반식(I)의 화합물을 제조하는 방법.
    상기 식에서
    Q 및 T는 각각 산소원자 또는 이가의 황원자이며, R은 수소, 저급알킬, 저급알카노일 또는 벤조일이며, R1은 수소 또는 저급알킬이며, Ar은 임의 치환된 피리딜, 피릴, 티에닐, 푸라닐 또는 임의 치환된 페닐이다.
  2. 일반식(IV)의 이미다졸-2-온을 루이스산 촉매 존재하에서 아로일 할라이드와 반응시키고, 경우에 따라 T가 산소원자인 생성물을 오황화인과 반응시켜 T가 이가의 황원자인 화합물을 수득하고, 경우에 따라 R이 수소인 생성물을 아실 할라이드 또는 알킬화제와 반응시켜 R이 수소 이외의 기인 화합물을 수득하고, 경우에 따라 수득된 화합물을 금속 염기염 또는 무기 또는 유기산과 반응시켜 약제학적으로 허용 할 수 있는 염을 생성시킴을 특징으로 하여 Q가 산소원자인 일반식(I)의 아로일 이미다졸-2-온을 제조하는 방법.
    상기 식에서
    Q는 산소원자이고, T는 산소원자 또는 이가의 황원자이며, R1은 수소, 또는 저급알킬이며, R은 수소, 저급알킬, 저급알카노일 또는 벤조일이며, Ar은 임의 치환된 피리딜, 피릴, 티에닐 푸라닐 또는 임의 치환된 페닐이다.
  3. 제1항 또는 제2항에 있어서, R이 수소이고, Q 및 T가 각각 산소원자인 화합물을 제조하는 방법.
  4. 제3항에 있어서, Ar이 저급알킬, 할로겐 또는 저급알콕시로 임의 치환된 2- 또는 4-피리딜인 화합물을 제조하는 방법.
  5. 제4항에 있어서, R1이 수소, 메틸 또는 에틸인 화합물을 제조하는 방법.
  6. 제3항에 있어서, Ar이 저급알킬, 할로겐 또는 저급알콕시로 임의 치환된 4-피리딜인 화합물을 제조하는 방법.
  7. 제6항에 있어서, R1이 수소, 메틸 또는 에틸인 화합물을 제조하는 방법.
  8. 제7항에 있어서, Ar이 비치환된 4-피리딜인 화합물을 제조하는 방법.
  9. 제1항 또는 제2항에 있어서, Ar이 비치환된 4-피리딜이고 R이 수소이며, R1이 수소인 1,3-디하이드로-4-이소니코티노일-2H-이미다졸-2-온을 제조하는 방법.
  10. 제1항 또는 제2항에 있어서, Ar이 비치환된 4-피리딜이고 R이 수소이며, R1이 메틸인 1,3-디하이드로-4-이소니코노일-5-메틸-2H-이미다졸-2-온을 제조하는 방법.
  11. 제1항 또는 제2항에 있어서, Ar이 비치환된 4-피리딜이고 R이 수소이며, R1이 에틸인 1,3-디하이드로-4-에틸-5-이소니코티노일-2H-이미다졸-2-온을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8200933A 1981-03-05 1982-03-04 아로일이미다졸론 및 그의 제조방법 Expired KR890000765B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24088981A 1981-03-05 1981-03-05
US240889 1981-03-05
US06/314,312 US4405628A (en) 1981-03-05 1981-10-23 4-Pyridylimidazolones and method of use
US314312 1981-10-23

Publications (2)

Publication Number Publication Date
KR830009046A true KR830009046A (ko) 1983-12-17
KR890000765B1 KR890000765B1 (ko) 1989-04-05

Family

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Application Number Title Priority Date Filing Date
KR8200933A Expired KR890000765B1 (ko) 1981-03-05 1982-03-04 아로일이미다졸론 및 그의 제조방법

Country Status (18)

Country Link
US (1) US4405628A (ko)
EP (1) EP0059948B1 (ko)
KR (1) KR890000765B1 (ko)
AT (1) ATE16489T1 (ko)
AU (1) AU557590B2 (ko)
CA (1) CA1190550A (ko)
DE (1) DE3267352D1 (ko)
DK (1) DK168627B1 (ko)
ES (2) ES510087A0 (ko)
GB (1) GB2096600B (ko)
GR (1) GR76518B (ko)
HK (1) HK61686A (ko)
IE (1) IE52387B1 (ko)
IL (1) IL65137A (ko)
MY (1) MY8600700A (ko)
NO (1) NO157175C (ko)
NZ (1) NZ199885A (ko)
PH (1) PH18345A (ko)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367236A (en) * 1981-11-04 1983-01-04 Merrell Dow Pharmaceuticals Inc. Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US4552880A (en) * 1983-02-15 1985-11-12 Merrell Dow Pharmaceuticals Inc. Aroylimidazolones
US4532250A (en) * 1983-11-23 1985-07-30 American Hospital Supply Corporation 5-Heteroarylimidazol-2-ones having cardiotonic activity
US4556665A (en) * 1984-07-09 1985-12-03 Schering A.G. Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones
CA1262732A (en) * 1984-07-30 1989-11-07 Richard A. Schnettler Preparation of 1,3-dihydro-4-pyridoyl-2h-imidazol-2- ones
US4803278A (en) * 1984-07-30 1989-02-07 Merrell Dow Pharmaceuticals, Inc. Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones
ZA881807B (en) * 1987-03-20 1988-09-05 Merrell Dow Pharmaceuticals Inc. Method for reducing reperfusion injury with imidazol-2-thiones
US4999365A (en) * 1987-03-20 1991-03-12 Merrell Dow Pharmaceuticals Inc. Method of reducing reperfusion injury with imidazol-2-thiones
ZA887662B (en) * 1987-10-19 1989-06-28 Merrell Dow Pharma Method for reducing reperfusion injury with imidazol-2-thione-carboxamides
AU8212491A (en) * 1990-06-29 1992-01-23 Upjohn Company, The Substituted 1-(alkoxyphenyl)piperazines with cns and antihypertensive activity
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA3100941C (en) 2011-03-01 2024-03-05 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
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AU2014305843B2 (en) 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441933A (en) * 1945-07-30 1948-05-18 Hoffmann La Roche Substituted imidazolones and process of making them
US3538104A (en) * 1969-02-28 1970-11-03 Geigy Chem Corp Pyridyl-2-imidazolones
ZA803332B (en) * 1979-06-18 1981-01-28 Richardson Merrell Inc Novel 4-aroylimidazol-2-ones
NZ193935A (en) * 1979-06-18 1985-05-31 Richardson Merrell Inc 4-aroyl-imidazol-2-one derivatives;pharmaceutical compositions
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones

Also Published As

Publication number Publication date
DE3267352D1 (en) 1985-12-19
IL65137A0 (en) 1982-05-31
DK95482A (da) 1982-09-06
ES8305352A1 (es) 1983-04-16
AU8103782A (en) 1982-09-09
NZ199885A (en) 1985-04-30
NO157175B (no) 1987-10-26
ES510087A0 (es) 1983-04-16
EP0059948A1 (en) 1982-09-15
ES8402827A1 (es) 1984-03-01
IE820491L (en) 1982-09-05
GR76518B (ko) 1984-08-10
GB2096600A (en) 1982-10-20
DK168627B1 (da) 1994-05-09
AU557590B2 (en) 1986-12-24
MY8600700A (en) 1986-12-31
CA1190550A (en) 1985-07-16
ES519254A0 (es) 1984-03-01
GB2096600B (en) 1985-06-05
IE52387B1 (en) 1987-10-14
ATE16489T1 (de) 1985-11-15
NO157175C (no) 1988-02-03
US4405628A (en) 1983-09-20
IL65137A (en) 1987-02-27
NO820686L (no) 1982-09-06
PH18345A (en) 1985-06-05
KR890000765B1 (ko) 1989-04-05
EP0059948B1 (en) 1985-11-13
HK61686A (en) 1986-08-29

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