JPH0327524B2 - - Google Patents

Description

[Detailed description of the invention]

(Technical Field) The present invention relates to a hair nourishing cosmetic containing a specific thioctic acid compound described below. For more details,
The present invention relates to a hair nourishing cosmetic that activates hair matrix cells and has excellent effects on hair growth, hair nourishment, hair loss prevention, dandruff prevention, etc. (Prior Art) Hair nourishing cosmetics containing various ingredients having a hair matrix activation effect or a blood circulation promoting effect have been proposed. In addition, in recent years, it has become popular to use a brush (patting brush) in conjunction with the application of hair-growth cosmetics to promote blood circulation in the scalp through pine surge or pat-staining, and it is known that the desired hair-growth effect can be achieved. There is. However, it has been difficult to obtain hair-growth cosmetics that are excellent enough to positively promote hair-growth or hair-growth effects. (Disclosure of the Invention) Therefore, as a result of intensive research on ingredients that activate hair matrix cells, the present inventor found that the specific thioctic acid-based compound described below has a hair growth effect (mouse hair growth promoting effect).
It exhibits excellent properties such as hair growth promotion effect (human hair growth promotion effect), hair growth, hair loss prevention, and dandruff prevention effects.Furthermore, by adding and blending ingredients that have a blood circulation promotion effect, hair growth effect, hair growth effect, etc. The present invention was completed based on the discovery that the present invention exhibits remarkable effects. (Objective of the Invention) That is, the object of the present invention is to achieve a hair growth effect (mouse hair growth promoting effect, human hair growth promoting effect), hair growth,
An object of the present invention is to provide a hair nourishing cosmetic that is excellent in effects such as preventing hair loss and preventing dandruff. (Structure of the Invention) The present invention is a hair nourishing cosmetic containing at least one compound represented by the following general formula (hereinafter referred to as a thioctic acid compound for convenience). general formula (In the formula, R is -OH group, -OM group, _-NH2 group, -
OC _o H _2o+1 group or -OC _o H _2o-1 group. However, M is a cation derived from an alkali metal, an alkanolamine, or a basic amino acid. ) (Specific description of the structure) Examples of the thioctic acid-based compounds represented by the above general formula in the present invention include thioctic acid, thioctic acid amide, sodium thioctic acid, potassium thioctic acid, methyl thioctic acid, ethyl thioctic acid, and thioctic acid. Examples include octyl thioctoate, isooctyl thioctoate, hexadecyl thioctoate, stearyl thioctoate, isostearyl thioctoate, oleyl thioctoate, monoethanolamine thioctoate, triethanolamine thioctoate, L-arginine thioctoate, L-lysine thioctoate, etc. It will be done. The above-mentioned thioctic acid compound incorporated into the hair-growth cosmetic of the present invention activates the hair matrix cells of the scalp, exhibits excellent hair-growth effects and hair loss prevention effects, and further normalizes the scalp metabolic function. It can enhance the anti-dandruff effect.
It can be particularly effective when applied to androgenetic alopecia. The blending amount of the thioctic acid compound is 0.05 to 2.0% by weight (hereinafter referred to as
(abbreviated as wt%). If it is less than 0.05wt%, the desired effect of the present invention will not be sufficient;
Even if it exceeds 2.0wt%, it is not possible to expect an improvement in effectiveness commensurate with the increase. Further, it is more preferable that the hair nourishing cosmetic of the present invention contains a component having a blood circulation promoting effect as described above with the above-mentioned essential component. As the blood circulation promoting substance, for example, Japanese cabbage extract, carrot extract, reishi extract, vitamin E nicotinate, benzyl nicotinate, etc. are applied. Among the above ingredients, the methods for producing the natural product extracts, such as Jasperia japonica extract, carrot extract, and Reishi extract, are not specified, but the outline of each production method is described below. [Production method of Swertia Japonica Makino] This is an extract obtained by digesting the dried and crushed whole plant of Swertia Japonica (Swertia Japonica Makino) in the flowering stage in ethanol or aqueous ethanol and filtering it. In the Examples, an extract obtained by the following method was used. After digesting 50 g of pulverized C. asperia in 250 ml of aqueous ethanol (ethanol 90 wt%) at a temperature of 40 to 50° C. and filtering it out, the residue was digested in the same manner several times again to obtain extract 1.5. 100 ml of purified water was added to the residue obtained by concentrating this under reduced pressure, and after aging for one week, the insoluble portion was filtered out and the obtained extract was concentrated under reduced pressure. Then, ethanol was added to make the ethanol content of the extract 40 wt%. The mixture was adjusted as follows to obtain 100 ml of Aspergillus japonica extract. [Production method of carrot extract] Panax ginseng (Panax ginseng CAMeyer)
This is an extract obtained by cold soaking a 5- to 6-year-old dried and crushed root in ethanol or water-containing ethanol and filtering it. In the Examples, an extract obtained by the following method was used. 50g of crushed Panax ginseng was cold soaked in 200ml of aqueous ethanol (90wt% ethanol) for one week, filtered, the ethanol was distilled off from the resulting extract, and purified water was added to reduce the ethanol content of the extract to 50wt.
%, and after ripening in a cold place for 7 to 10 weeks, it was filtered to obtain 100 ml of carrot extract. [Production method of Ganoderma Lucidum] This is an extract obtained by digesting dried crushed Ganoderma Lucidum in ethanol or aqueous ethanol and filtering it. In the examples, an extract obtained by the following method was used. Digest 50 g of dry powder of Reishi mushrooms in 200 ml of aqueous ethanol (90 wt% ethanol) at 50°C for 3 days, filter and concentrate the resulting extract under reduced pressure. Purified water was added to the resulting residue to determine the ethanol concentration. 50wt%
The mixture was filtered and separated to obtain 100 ml of Reishi extract. The amount of these ingredients having a blood circulation promoting effect to be blended into the hair nourishing cosmetic of the present invention is adjusted as appropriate depending on the effect of each ingredient or the dosage form of the hair nourishing cosmetic. Generally, the amounts shown in Table 1 are suitable. Incidentally, the blending amount was based on the total amount of the hair nourishing cosmetic.

[Table] The hair nourishing cosmetic composition of the present invention can be formulated into a hair tonic, hair lotion, hair cream, etc. according to a conventional method. The hair nourishing cosmetic composition of the present invention may contain pigments, fragrances, bactericidal agents, preservatives, keratolytic agents, anti-androgens, hair nourishing agents, antioxidants, etc. as appropriate within the scope of achieving the purpose of the present invention. can. (Examples) Hereinafter, the present invention will be explained in detail based on Examples and Comparative Examples. A mouse hair growth promoting effect test, a human hair growth promoting effect test, and a practical test are shown below. (1) Mouse hair growth promotion effect test ddY white mice (male, 6 weeks old, average weight 35
g) After cutting the dorsal skin from the tail with electric clippers, the hair is completely removed with hair removal cream, and from the next day, each sample of the Example and Comparative Example is applied to the test skin twice a day in the morning and evening, 0.1 ml per animal. Coated. A group of 10 animals was used for each sample. The hair growth effect was determined by comparing the visual evaluation score, hair length, and hair weight with the control group according to the criteria shown in the table below. On the 15th day after the start of the experiment, the animals were sacrificed and evaluated visually according to criteria, and the evaluation scores were totaled to determine the average evaluation score per animal. Furthermore, the skin of the test area was excised, a certain area of skin was punched out with a punch with a diameter of 12 mm, and after drying, the weight of the hair was measured.
We also measured the length of 20 of the hairs,
It is shown as each average value.

[Oily Hair Tonik]

In the following raw material composition, each hair tonic was prepared by blending a thioctic acid compound and a blood circulation promoting ingredient as shown in Table 2, and the various tests described above were conducted. (1) Composition

【table】

[Hair cream]

Each hair cream was prepared in the same manner as in Example 1 and various tests were conducted, and the results are listed in the right column of Table 3. (1) Composition

【table】

[Table] (2) Of the (C) components, thioctic acid salts are blended into the (B) component and the others are blended into the (A) component, and the (A) and (B) components are heated to a temperature of 80℃. After mixing the heated and dissolved materials, cool while stirring until the temperature reaches 50℃ (D)
Each hair cream was prepared by adding the ingredients and continuing stirring until the temperature reached 30°C. (3) Properties As shown in Table 3, the hair creams of Examples 11 to 21, which are hair nourishing cosmetics of the present invention, were found to be superior in various properties compared to Comparative Examples 3 to 4. It was done. In particular, compared to the hair cream containing biotin (hair matrix activation ingredient) and vitamin E nicotinate of Comparative Example 4, which is a conventional technique, the "thioctic acid compound" and "blood circulation promoting ingredient" of Examples 18 to 21 are more effective. ” each at least 1
The hair cream of the present invention, which contains the following, clearly exhibits remarkable effects.

【table】

【table】

[Table] (Effects of the invention) As described above, the present invention activates hair matrix cells to promote hair growth (hair growth effect), and has an excellent hair growth effect as well as an especially excellent hair loss prevention effect and dandruff prevention effect. It is clear that hair nourishing cosmetics are provided.

Claims (1)

[Scope of Claims] 1. A hair nourishing cosmetic containing at least one compound represented by the following general formula. general formula (In the formula, R is -OH group, -OM group, _-NH2 group, -
OC _o H _2o+1 group or -OC _o H _2o-1 group. However, M is a cation derived from an alkali metal, an alkanolamine, or a basic amino acid. ) 2. The hair nourishing cosmetic according to claim 1, which further contains a blood circulation promoting substance. 3. Hair growth according to claim 2, wherein the promoting substance is at least one substance selected from the group consisting of Oriental japonica extract, carrot extract, Reishi extract, vitamin E nicotinate, and benzyl nicotinate. Cosmetics.