JP2774071B2 - Hair restoration cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing cosmetic having an excellent hair-growth effect and an effect of preventing hair loss.

[0002]

2. Description of the Related Art Conventionally, hair restoration cosmetics containing a blood circulation promoting substance such as pepper tincture and nicotinic acid derivatives, and amino acids and vitamins which are nutritional components of hair have been known. Have been.
Further, many medical hair restorers and cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.

[0003] However, conventionally used blood circulation promoting substances are highly irritating to the skin, and the amount thereof is limited,
The disadvantage is that the duration of blood circulation promotion is short. Also,
At a low concentration, the nutritional components of the hair also have a problem that the permeability to the skin is low and the effect is not sufficiently exerted by itself.

[0004] By the way, androgenetic alopecia is said to be one of the causes of the excessive action of male hormones. Phenomena such as poor circulation, decreased activity of hair matrix cells, enlargement of sebaceous glands, fibrosis of the scalp, and the like are considered. It is presumed that it is caused by complicated intertwining.

[0005] However, in order to suppress the decrease in the activity of the hair matrix and the enlargement of the sebaceous glands, which are said to be caused by the excessive action of the male hormone, even if a male hormone agent or the like is simply used as a hair restorer, the hair growth effect is not exhibited. At present. In addition, good results cannot be obtained even when the hair matrix activator or the blood circulation promoter is used alone.

As means for solving the above-mentioned problems, a large number of hair-growth and hair-growing agents have been proposed, including Japanese Patent Application Laid-Open Nos. 5-58850, 5-139336 and 5-170625. However, no remarkable hair-growth effect was found even when a substance that promotes peripheral blood flow and activates hair matrix cells was used alone.

[0007] The present inventors, in view of such circumstances, the substance having a activation action of promoting and Mohaha cells of the scalp in peripheral blood flow, results of extensive studies, assembly extract,
Contains active ingredients such as Korean ginseng extract, Duke extract, Pepper tincture, diisopropylamine dichloroacetate, γ-aminobutyric acid, hinokitiol, vitamin E derivatives, pantothenic acid derivatives, nicotinic acid derivatives, glycyrrhizin derivatives, and hydrogenated bisabolol at the same time Hair nourishing cosmetics, with a synergistic effect, excellent hair nourishing,
The present inventors have found that a hair growth effect is exhibited and completed the present invention.

[0008]

That is, the present invention relates to an assembly extract, a Korean ginseng extract, a Duke extract, a pepper tincture, diisopropylamine dichloroacetate, γ-aminobutyric acid, hinokitiol, a vitamin E derivative, a pantothenic acid derivative, and a nicotinic acid derivative. And one or more components selected from the group consisting of glycyrrhizic acid derivatives;

Embedded image The present invention provides a hair restoration cosmetic comprising the compound represented by the formula (1).

Hereinafter, the configuration of the present invention will be described in detail.

[0010] The assembly extract used in the present invention is an extract obtained by digesting a dried and ground whole plant (Swertia Japonica Makino) of the whole plant at the flowering stage in ethanol or hydrous ethanol and filtering off.

The ginseng extract used in the present invention is 5 to 5 ginseng of Panax ginseng C.A. Meyer.
It is an extract obtained by cold soaking the dried ground pulverized product in ethanol or hydrous ethanol for 6 years and filtering.

The Duke extract used in the present invention is:
It is an extract obtained from the skin of R. domesticum jack barduke or R. domesticum jack barrancer by the method described in JP-A-60-243020.

The pepper tincture used in the present invention,
As diisopropylamine dichloroacetate, γ-aminobutyric acid, and hinokitiol, raw materials used as ordinary cosmetic raw materials can be used.

As the vitamin E derivative used in the present invention, free vitamin E or ester compounds such as vitamin E acetate, vitamin E succinate, vitamin E linoleate and vitamin E orotate can be used as typical substances. Here, vitamin E is α-,
β-, γ-, and δ-tocopherol can be used.

[0015] The pantothenic acid derivatives used in the present invention include free pantothenic acid, pantothenyl alcohol, pantothenyl ethyl ether, acetyl pantothenyl ethyl ether, benzoyl pantothenyl ethyl ether, D-pantetheine, D-pantethine, A series of compounds such as D-pantothenoyl-L-cysteine and di-D-pantothenoyl-L-cysteine are exemplified.

The nicotinic acid derivative used in the present invention is nicotinic acid, nicotinamide or nicotinic acid.
For example, compounds such as nicotinic acid-α-tocopherol, benzyl nicotinate, methyl nicotinate, and ethyl nicotinate can be used as the ester.

As the glycyrrhizic acid derivative used in the present invention, compounds such as glycyrrhizic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, and stearyl glycyrrhetinate can be used.

The hydrogenated bisabolol used in the present invention is represented by the above structural formula 2, and the extraction method and production method are not particularly limited. The compound has stereoisomers, but any one of them or a mixture of two or more thereof may be used. The present compound can be obtained, for example, by converting α-bisabolol to Z.
Natureforsch. , C: Biosci. , 46
(5-6), 349-356 (1991), and can be prepared using the method of Hashidoko et al. The hydrogenated bisabolol used in the present invention is hereinafter referred to as hydrogenated bisabolol.

The amount of the hydrogenated bisabolol used in the present invention is not particularly limited, but is 0.01 to 20% by weight (hereinafter abbreviated as wt%) based on the total amount of the hair growth cosmetic. Is preferred.

The amounts of the assembly extract, Korean ginseng extract and Duke extract used in the present invention are calculated as a dry residue based on the total amount of the hair growth cosmetic.
The content is preferably 0.001 to 10.0 wt%, more preferably 0.01 to 5.0 wt%.

The pepper tincture used in the present invention,
The compounding amount of diisopropylamine dichloroacetate, γ-aminobutyric acid, hinokitiol, vitamin E derivative, pantothenic acid derivative, nicotinic acid derivative, and glycyrrhizic acid derivative is 0.00% based on the total amount of the hair growth cosmetic.
The content is preferably 1 to 5.0 wt%, more preferably 0.01 wt%.
~ 2.0 wt%.

The hair nourishing cosmetic composition of the present invention may be used in accordance with a conventional method, for example, for hair tonic, hair lotion, hair cream, hair conditioner, shampoo, rinse,
It can be manufactured and used in dosage forms such as hair gel, hair mist, and hair foam.

The hair growth cosmetic composition of the present invention is applied or sprayed to a topical area (scalp) for the purpose of hair growth, hair growth and / or hair loss prevention according to the dosage form.

The hair nourishing cosmetic composition of the present invention includes a pigment, a fragrance, a bactericide, a preservative, a keratolytic agent, an antiandrogen,
An antioxidant and the like can be appropriately compounded within a range that achieves the object of the present invention.

[0025]

The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to these examples. The test method used in the present invention is as follows.

(1) Mouse Hair Growth Promotion Effect Test Method The skin at the center of the back of a C3H mouse (male, 8 weeks old, average body weight: 35 g) was cut with an electric clipper, and the hair was completely removed with a shaver. From the next day, each sample of Example and Comparative Example was applied to the skin of the test part once a day, 0.2 ml per animal. A group of 10 animals was used for one sample. The base alone was applied as a control. 14 after the start of the experiment
On the day, the animals were sacrificed and the skin of the test area was photographed. Next, the photograph was taken into an image analyzer, and the area (A) of initial shaving and the area of hair growth (B) were determined. Further, the hair growth rate (%) = [(B) / (A)] × 100 Was calculated for each animal. Finally, the value obtained by dividing the average value of each group of the examples or comparative examples by the average value of the control group was used as a hair growth promoting effect in the determination.

(2) Practical test method Twice in the morning and evening twice a day on the head of 20 male pattern baldness patients
The effect after applying the sample for a month was evaluated. The test results are for hair growth and hair loss prevention.
The number of respondents who answered "the hair has become bristle or has increased bristles" and "the hair loss has decreased" are shown.

(3) Production method of each active ingredient The production methods of the assembly extract, Korean ginseng extract and Duke extract used in the examples are not specified, but the outline of each production method is described below.
As components such as pepper tincture and hinokitiol, those used as ordinary cosmetic raw materials were used as samples.

[Production method of assembly extract] 50 g of milled assembly was added to aqueous ethanol (ethanol 50 wt%) 2
After digestion in 50 ml at a temperature of 40 to 50 ° C., the residue was digested again to obtain 1.5 liter of extract. This was concentrated under reduced pressure, and 100 ml of purified water was added to the residue.
In addition, after aging for one week, the extract obtained by filtering off the insoluble portion was concentrated under reduced pressure, and then ethanol was added to adjust the extract to have an ethanol content of 50% by weight.
ml of assembly extract was obtained.

[Production method of Korean ginseng extract] 50 g of dried ginseng of Panax ginseng in 5 to 6 years was cold-immersed in 200 ml of aqueous ethanol (50 wt% of ethanol) for 1 week, and the ethanol of the extract obtained by filtration was distilled off. Then, purified water was added to adjust the ethanol content of the extract to 50 wt%, and the extract was aged in a cool place for 7 to 10 weeks, and then filtered to obtain 100 ml of a ginseng extract.

[Manufacturing Method of Duke Extract] Duke extract is prepared by crushing 50 g of Randium domesticum jack barduke peel and immersing it in 200 ml of ethanol.
Left at room temperature for a week. Further, the mixture was filtered and concentrated under reduced pressure to obtain 5.2 g of an oily substance.

In the following text, the compounding amount is indicated on the basis of the pure content (converted to the dry residue) of the extract obtained by extraction with the 50% aqueous ethanol solution as described above.

Examples 1 to 13 and Comparative Examples 1 to 13 (Heart Tonic) Hair tonics were prepared by blending active ingredients as shown in Table 2 in the raw material composition shown in Table 1, and the above-mentioned various tests were carried out. . Incidentally,% in the table indicates% by weight.

[0034]

[Table 1]

[0035]

[Table 2]

(1) Preparation Method After dissolving the component (B) shown in Table 1 in the component (A), the component (C) was added, and the mixture was stirred, dispersed and filled into a container. At the time of use, the contents were uniformly shaken and used.

(2) Characteristics Table 2 shows the results of various tests performed on each hair tonic. As shown in Table 2, Comparative Examples 1 to 13 had low mouse hair growth promoting effect and human hair loss improving effect, and the results of practical tests were not good.

On the other hand, the hair restoration cosmetics of the present invention of Examples 1 to 13 show high mouse hair growth promoting effect and human hair loss improving effect, and the results of practical tests are also good. Showed good results. In addition, when using the hair restoration cosmetics of any of the examples, inflammation and other symptoms considered to be side effects do not occur in mice and humans, and it is clear that the hair restoration cosmetics of the present invention are also excellent in safety. Met.

[0039]

EFFECT OF THE INVENTION The hair restoration cosmetic of the present invention has an effect of activating hair matrix cells, and is excellent in hair growth effect, hair loss preventing effect and safety.

──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int. Cl. ⁶ , DB name) A61K 7/00-7/155 CA (STN) REGISTRY (STN) WPIDS (STN)

Claims (1)

(57) [Claims] 1. An assembly extract, a Korean carrot extract,
Duke extract, pepper tincture, diisopropylamine dichloroacetate, γ-aminobutyric acid, hinokitiol, vitamin E derivative, pantothenic acid derivative, nicotinic acid derivative, glycyrrhizic acid derivative and at least one or more components selected from the group consisting of: Formula 1 A hair restoration cosmetic comprising the compound represented by the formula: