JPH0755900B2 - Acne vulgaris remedy - Google Patents

Description

TECHNICAL FIELD The present invention relates to a remedy for acne vulgaris, and more specifically, it quickly wipes into oversecreted sebum and dissolves it, so that it can be wiped with cotton or the like. The present invention relates to a therapeutic agent for acne vulgaris, which can efficiently remove it, kill the causative bacterium without irritating the affected area and the skin around the affected area, and maintain its effect.

[Conventional technology]

Traditionally, the most basic treatment of acne vulgaris (so-called “acne”) has been degreasing and sterilization by washing. Acne generally occurs during puberty, when there is a lot of sebum secretion, and is caused by blebbing and bacterial infection of the sebaceous glands. Bacteria that cause infection are mainly staphylococci, and other bacteria such as bacilli, staphylococci, and viruses are also included. Therefore, it is best to sterilize the causative bacteria by removing excess secreted sebum by frequently washing with soap etc. and then applying a fungicide or a drug containing a sulfa drug. It was a general treatment.

[Problems to be solved by the invention]

Acne usually occurs in the mid-teens to mid-twenties. At this time, most of the day is spent at school or at work, and it is difficult to wash the face frequently. Then, if the drug is applied as it is, this causes the sebaceous glands to be squeezed, thereby exacerbating the infected site. In addition, at this time, I am very sensitive to my appearance, so I have to apply only the drug many times a day,
Frequently touching with the hands often exacerbates the affected area.

On the other hand, conventionally, anti-acne agents are generally defatted with ion, camphor, alcohol, etc., a liquid agent for the purpose of sterilization, and a sulfa agent, a bactericide, a bactericidal agent containing an anti-inflammatory agent, and anti-inflammatory. There is a desired ointment or cream. However, these therapeutic agents are aimed only at eliminating the causes of mottled pimples and acne, and their effects on skin composition are hardly considered. Therefore, if the therapeutic agent is applied many times, the skin around the inflamed papule may be degreased more than necessary, or the normal physiological function may be impaired.

Therefore, the skin can be easily and easily degreased and cleansed anywhere, and it does not irritate the skin around the affected area, retains physiological functions, and has an effective bactericidal effect. A cure for acne was desired.

[Means for solving problems]

Under such circumstances, as a result of intensive studies, the present inventor has found that an oily base having a specific composition mixed with bisabolol satisfies the above object, and completed the present invention.

That is, the present invention provides the following components (a) to (d) (a) 0.025 to 10% by weight of bisabolol as an active ingredient, (b) cyclic silicone or / and liquid isoparaffin having a viscosity of 10 cs at 5 ° C. A therapeutic agent for acne vulgaris, characterized by containing 10 to 70% by weight of the following, (c) 2 to 50% by weight of an oily substance other than (b) component, and (d) 10 to 80% by weight of lower alcohol. Is provided.

Although the bisabolol which is the component (a) of the present invention may be used as such, it may be blended as a bisabolol-containing plant extract. Bisabolol-containing plant extracts are chamomile, poplar and myrocarpus fro
mdosus Fr Allem), Lavender (L. officinalis Chai
x), Hamachi Chinyo (Myoporum Crassifolium Forst)
It can be obtained by extracting the plant with an organic solvent such as ethanol, ether or acetone. Component (a) is bisabolol or a plant extract containing it is 0.025% of the total composition.
.About.10% by weight (hereinafter, simply indicated by%) is preferable.

The component (b) is cyclic silicone or / and liquid isoparaffin having a viscosity of 10 cs or less at 5 ° C., but these have a function of removing sebum, and the compounding amount thereof is 10 to 70. %, Especially 20-60% is preferred.
If it is less than this range, the removal of sebum will be insufficient, and if it is too large, the removal of sebum will be excessive.

Examples of the oily substance as the component (c) include those other than the component (b), such as avocado oil, almond oil, olive oil, hydrogenated olive oil, carrot oil, quincumber oil, quinonine oil, sasanqua oil, camellia oil, sunflower oil, sasan oil. Vegetable oils such as flower oil, jojoba oil, sesame oil, balm oil, cottonseed oil and coconut oil; animal oils such as lanolin, turtle oil, beeswax, mink oil, squalene, squalane and pristane;
Triglycerides such as glycerin tri-2-ethylhexanoate, lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, ricinoleic acid, behenic acid, lanolin fatty acid and other fatty acids, lauryl alcohol, cetanol , 2-
Hexyldecanol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, 2-octyldodecanol, behenyl alcohol, lanolin alcohol, cholesterol, higher alcohols such as phytosterol, diisopropyl adipate, hexyldecyl isostearate, cetyl isooctanoate, oleic acid. Oleyl, decyl oleate, lanolin acetate, hexyldecyl dimethyloctanoate, butyl stearate, diisopropyl sebacate, trioleyl phosphate, cetyl lactate, myristyl lactate, isopropyl palmitate, isopropyl myristate, diethyl phthalate, octyldodecyl myristate. , Esters such as myristyl myristate, hexyl laurate, liquid polyisobutylene, α-olefin Goma, squalane, synthetic oils, such as hydrocarbons such as ceresin. These oily substances are for preventing excessive sebum removal by volatile oil and imparting appropriate oiliness to the skin, and the compounding amount thereof is preferably 2 to 50%, particularly preferably 5 to 30%.

As the lower alcohol as the component (d), for example, ethanol, isopropanol or the like is used. This lower alcohol is added to improve the compatibility of the volatile component of the component (b) and the oily substance of the component (c), and the blending amount is preferably 10 to 80%, particularly 10 to 60%. .

If an antibacterial substance other than (a) is further added to the above essential components (a) to (d), a more effective therapeutic effect can be obtained. Examples of the antibacterial substance include chlorxylenol, benzethonium chloride, isopropylmethylphenol, thymol, resorcin, lysozyme chloride, chlorhexidine gluconate, orthophenylphenol, sorbic acid, dehydroacetic acid, sodium hypochlorite, iodine, iodotinki, Povidone iodine, boric acid, borax, oxidol, potassium permanganate, formalin, phenol, hexachlorophene, creosote, methylrosarinine chloride, benzalkonium chloride, sodium lauryl sulfate, urea, alkylpolyaminoethylglycine chloride,
Ictamol etc. are mentioned. These antibacterial substances are
In such a case 1/10 to 1/20 of the standard blending amount that is blended alone
00 gives a sufficient effect.

In addition, the therapeutic agent for acne vulgaris of the present invention, if necessary,
Other anti-inflammatory agents, vitamins, antioxidants, wetting agents, astringents, antihistamines, antibiotics, sulfa agents, fragrances, coloring agents and the like can also be added.

When the therapeutic agent of the present invention is prepared to have a viscosity of 30 cs or less (5 ° C.), the sebum can be more easily removed and the stickiness is reduced, which is more preferable.

It is preferable that the therapeutic agent be filled in a spray, a squeeze bottle, or the like to have a convenient form for carrying.

[Action and effect]

The therapeutic agent for acne vulgaris of the present invention has the following actions and effects.

The low-viscosity oily base well dissolves sebum that is excessively secreted into the skin, so that sebum can be easily removed by simply wiping the skin surface with cotton or the like.

The low-viscosity oily base reduces mechanical friction between the cotton swab and the like and the skin surface, and thus does not damage the skin.

Since the volatile main base [component (b)] and the lower alcohol volatilize and do not remain after application, the effect is increased due to a high drug concentration on the skin surface.

The remaining components are covered with a thin oily film, so the effect continues.

Acne is effectively treated by the antibacterial, anti-inflammatory and anti-ulcer effects of bisabolol.

〔Example〕

 Next, examples will be described.

Example 1 (i) Preparation of Inventive Product 1 Oil-soluble chamomile extract (bisabolol about 5 mg / g) 5 g Chlorxylenol 0.005 g Torre silicone SH334 (cyclic silicone oil) 50 g Idemitsu IP solvent (fluid isoparaffin) 10 g avocado Oil 5 g Ethanol Residue (total 100 g) At room temperature, and are mixed, and while stirring and adding, and after stirring for 2 hours, is added and viscosity is 3cs (5 ° C)
I got acne remedy.

(Ii) Use test of the product 1 of the present invention Nine patients with acne vulgaris were allowed to use the product 1 of the present invention, and the effect (therapeutic effect on acne) was examined.

Results: Very effective 3 people Effective 4 people and effective 2 people Comparative Example 1 A comparative product 1 having the following composition was prepared and used by 9 patients same as Example 1 (ii), and its use effect ( The bulkiness of the face and the therapeutic effect) were examined.

Comparative product 1: Sulfur-canful lotion Sulfur 60g Camphor 5g Gum arabic powder 30g Calcium hydroxide 1g Fragrance A suitable amount of water residue (100g) Result: Inventive product 1 is very good 2 Inventive product 1 is good 5 Equally two people Comparative Example 2 (i) Preparation of Comparative Product 2 Chlorxylenol 0.01 g Torre Silicone SH344 50 g Idemitsu IP Solvent 15 g Avocado Oil 5 g Ethanol Residue (100 g) At room temperature, and were mixed with It was added with stirring and after stirring for 2 hours, was added to obtain a therapeutic agent for acne.

(Ii) Irritation test of comparative product 2 In the same manner as (ii) of Example 1, the irritation property (itch, tingling sensation) of comparative product 2 was examined.

Results: 5 people who feel 4 people who do not feel (iii) Comparison test with product 1 of the present invention The same test as in Comparative Example 1 was carried out.

Result: Inventive product 1 is very good 8 people Inventive product 1 is good 1 person Comparative Example 3 (i) Preparation of comparative product 3 Bisabolol 0.3 g, avocado oil 50 g, and ethanol 49.7 g were stirred at room temperature for 2 hours. Prepared.

(Ii) Usability test of comparative product 3 The usability (greasiness) was examined in the same manner as in (ii) of Example 1.

Results: 8 people who feel 1 person who does not feel (iii) Comparison test with product 1 of the present invention The same test as in Comparative Example 1 was carried out.

Result: The product of the present invention 1 is very good. 9 persons

Claims (2)

[Claims] 1. The following components (a) to (d), (a) 0.025 to 10% by weight of bisabolol as an active ingredient, (b) Cyclic silicone or / and liquid isoparaffin having a viscosity of 10 cs at 5 ° C. A therapeutic agent for acne vulgaris, characterized by containing 10 to 70% by weight, (c) 2 to 50% by weight of an oily substance other than (b) component, and (d) 10 to 80% by weight of lower alcohol. . 2. The therapeutic agent for acne vulgaris according to claim 1, which has a viscosity at 5 ° C. of 30 cs or less.