JPH06157248A - Hair tonic - Google Patents
Hair tonicInfo
- Publication number
- JPH06157248A JPH06157248A JP33248392A JP33248392A JPH06157248A JP H06157248 A JPH06157248 A JP H06157248A JP 33248392 A JP33248392 A JP 33248392A JP 33248392 A JP33248392 A JP 33248392A JP H06157248 A JPH06157248 A JP H06157248A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- dantrolene
- hair tonic
- effect
- blended
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000001256 tonic effect Effects 0.000 title abstract description 11
- OZOMQRBLCMDCEG-CHHVJCJISA-N 1-[(z)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione Chemical compound C1=CC([N+](=O)[O-])=CC=C1C(O1)=CC=C1\C=N/N1C(=O)NC(=O)C1 OZOMQRBLCMDCEG-CHHVJCJISA-N 0.000 claims abstract description 25
- 229960001987 dantrolene Drugs 0.000 claims abstract description 25
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 14
- 230000003779 hair growth Effects 0.000 abstract description 12
- 238000007796 conventional method Methods 0.000 abstract description 7
- 239000000654 additive Substances 0.000 abstract description 3
- 239000006071 cream Substances 0.000 abstract description 3
- 239000006210 lotion Substances 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 210000004761 scalp Anatomy 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 239000002674 ointment Substances 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract description 2
- 230000035617 depilation Effects 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 11
- 201000004384 Alopecia Diseases 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 8
- 230000003676 hair loss Effects 0.000 description 7
- 208000024963 hair loss Diseases 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical group CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 4
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- -1 milky Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000003405 preventing effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000003158 myorelaxant agent Substances 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 235000015961 tonic Nutrition 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 230000003658 preventing hair loss Effects 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000012679 serum free medium Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 229960000716 tonics Drugs 0.000 description 2
- 229930007845 β-thujaplicin Natural products 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 239000004358 Butane-1, 3-diol Substances 0.000 description 1
- 238000011735 C3H mouse Methods 0.000 description 1
- VQAWRQZAAIQXHM-UHFFFAOYSA-N Cepharanthine Natural products O1C(C=C2)=CC=C2CC(C=23)N(C)CCC3=CC=3OCOC=3C=2OC(=CC=23)C(OC)=CC=2CCN(C)C3CC2=CC=C(O)C1=C2 VQAWRQZAAIQXHM-UHFFFAOYSA-N 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 241001248610 Ophiocordyceps sinensis Species 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical class CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000002280 anti-androgenic effect Effects 0.000 description 1
- 239000000051 antiandrogen Substances 0.000 description 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- JFIOVJDNOJYLKP-UHFFFAOYSA-N bithionol Chemical compound OC1=C(Cl)C=C(Cl)C=C1SC1=CC(Cl)=CC(Cl)=C1O JFIOVJDNOJYLKP-UHFFFAOYSA-N 0.000 description 1
- 229960002326 bithionol Drugs 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 229940007061 capsicum extract Drugs 0.000 description 1
- 239000001943 capsicum frutescens fruit extract Substances 0.000 description 1
- RZMKWKZIJJNSLQ-UHFFFAOYSA-M carpronium chloride Chemical compound [Cl-].COC(=O)CCC[N+](C)(C)C RZMKWKZIJJNSLQ-UHFFFAOYSA-M 0.000 description 1
- 229950003631 carpronium chloride Drugs 0.000 description 1
- YVPXVXANRNDGTA-WDYNHAJCSA-N cepharanthine Chemical compound C1C(C=C2)=CC=C2OC(=C2)C(OC)=CC=C2C[C@H](C2=C3)N(C)CCC2=CC(OC)=C3OC2=C(OCO3)C3=CC3=C2[C@H]1N(C)CC3 YVPXVXANRNDGTA-WDYNHAJCSA-N 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 229960004042 diazoxide Drugs 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 230000003659 hair regrowth Effects 0.000 description 1
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
- 229960004068 hexachlorophene Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229960003742 phenol Drugs 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は養毛剤、さらに詳しく
は、医薬品、医薬部外品あるは化粧品分野において利用
される優れた脱毛防止、発毛効果等の養毛作用を持つ養
毛剤に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing agent, and more particularly to a hair nourishing agent which is used in the fields of pharmaceuticals, quasi-drugs and cosmetics and has excellent hair-preventing action such as hair loss prevention and hair growth effect.
【０００２】[0002]
【従来の技術・発明が解決しようとする課題】従来よ
り、禿や脱毛の原因を取り除く、あるいは、軽減するた
めに、各種薬剤を配合した養毛化粧料が知られている。
例えば、毛根への血流量の改善を目的とするセンブリエ
キスやアセチルコリン誘導体など、抗男性ホルモンとし
てエストラジオールなどの女性ホルモン剤、頭皮代謝の
改善を目的とするヒノキチオールなどを養毛成分として
配合された養毛化粧料が、脱毛症の予防および治療に用
いられている。しかし、脱毛や発毛の機構は非常に複雑
であり、従来の養毛化粧料のように、血行促進や男性ホ
ルモンの低活性化のために、センブリエキス等を配合す
るだけでは満足する脱毛防止や発毛効果は得られていな
いのが現状である。2. Description of the Related Art Conventionally, hair nourishing cosmetics containing various chemicals have been known in order to remove or reduce the causes of baldness and hair loss.
For example, the herbaceous extract and acetylcholine derivative for the purpose of improving the blood flow to the hair root, female hormone agents such as estradiol as an anti-male hormone, and hinokitiol for the purpose of improving scalp metabolism have been added as hair nourishing ingredients. Hair cosmetics are used for the prevention and treatment of alopecia. However, the mechanism of hair loss and hair growth is very complicated, and just as with conventional hair nourishing cosmetics, it is sufficient to prevent the hair loss by only combining Sengburi extract, etc. for promoting blood circulation and deactivating male hormones. The current situation is that the hair growth effect is not obtained.
【０００３】一方、式（Ｉ）で表されるダントロレンは
末梢性筋弛緩剤として用いられているが（Yano E. et a
l. Masui to Sosei 27, Suppl. 25: 113-118(1991)、Dh
illon D.S.et al. Drug Dev Res 25, 2: 161-169(199
2)）、その養毛作用については未だ全く報告されていな
い。On the other hand, the dantrolene represented by the formula (I) is used as a peripheral muscle relaxant (Yano E. et a
l. Masui to Sosei 27, Suppl. 25: 113-118 (1991), Dh
illon DSet al. Drug Dev Res 25, 2: 161-169 (199
2)), its hair nourishing effect has not been reported yet.
【０００４】[0004]
【化２】 [Chemical 2]
【０００５】本発明の目的は、新規な養毛成分を配合す
ることにより、脱毛防止効果および発毛促進効果を充分
に発揮し得る養毛剤を提供することにある。An object of the present invention is to provide a hair nourishing agent capable of sufficiently exhibiting a hair loss preventing effect and a hair growth promoting effect by incorporating a novel hair nourishing component.
【０００６】[0006]
【課題を解決するための手段】本発明は、前記課題を解
決すべく鋭意研究を重ねた結果、従来は末梢性筋弛緩剤
として用いられているダントロレンを養毛成分として配
合することにより、脱毛防止効果および発毛促進効果が
得られることを見いだし、本発明を完成するに至った。Means for Solving the Problems As a result of intensive studies to solve the above problems, the present invention removes hair by incorporating dantrolene, which has been conventionally used as a peripheral muscle relaxant, as a hair-feeding component. It was found that an effect of preventing the hair growth and an effect of promoting hair growth were obtained, and the present invention was completed.
【０００７】すなわち、本発明の要旨は、式（Ｉ）：That is, the gist of the present invention is the formula (I):
【０００８】[0008]
【化３】 [Chemical 3]
【０００９】で示されるダントロレンを有効成分として
含有することを特徴とする養毛剤を提供するものであ
る。The present invention provides a hair nourishing agent characterized by containing dantrolene as an active ingredient.
【００１０】本発明で用いるダントロレンは前記のよう
に末梢性筋弛緩剤として公知の物質であり、商業上容易
に入手可能である（例えば、シグマ社製）。また、公知
の方法により容易に合成することができる（Ellis K.O.
et al., J. Pharm. Sci., 69, 3, 327-331,(1980)) 。
本発明においてダントロレンの配合量は養毛剤全量に対
し、通常 O.OOO1 〜1O重量％程度、好ましくは、O.OO1
〜5 重量％である。かかる配合量が O.OOO1 重量％より
少ないと脱毛防止効果および発毛促進効果が充分でな
く、また、1O重量％を超えて配合しても、その配合量に
見合うだけの効果が得られず、また養毛剤としての安定
性に問題を示すようになる。The dantrolene used in the present invention is a substance known as a peripheral muscle relaxant as described above, and is easily commercially available (for example, manufactured by Sigma). In addition, it can be easily synthesized by a known method (Ellis KO
et al., J. Pharm. Sci., 69, 3, 327-331, (1980)).
In the present invention, the compounding amount of dantrolene is usually about O.OOO1 to 1O% by weight, preferably about O.OO1 based on the total amount of the hair restorer.
~ 5% by weight. If the blending amount is less than O.OOO1% by weight, the hair loss preventing effect and the hair growth promoting effect are not sufficient, and even if the blending amount exceeds 1O% by weight, the effect corresponding to the blending amount cannot be obtained. Moreover, the stability of the hair nourishing agent becomes problematic.
【００１１】本発明の養毛剤において、有効成分である
ダントロレンのほか、発毛および養毛促進効果を高める
ために、他の成分としてミノキシジル、ジアゾキシド、
各種抗男性ホルモン剤、例えば、オキセンドロン、４−
アンドロステン−３，１７−ジオン−１７−サイクリッ
クエチレンケタール誘導体など、ニコチン酸及びその誘
導体、塩化カルブロニウム、ビタミンＥアセテート、ビ
タミンＥニコチネート、パントテン酸及びその誘導体、
ビオチン、グリチルリチン酸、グリチルレチン酸、冬虫
夏草エキス、朝鮮ニンジンエキス、センブリエキス、ト
ウガラシエキス、セファランチン、プラセンタエキス、
エチニルエストラジオール、塩化カルプロニウム、感光
素、その他ビタミン類及びアミノ酸などを本発明の効果
を増大させる目的で、同時に適宜選択し配合することが
できる。In the hair nourishing agent of the present invention, in addition to dantrolene, which is an active ingredient, minoxidil, diazoxide, and
Various antiandrogens, such as oxendron, 4-
Androstene-3,17-dione-17-cyclic ethylene ketal derivatives such as nicotinic acid and its derivatives, carbronium chloride, vitamin E acetate, vitamin E nicotinate, pantothenic acid and its derivatives,
Biotin, glycyrrhizinic acid, glycyrrhetinic acid, Cordyceps sinensis extract, Korean ginseng extract, assembly extract, capsicum extract, cepharanthin, placenta extract,
For the purpose of increasing the effect of the present invention, ethinyl estradiol, carpronium chloride, photosensitizer, other vitamins, amino acids and the like can be appropriately selected and mixed at the same time.
【００１２】更に、本発明の養毛剤において、通常養毛
化粧料に用いられる添加剤、例えば、ヒノキチオール、
ヘキサクロロフェン、フェノール、ベンザルコニウムク
ロリド、セチルピリジニウムクロリド、ウンデシレン
酸、トリクロロカルバニリド及びビチオノールなどの抗
菌剤、メントールなどの清涼剤、サリチル酸、亜鉛及び
その誘導体、乳酸及びそのアルキルエステルなどの薬
剤、オリーブ油、スクワラン、流動パラフィン、イソプ
ロピルミリステート、高級脂肪酸、高級アルコールなど
の油分、その他界面活性剤、香料、酸化防止剤、紫外線
吸収剤、色素、エタノール、水、保湿剤、増粘剤などを
本発明の効果を損なわない範囲で適宜選択し配合するこ
とができる。Further, in the hair nourishing agent of the present invention, additives usually used in hair nourishing cosmetics, such as hinokitiol,
Hexachlorophene, phenol, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, antibacterial agents such as trichlorocarbanilide and bithionol, cooling agents such as menthol, salicylic acid, zinc and its derivatives, drugs such as lactic acid and its alkyl esters, Oil oil such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, higher alcohols, other surfactants, fragrances, antioxidants, UV absorbers, pigments, ethanol, water, moisturizers, thickeners, etc. It can be appropriately selected and blended within a range that does not impair the effects of the invention.
【００１３】本発明の養毛剤は公知の方法に従って製造
することができる。即ち、ダントロレンは通常粉末状で
あるため、エタノール等に溶解させ、所定の濃度になる
ように調整し、必要に応じてその他前記の有効成分や添
加剤等と共に配合した後、常法に従った処理をすること
により、液状、乳状、軟膏など頭皮に適用しうるいずれ
の形状、例えば、ヘアトニック、ローション、ヘアクリ
ーム等として調製することができる。得られた養毛剤は
常法に従い、適当量が適宜使用されることにより、脱毛
防止効果および発毛促進効果が達成される。The hair nourishing agent of the present invention can be produced by a known method. That is, since dantrolene is usually in the form of powder, it is dissolved in ethanol or the like, adjusted to have a predetermined concentration, and optionally blended with the above-mentioned other active ingredients, additives, etc., and then according to a conventional method. By treatment, it can be prepared in any shape applicable to the scalp, such as liquid, milky, ointment, etc., for example, hair tonic, lotion, hair cream and the like. The obtained hair nourishing agent achieves the hair loss preventing effect and the hair growth promoting effect by appropriately using an appropriate amount according to a conventional method.
【００１４】[0014]
【実施例】以下、実施例および試験例により本発明をさ
らに詳しく説明するが、本発明はこれらの実施例等によ
りなんら限定されるものではない。 試験例１ 培養毛母細胞の増殖に対する試験 マウスの毛組織を採取し、無血清培地で３７℃、５％Ｃ
Ｏ2 の条件の下、６日間毛母細胞を培養した（Tanigaki
N. et al. Arch Dermatol Res 282:4O2-4O7(199O)）。
シグマ社より入手したダントロレンを培地に溶解した際
に10-9〜1O-4 Mの濃度になるように調整し、培養開始１
日目に各培地にダントロレンを添加した。尚、対照群に
はダントロレンを添加せずに無血清培地のみで培養を行
なった。６日間培養した後、細胞をシャーレより剥離
し、細胞数を求めた。ダントロレンの効果は、対照群の
細胞数を 1OO% とした場合の相対的割合で表した。その
結果を表１に示す。EXAMPLES The present invention will be described in more detail with reference to Examples and Test Examples, but the present invention is not limited to these Examples. Test Example 1 Test for Proliferation of Cultured Hair Mother Cells Hair tissues of a mouse were collected and incubated in serum-free medium at 37 ° C., 5% C
Hair mother cells were cultured for 6 days under O 2 condition (Tanigaki
N. et al. Arch Dermatol Res 282: 4O2-4O7 (199O)).
Dantrolene obtained from Sigma was adjusted to a concentration of 10 -9 to 10 -4 M when dissolved in the medium, and the culture was started 1.
Dantrolene was added to each medium on the day. The control group was cultured only in serum-free medium without adding dantrolene. After culturing for 6 days, the cells were detached from the dish and the number of cells was determined. The effect of dantrolene was expressed as a relative ratio when the number of cells in the control group was 100%. The results are shown in Table 1.
【００１５】[0015]
【表１】 [Table 1]
【００１６】表１より明らかなように、ダントロレンは
培養毛母細胞の増殖促進効果を示し、特に培地中のダン
トロレンの濃度が1O-6 Mおよび1O-7 Mであるときに、著
しい増殖促進効果を示した。As is clear from Table 1, dantrolene exhibits a growth promoting effect on cultured hair mother cells, and particularly when the concentration of dantrolene in the medium is 1 O -6 M and 1 O -7 M, a remarkable growth promoting effect. showed that.
【００１７】試験例２ Ｃ３Ｈマウスによる発毛促進試験 シグマ社より入手したダントロレンをエタノールに溶解
して１重量％の濃度になるように調製した。Ｃ３Ｈ雄性
マウス（８週令）の背部を約２×４ cm の大きさに刈毛
後、翌日より前記溶液を１日、１回、１５日間刈毛部に
O.1 ml ずつ塗布し、その部位の毛の再生に及ぼす影響
を検討した。尚、対照群にはダントロレンを含有しない
エタノールを塗布した。ダントロレンの効果は、対照群
（エタノール塗布群）の毛重量を 1OO %とした場合の相
対的割合で表した。その結果を表２に示す。Test Example 2 Hair Growth Acceleration Test Using C3H Mice Dantrolene obtained from Sigma was dissolved in ethanol to prepare a concentration of 1% by weight. The back of a C3H male mouse (8 weeks old) was shaved to a size of about 2 × 4 cm, and the solution was applied to the shaved portion once a day for 15 days from the next day.
O. 1 ml of each was applied, and the effect on hair regrowth at that site was examined. In addition, ethanol containing no dantrolene was applied to the control group. The effect of dantrolene was expressed as a relative ratio when the hair weight of the control group (ethanol application group) was 100%. The results are shown in Table 2.
【００１８】[0018]
【表２】 [Table 2]
【００１９】表２より明らかなように、ダントロレンは
対照群に比べて顕著な発毛促進効果を示した。As is clear from Table 2, dantrolene showed a remarkable hair growth promoting effect as compared with the control group.
【００２０】実施例１ 下記の処方により各成分を混合して、常法によりヘアト
ニックを製造した。 〔成 分〕 〔配合量（W/V ％）〕 ダントロレン ０．０３ 95 % エタノール ７０ ポリオキシエチレン 硬化ヒマシ油［6OE.O.］ １ プロピレングリコール ５ 香料 微量 水 残部（１００に調整）Example 1 Hair tonics were produced by a conventional method by mixing the components according to the following formulation. [Components] [Blended amount (W / V%)] Dantrolene 0.03 95% Ethanol 70 Polyoxyethylene hydrogenated castor oil [6OE.O.] 1 Propylene glycol 5 Perfume Trace water balance (Adjust to 100)
【００２１】実施例２ 下記の処方により各成分を混合して、常法によりローシ
ョンを製造した。 〔成 分〕 〔配合量（W/V ％）〕 ヒドロキシエチルセルロース ０．４ エタノール ５ ブタン−1,3 −ジオール ５ パラオキシ安息香酸エステル ０．２ ダントロレン ０．０５ 香料 １ 水 残部（１００に調整）Example 2 A lotion was produced by a conventional method by mixing the components according to the following formulation. [Components] [Blending amount (W / V%)] Hydroxyethyl cellulose 0.4 Ethanol 5 Butane-1,3-diol 5 Paraoxybenzoic acid ester 0.2 Dantrolene 0.05 Perfume 1 Water balance (adjusted to 100)
【００２２】実施例３ 下記の処方により各成分を混合して、常法によりヘアク
リームを製造した。 〔成 分〕 〔配合量（W/V ％）〕 ミツロウ ５ ラノリン ４ ワセリン ５ 流動パラフィン ３３ ポリオキシエチレン 2OE.O. ４ ソルビタンモノステアレート パラオキシ安息香酸エステル ０．２ 香料 微量 ダントロレン ０．１ ホウ砂 １ 水 残部（１００に調整）Example 3 A hair cream was produced by a conventional method by mixing the components according to the following formulation. [Components] [Amount (W / V%)] Beeswax 5 Lanolin 4 Vaseline 5 Liquid paraffin 33 Polyoxyethylene 2OE.O. 4 Sorbitan monostearate paraoxybenzoate 0.2 Perfume Trace amount dantrolene 0.1 Borax 1 water balance (adjusted to 100)
【００２３】実施例４ 下記の処方により各成分を混合して、常法によりヘアト
ニックを製造した。 〔成 分〕 〔配合量（W/V ％）〕 ポリオキシエチレン 硬化ヒマシ油［6OE.O.］ １ プロピレングリコール ５ 香料 微量 ダントロレン ３ ９５％エタノール ６０ 水 残部（１００に調整）Example 4 Hair tonics were produced by a conventional method by mixing the components according to the following formulation. [Components] [Blended amount (W / V%)] Polyoxyethylene hydrogenated castor oil [6OE.O.] 1 Propylene glycol 5 Perfume Trace amount dantrolene 3 95% Ethanol 60 Water balance (adjusted to 100)
【００２４】[0024]
【発明の効果】本発明の養毛剤は強力な養毛作用を有
し、脱毛防止および発毛促進などの効果を有意に発揮す
ることができる。EFFECTS OF THE INVENTION The hair nourishing agent of the present invention has a strong hair nourishing action and can significantly exhibit effects such as hair loss prevention and hair growth promotion.
Claims (1)
を特徴とする養毛剤。1. Formula (I): A hair nourishing agent containing dantrolene represented by the formula (1) as an active ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33248392A JPH06157248A (en) | 1992-11-17 | 1992-11-17 | Hair tonic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33248392A JPH06157248A (en) | 1992-11-17 | 1992-11-17 | Hair tonic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH06157248A true JPH06157248A (en) | 1994-06-03 |
Family
ID=18255464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP33248392A Withdrawn JPH06157248A (en) | 1992-11-17 | 1992-11-17 | Hair tonic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH06157248A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007308403A (en) * | 2006-05-17 | 2007-11-29 | Kenji Yoshida | Skin care preparation |
-
1992
- 1992-11-17 JP JP33248392A patent/JPH06157248A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007308403A (en) * | 2006-05-17 | 2007-11-29 | Kenji Yoshida | Skin care preparation |
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