JP2001131025A - Cosmetic for scalp and hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cosmetic which is used for scalp and hair, can persistently stimulate the activity of tyrosinase playing a fundamental role on the production of melamine in the hair and thereby has excellent effects for inhibiting the generation of gray hair and improving the gray hair. SOLUTION: This cosmetic for scalp and hair, characterized by containing (a) a tyrosinase activity-stimulating agent and (b) an antibacterial agent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a cosmetic for scalp hair. More specifically, a tyrosinase activity promoter,
The present invention relates to a scalp and hair cosmetic composition containing an antibacterial agent and useful for improving gray hair.

[0002]

2. Description of the Related Art Tyrosinase is an essential enzyme in human skin for biosynthesizing melanin from tyrosine. It is known that this tyrosinase is deeply involved in the formation of "spots" and "freckles", which are phenomena caused by excessive exposure to sunlight or ultraviolet rays at sites such as the face and arms.

[0003] In addition, it has been revealed that this tyrosinase is deeply involved in the blackening of the scalp (darkening of the hair) in the scalp, and it has been revealed that the decrease in tyrosinase activity in the scalp is one of the causes of the graying of the hair. I have.

[0004] Attempts have been made to promote the activity of tyrosinase to suppress the generation of gray hair or to improve it.
No. 222, Japanese Unexamined Patent Publication No. 7-285874 and Japanese Unexamined Patent Publication No. 7-316026, and Japanese Unexamined Patent Publication No. 7-11 which has both effects of hair growth and white hair prevention.
The inventions described in JP-A-2978 and JP-A-7-126129 have been proposed.

[0005]

However, in the conventionally proposed invention, blackening can be expected due to a high tyrosinase activity promoting effect, but the effect is inferior in persistence. There has been a problem that sufficient effects have not been obtained that can be recognized as suppressing or improving gray hair.

[0006] Further, even in the invention having both the hair-growth effect and the gray-hair-preventing effect, it is not always possible to obtain the same effect as a method of removing the white hair and making it inconspicuous and expected to grow into black hair. It was not effective in improving the quality.

The present inventor has conducted intensive studies in view of the above viewpoints. As a result, when a tyrosinase activity promoter is used in combination with an antibacterial agent, the continuity of the effect of the tyrosinase activity promoter is improved, and the prevention of gray hair development and gray hair The present inventors have found that a cosmetic for scalp hair having an excellent improvement effect can be obtained, and have completed the present invention.

[0008] An object of the present invention is to provide a scalp and hair for hair which is excellent in suppressing the generation of gray hair and improving gray hair by continuously promoting the activity of tyrosinase which plays a fundamental role in melanin production in hair. To provide cosmetics.

[0009]

That is, the present invention provides:
An object of the present invention is to provide a cosmetic for scalp and hair, comprising (a) a tyrosinase activity promoter and (b) an antibacterial agent.

[0010] In the present invention, the (a) tyrosinase activity promoter is a group consisting of salamander extract, cayulape, guacomist, pinica (Pinguica), alitasou (Epazote), zapote (Zapote), and Axcopaque. And a solvent extract of one or more plants selected from the group consisting of scalp and hair.

Further, the present invention provides the antibacterial agent (b),
Hexachlorophen, benzalkonium chloride, undecylenic acid, trichlorocarbanilide, bitionol,
Benzalkonium chloride, isopropylmethylphenol, resorcinol, zinc pyrithione, Photosensitizer No. 101,
Photosensitizer 201, salicylic acid, sodium salicylate,
One or more compounds selected from the group consisting of octopirox and hinokitiol; or an amateur,
Solvent extract of one or more plants selected from the group consisting of Agetsu, Oubak, Ouren, Kaika, Kagosou, Karin, Kujin, Gomeshi, Peonies, Bowwort, Buttonpi, Jiyu It is intended to provide the scalp hair cosmetic.

Further, the present invention provides the scalp, wherein the content of the (a) tyrosinase activity promoter is 0.0001 to 10.0% by weight based on the total amount of the scalp hair cosmetic. A cosmetic for hair is provided.

Further, in the present invention, the content of the antibacterial agent (b) is 0.001 to 5 with respect to the total amount of the scalp hair cosmetic.
The above-mentioned cosmetic for scalp hair is provided by weight.

Further, the present invention provides the scalp hair cosmetic, wherein the scalp hair cosmetic is an anti-grey hair cosmetic.

[0015]

Embodiments of the present invention will be described below.

The tyrosinase activity promoter (a) incorporated in the cosmetic for scalp and hair of the present invention comprises:
Kayurape, Guacomist, Pinguic
a), Aritasou (Epazote), Zapote (Zap)
ote) and one or more tyrosinase activity promoters selected from the group consisting of Axcopaque.

Particularly preferred is a salmon extract. The salamander is a salamander (Zanthoxylum piperitum (L.) DC) belonging to the genus Salamander, and it is possible to use an extract obtained by extracting a fruit (pericarp), a flower, a leaf, a bark or the like as a raw material. In particular, it is preferable to blend the extract from the fruit (peel) into the cosmetic for scalp hair.

The salamander extract is extracted by an extraction method generally used in extracting a plant-derived extract. That is, an extract (plant extract) can be obtained by subjecting the above-mentioned raw materials as they are or after drying them as necessary, and then subjecting them to solvent extraction as they are or pulverized.

The extraction solvent can be selected from those generally used when extracting its components from plants, and is not particularly limited. For example, hot water or water; lower alcohols such as ethanol, isopropyl alcohol and n-butanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrates of these alcohols; Hydrogen-based solvents and the like can be mentioned, but when a lower alcohol such as ethanol is used as the extraction solvent, the obtained extract can be directly blended into the cosmetic for scalp and hair, but the extraction solvent is once distilled off. It is also possible to mix after drying if necessary.

A commercially available sansho extract can also be blended (Havex Sansha Extract (Koei Kogyo), Falco Rex Sansha (Ichimaru Falcos), Sansha Extract (Maruzen Pharmaceutical), etc.).

The amount of the tyrosinase activity promoter (a), such as salamander extract, should be appropriately selected according to the dosage form and form of the scalp / hair cosmetic, the extract concentration, and the like. Although it is not performed, 0.0001 to 10.0% by weight, preferably 0.001% by weight based on the total amount of the cosmetic.
05 to 5.0% by weight. If the amount of the extract is less than 0.0001% by weight based on the total amount of the cosmetic, the desired effect of preventing gray hair is not sufficiently exhibited, and 10.0% by weight.
Above this, formulation problems may occur. In addition,
The above compounding amount is a weight percentage as a dried product or an extract after removing the extraction solvent.

The antimicrobial agent (b) to be blended in the scalp hair cosmetic together with the (a) tyrosinase activity promoter is as follows:
For example, hexachlorophen, benzalkonium chloride, undecylenic acid, trichlorocarbanilide, bithionol, benzalkonium chloride, isopropylmethylphenol, resorcin, zinc pyrithione, photosensitizer 10
No. 1, photosensitive element 201, salicylic acid, sodium salicylate, octopirox, compounds such as hinokitiol, or amateur, Eijitsu, oubaku, spinach,
Solvent extracts of plants such as squid, kagosou, karin, kujin, goshi, peonies, boufu, buttonpi, jiyu and the like.

The solvent extract of a plant is extracted by an extraction method generally used for extracting a plant-derived extract. That is, an extract (plant extract) can be obtained by subjecting the above-mentioned raw materials as they are or after drying them as necessary, and then subjecting them to solvent extraction as they are or pulverized.

The extraction solvent can be selected from those generally used when extracting its components from plants, and is not particularly limited. For example, hot water or water; lower alcohols such as ethanol, isopropyl alcohol and n-butanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrates of these alcohols; Hydrogen-based solvents and the like can be mentioned, but when a lower alcohol such as ethanol is used as the extraction solvent, the obtained extract can be directly blended into the cosmetic for scalp and hair, but the extraction solvent is once distilled off. It is also possible to mix after drying if necessary.

(B) The amount of the antibacterial agent should be appropriately selected according to the dosage form and form of the cosmetic for scalp and hair, the extract concentration, etc., and is not particularly limited. The content is preferably 0.001 to 5% by weight based on the total amount of the ingredients. If the amount of the antibacterial agent is less than 0.001% by weight based on the total amount of the cosmetic, the desired effect of preventing gray hair is not sufficiently exhibited, and if it exceeds 5% by weight, there may be a problem in formulation. is there. In the case where the antibacterial agent is a plant extract, the above-mentioned amount is the weight percentage of the dried product or extract after removing the extraction solvent.

In this way, by combining the tyrosinase activity promoter and the antibacterial agent in combination, the scalp / head hair is extremely excellent in the effect of preventing or suppressing the generation of gray hair as compared with the case where the tyrosinase activity promoter is blended alone. Cosmetics are provided.

The scalp and hair cosmetic composition of the present invention contains general base ingredients and medicinal ingredients which can be blended with ordinary skin cosmetics or hair cosmetics, according to the specific form and form of the cosmetic. Thus, it can be blended as long as the effects of the present invention are not impaired.

Specifically, diluents, surfactants, higher alcohols, oils, humectants, thickeners, solvents, usability improvers, preservatives, antioxidants, sequestering agents, ultraviolet protective agents, Powder components, various chemicals, coloring agents, fragrances, and the like can be appropriately selected and blended according to the intended dosage form and form.

Examples of the diluent include water, ethanol, isopropyl alcohol, glycols and the like.

Among the surfactants, examples of the anionic surfactant include alkyl benzene sulfonate, polyoxyalkylene alkyl sulfate, alkyl sulfate, olefin sulfonate, alkyl phosphate, and polyoxyalkylene alkyl. Examples thereof include ether phosphates, dialkyl sulfosuccinates, and fatty acid salts. Examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyhydric alcohol fatty acid partial ester, polyoxyethylene polyhydric alcohol fatty acid partial ester, polyglycerin fatty acid ester, and polyoxyethylene hydrogenated castor oil derivative. And fatty acid diethanolamide. Examples of the cationic surfactant include a tertiary aliphatic amine salt, an alkyltrimethylammonium halide, a dialkyldimethylammonium halide and the like. Examples of the amphoteric surfactant include amidobetaine type, imidazolinium betaine type, and sulfobetaine type amphoteric surfactants.

Examples of higher alcohols include cetyl alcohol, stearyl alcohol, behenyl alcohol and the like.

Examples of the oil component include higher fatty acids, solid paraffin, liquid paraffin, silicone oil, high molecular silicone and derivatives thereof, squalane, petrolatum, ester oil and the like.

Examples of the humectant include glycerin, propylene glycol, 1,3-butylene glycol, dipropylene glycol, sorbitol and the like.

Examples of the thickener include methylcellulose, hydroxyethylcellulose, carrageenan, carboxymethylcellulose, and cationized cellulose.

As the solvent, for example, water, ethanol,
Examples thereof include isopropyl alcohol and benzyl alcohol.

Usability improvers include, for example, methylpolysiloxane, methylaminopropylsiloxane and the like.

Examples of the preservative include benzoic acid, dehydroacetic acid, paraoxybenzoic acid esters (eg, methyl paraoxybenzoate, butyl paraoxybenzoate), and phenoxyethanol.

Examples of the antioxidant include ascorbic acid and BHA.

Examples of the sequestering agent include ethylenediaminetetraacetic acid (edetic acid) and tripolyphosphate.

Examples of the ultraviolet protective agent include oxybenzone and butylmethoxybenzoylmethane.

Examples of the powder component include powder resins such as silica, nylon powder, and polyethylene powder.

Examples of various drugs include plant extracts such as carrot extract; vitamins other than vitamin E such as vitamin B6 and biotin; pantothenic acid and its derivatives, glycyrrhizic acid and its derivatives; serine, methionine and the like. Amino acids; nicorandil, cyclosporic acid; female hormones such as estradiol;

Other components that can be blended include, for example,
Allantoin, icutamol, azulene, guaiazulene, epsilon aminocaproic acid, lysozyme chloride, diphenhydramine hydrochloride, glycyrrhetinic acid and derivatives thereof, D-menthol, L-menthol, DL-menthol, D-camphor, L-camphor, DL-camphor and the like Inflammatory agents; active substances such as salicylic acid, zinc and its derivatives, lactic acid and its alkyl esters; and organic acids such as citric acid.

Any one or more of the above-mentioned components that can be blended are blended together with the essential components of the present invention, and a cosmetic for scalp and hair is produced by a conventional method.

The dosage form of the scalp / hair cosmetic composition of the present invention may be any liquid, emulsion, ointment or any other form applicable to the skin or scalp, and is generally a lotion, cream, oil, gel or the like. , Hair tonic, hair liquid, treatment, aerosol mousse, aerosol spray and the like. The cosmetic for scalp hair of the present invention is applicable also in the fields of pharmaceuticals and quasi-drugs.

The scalp hair cosmetic composition of the present invention is generally administered by transdermal administration such as directly applying or spraying on the skin.
The dose should be appropriately determined according to age, individual differences such as the degree of gray hair, and its dosage form and form, but the dose for general adults is 25 to 150 mg per kg of body weight.
/ Day, preferably 50 to 100 mg / day, which can be administered once a day or divided into 2 to 4 times a day.

[0047]

The present invention will be described in more detail with reference to the following examples, which should not limit the scope of the present invention. In addition, the compounding amount in these Examples and the like is a percentage by weight based on the entire system in which the component is compounded, unless otherwise specified.

[Preparation of Sansha Extract] 500 g of pericarp was immersed in ethanol at room temperature for one week, and ethanol in the extract was distilled off to obtain 9.7 g of a sansha extract. In the test examples and prescription examples described below,
This extract was used as a "salmon extract".

[Effects of Preventing or Inhibiting Human Gray Hair Development by Cumulative Application] <Test Method> Twenty times a day (morning and night) were given to a total of 40 men and women of 40 to 60 years old who had gray hair for each lotion. )
For 4 months in a row, separate lotions were applied to the left and right crowns by the half-head method, and the number of white hairs per 1000 hairs on the left and right crowns was counted before and 4 months after the start of application, and white hair was generated. The preventive or inhibitory effect of was investigated. The criteria are as follows.

<Judgment Criteria> +++: (Very effective) 50% or more of the subjects have less than 70% of the gray hair after the application compared to the number of the white hair before the application. ++: (Remarkably effective) 50% or more of the subjects had 70% or more and less than 80% of the number of white hairs after application with respect to the number of white hairs before application. +: (Effective) 50% or more of the subjects have 80% or more and less than 90% of the number of white hairs after application with respect to the number of white hairs before application start. ±: (Slightly effective) 50% or more of the subjects had 90% or more and less than 100% of the number of white hairs after application with respect to the number of white hairs before application. -: (Invalid) Less than 50% of the subjects have 90% or more and less than 100% of the number of white hairs after application with respect to the number of white hairs before application is started.

Each lotion was prepared according to the formulation shown in Table 1 according to the following method. <Production method> A plant extract and succinic acid were added to purified water and uniformly dissolved. Other raw materials were dissolved in ethanol and added to the aqueous phase to dissolve.

[0052]

[Table 1]

From the results shown in Table 1, Comparative Example 1, in which only the extract of the tyrosinase activity was added, was effective in preventing or suppressing the generation of gray hair, but in Examples 1 to 12, in which an antibacterial agent was added. It has been found that has a better effect of preventing or suppressing the generation of gray hair than Comparative Example 1. In addition, it was also revealed that even if only the antibacterial agent was blended without blending the salmon extract, the effect of preventing or suppressing the generation of gray hair was not observed (Comparative Examples 2 to 11).

That is, it has been clarified that the lotions 1 to 12 of the present invention in which an antibacterial agent is combined with a salamander extract have a remarkable effect of synergistically preventing or suppressing the generation of gray hair. This indicates that the desired effect can be obtained only by using a small amount of the salamander extract and the antibacterial agent.

Hereinafter, other formulation examples of the scalp hair cosmetic composition of the present invention will be described as examples. In these examples, the effect of preventing or suppressing the generation of human gray hair was examined. In all the examples, results of "effective" to "extremely effective" were obtained.

Example 13 Hair Tonic (Blending Components) Blending Amount (% by Weight) (1) Hardened Castor Oil Ethylene Oxide (40 Mol) Adduct 2.0 (2) Salmon Extract 0.1 (3) 95 % Ethanol 70.0 (4) Ginger extract 0.1 (5) Appropriate amount of flavor (6) Residual amount of purified water

<Manufacturing method> (3) to (1), (4) and (5)
Was added and stirred to dissolve, and then (2) was added to (6),
A hair tonic was obtained by adding the solution dissolved by stirring.

Example 14 Hair Tonic (Blending Components) Blending Amount (% by Weight) (1) Glycerin 2.0 (2) L-Menthol 0.1 (3) Sansho Extract 0.01 (4) 95 % Ethanol 60.0 (5) Age extract 0.1 (6) Appropriate amount of perfume (7) Residual amount of purified water

<Manufacturing method> (1), (2) and (5)
After adding (6) and stirring and dissolving, (3) was added to (7), and the resulting solution was stirred and dissolved to obtain a hair tonic.

Example 15 Hair Tonic (Blending Components) Blending Amount (% by Weight) (1) Polyethylene Glycol 2.0 (2) L-Menthol 0.2 (3) Sansho Extract 0.05 (4) 95% ethanol 50.0 (5) Oat extract 0.1 (6) Appropriate amount of perfume (7) Residual amount of purified water

<Manufacturing method> (1), (2) and (5)
After adding (6) and stirring and dissolving, (3) was added to (7), and the resulting solution was stirred and dissolved to obtain a hair tonic.

Example 16 Hair Liquid (Blending components) Blending amount (% by weight) (1) Polyoxypropyl butyl ether (40PO) 15.0 (2) Polyoxypropyl butyl ether phosphoric acid (40PO) 15.0 (3 ) Salmon extract 0.001 (4) 1,3-butylene glycol 5.0 (5) 95% ethanol 50.0 (6) Peony extract 0.1 (7) Perfume appropriate amount (8) Dye appropriate amount (9) Appropriate amount of edetic acid (10) Residual amount of purified water

<Manufacturing Method> (1), (2) and (4)
(6) After adding (7) and stirring and dissolving, (3), (8) and (9) were added to (10), and the resulting solution was stirred and dissolved to obtain a hair liquid.

Example 17 Scalp Treatment (Blending Components) Blending Amount (% by Weight) (1) 1,3-Propylene Glycol 0.5 (2) Pentaerythritol Tetra-2-ethylhexanate 1.2 (3) 95% ethanol 60.0 (4) Salmon extract 0.001 (5) Silkworm extract 0.1 (6) Flavor appropriate amount (7) Dimethyl ether / LPG (95/5) appropriate amount

<Manufacturing Method> (1), (2) and (4)
(5) (6) was added and dissolved by stirring to prepare a stock solution.
The can was filled with the stock solution, and after mounting the valve, (7) was filled to obtain a scalp treatment.

Example 18 Hair Cream (Blending Components) Blending Amount (% by Weight) <A Phase> (1) Liquid Paraffin 5.0 (2) Cetostearyl Alcohol 5.5 (3) Vaseline 5.5 (4) ) Glyceryl monostearate 3.0 (5) Polyoxyethylene (20 mole addition) -2-octyldodecyl ether 3.0 (6) Kagosou extract 0.01 (7) Tocophenol acetate 0.05 (8) Propyl Paraben 0.3 (9) Fragrance 0.05 <B phase> (10) Salmon extract 0.005 (11) Glycerin 7.0 (12) Dipropylene glycol 20.0 (13) Polyethylene glycol 4000 5.0 (14) Sodium hexametaphosphate 0.005 (15) Residual amount of purified water

<Production method> (1-9) was mixed and dissolved by heating to prepare phase A. Separately, (10) to (15) were mixed and dissolved by heating to prepare phase B. Thereafter, phase B was added to phase A and emulsified with a homomixer to obtain a hair cream.

Example 19 Hair Gel (Blending Components) Blending Amount (% by Weight) (1) Carboxyvinyl Polymer 0.7 (2) Polyvinylpyrrolidone 2.0 (3) Glycerin 4.0 (4) Sansha Extract 0.01 (5) Sodium hydroxide suitable amount (6) Ethanol 20.0 (7) Polyoxyethylene octyl dodecyl ether proper amount (8) Pomapi extract 2.0 (9) Flavor proper amount (10) Edetic acid suitable Amount (11) Purified water balance

<Production method> (1) and (3) were dispersed in a part of purified water. The other components were dissolved in the remaining purified water, and this was added to the above dispersion with stirring to obtain a hair gel.

Example 20 Hair Gel (Blending Components) Blending Amount (% by weight) (1) Carboxyvinyl polymer 0.7 (2) Glycerin 50.0 (3) Sodium hydroxide proper amount (4) Ethanol 20.0 (5) Salmon extract 0.001 (6) Polyoxyethylene octyl dodecyl ether qs (7) Kudzin extract 2.0 (8) Flavor qs (9) Edetate qs (10) Purified water balance

<Production method> (1) and (2) were dispersed in a part of purified water. The other components were dissolved in the remaining purified water, and this was added to the above dispersion with stirring to obtain a hair gel.

Example 21 Hair Spray (Undiluted Formulation) Compounding Amount (% by Weight) (1) Acrylic Resin Alkanolamine Salt 7.0 (2) Cetyl Alcohol 0.1 (3) Silicone Oil (Methylphenyl Polysiloxane) 0.3 (4) Ethanol 90.0 (5) Salmon extract 0.1 (6) Appropriate amount of perfume (7) Dust extract 0.01 (filling formula) (8) Stock solution 50.0 (9) Dimethyl ether 45.0 (10) LPG 5.0

<Production method> (1), (2) and (3) were uniformly emulsified with a homomixer. This is (4) to (5) ~
(7) was added, and the mixture was added to the solution which was stirred and dissolved to prepare a stock solution (8). The stock solution (8) was filled in a can, and after the valve was attached, (9) and (10) were filled to obtain a hair spray.

[0074]

According to the present invention, there is provided a scalp and hair cosmetic composition which is extremely useful for preventing and preventing the occurrence of gray hair and which is excellent in safety.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Naomi Ota 1050 Nippa-cho, Kohoku-ku, Yokohama, Kanagawa Prefecture Inside Shiseido Daiichi Research Center Co., Ltd. Address: Shiseido Daiichi Research Center Co., Ltd. (72) Inventor: Masaaki Uemura 1050, Nippa-cho, Kohoku-ku, Yokohama, Kanagawa Prefecture F-term (reference) 4C083 AB032 AB282 AC012 AC022 AC072 AC102 AC122 AC182 AC292 AC422 AC432 AC442 AC472 AC482 AC532 AC692 AC852 AC902 AC932 AD042 AD072 AD092 AD112 AD152 AD552 AD662 BB48 CC32 CC33 CC37 DD08 EE24

Claims (6)

[Claims] (A) a tyrosinase activity promoter,
(B) A scalp hair cosmetic comprising an antibacterial agent. 2. The tyrosinase activity promoter (a),
Salamander extract, cayulape, guacomist, pinica (Pinica), apricot (Epazot)
e), Zapote, Axcopaque (Ax)
The scalp hair cosmetic according to claim 1, wherein the cosmetic is a solvent extract of one or more plants selected from the group consisting of (copaque). 3. The antibacterial agent (b) is hexachlorophen, benzalkonium chloride, undecylenic acid, trichlorocarbanilide, bithionol, benzalkonium chloride, isopropylmethylphenol, resorcin, zinc pyrithione, photosensitive element 101, photosensitive Element No. 201, salicylic acid, sodium salicylate, octopirox,
A compound of one or more selected from the group consisting of hinokitiols; or a compound selected from the group consisting of amacha, Eijitsu, Oubak, Ouren, Kaika, Kagosou, Karin, Kujin, Gomashi, Peony, Bofu, Buttonpi, Jiyu 3. A scalp hair cosmetic according to claim 1, wherein the solvent extract is one or more plant extracts. 4. The content of the (a) tyrosinase activity promoter is 0.0001 to 0.0001 of the total amount of the scalp hair cosmetic.
The scalp hair cosmetic according to claim 1, 2 or 3, which is 10.0% by weight. 5. The composition according to claim 1, wherein the content of the antibacterial agent (b) is 0.001 to 5% by weight based on the total amount of the scalp hair cosmetic. Cosmetic for scalp hair. 6. The scalp hair cosmetic composition is an anti-grey-hair cosmetic composition.
The scalp hair cosmetic according to the above.