JPH05246875A - Agent for improving and treating diabetes - Google Patents

Abstract

PURPOSE:To provide the diabetes-improving and treating agent containing the extract of Asparagus.linearis as an active ingredient, not causing adverse actions, capable of rapidly treating diabetes and having excellent safety. CONSTITUTION:The objective diabetes-improving and treating agent contains as an active ingredient an Asparagus.linearis extract which is obtained e.g. by adding a 50-1000 times volume of water to the leaves or stems of the Asparagus.linearis belonging to the genus Leguminosae, boiling the mixture, further boiling and extracting the mixture for 5-30min, and subsequently subjecting the treated mixture to a lyophilization treatment, etc. The agent is preferably drunk at a dose of 100-1500ml/day as a solution of 1-5g dried leaves/liter, when commonly administered as a beverage.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a therapeutic agent for diabetes mellitus, which contains, as an active ingredient, a component of Aspalathus linealis belonging to the legume family.

[0002]

2. Description of the Related Art In recent years, diabetes has become a social problem because not only middle-aged and elderly people but also young people have many diabetics with glucose in their urine. Diabetes mellitus includes insulin-dependent diabetes mellitus whose therapeutic effect is improved by insulin administration and non-insulin-dependent diabetes mellitus in which insulin administration does not show a significant effect.

[0003]

However, conventionally, non-insulin-dependent diabetes mellitus has no appropriate therapeutic method and diet or exercise therapy is used, but it depends on the strength of the patient's will. Many have little effect and it is difficult to treat diabetes stably.

[0004] Further, there is no known therapeutic drug that stabilizes diabetes by eating and drinking in the same way as a normal person in daily life without requiring a strong will.

An object of the present invention is to solve the above problems and to provide an effective therapeutic agent for improving symptom by ingesting diabetes daily orally.

[0006] The inventors of the present invention have conducted extensive studies to achieve the above-mentioned object, and as a result, the Aspalathus linealis extract belonging to the legume family has an excellent effect on diabetic patients, and The present invention has been completed based on the finding that it can be safely improved without side effects.

The active ingredient of the present invention comprises an extract of Aspalathus linealis. As an extraction method, leaves or stems of Aspalathus linealis are extracted with water and / or an organic solvent, and the extraction solvent is extracted from the extract. Can be obtained by distilling off or by crushing leaves or stems of Aspalathus linealis. In addition, it may be extracted in the same manner as in the production method of ordinary Japanese tea, Chinese tea, black tea and the like.

In the case of extraction with water, it is preferable to add 50 to 1000 times as much water as Aspalathus linealis, boil and then carry out boiling extraction for about 5 to 30 minutes. Also, when extracting in the same way as ordinary tea, use 3 to 50 times the hot water of 80 to 100 degrees, which is 50 to 500 times the dry leaves of Aspalathus linearis.
Leave for about 30 minutes to obtain an extract.

Specific examples of the organic solvent include methanol,
Ethanol, acetone and the like can be mentioned, and conventional means such as warm extraction can be used for extraction. Further, for the separation of the extract, conventional means such as decantation or centrifugation can be used.

A conventional means such as freeze-drying can be used for distilling off the extraction solvent. Also, Aspalathus linealis itself can be crushed and powdered for use.

According to the present invention, a mixture is directly administered in any form such as a solution, powder granules, tablets, emulsions or jellies.
Alternatively, it can be mixed with other foods and drinks.

The dose varies depending on the type and degree of the target disease, but in the case of regular use as a drink, 1 to 5 g
It is preferable to eat and drink 100 ml to 1500 ml / day of the dried leaf / 1 solution.

[0013] Aspalathus linealis showed no death in an acute toxicity test in rats, and no abnormality was observed in biochemical blood tests and histopathological tests.

[0014]

The present invention can rapidly improve and treat diabetic diseases of mammals including humans without side effects.

[0015]

【Example】

Production example Collected Aspalathus linealis leaves (with stem)
After cutting to a length of 5 mm, dried leaves are subjected to the steps of rolling, enzyme fermentation, and sun drying. 4 g of dried leaves were boiled with 1.5 liters of water for 15 minutes to obtain an extract.

Example 1 The extract obtained in the production example was applied to the patients shown in Table 1 at 200 m per day.
1000 mL of L was given to examine the improvement of symptoms. The results are shown in Table 1.

[Table 1]

The results of chemical analysis of Aspalathus linealis are as follows. Iron 23.40 mg / 100 g Calcium 187.00 mg / 100 g Potassium 398.00 mg / 100 g Magnesium 207.00 mg / 100 g Copper 2.25 ppm Zinc 6.74 ppm Selenium 0.13 ppm Vitamin E 17.00 mg / 100 g Protein 8.00% Flavonoids 41 0.000 mg / 100 g Antioxidant / SOD-like potency 69,000 unit / g Acid-insoluble protein component 150 mg / 100 g Aroma component 100 mg / 100 g Sugar-containing compound 690 mg / 100 g

As aroma components, carbonyl compound (15%), carotenoid decomposition product (17%), carbon number 2
~ 12 organic acids (22%), phenolic compounds (13
%), Aromatic oxygen-containing compounds (7%), aromatic hydrocarbons (5.5%), terpenoids (4%) and the like.
The acid-insoluble protein is a protein component having a relatively large molecular weight.

Claims (1)

[Claims] 1. A therapeutic agent for diabetes mellitus comprising an Aspalathus linealis extract as an active ingredient.