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JPH04279530A - 成長因子を投与するためのドラッグデリバリーシステム - Google Patents

成長因子を投与するためのドラッグデリバリーシステム

Info

Publication number
JPH04279530A
JPH04279530A JP3163080A JP16308091A JPH04279530A JP H04279530 A JPH04279530 A JP H04279530A JP 3163080 A JP3163080 A JP 3163080A JP 16308091 A JP16308091 A JP 16308091A JP H04279530 A JPH04279530 A JP H04279530A
Authority
JP
Japan
Prior art keywords
microspheres
growth factor
heparin
water
powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3163080A
Other languages
English (en)
Japanese (ja)
Inventor
Ponti Roberto De
ロベルト・デ・ポンテイ
Clara Torricelli
クララ・トツリチエリ
Carlo Confalonieri
カルロ・コンフアロニエリ
Adami Marco
マルコ・アダミ
Alessandro Martini
アレツサンドロ・マルテイニ
Ercole Lardini
エルコーレ・ラルデイニ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of JPH04279530A publication Critical patent/JPH04279530A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP3163080A 1990-07-05 1991-07-03 成長因子を投与するためのドラッグデリバリーシステム Pending JPH04279530A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909014871A GB9014871D0 (en) 1990-07-05 1990-07-05 Drug delivery system for administering growth factor
GB9014871.9 1990-07-05

Publications (1)

Publication Number Publication Date
JPH04279530A true JPH04279530A (ja) 1992-10-05

Family

ID=10678678

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3163080A Pending JPH04279530A (ja) 1990-07-05 1991-07-03 成長因子を投与するためのドラッグデリバリーシステム

Country Status (4)

Country Link
JP (1) JPH04279530A (it)
DE (1) DE4121891A1 (it)
GB (2) GB9014871D0 (it)
IT (1) IT1248543B (it)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027630A1 (en) * 1993-05-31 1994-12-08 Kaken Pharmaceutical Co., Ltd. Cross-linked gelatin gel preparation containing basic fibroblast growth factor
JP2001233786A (ja) * 2000-02-28 2001-08-28 Ltt Institute Co Ltd ヘパリン結合性成長因子用徐放基材、およびヘパリン結合性成長因子徐放剤
KR100720056B1 (ko) * 2005-10-06 2007-05-18 (주) 차바이오텍 성장인자가 함유된 나노입자가 코팅된 마이크로스피어의제조 및 이의 신경분화로의 이용 방법
JP2010530856A (ja) * 2007-06-22 2010-09-16 シュー，ハンメイ 血管生成の抑制剤、並びにその製造方法、修飾方法及び抗腫瘍薬の製造における用途
CN110051877A (zh) * 2018-01-18 2019-07-26 近镒生技股份有限公司 止血材料、其制备方法及包含其的药物组合物

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352589A (en) * 1988-09-16 1994-10-04 Farmitalia Carlo Erba S.R.L. Deletion mutant of basic fibroblast growth factor and production thereof
AU1052492A (en) * 1991-01-31 1992-08-06 Farmitalia Carlo Erba S.R.L. Synergistic composition comprising a fibroblast growth factor and a sulfated polylsaccharide, for use as antiviral agent
AUPM572294A0 (en) * 1994-05-18 1994-06-09 Vaccine Technologies Pty. Ltd. Delivery vehicle for bioactive molecule
EP0914168A1 (en) * 1996-05-03 1999-05-12 Innogenetics N.V. New medicaments containing gelatin cross-linked with oxidized polysaccharides
CA2361555A1 (en) * 1999-02-03 2000-08-10 Powderject Research Limited Hydrogel particle formulations
EP2680827B1 (en) * 2011-03-04 2020-01-08 Institut National de la Santé et de la Recherche Médicale Particles containing a growth factor, and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ235556A (en) * 1986-11-05 1991-06-25 Ethicon Inc Breast milk substitute containing recombinant human egf
NZ226170A (en) * 1987-09-18 1990-07-26 Ethicon Inc Stable freeze-dried pharmaceutical composition containing epidermal growth factor
NZ226171A (en) * 1987-09-18 1990-06-26 Ethicon Inc Gel formulation containing polypeptide growth factor

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027630A1 (en) * 1993-05-31 1994-12-08 Kaken Pharmaceutical Co., Ltd. Cross-linked gelatin gel preparation containing basic fibroblast growth factor
US6831058B1 (en) 1993-05-31 2004-12-14 Kaken Pharmaceutical Co., Ltd. Crosslinked gelatin gel preparation containing basic fibroblast growth factor
JP2001233786A (ja) * 2000-02-28 2001-08-28 Ltt Institute Co Ltd ヘパリン結合性成長因子用徐放基材、およびヘパリン結合性成長因子徐放剤
KR100720056B1 (ko) * 2005-10-06 2007-05-18 (주) 차바이오텍 성장인자가 함유된 나노입자가 코팅된 마이크로스피어의제조 및 이의 신경분화로의 이용 방법
JP2010530856A (ja) * 2007-06-22 2010-09-16 シュー，ハンメイ 血管生成の抑制剤、並びにその製造方法、修飾方法及び抗腫瘍薬の製造における用途
CN110051877A (zh) * 2018-01-18 2019-07-26 近镒生技股份有限公司 止血材料、其制备方法及包含其的药物组合物

Also Published As

Publication number Publication date
GB2245831B (en) 1994-03-23
DE4121891A1 (de) 1992-01-09
IT1248543B (it) 1995-01-19
GB9114493D0 (en) 1991-08-21
ITMI911741A0 (it) 1991-06-25
ITMI911741A1 (it) 1992-12-25
GB9014871D0 (en) 1990-08-22
GB2245831A (en) 1992-01-15

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