JP5849001B2 - Laminated body for PTP or blister pack, and PTP or blister pack molded using the same - Google Patents

Description

  The present invention relates to a laminate for PTP or blister pack used for PTP or blister pack, and a PTP or blister pack molded using the same.

  Conventionally, PTP (press-through package) has been used as a packaging container for capsules containing solid preparations such as tablets and medicines. PTP is also called a blister pack and is widely used for packaging pharmaceutical products.

  The laminate for PTP or blister pack is a film or sheet material used for forming PTP or blister pack before the preparation is encapsulated. A PTP or blister pack molding machine forms a dome-shaped (or bowl-shaped) pocket portion by applying heat to a sheet-like laminate as a material while pressing it with a molding die.

  The PTP or blister pack molded from the laminate is a PTP or blister in which the preparation is enclosed by heat-sealing a lid material on the hem that extends around the periphery in the state where the preparation is accommodated inside the pocket portion. It becomes a pack package. If the PTP or blister pack used for packaging is transparent, the preparation enclosed in it can be easily visually confirmed. Further, the encapsulated preparation can be easily taken out by pushing the PTP or blister pack together with a finger or the like so that the lid material breaks through. The name “press-through package” comes from this form of use.

  There are various drugs that are active ingredients of preparations enclosed in PTP or blister packs. Among them, there are drugs with low moisture resistance and drugs with strong odor. Therefore, there is a prior art in which a PTP or blister pack after molding has an adsorption function by forming an adsorption layer in advance inside the PTP or blister pack (see, for example, Patent Document 1). According to this prior art, even if a desiccant or the like is not enclosed inside the PTP or blister pack package, the dry state of the drug is maintained as a package, oxidation is prevented, and odors are absorbed efficiently. It is disclosed that it can be done.

  Olmesartan medoxomil is used for hypertension or a disease derived from hypertension (more specifically, hypertension, heart disease [angina, myocardial infarction, arrhythmia, heart failure or hypertrophy), kidney disease [diabetic nephropathy, thread Spherical nephritis or nephrosclerosis] or cerebrovascular disease [cerebral infarction or cerebral hemorrhage]). This olmesartan medoxomil is a compound having a medoxomil group in the molecule, and the medoxomil ester is gradually cleaved by water to be converted into an active body, whereby low molecular 2,3-butanedione (hereinafter referred to as “diacetyl”) is converted. It is a generated compound. This diacetyl itself is known as a causative substance of a unique odor, and is considered to be an odor causative substance of a preparation containing olmesartan medoxomil.

International Publication WO2006 / 115264

  In the above prior art (Patent Document 1), a film for PTP or blister pack is composed of a laminate, a barrier layer is disposed on the outermost layer, and a moisture absorbing layer is disposed on the inner layer. The hygroscopic layer has a three-layer structure of two sub hygroscopic layers and a main hygroscopic layer (corresponding to the intermediate layer of the present invention) sandwiched therebetween. Of these, the outer sub-moisture absorbing layer (corresponding to the outer skin layer of the present invention) improves adhesion to the barrier layer by dry lamination, and the inner sub-moisture absorbing layer (corresponding to the inner skin layer of the present invention) is heat sealed. Adhesion with the lid material is improved.

  The inventors of the present invention preferably use polymers such as LDPE (low density polyethylene), LLDPE (linear low density polyethylene), and PP (polypropylene) as the resin used for the main moisture absorption layer in the prior art. Have confirmed. In particular, if LDPE or LLDPE close to the thermal shrinkage rate of polypropylene used for the barrier layer is used, even if the pigment (absorbent) content is somewhat high, a thermal shrinkage rate equivalent to that of the barrier layer is achieved. This is advantageous in that This is because if the thermal contraction rate of the barrier layer and the moisture absorption layer are the same, it is difficult for processing wrinkles to occur after molding of the PTP or blister pack, and high quality can be maintained. For this reason, the inventors of the present invention recognize that LDPE or LLDPE is preferable in order to make the thermal contraction rate equal between the upper and lower sub-absorbent layers sandwiching the main hygroscopic layer.

In addition, the inventors of the present invention have further researched, the barrier layer as used in the prior art is a base layer, the main moisture absorption layer is an intermediate layer, the sub moisture absorption layers on both sides are skin layers, and the base layer is formed. Uses PP or PVC (Polyvinyl Chloride), a mixture of pigment (absorbent) and LDPE for the intermediate layer, and PP or LDPE for both skin layers, respectively, PTP or blister The following problems were encountered in the pack laminate.
(1) When a film serving as an absorption layer is coextruded with an air-cooled inflation molding machine, the film quality may not be uniform and wrinkles may occur (problem of film formation).
(2) In the PTP or blister pack package in which the adhesion between the intermediate layer and both skin layers in the absorbent layer is difficult and the lid material is heat-sealed after molding as a PTP or blister pack, Delamination may occur (interlayer adhesion / delamination problem).

  The present invention has been made in view of the above problems. That is, this invention makes it a subject to improve the film forming property as a laminated body which gave the absorptivity, and to suppress delamination in the absorption layer of PTP or a blister pack package.

  As a result of extensive research, the inventors of the present invention have optimized the mixing ratio (% by weight) of the absorbent and resin used for the intermediate layer, and have selected the resin material used for the intermediate layer and optimized the weight ratio. By optimizing the resin materials used for the inner and outer skin layers, (1) Excellent film forming properties as an absorbent layer (film) and (2) Lamination for PTP or blister pack that does not cause delamination Invented the body.

  That is, the present invention comprises a base material layer that is an outermost layer as a PTP or blister pack, and is laminated on the base material layer via an adhesive layer, and faces liquids and gases when molded as a PTP or blister pack. It is a laminate for PTP or blister pack including an absorption layer that absorbs at least one. Here, specific examples of “liquid” are water, and specific examples of “gas” are water vapor and diacetyl.

In particular, the present invention solves the problem by the following configuration.
The absorbent layer has a three-layer structure of an intermediate layer and inner and outer skin layers laminated on both sides (inner side and outer side) with the intermediate layer therebetween. That is, the absorption layer has a configuration in which an outer skin layer, an intermediate layer, and an inner skin layer are laminated in this order, and the outer skin layer is bonded to the base material layer via the adhesive layer. Among these, the intermediate layer is composed of a mixture of a polypropylene resin and a blend resin of polyethylene resin and an absorbent.

In the intermediate layer, the proportion of the polypropylene (PP) resin in the blend resin is 66 to 95% by weight, and the proportion of the polyethylene (PE) resin is 34 to 5% by weight.
The outer skin layer and the inner skin layer both use polypropylene resin.

  According to said structure, in the process of coextrusion molding the film used as an absorption layer with an inflation molding machine, there is almost no wrinkle in a film (improvement of film forming property), and delamination occurs after molding of PTP or blister pack Does not occur (interlayer adhesion / delamination strength improvement).

More preferably, the proportion of the polypropylene resin in the blend resin of the intermediate layer is 70 to 85% by weight, and the proportion of the polyethylene resin is 15 to 30% by weight.
Within the above numerical range, no wrinkles are generated particularly in the coextrusion molding process using an inflation molding machine. Further, there is no delamination (for example, delamination between the intermediate layer and the inner skin layer) in the absorption layer after molding of the PTP or blister pack.

For the inner skin layer, a polypropylene resin having a higher melting point as a material than the temperature of heat applied in the molding process as PTP or blister pack is used.
Thereby, dissolution of the inner skin layer due to preheating during molding of the PTP or blister pack is prevented.

In the intermediate layer, the polypropylene resin in the blend resin is preferably a random copolymer (random PP).
In the present invention, it is not particularly excluded that the polypropylene resin in the blend resin constituting the intermediate layer is a homopolymer, but the use of a random copolymer (random PP) significantly improves the film forming property of the absorbent layer. ing.
Therefore, if the polypropylene resin in the blend resin constituting the intermediate layer is a random copolymer (random PP), a high-quality PTP or blister pack laminate can be obtained as a whole.

In the intermediate layer, the polyethylene resin in the blend resin is preferably low-density polyethylene (LDPE) or linear low-density polyethylene (LLDPE).
Blending LDPE or LLDPE in the intermediate layer has the effect of contributing to an improvement in melt flow rate (MFR) for the mixture of absorbent and blend resin. That is, LDPE or LLDPE is originally a high melt flow rate resin, and even if the melt flow rate is lowered by mixing with an absorbent, a certain degree of flexibility (flexibility) is ensured, so that it can be shared by an inflation molding machine. The film forming property at the time of extrusion molding can be improved. In particular, it is preferable to use a melt flow rate of 10 or more.

  The PTP or blister pack of the present invention is formed using the PTP or blister pack laminate described above. That is, the PTP or blister pack of the present invention is laminated with a base material layer constituting the outermost layer of the pocket portion containing the contents, and an adhesive layer on the base material layer, and faces the contents with liquid and gas. An absorption layer that absorbs at least one of the above, and the absorption layer has a configuration in which an outer skin layer, an intermediate layer, and an inner skin layer are laminated in this order, and the outer skin layer is formed on the base material layer via the adhesive layer. The outer skin layer and the inner skin layer are made of a polypropylene resin, and the intermediate layer is made of a blended resin and absorbent mixture having a polypropylene resin of 66 to 95% by weight and a polyethylene resin of 34 to 5% by weight.

  According to the PTP or blister pack of the present invention, the quality as a PTP or blister pack or a package using the same can be improved by using the material having the advantages as the laminate described above, and contains olmesartan medoxomil. It is particularly suitable as a formulation in which the formulation is encapsulated.

  ADVANTAGE OF THE INVENTION According to this invention, the laminated body used as the material suitable for shaping | molding of PTP or a blister pack which has an absorption function can be provided. Further, the quality and reliability of the PTP or blister pack formed using the laminate can be improved, and the absorption function can be sufficiently exhibited.

It is a longitudinal cross-sectional view which shows the structure of a blister package roughly. It is the longitudinal cross-sectional view which showed roughly the structure of the laminated body used as the material of PTP or a blister pack. It is the table | surface which showed the evaluation result of the polypropylene compounding rate (PP rate) in each intermediate | middle layer and each evaluation item (A)-(C) about Examples 1-6 and Comparative Examples 1-4. It is the table | surface which showed the brand of the polypropylene resin used for an intermediate | middle layer, and the evaluation result of evaluation item "film forming property" as a list about Examples 7-9. About Example 10, 11, the brand of the polyethylene resin used for an intermediate | middle layer and the evaluation result of evaluation item "film forming property" are shown as a list.

  Hereinafter, the PTP or blister pack laminate of the present invention, the PTP or blister pack using the same, and the embodiment of the PTP or blister pack package will be described. The following description will be made using PTP as an example, but the same applies to the blister pack.

  FIG. 1 is a longitudinal sectional view schematically showing the structure of a PTP package 10 in a form in which a preparation 20 is enclosed in a PTP 40. The PTP package 10 is an application example of PTP 40 formed by using a PTP material or a laminated body for blister packs. Such a PTP package 10 is suitable for applications in which a granular or capsule-shaped preparation 20 is individually packaged.

  The shape of the PTP 40 can be variously changed depending on the outer shape of the preparation 20 to be contained. In the example of FIG. 1, the PTP 40 has a dome shape, but the PTP 40 may have a hollow cylindrical shape, a truncated cone shape, a prismatic shape, or a truncated pyramid shape. Further, when the preparation 20 is a long and thin capsule, the PTP 40 is formed into a long and thin protruding shape according to the outer shape of the capsule.

  Such a PTP 40 is obtained by forming a film-like or sheet-like laminate (PTP or blister pack laminate) as a material (raw material). Examples of the method for forming PTP 40 from a laminate of materials include PTP forming methods such as a flat plate pressure forming method, a plug assist pressure forming method, a drum type vacuum forming method, and a plug forming method.

  The PTP 40 has a pocket portion 40a on the inner side, and protects the formulation 20 in a state where the formulation 20 is accommodated in the pocket portion 40a. In addition, a flat hem portion 40b extends around the pocket portion 40a, and the hem portion 40b serves as a base (or flange) of the PTP 40.

  Although only the cross section of one PTP package 10 is shown in FIG. 1, a plurality of PTPs 40 may be connected via, for example, a skirt portion 40 b. For example, assuming that the skirt portion 40b is a single substrate, a plurality of PTPs 40 are arranged in a matrix on the substrate. Half-cut lines and perforations (not shown) for dividing the individual PTPs 40 or their columns can be formed in the skirt portion 40b serving as the substrate.

  The PTP package 10 has a structure in which the preparation 20 is accommodated in the PTP 40 and is sealed with the lid 30. The lid member 30 is a film-like or sheet-like member having, for example, airtightness (gas barrier property). The lid member 30 may be made of PVC or EVA (Ethylene Vinyl Acetate) coated AL (aluminum).

  The lid member 30 and the PTP 40 (the skirt portion 40b) are bonded together by heat-sealing them in a state where the inner surfaces of the lid member 30 and the PTP 40 are overlapped. When the adhesiveness is insufficient as it is, an adhesive layer or a heat-sealable resin layer may be further formed on either the lid member 30 or the PTP 40.

  The PTP package 10 is capable of taking out the formulation 20 while the lid member 30 is pierced by extruding the formulation 20 together with the PTP 40 with a finger or the like from the outside.

[Structure of laminate]
FIG. 2 is a longitudinal sectional view schematically showing the structure of a laminate that is a material of the PTP 40. The laminated structure shown in FIG. 2 remains in the form even after the laminated body of materials is formed as PTP 40 (enclosed portion indicated by a two-dot chain line in FIG. 1: reference symbol II). Hereinafter, the structure of the laminated body (PTP or blister pack laminated body) used as the material of the PTP 40 will be described by taking the laminated structure of FIG. 2 as an example.

  The PTP 40 includes a base material layer 70 as an outermost layer and an absorption film (absorption layer) 50 inside the surface facing the contents. The absorption film 50 is laminated on the base material layer 70 via the adhesive layer 60.

  As the base material layer 70, PVC, PVC coated with polyvinylidene chloride (PVDC), PP, or the like can be used. The base material layer 70 may be a single layer, but may be composed of two or more layers including other layers such as an AL foil as long as the PTP moldability, gas barrier property, and water vapor barrier property are not impaired. The thickness of the base material layer 70 is preferably 150 to 300 μm from the viewpoint of moldability.

  The absorption film 50 and the base material layer 70 are laminated by dry lamination, sand lamination, or the like. As the adhesive layer 60, an adhesive for dry lamination, low density polyethylene (LDPE), linear low density polyethylene (LLDPE), or the like can be used. Further, an anchor coat layer may be formed on either one or both of the absorption film 50 and the base material layer 70 so as to facilitate lamination.

  The absorption film 50 is a film having a three-layer structure. That is, the absorption film 50 has an intermediate layer 51 and an outer skin layer 52 and an inner skin layer 53 sandwiching the intermediate layer 51. Among these, the intermediate | middle layer 51 makes the septum as a functional layer which mainly absorbs water, water vapor | steam, and an odor component. Further, the outer skin layer 52 and the inner skin layer 53 are mainly formed as a skin layer of the intermediate layer 51 by being laminated inside and outside (up and down as viewed in the lamination direction) with the intermediate layer 51 interposed therebetween. The inner and outer skin layers 52 and 53 are not given an absorption function.

As the outer skin layer 52 and the inner skin layer 53, a polypropylene resin can be used.
The intermediate layer 51 is composed of a blend of a polypropylene-based resin and a polyethylene-based resin and an absorbent, and the proportion of the absorbent in the entire mixture is 10 to 30% by mass, and the proportion of the blended resin is 70 to 90 mass. % Is preferred. If it is said mass ratio, the outstanding film forming property and delamination strength can be exhibited according to the combination of the resin material used for an outer skin layer and an inner skin layer. As the polypropylene resin, a polypropylene homopolymer (homo PP), a random copolymer (random PP), or a block copolymer (block PP) can be used. As the polyethylene resin, low density polyethylene (LDPE) or linear low density polyethylene (LLDPE) can be used. As the absorbent, silica gel, zeolite, calcium oxide, magnesium sulfate, and the like can be appropriately selected depending on the object to be absorbed, such as water, water vapor, and smell.

  As zeolite, natural zeolite, artificial zeolite, synthetic zeolite and the like can be used. Since zeolite has a high absorption rate, it can absorb water, water vapor, and odor components quickly. Molecular sieve, which is an example of zeolite, is a porous granular material used to separate materials according to the difference in molecular size, and has a structure with uniform pores. Absorbs molecules and acts as a kind of sieve. In the case of absorbing water or water vapor, the pore (absorption port) diameter of zeolite is preferably 0.3 nm to 1 nm, and usually, molecular sieves having pore diameters of 0.3 nm, 0.4 nm, 0.5 nm, and 1 nm, respectively, They are referred to as molecular sieve 3A, molecular sieve 4A, molecular sieve 5A, and molecular sieve 13X. The average particle size of the molecular sieve (particle size at an integrated value of 50% in the particle size distribution determined by the laser diffraction / scattering method) is, for example, about 10 μm.

  Further, when absorbing an odor component, hydrophobic zeolite is used. Hydrophobic zeolite is a generic term for a so-called high silica zeolite in which aluminum atoms in the crystal skeleton of the zeolite are reduced by dealumination to increase the silica-alumina ratio. Hydrophobic zeolite is a zeolite that loses its affinity for polar substances such as water and absorbs nonpolar substances such as odor components more strongly. Especially for hydrophobic molecular sieves, the pore diameter is 0.6 to 0.9 nm. Abscents 1000, Abscents 2000, Abscents 3000 (manufactured by Union Showa Co., Ltd.) and the like are preferable. The pore diameter can be confirmed by structural analysis by X-ray diffraction. The average particle size of Abscents (particle size at an integrated value of 50% in the particle size distribution determined by the laser diffraction / scattering method) is, for example, 3 to 5 μm.

〔Layer structure〕
The material and thickness (layer thickness) of each layer in the PTP or blister pack laminate are, for example, as follows.
Base material layer: Material: Polypropylene resin (base material PP), Layer thickness: 200 μm
Adhesive layer: Material: Polypropylene resin (PP-4), Layer thickness: 20 μm
Outer skin layer: Material: Polypropylene resin (PP-2), Layer thickness: 10 μm
Intermediate layer: Material: Absorbent and blend resin (PP-2, PE-1), Layer thickness: 60 μm
Inner skin layer Material: Polypropylene resin (PP-1), Layer thickness: 10 μm
In the above conditions, the abbreviation “PP” for “polypropylene”, such as “− (hyphen) 1”, “− (hyphen) 2”, “− (hyphen) 4”, is an identifier of a resin with a different brand name ( Serial number). The brand of resin used will be described later.

[Film forming conditions]
First, PP-2 pellets, PE-1 pellets and an absorbent, which are the materials of the intermediate layer 51, are respectively put into a kneading extruder so as to have a predetermined absorbent content, while melting the resin by heating. After mixing, extrusion is performed to produce mixed pellets.
The absorption film 50 is formed by co-extrusion molding by air-cooling inflation using the prepared pellets as the material for the intermediate layer 51. The film forming conditions are as follows.
Machine name: Three-layer inflation molding machine Manufacturer: Plako Co., Ltd. Resin temperature: 180 ° C for both the intermediate layer and inner and outer skin layers
Take-up speed: 13m / min
The formed absorption film 50 was laminated on the base material layer 70 via the adhesive layer 60 by a dry laminating method, and this was used as a material of PTP 40 (PTP or blister pack laminate).

[Seal conditions]
After the PTP 40 was molded, the lid 30 was heat sealed to complete the PTP package 10. The sealing conditions are as follows.
Sealing machine name: Thermal tilt tester Manufacturer: Toyo Seiki Seisakusho Co., Ltd. Sealing pressure: 0.15 MPa
Sealing temperature: 210 ° C
Sealing time: 0.2 seconds Sealing width: 10 mm

[Configuration of the lid 30]
The lid member has a structure shown in the following materials.
Manufacturer: Sumi Light Aluminum Foil Co., Ltd.
Product name: Printing aluminum foil (for CPP) Material: Heat-resistant overcoat layer / AL (aluminum) 17 μm / Adhesive resin layer Adhesive resin layer: PP (polypropylene, several Μm)
Barrier layer (lid material): Heat-resistant overcoat AL (aluminum, 17 μm)

[Used resin and absorbent]
[Table 1] below lists the brand, model number, physical properties, manufacturer name, and the like of the resin used in the laminate.

  Here, brands (trade names) in Table 1 include registered trademarks.

The absorbent contained in the intermediate layer 51 is as follows.
Absorbent: Zeolite Product name: Abscents 3000 (manufactured by Union Showa Co., Ltd.)

  Next, specific examples will be described. Further, in the following description, a comparative example will be given separately from the examples of the present invention, and the usefulness of the examples will be verified by comparison with these. However, the present invention is not limited to these examples.

  First, as Examples 1 to 6, the brand of resin used for each layer of the absorption film 50 and the blending rate (PP rate) of the polypropylene resin in the resin of the intermediate layer 51 are shown in FIG.

In all of Examples 1 to 6, the base material layer 70 uses the base material PP (brand: super foil) in Table 1, and the adhesive layer 60 uses PP-4 (brand: Novatec, random PP). It was used.
The intermediate layer 51 had a zeolite content of 20% by weight and a resin content of 80% by weight. As the zeolite, Abscents 3000 (manufactured by Union Showa Co., Ltd.) was used.

〔Evaluation item〕
The absorption film 50 is actually blow-molded at the blending ratio (PP ratio) of the polypropylene resin shown in each of Examples 1 to 6. Moreover, PTP40 was actually shape | molded using the laminated body obtained from there, and it evaluated from the following (A) and (B) two viewpoints, respectively.

(A) Film-forming property The laminated body obtained by laminating | stacking on the obtained absorption film 50 or the base material layer 70 was visually inspected, and the generation | occurrence | production frequency of wrinkles was evaluated in three steps. The three-level evaluation is “○”, “△”, and “×”, and the highest score “○” corresponds to the case where no wrinkle occurs. In addition, “△” of the next point corresponds to a case where it can be judged that the influence on the product is small (for example, when wrinkles occur once or twice per 1000 m), and “x” of the lowest point Applicable for cases of frequent epilepsy.

(B) Delamination After forming PTP40 using the laminated body obtained by laminating | stacking the absorption film 50 on the base material layer 70, the lid | cover material 30 was sealed and the PTP package 10 was created. A peel test between the PTP 40 and the lid member 30 (based on ISO 8510-2 (Japanese Industrial Standard JIS K6854)) is performed on the created PTP package 10, and the inner skin layer 53 and the intermediate layer 51 are separated in two stages. evaluated. The two-step evaluation is “◯” and “×”, and the pass score “◯” is applicable to the case where delamination does not occur and peeling occurs between the PTP 40 and the lid 30. “×” corresponds to the case where delamination occurs before peeling between the PTP 40 and the lid 30.

  FIG. 3 is a table showing the blending ratio (PP ratio) of the polypropylene resin in the intermediate layer 51 and the evaluation results of the respective evaluation items (A) and (B) in a list for Examples 1 to 6. is there. Furthermore, in the same figure, about Comparative Examples 1-4 contrasted with Examples 1-6, the compounding rate (PP rate) of each polypropylene resin and the evaluation result of each evaluation item (A) and (B) are united. It was described.

  In Comparative Examples 1 to 4, the base material layer 70 uses the base material PP (brand: super foil) in Table 1 and the adhesive layer 60 uses PP-4 (brand: Novatec, random PP). ing. The zeolite content and brand conditions (Abscents 3000: 20% by weight) are the same as in Examples 1-6.

The following points are clear from FIG.
(1) In Examples 1 and 2, the evaluation result (A) “film forming property” was evaluated as “△: small impact on commercialization”, but the other Examples 3 to 6 were all An evaluation result of “◯: No wrinkle” was obtained.
(2) In each of Examples 1 to 6, an evaluation result of “◯: No peeling” was obtained for “interlayer peeling” of the evaluation item (B).

(3) On the other hand, since Comparative Example 1 is evaluated as “x: frequent occurrence of wrinkles” for the “film forming property” of the evaluation item (A), there is still a problem at the time of inflation molding of the absorbent film 50. I understand that. In Comparative Example 1, the evaluation result of “O: No delamination” was obtained for “interlayer delamination” in the evaluation item (B), and therefore Comparative Example 1 had a problem in “film forming property”. It is believed that there is.

(4) Next, Comparative Examples 2 and 3 resulted in an evaluation result of “B: No wrinkle” for “Filmability” of the evaluation item (A), but reached “Blamination” in (B). Is evaluated as “×: delamination”. Therefore, it is considered that Comparative Examples 2 and 3 have a problem in “delamination”.

(5) In Comparative Example 4, although the evaluation result “O: No wrinkle” was obtained for the “film forming property” of the evaluation item (A), “×: It is evaluated as “delamination”. Therefore, it is considered that Comparative Example 4 also has a problem in “delamination strength”.

[Verification of PP blending range for film forming properties]
From the comparison between Examples 1 to 6 and Comparative Examples 1 to 4, the following matters regarding “film forming property” are clear.

  When polyethylene is not blended in the resin of the intermediate layer 51 and the PP ratio is 100% by weight as in Comparative Example 1, the evaluation result of (A) “Film Formability” is “×: Frequent wrinkles”. . This is considered to be because if the intermediate layer 51 is made of 100% polypropylene resin, the flexibility (flexibility) of the entire resin is lowered during the inflation molding process.

  On the other hand, as in Comparative Example 4, even when the resin of the intermediate layer 51 is 100% polyethylene resin and the PP ratio is 0% by weight, the evaluation result of (A) “Film Formability” is “◯: No wrinkle” It has become. This means that even if the intermediate layer 51 is made of 100% polyethylene resin, the film formability of the absorbent film 50 is not particularly deteriorated.

[Verification result 1]
From the above, it is appropriate that the PP ratio in the resin of the intermediate layer 51 is 95% by weight as the upper limit.

[Verification result 2]
More preferably, while considering the upper limit of 95% by weight obtained in the verification result 1, in particular, in Examples 3 to 6, the “film forming property” has a high evaluation of “O: No wrinkle”, so The PP ratio in the resin of the layer 51 may be up to 85% by weight.

[Verification of PP blending range for delamination]
Next, from the comparison between Examples 1 to 6 and Comparative Examples 1 to 4, the following matters are clear with respect to “delamination (strength)”.

Even when the PP ratio (= 70 wt%) of Example 6 is set, there is no problem in “delamination” of the obtained laminate.
On the other hand, when the PP ratio of the intermediate layer 51 is lowered to 65% by weight as in Comparative Example 2, a problem occurs in “delamination”.

[Verification result 3]
From the above, it is appropriate that the blending ratio of the polypropylene-based resin in the resin of the intermediate layer 51 is 66% by weight exceeding 65% by weight.

[Verification result 4]
More preferably, based on the evaluation result of Example 6 based on the lower limit of 66% by weight obtained in the verification result 3, the blending ratio of the polypropylene-based resin in the blend resin of the intermediate layer 51 is set to 70% by weight as the lower limit. Also good.

[Optimum PP blending range]
From the above verification results 1 to 4, the blending ratio of the polypropylene resin for the blend resin (polypropylene resin and polyethylene resin) used for the intermediate layer 51 is in the range of 66 to 95% by weight. Therefore, the blending ratio of the polyethylene resin is set to the remaining 5 to 34% by weight.

  In light of the above range, more preferably, the blending ratio of the polypropylene resin of the resin used for the mid layer 51 can be optimized within a range of 70 to 85% by weight. Therefore, the blending ratio of the polyethylene resin can be optimized within the remaining 15 to 30% by weight.

[Selection of polypropylene resin brand]
Next, selection of the polypropylene resin brand used for the intermediate layer 51 was replaced with Examples 7 to 9. In Examples 7 to 9, PP-4 (brand: Novatec, random PP) is used for the adhesive layer 60. The zeolite content and brand conditions (Abscents 3000: 20% by weight) are the same as in Examples 1-6.

  FIG. 4 is a table showing a list of brands of the polypropylene-based resin used in the intermediate layer 51 and evaluation results of the evaluation item “film forming property” in Examples 7 to 9.

  As shown in FIG. 4, in each of Examples 8 and 9, an evaluation result of “◯: no wrinkle” was obtained in the “film forming property” of the evaluation item. In Example 7, although the evaluation result did not reach the highest point, the evaluation of “△: small influence on commercialization” was obtained for the “film forming property”.

  The major difference between Example 7 and Examples 8 and 9 is that the polypropylene resin used for the intermediate layer 51 is a random copolymer. It can be seen that when a homopolymer is used for the polypropylene resin as in Example 7, the film formation is not as good as that of a random copolymer. However, even when polypropylene resin is used as a homopolymer as in Example 7, the evaluation of “film forming property” does not become the lowest point “x: frequent occurrence of wrinkles” and is still suitable as an example of the present invention. no change.

[Verification of random copolymer effect]
In addition, it was verified that better “film-formability” can be obtained by using a random copolymer for the polypropylene resin used for the intermediate layer 51.

[Selection of the best polypropylene resin brand]
From the above verification results, it is optimal that the polypropylene resin used for the intermediate layer 51 is a random copolymer. Therefore, in selecting a brand to be used, it is preferable to select a resin corresponding to random PP.

[Selection of polyethylene resin brand]
Next, Examples 10 and 11 were made by replacing the selection of the polyethylene resin brand used for the intermediate layer 51. Similarly in these Examples 10 and 11, PP-4 (brand: Novatec, random PP) is used for the adhesive layer 60. The zeolite content and brand conditions (Abscents 3000: 20% by weight) are the same as in Examples 1-6.

  FIG. 5 is a table showing a list of brands of polyethylene-based resin used in the intermediate layer 51 and evaluation results of the evaluation item “film forming property” in Examples 10 and 11.

  As shown in FIG. 5, in Example 10, an evaluation result of “◯: no wrinkle” was obtained in the “film forming property” of the evaluation item. In Example 11, although the evaluation result did not reach the highest point, the evaluation of “△: small influence on commercialization” was obtained for “film forming property”.

  The major difference between Example 10 and Example 11 is the melt flow rate (MFR) of the polyethylene resin used for the intermediate layer 51. As in Example 11, when a polyethylene resin having a relatively high melt flow rate is used, it is found that the film forming property does not reach the polyethylene resin having a relatively low melt flow rate. However, even when a polyethylene resin having a relatively high melt flow rate was used as in Example 11, the evaluation of “film forming property” was not the lowest point “x: frequent occurrence of wrinkles”, and the present invention was still carried out. It remains unchanged as an example.

[Verification of the effect of melt flow rate]
On that basis, it was verified that a better “film forming property” can be obtained by using a polyethylene resin having a relatively low melt flow rate for the intermediate layer 51.

[Selecting the optimal polyethylene resin brand]
From the above verification results, it is optimal that the polyethylene resin used for the intermediate layer 51 has a relatively low melt flow rate. Therefore, the inventors of the present invention propose to select a resin corresponding to a polyethylene resin having a low melt flow rate instead of a high melt flow rate in selecting a brand to be used.

  The present invention can be implemented with various modifications and substitutions without being limited to the above-described embodiments and examples. Moreover, it is needless to say that the configurations and materials of the laminate and the packaging container mentioned in the above-described embodiments and examples are all preferable examples, and can be implemented by appropriately modifying them.

10 PTP Package 20 Formulation 30 Lid 40 PTP
50 Absorption film (absorption layer)
60 Adhesive layer 70 Base material layer

Claims (13)

A base material layer as an outermost layer as a PTP or blister pack,
An adhesive layer that is laminated to the base material layer via an adhesive layer, and absorbs at least one of liquid and gas facing the contents at the time of molding as a PTP or blister pack,
The absorbent layer has a configuration in which an outer skin layer, an intermediate layer, and an inner skin layer are laminated in this order, and the outer skin layer is bonded to the base material layer via the adhesive layer,
The outer skin layer and the inner skin layer are made of polypropylene resin,
The intermediate layer is a laminate for a PTP or blister pack, comprising a mixture of a blend resin and an absorbent having 66 to 95% by weight of a polypropylene resin and 34 to 5% by weight of a polyethylene resin. In the laminate for PTP or blister pack according to claim 1,
The PTP or blister pack laminate, wherein the blend resin of the intermediate layer has 70 to 85% by weight of a polypropylene resin and 30 to 15% by weight of a polyethylene resin. In the laminate for PTP or blister pack according to claim 1 or 2,
The inner skin layer is
A laminate for PTP or blister pack, characterized in that it is composed of a polypropylene resin having a higher melting point as a material than the temperature of heat applied in the molding process as PTP or blister pack. In the laminate for PTP or blister pack according to any one of claims 1 to 3,
The intermediate layer is
A laminate for PTP or blister pack, wherein the polypropylene resin in the blend resin is a random copolymer. In the laminate for PTP or blister pack according to any one of claims 1 to 4,
The intermediate layer is
A laminate for PTP or blister pack, wherein the polyethylene resin in the blend resin is low density polyethylene (LDPE) or linear low density polyethylene (LLDPE).   The laminate for PTP or blister pack according to any one of claims 1 to 5, wherein the absorbent is a synthetic zeolite that absorbs odor. PTP or blister packs Ru consists of PTP or blister pack laminate according to any one of claims 1 to 6.   A PTP package or a blister package comprising the PTP or blister pack according to claim 7 and a preparation contained in the PTP or blister pack.   An olmesartan medoxomil-containing preparation packaged with the PTP or blister pack according to claim 7.   The olmesartan medoxomil-containing preparation according to claim 9, wherein the odor generated from the contained olmesartan medoxomil preparation is reduced.   A method for reducing odor generated from an olmesartan medoxomil-containing preparation, which is packaged with the PTP or blister pack according to claim 7.   Use of the PTP or blister pack according to claim 7 for packaging of olmesartan medoxomil-containing preparations.   Use of the PTP or blister pack according to claim 7 for odor-reducing packaging in a preparation containing olmesartan medoxomil.

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