JP2018187107A - Exposure prevention box, safety cabinet, and local exhaust - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an exposure prevention box for preventing an operator from erroneously sticking a needle of a syringe to a hand and staining gloves with a medicine, an organic solvent, or the like when preparing an anticancer agent, the organic solvent, or the like in an open-type safety cabinet and a local exhaust device.SOLUTION: Exposure prevention boxes 10 of this invention are installed in an open-type safety cabinet 100 and an operation room of a local exhaust device to be used. An exposure prevention box forms a hollow box body composed of a bottom wall, a top wall and side walls, and is provided with a container holding part 53 for holding a medicine sealing container on the bottom wall. The bottom wall has an exhaust port 51a communicating with a lower space of the operation room, and the top wall has a filling tool insertion port 63 at a position facing the container holding part.SELECTED DRAWING: Figure 1

Description

  The present invention relates to an exposure prevention box for preventing exposure to an anticancer agent, an organic solvent, or the like in an operation of dissolving a drug such as an ampoule or a vial using a syringe at the time of preparation of the anticancer agent, or when handling a highly toxic organic solvent. More particularly, the present invention relates to an open-type safety cabinet having a working opening and an exposure prevention box used by being attached to a local exhaust device, as well as a safety cabinet and a local exhaust device having the same.

  In recent years, even if it is a local exhaust system that is obligated when using an all-exhaust type B2 or higher type of an open type biohazard countermeasure class II cabinet that shields the work opening with an airflow, or a highly toxic organic solvent. It has been pointed out that exposure accidents during preparation of anticancer agents and organic solvents may not be sufficiently prevented.

  Therefore, a closed system (closed type drug mixing system) that can transfer a drug solution in a state where the connecting portion between the syringe needle and the vial is covered is used when preparing the anticancer agent. For example, in Patent Document 1, in addition to the connecting portion between the syringe needle and the vial, the base end portion of the syringe is sealed to prevent the medicine from flowing out from the syringe base end portion, and the air chamber behind the syringe piston There has been proposed a connector for preventing the evaporation of a chemical solution by providing an air needle for allowing air to flow into the vial from the inside and keeping the pressure in the vial constant during the transfer of the chemical solution.

  On the other hand, Patent Document 2 proposes a small adjustment case that is installed in a safety cabinet to ensure double safety. The adjustment case of Patent Document 2 is configured to insert a hand from a pair of openings and adjust the medicine in the case, and is configured to exhaust air through an exhaust port provided with an activated carbon filter.

JP-T-2006-521176 Utility Model Registration No. 314520

However, the closed system disclosed in Patent Document 1 has a problem that it is expensive and expensive because it is disposable, and the range of use is limited to those that are volatile and highly toxic. Moreover, since the small adjustment case of patent document 2 puts a hand in a case and works, an operator accidentally stabs a hand with a needle, or a sprayed medicine adheres to a worker's gloves. There's a problem.
The present invention has been made in view of the above problems, and even when working with an open class II cabinet or a local exhaust system, it is possible to suppress exposure prevention accidents at low cost, and an operator is mistaken. The purpose is to provide an anti-exposure box that does not pierce hands with needles or attach chemicals or organic solvents to gloves.

  The invention made in order to solve the above-mentioned problems is that the working opening is sucked into the lower space of the working chamber by sucking external air flowing in from the working opening and air in the working chamber into the airflow. It is an exposure prevention box that is attached to the working room of an open safety cabinet to be shielded or a local exhaust system, and is used when preparing drugs and organic solvents in drug sealed containers using filling tools such as syringes and pipettes. A hollow box made up of a bottom wall, a top wall, and a side wall, and one or a plurality of container holding portions that are provided on the bottom wall and hold a drug-sealed container, the bottom wall including the work chamber An exhaust port communicating with the lower space of the container is provided, and the ceiling wall has a filler insertion port at a position facing the container holding portion.

Thus, in the exposure prevention box of the present invention, the container holding part for holding the drug-sealed container is provided on the bottom wall, and the filler insertion port is provided at a position facing the container holding part on the top wall. Hold the drug-sealed container, insert the syringe or pipette with the tip down from the filler insertion port, insert the syringe needle into the vial (drug-sealed container) inside the exposure prevention box, The tip of the pipette can be inserted into an organic solvent container with the lid open. As a result, it is possible to physically isolate the connecting part between the filling device and the drug-sealed container from the operator, and the drug can be transferred without putting a hand inside. It is possible to suppress sticking of hands and adhesion of sprayed chemicals and organic solvents to workers' gloves.
In addition, an exhaust port communicating with the lower space of the safety cabinet and local exhaust device is provided on the bottom wall, and the air inside the exposure prevention box is sucked into the lower space using the negative pressure function of the safety cabinet and local exhaust device. Since it comprised so that the chemical | medical agent and organic solvent which leaked inside the exposure prevention box with the simple structure can be prevented.

  The top wall and the side wall are preferably made of a transparent material. Thus, by making the side wall and the top wall transparent, it is possible to adjust the drug while confirming the position of the drug sealed container and the tip of the needle or pipette from the outside of the exposure prevention box, In addition, even if the syringe is accidentally dropped to the other side of the exposure prevention box, the syringe position can be checked and picked up from the front of the exposure prevention box. There is no stab.

  It is preferable that the box body is configured such that the side wall and the top wall are integrally formed to form a cover box, and the cover box is attached to and detached from the bottom wall to open and close. By doing so, the inside of the exposure prevention box can be easily cleaned.

  It is preferable that the side wall has a bubble extraction window that can be inserted from the needle tip in a state where the syringe is laid down. In this way, after injecting the solution from the syringe into the drug-sealed container, the tip of the syringe can be inserted into the exposure prevention box from the bubble extraction window, and the bubbles that have entered the syringe can be discharged from the needle tip. .

  The bottom wall preferably has a discharge port in a syringe insertion direction of the bubble removal window in a plan view. By doing so, the air discharged from the syringe can be discharged without leaking to the working chamber.

  It is preferable that the container holding part is configured to fix the drug sealed container to the adhesive sheet. In this way, various sizes of drug-sealed containers can be held by the container holding portion, and the drug-sealed containers can be prevented from falling.

  The container holding part may be configured to fix the drug sealed container with a winding spring. By doing so, the drug-sealed container can be supported more stably.

  It is preferable that the exposure prevention box of the present invention has an adapter installed at the filler insertion port so as to change the inner diameter of the filler insertion port according to the outer diameter of the syringe to be used. By attaching an adapter adapted to the outer diameter of the syringe or pipette to be used, the syringe or pipette to be inserted into the filler insertion port can be reliably guided. One exposure prevention box can be used for a plurality of types of syringes and pipettes.

  It is preferable that the filling tool insertion port has a long hole shape, and the container holding portion is supported so as to be swingable along the filling tool insertion port. By doing so, for example, the syringe and the drug sealed container can be swung along the long hole-shaped filler insertion port while the needle of the syringe is pierced into the drug sealed container.

The present invention is an open type in which the work opening is shielded by an air flow by sucking outside air flowing in from the work opening and air in the work chamber into a lower space of the work chamber, Includes safety cabinet with any exposure control box, and local exhaust.
The safety cabinet and the local exhaust device of the present invention include an exposure prevention box installation opening that passes through a work plate forming a bottom wall of the work chamber and communicates with the lower space, and the exposure prevention box installation opening. And the exposure prevention box is installed in the exposure prevention box installation opening in a state where the flat cover is opened.
In this way, the safety cabinet work plate is provided with an opening for exposure prevention box installation that communicates with the lower space, and the exposure prevention box is installed at the opening for exposure prevention box installation. The mouth can easily communicate with a lower space such as a safety cabinet. In addition, a flat lid is provided to close the exposure prevention box installation opening, so if you do not prepare medicines, remove the exposure prevention box and close the exposure prevention box installation opening with a flat cover. Can be widely used.

  The safety cabinet and the local exhaust device of the present invention preferably include a plurality of the exposure prevention boxes, and each exposure prevention box has a filler insertion opening having a different size. In this way, it is possible to easily prepare drugs and handle organic solvents with syringes and pipettes of various sizes simply by selecting an appropriate exposure prevention box. In addition, by making it possible to select the filler insertion port that matches the diameter of the syringe, etc., the gap between the side wall of the syringe and the filler insertion port can be reduced, so that the drug leaks out of the exposure prevention box. It can suppress more effectively.

  As described above, according to the exposure prevention box, the safety cabinet, and the local exhaust device of the present invention, it is possible to suppress exposure accidents at low cost, and the drug accidentally stabbed with a needle or sprayed on gloves And accidents such as attaching organic solvents can be suppressed.

It is the fragmentary perspective view which showed the work bench periphery of the safety cabinet which concerns on 1st Embodiment of this invention. It is a disassembled perspective view of the exposure prevention box shown in FIG. It is the top view of the (a) bottom wall of the exposure prevention box shown in FIG. 1, (b) The top view of a cover box, (c) The front view of a cover box. It is explanatory drawing which showed a mode that the chemical | medical agent in a chemical | medical agent sealing container was prepared using the exposure prevention box shown in FIG. FIG. 2 is a plan view of a work table of the safety cabinet with an exposure prevention box in FIG. 1. FIG. 2 is a cross-sectional view of the work table with the exposure prevention box of the safety cabinet of FIG. 1 removed. FIG. 2 is a plan view of a work table in a state where a support for an exposure prevention box is installed in the safety cabinet of FIG. 1. FIG. 2 is a cross-sectional view of a work table showing a state where an exposure prevention box is installed in the safety cabinet of FIG. 1. It is explanatory drawing which shows the flow of the air in the safety cabinet of FIG. 1 by a side view. It is (a) front view and (b) top view which looked through and showed the inside of the exposure prevention box which concerns on 2nd Embodiment of this invention. It is (a) front view, (b) right view, (c) top view, (d) bottom view of the box of the exposure prevention box shown in FIG. It is explanatory drawing which showed a mode that the chemical | medical agent in a chemical | medical agent sealing container was prepared using the exposure prevention box shown in FIG. It is (a) top view of the adapter of FIG. 12, (b) longitudinal cross-sectional view (c). (A) Front view of container holding part according to third embodiment of the present invention, (b) Plan view of neck part holding part, (c) Plan view of trunk part holding part, (d) Plan view of pedestal, ( e) an exploded front view, (f) a front view showing a use state. It is an exposure prevention box which concerns on 4th Embodiment of this invention. It is explanatory drawing which shows the usage method of the exposure prevention box of FIG. (A) Front view of the entire container holding part of the exposure prevention box according to the fifth embodiment of the present invention, (b) Plan view of the neck holding part, (c) Plan view of the lower holding part (d) Whole It is a top view. It is (a) front view of the exposure prevention box which concerns on 5th Embodiment of this invention, (b) It is a transparent front view.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings as appropriate. The present invention is not limited to the following embodiment. Moreover, the structure of each embodiment can be combined suitably.

(First embodiment)
FIG. 1 shows a safety cabinet 100 according to a first embodiment of the present invention. The safety cabinet 100 is configured as an open type / all exhaust type belonging to the class B2 of the class II cabinet for biohazard countermeasures in Japanese Industrial Standard JISK3800.
As shown in FIG. 1, the safety cabinet 100 mainly includes a shutter 1, a work table 2, a work opening 3 provided therebetween, and an exposure prevention box 10. The work opening 3 is shielded by an air flow provided by sucking the air in the work chamber 4 and the air flowing in from the work opening 3 from the air inlet 24 a of the grating 24 in front of the work table 2.

As illustrated in FIG. 2, the exposure prevention box 10 includes a support base 5 and a cover box 6.
The support base 5 is formed by subjecting a stainless steel plate to sheet metal and welding processing, and includes a bottom wall 51 having a rectangular flat plate shape, and four support legs 52, 52,... Hanging from four corners of the lower surface of the bottom wall 51. Have.
The bottom wall 51 forms a rectangular parallelepiped box together with the cover box 6.
Adjacent support legs 52 are connected and fixed to each other at the lower ends thereof by a cross rail 11 (not shown in FIG. 2, see FIG. 8). The bottom wall 51 has a container holding portion 53 made of a rectangular plate member made of silicon attached to the upper surface. The container holding part 53 is provided with a so-called weak adhesive material layer on both the upper and lower surfaces, detachably attaches and supports the drug-sealed container to be placed, and is also detachable from the bottom wall 51 so that it can be replaced for each operation. It is a member. The bottom wall 51 is provided with one or a plurality (four in the illustrated example) of exhaust ports 51a so as to surround the container holding portion 53, and also the ends on the left and right end sides (left side in FIG. 2) in plan view. An exhaust port 51b is provided along the side. The wearing mouth 51b is provided so as to intersect with the syringe insertion direction of the bubble removal window 65 in plan view.

  The cover box 6 is made of a resin such as acrylic or vinyl chloride, or a chemical-resistant transparent plate material such as glass, and as shown in FIG. 2, the cover box 6 has five surfaces including a top wall 62 and four side walls 64a to 64d. It has a rectangular parallelepiped box shape that opens downward. The cover box 6 is provided in substantially the same size as the bottom wall 51 in a plan view, and the lower opening 61 is fitted in an airtight and detachable manner to the periphery of the bottom wall 51 by a fitting means (not shown). Is done. Further, the top wall 62 is provided with a filler insertion port 63 at a position directly above the container holding part facing the container holding part 53, and a bubble venting window 65 is provided on the right side wall 64a. ing.

  The filling tool insertion port 63 is formed by a circular hole formed in the top wall 62. A square frame 63b is provided around the filling hole 63 and is opened and closed by a door 63a fitted to the square frame 63b. The bubble extraction window 65 is a rectangular through hole, and is opened and closed by a door 65a.

As shown in FIG. 1, a total of five exposure prevention boxes 10 are arranged in the front and rear two rows in the center of the work table 2 of the safety cabinet 100. Each of the five exposure prevention boxes 10 includes a filler insertion port 63 and a bubble removal window 65 having different diameters.
The two front exposure prevention boxes 10 and the three rear exposure prevention boxes 10 (bottom walls 51) are connected to and detached from each other by connecting the supporting legs 52 and the support bases 5 by the cross rails 11 (see FIG. 8). It is configured to be possible.
Between the adjacent bottom walls 51, the opening part 12 (refer FIG. 1) is provided.

As shown in FIG. 5, the work plate 21 of the work table 2 has two front and rear exposure prevention box installation openings 22 and 23. As shown in FIG. 6, the exposure prevention box installation openings 22 and 23 penetrate the work plate 21 in the vertical direction and communicate the work chamber 4 with the lower space 7 of the work table 2. As shown in FIG. 7, the front and rear exposure prevention box installation openings 22 and 23 accommodate two and three support bases 5, respectively. At this time, as shown in FIG. 8, the support base 5 is installed so that the lower end of the support leg 52 contacts the bottom surface 71 of the lower space 7, and the bottom wall 51 is provided so as to be flush with the work plate 21. ing.
When the exposure prevention box 10 is not used, the work table 2 can be widely used as a work table by closing the exposure prevention box installation openings 22 and 23 with flat covers 22a and 23a as shown in FIG. it can.
It should be noted that the exposure prevention box installation openings 22 and 23 can be changed according to the number of the exposure prevention boxes 10 to be installed. Moreover, the method of installing the exposure prevention box 10 can use various methods, such as attaching to the work table 2 with a screw other than the method of installing with four legs.

Next, using the safety cabinet 100, the procedure for adjusting the medicine and the effects of each part will be described.
When the medicine is adjusted using the safety cabinet 100, first, as shown in FIG. 7, the support 5 is installed in the exposure prevention box installation openings 22 and 23 of the work table 2. Although FIG. 7 shows a state in which the support base 5 is installed in both of the two exposure prevention box installation openings 22 and 23, the support base 5 is provided only in the front opening 22 or the rear opening 23. May be installed.

  When the support base 5 is installed, as shown in FIG. 4A, the drug-sealed container A such as a vial is placed on the container holding portion 53 of the support base 5 with the rubber stopper side serving as the needle puncture portion facing upward. Next, as shown in FIG. 4B, the support box 5 is covered with the cover box 6 so as to accommodate the drug-sealed container A. At this time, the door 63a is opened for later work. The door 65a is opened only when bubbles are removed from the syringe B. When the cover box 6 is put on the support base 5, the filling tool insertion port 63 is configured to be located immediately above the drug sealed container A.

In this state, as shown in FIG. 4 (c), the syringe B is inserted from the needle side into the filler insertion port 63 and the inside of the drug sealed container A is visually confirmed through the transparent cover box 6. For example, the needle of the syringe B is inserted into the stopper, and for example, an infusion or the like is transferred from the syringe into the drug sealed container A to dissolve the drug. At this time, only a part of the entire length of the syringe is inserted into the exposure prevention box 10, and the piston operation can be performed outside the exposure prevention box 10. Further, the bubble extraction window 65 is closed during the medicine adjustment operation.
When the adjustment of the medicine is completed, the needle is withdrawn from the medicine sealed container A, and the syringe B is withdrawn from the filler insertion port 63.
Thus, with the safety cabinet and 100, the medicine can be prepared without putting the hand into the exposure prevention box 10, and the hand is not accidentally pierced with the needle of the syringe.

  To perform the bubble removal operation, the syringe B is pulled out from the cover box 6 at one end, and as shown in FIG. 4E, the filling tool insertion port 63 is closed by the door 63a, and the syringe B is inserted into the bubble removal window 65 on the needle tip side. Insert from. The needle tip is inserted to just above the exhaust port 51b, and the piston of the syringe B is pushed and discharged from the needle tip while visually confirming the bubbles in the syringe B through the transparent cover box 6. The air exhausted here is exhausted from the exhaust port 51 b to the lower space 7 of the work table 2.

  FIG. 9 shows a side view of the air flow of the safety cabinet 100 during the above-described drug preparation operation. The air sucked from the room by a non-illustrated air supply fan is dust-removed and sterilized by the HEPA filter 9 and is supplied from the top wall 91 to the work room 4. The air flowing in from the work opening 3 and the air in the work chamber 4 are sucked into the lower space 7 through the front air inlet 24a. The air in the working chamber 4 is also sucked into the exhaust path 8 from a suction port 81 provided in the lower part of the rear wall of the working chamber.

  In the exposure prevention box 10, the air in the work chamber 4 is taken into the cover box 6 through the filler insertion port 63 and discharged into the lower space 7 through the exhaust ports 51 a and 51 b. In this way, harmful dust or the like of the medicine leaked into the cover box 6 is discharged to the lower space 7. The air discharged to the lower space 7 passes through the exhaust path 8 and is exhausted to the outside through an exhaust fan and a HEPA filter (not shown).

The exposure prevention box 10 is taken out of the safety cabinet 100 or out of the safety cabinet 100 and cleaned for the removal of the anticancer agent and the like after the completion of the work such as the preparation of the medicine. The container holding part 53 is removed and discarded.
As described above, the safety cabinet 100 is economical because there are few members to be discarded at every work.

(Second Embodiment)
10 and 11 show an exposure prevention box 20 according to the second embodiment of the present invention. The exposure prevention box 20 has a rectangular parallelepiped box 260 integrally formed of a transparent plate material, and a container holding portion 253 provided inside the box 260. As the transparent plate material forming the box 260, a resin such as acrylic or vinyl chloride, or a chemical resistant plate material such as glass is used. In this case, the bottom wall 251 of the box 260 is preferably fixed to a part of the work table 2 with screws or the like.

  As shown in FIG. 10, the box 260 has a rectangular parallelepiped shape in which the bottom wall 251 forms a substantially square shape. The box 260 has a filler insertion port 263 that is opened and closed by the door 263a on the top wall 262, and a bubble vent window 265 that is opened and closed by the door 265a on the right side wall (264a in FIG. 10). ing. The front side wall 264d is provided with a carry-in port 267 (see FIG. 11) through which the medicine sealed container A is taken in and out. The carry-in entrance 267 is opened and closed by a door 267a.

As shown in FIG. 10, a container holding portion 253 is provided at the center of the bottom wall 251. The container holding unit 253 includes a container holding tool 253a formed of a helical spring for holding the drug sealed container A, a cylindrical base 253b that supports the container holding tool 253a, and a base 253b on the bottom wall 251. A fixing flange 253c is provided. The container holder 253a is fixed to the base 253b by bolts and nuts 253e, and the flange 253c is fixed to the bottom wall by screws 253d.
A plurality of container holding portions 253 having different inner diameters of the container holding tool 253a are provided so as to correspond to the outer dimensions of different drug sealed containers A. For this reason, since one exposure prevention box 20 according to the second embodiment can correspond to a plurality of sizes of drug sealed containers A, it is sufficient to install only one in the safety cabinet 100, and the work plate 21 exposure prevention box is installed. Only one opening is required.

As shown in FIG. 10B, the bottom wall 251 has four rectangular exhaust ports 251 a around the container holding portion 253. One of the exhaust ports 251 a is provided in the syringe insertion direction of the bubble extraction window 265.
Further, on the lower surface (outer surface) of the bottom wall 251, as shown in FIG. 11D, leg base portions 252 made of four rectangular plates are provided so as to surround the exhaust port 251a. A support leg (not shown) is connected to the leg base 252.

The exposure prevention box 20 has a plurality of adapters 27 that can be exchanged according to the diameter of the syringe B as shown in FIG. The adapter 27 includes a syringe insertion part 27a made of a flat cylinder, a tapered part 27c for guiding the rectangular outer frame b to the filler insertion port 263, a support part 27d for connecting the outer frame 27b and the syringe insertion part 27a. It has. Although illustration of all the plurality of adapters 27 is omitted, the plurality of adapters 27 are all provided with different inner diameters in accordance with the outer diameter of the syringe used by the syringe insertion portion 27a.
Also in the safety cabinet used for the exposure prevention box 20 according to the second embodiment, although not shown in particular, an opening for setting the exposure prevention box is provided on the work table so that the exposure prevention box 20 can be accommodated without a gap.

  When preparing the drug in the drug sealed container A using the exposure prevention box 20, as preparation, first, as shown in FIG. 12 (a), the filling tool insertion port 263 has an outer shape of the syringe to be used. The fitted adapter 27 is attached, and the container holding part 253 suitable for the outer diameter of the drug-sealed container A used on the bottom wall 251 is fixed. Thereafter, the door 263a is opened so that the door 267a can be easily opened.

When this preparation is completed, as shown in FIG. 12B, the door 267a is opened, the drug sealed container A is carried into the exposure prevention box 20 from the carry-in entrance 267, and set in the container holding portion 253a. As shown in (c), the door 267a is closed.
Next, in the working chamber 4, the solution is sucked into the syringe B, and the syringe B is inserted into the filler insertion port 263 from the needle side. And while visually recognizing the inside through the transparent box 260, the needle of the syringe B is inserted into the rubber stopper of the drug sealed container A, and the solution in the syringe B is injected into the drug sealed container A and dissolved. .

  When a bubble removal operation is required during the dissolution operation, the syringe B is inserted into the bubble extraction window 265 from the needle tip, and the bubbles accumulated in the syringe B are discharged. The air discharged from the syringe B is sucked from the bubble extraction window 265 and discharged to the lower space 7 according to the air discharged from the exhaust port 251a. By carrying out like this, the exposure accident by the air venting operation | work after attracting | sucking a chemical | medical agent in the syringe B can be suppressed effectively.

  When the dissolution of the drug is completed, the needle of the syringe B is pulled out from the drug sealed container A and the syringe B is taken out from the filler insertion port 263.

  At this time, the air in the work chamber 4 of the safety cabinet 100 flows into the exposure prevention box 20 from the space between the syringe insertion portion 27a and the outer frame 27b, and is discharged from the exhaust port 251a to the lower space 7 of the safety cabinet 100. The For this reason, since the harmful dust etc. of the medicine leaked by the work of transferring the medicine between the syringe B and the medicine sealed container A are discharged to the lower space 7, it is possible to effectively prevent the operator's exposure accident.

(Third embodiment)
FIG. 14 shows a container holding part 353 of the exposure prevention box according to the third embodiment of the present invention. Since the box body of 3rd Embodiment is common with the box body 260 of 2nd Embodiment, illustration and description are abbreviate | omitted.

  As shown in FIG. 14E, the container holding portion 353 fixes the holding frame 353a that holds the drug-sealed container A, the base 353b that supports the holding frame 353a, and the base 353b to the bottom wall 251. And a flange 353c.

  As shown in FIG. 14A, the holding frame 353a is provided in a circular arc shape longer than a semicircle, a neck holding portion 353a1 (see FIG. 14B) that holds the neck portion of the drug sealing container A, and drug sealing. It consists of a trunk part holding part 353a2 (see FIG. 14C) that supports the trunk part of the container A, a column 353a3, and a disk-shaped base 353a4 (see FIG. 14D). The support column 353a3 is erected on the periphery of the pedestal 353a4, and the neck holding portion 353a1 and the trunk portion holding portion 353a2 are arranged on the support column 353a3 so that the opening portion faces the carry-in entrance 267 of the box 260 at the center in the circumferential direction. It is connected.

  The base 353b is formed of a solid column having a vertical direction in the axial direction or a cylindrical shape with a lid, and has a lower end bonded and fixed to the flange 353c. In the holding frame 353a, the base 353a4 is screwed to the base 353b. The flange 353c is screwed to the bottom wall 251. It is also possible to equip the base 353a4 and the base 353b with a mechanism that allows the adapter to be replaced according to the size of the drug-sealed container or the like by attaching an instrument that can be easily attached and detached with one touch.

(Fourth embodiment)
FIG. 15 shows an exposure prevention box 40 according to the fourth embodiment of the present invention. The exposure prevention box 40 includes a box body 460 and a container holding part 453. In the fourth embodiment, the container holding portion 453 is configured to be swingable.
Since the box body 460 of the fourth embodiment is common to the box body 260 of the second embodiment except for the top wall 462, the same reference numerals are given and description thereof is omitted.

The top wall 462 of the box 460 is formed in a gable roof shape as shown in FIG. 15 (a), and the central ridge 462a in the left-right direction in the front view and the left-right direction in the front view from the ridge 462a. It has a pair of left and right inclined portions 462b, 462b. As shown in FIG. 15B, the top wall 462 has a band-shaped filler insertion port 463 extending in the left-right direction at the center in the front-rear direction. The filler insertion port 463 passes directly above the container holding part 453, and divides the top wall 462 into two front and rear parts.
In the exposure prevention box 40, air is sucked from the filler insertion port 463 and exhausted from the exhaust port 251a.

  The container holding portion 453 includes a holding frame 353a common to the third embodiment, a base 453b that supports the holding frame 353a so as to be swingable, and a flange 453c that fixes the base 453b to the bottom wall 251. .

  The base 453b is a solid column or covered cylindrical base main body 453b1 whose axial direction is the vertical direction, a swing support rod 453b2 extending from the center of the upper surface of the base main body 453b1, and a swing And a pivot portion 453b3 that supports the support rod 453b2 in a swingable manner.

  FIG. 16 shows a method for adjusting the medicine using the exposure prevention box 40. First, as shown in FIG. 16A, when the drug sealed container A is placed on the holding frame 353a, the needle of the syringe B that has previously sucked the solution from the filler insertion port 463 is inserted into the filler insertion port 463. Insert into. Then, while visually confirming the inside through the transparent box 460, the needle of the syringe B is inserted into the rubber stopper of the drug sealed container A, and the solution of the syringe B is injected into the drug sealed container A.

And in the state which stabbed the needle | hook of the syringe B into the chemical | medical agent sealing container A as it is, as shown to FIG.16 (d), (e), the syringe B is tilted alternately right and left, Swing left and right together with 453a. At this time, the needle of the syringe B travels in the band-shaped filler insertion port 463 while tilting left and right. In this way, it can be promoted that the medicine in the medicine sealed container A is dissolved by the dissolving liquid.
After dissolution of the drug is completed, the syringe B is degassed in the same manner as in the second embodiment.
In this way, by swinging the medicine sealing container A inside the box 460, the medicine leaked along with the swinging can be discharged from the exhaust port 251a.

(Fifth embodiment)
FIG. 18 shows an exposure prevention box 50 according to the fifth embodiment of the present invention. As shown in FIG. 18B, the exposure prevention box 50 includes a box 560 and a mounting table 59 that is housed in the box 560.

  The box 560 is formed in a horizontally long rectangular parallelepiped, and has five inlets 567 that are opened and closed by a door 567a on the side wall 564d on the front side, and five filler insertion ports 563 that are opened and closed by the door 563a on the top wall 562. And a left side wall 564a is provided with a bubble removal window 565 that is opened and closed by a door 565a. In the exposure prevention box 50, only the front side wall 564d including the door 567a is provided transparently, and the other walls are provided opaque.

  As shown in FIG. 17, the mounting table 59 is a substantially rectangular parallelepiped having a bottom plate 59a, a pair of left and right side plates 59b and 59b, and a back plate 59d, which are cut from a transparent resin plate material, and are opened forward and upward. A neck holding plate 59c, a trunk holding plate 59e, five pedestals 553c, and a back plate 59d that are formed in a box shape and are provided in a shelf shape on the back plate 59d. Further, the bottom wall 551 of the exposure prevention box 50 is provided with two slit-like exhaust ports 551a extending in the front-rear direction at positions between the pedestals 553c in plan view. Thus, at the same position in plan view, an exhaust slit 59g is provided in the bottom plate 59a of the mounting table 59, and an exhaust slit 59f is provided in the body holding plate 59e.

As shown in FIG. 18, the mounting table 59 has five container holding portions 553 on which the drug sealed containers A are mounted. The container holding portion 553 includes a neck holding portion 553a, a body holding portion 553b, and a pedestal 553c. The neck holding portion 553a and the body holding portion 553b include a shelf-like neck holding plate 59c and a body holding plate 59e. It is comprised by the notch which pierces in a U-shape in planar view from the front side edge. The neck holding plate 59c and the body holding plate 55 are supported by a pair of left and right side plates 59b and 59b.
The neck holding portion 553a, the body holding portion 553b, and the pedestal 553c are five container holding portions 553 that have different sizes, and are configured to hold the drug sealed containers A1 to A5 having different sizes. Yes. The filling tool insertion port 563 and the carry-in port 567 of the box 560 are provided so as to correspond to the container holding portion 553.

  As described above, the exposure prevention box, the safety cabinet, and the local exhaust device of the present invention are not limited to the above-described embodiments. For example, the number of the exposure prevention boxes is not limited to one or five, and two to four is also possible. It may be more than one. The air vent window may be provided not on the left and right side walls of the box, but on the front side wall, and instead of providing a door, a small hole with a small opening area is used to ensure a negative pressure inside the box. May be. Further, the bubble removal window may not be provided. The box of the exposure prevention box is not limited to a rectangular parallelepiped, and a cylindrical or other known form can be appropriately selected. Moreover, each structure of embodiment mentioned above can be combined suitably, for example, you may make it use the container holding part of 2nd, 3rd embodiment as a container holding part of 1st Embodiment. 2. The container holding part of the first embodiment can also be used as the container holding part of the third embodiment. You may use the container holding part of 2nd Embodiment for the container holding part of 4th Embodiment.

Safety cabinet 100
Exposure prevention box 10, 20, 40, 50
Work table 2
Work plate 21
Opening 22 and 23 for exposure prevention box installation
Flat lid 22a, 23a
Work opening 3
Working room 4
Support stand 5
Bottom wall 51,251,551
Container holding part 53,253,353,453,553
Support leg 52
Exhaust ports 51a, 51b, 251a, 551a
Cover box 6
Ceiling wall 62,262,462,562
Side walls 62a, 62b, 62c, 63d, 264a, 264b, 264c, 264d, 564a, 564d
Filler insertion port 63,263,463,563
Air extraction window 65,265,565
Lower space 7
Bottom 71

The invention made in order to solve the above-mentioned problems is that the working opening is sucked into the lower space of the working chamber by sucking external air flowing in from the working opening and air in the working chamber into the airflow. annexed to the working chamber of the shield to open safety cabinet or local exhaust device, a syringe, or Rukoto using a packed member comprising a pipette are possible, use in performing the preparation of a medicament or an organic solvent of a drug sealed container An exposure prevention box, comprising: a hollow box comprising a bottom wall, a top wall, and side walls; and one or a plurality of container holding parts that are provided on the bottom wall and hold a drug-sealed container. Is provided with an exhaust port communicating with the lower space of the working chamber, and the top wall has a filler insertion port into which the filler can be inserted at a position facing the container holding portion .
In the exposure prevention box according to the present invention, the box body is configured such that the side wall and the top wall are integrally formed to form a cover box, and the cover box is attached to and detached from the bottom wall to open and close. It is characterized by.

In the exposure prevention box of the present invention, the box is configured so that the side wall and the top wall are integrally formed to form a cover box, and the cover box is attached to and detached from the bottom wall to open and close. in the in which this, the internal exposure prevention box can be easily cleaned.

In addition to the above-mentioned premise, the present invention includes an exposure prevention box characterized in that the side wall has a bubble removal window that can be inserted from the needle tip in a state where the syringe is laid down. In this way, after injecting the solution from the syringe into the drug-sealed container, the tip of the syringe can be inserted into the exposure prevention box from the bubble extraction window, and the bubbles that have entered the syringe can be discharged from the needle tip. .

In addition to the above premise, the present invention provides an exposure prevention box characterized by having an adapter installed at the filler insertion port so as to change the inner diameter of the filler insertion port in accordance with the outer diameter of the syringe to be used. Including. Thereby, the syringe and pipette inserted in a filler insertion port can be reliably guided by mounting | wearing with the adapter match | combined with the outer diameter of the syringe and pipette to be used. One exposure prevention box can be used for a plurality of types of syringes and pipettes.

  In the exposure prevention box of the present invention, in addition to the above premise, the filler insertion port has a long hole shape, and the container holding part is supported so as to be swingable along the filler insertion port. Including those characterized by By doing so, for example, the syringe and the drug sealed container can be swung along the long hole-shaped filler insertion port while the needle of the syringe is pierced into the drug sealed container.

The top wall and the side wall are preferably made of a transparent material. Thus, the side walls and
By making the ceiling wall transparent, the medicine-sealed container and the tip of the needle or pipette can be
The drug can be adjusted while checking the position of the edge, and the other side of the exposure prevention box
If the syringe is accidentally dropped, check the position of the syringe from the front of the exposure prevention box.
Because it can be recognized and picked up, there is no chance to accidentally stab a hand with a needle.

  In the exposure prevention box provided with the bubble removal window, it is preferable that the bottom wall has an exhaust port in a syringe insertion direction of the bubble removal window in a plan view. By doing so, the air discharged from the syringe can be discharged without leaking to the working chamber.

The container holding part is preferably configured to fix the drug-sealed container to the adhesive sheet.
Good. In this way, drug-sealed containers of various sizes can be held by the container holder,
It can suppress that an agent sealing container falls.

  The container holding part may be configured to fix the drug sealed container with a winding spring. like this
By doing so, the drug sealed container can be supported more stably.

The present invention provides an open safety cabinet that shields the working opening with an air flow by sucking external air flowing in from the working opening and air in the working chamber into the lower space of the working chamber, or It is a local exhaust device that can be used as a filling device consisting of a syringe or pipette, and is used when preparing a drug or an organic solvent in a drug sealed container, and is a hollow consisting of a bottom wall, a top wall, and a side wall. A box body and one or a plurality of container holding portions that are provided on the bottom wall and hold a drug-sealed container, the bottom wall having an exhaust port communicating with a lower space of the working chamber, The top wall includes an exposure prevention box having a filling tool insertion port into which the filling tool can be inserted at a position facing the container holding portion, and passes through a work plate forming a bottom wall of the working chamber to the lower space. An opening for installing an anti-exposure box that communicates with A flat lid that closes the opening for setting the exposure prevention box, and the exposure prevention box is a safety cabinet installed in the opening for setting the exposure prevention box or a local exhaust with the flat cover open. Including equipment.
In this way, the safety cabinet work plate is provided with an opening for exposure prevention box installation that communicates with the lower space, and the exposure prevention box is installed at the opening for exposure prevention box installation. The mouth can easily communicate with a lower space such as a safety cabinet. further,
A flat lid that closes the opening for installing the exposure prevention box is provided, so if you do not prepare drugs, remove the exposure prevention box and close the opening for installing the exposure prevention box with a flat lid to use the workbench widely. be able to.

The present invention relates to an open type safety cabinet or a local type that shields the work opening with an air flow by sucking outside air flowing in from the work opening and air in the work room into a lower space of the work room. It is an exposure prevention box that is attached to the work chamber of the exhaust device and can be used as a filling device consisting of a syringe, and is used when preparing a drug or an organic solvent in a drug-sealed container. And a hollow box having a side wall, and one or a plurality of container holding portions that are provided on the bottom wall and hold a drug-sealed container, and the bottom wall communicates with a lower space of the working chamber has the top wall has the filling tool can be inserted filling instrument insertion opening at a position opposed to the container holder, wherein the side walls, can be inserted from the needle tip while the syringe sideways Characterized by having an air vent window That includes exposure prevention box. In this way, after injecting the solution from the syringe into the drug-sealed container, the tip of the syringe can be inserted into the exposure prevention box from the bubble extraction window, and the bubbles that have entered the syringe can be discharged from the needle tip. .

The present invention relates to an open type safety cabinet or a local type that shields the work opening with an air flow by sucking outside air flowing in from the work opening and air in the work room into a lower space of the work room. It is an exposure prevention box that is attached to the work chamber of the exhaust device and can be used as a filling device consisting of a syringe, and is used when preparing a drug or an organic solvent in a drug-sealed container. And a hollow box having a side wall, and one or a plurality of container holding portions that are provided on the bottom wall and hold a drug-sealed container, and the bottom wall communicates with a lower space of the working chamber The top wall has a filling tool insertion port into which the filling tool can be inserted at a position facing the container holding portion, and the inner diameter of the filling tool insertion port is set in accordance with the outer diameter of the syringe to be used. Install in the filler insertion port to change It comprises exposure prevention box and having an adapter. Thereby, the syringe and pipette inserted in a filler insertion port can be reliably guided by mounting | wearing with the adapter match | combined with the outer diameter of the syringe and pipette to be used. One exposure prevention box can be used for a plurality of types of syringes and pipettes.

Claims (11)

Work of an open type safety cabinet or local exhaust device that shields the work opening with an air flow by sucking outside air flowing in from the work opening and air in the work room into the lower space of the work room An exposure prevention box attached to a chamber and used when preparing a drug or an organic solvent in a drug-sealed container using a filling tool such as a syringe or pipette,
A hollow box consisting of a bottom wall, a top wall, and side walls;
One or a plurality of container holding portions provided on the bottom wall and holding a drug-sealed container;
The bottom wall has an exhaust port communicating with a lower space of the working chamber;
The said top wall has a filling tool insertion port in the position facing the said container holding | maintenance part, The exposure prevention box characterized by the above-mentioned.   The exposure prevention box according to claim 1, wherein the top wall and the side wall are made of a transparent material.   The said box body is comprised so that the said side wall and the said top wall may be formed integrally, and it forms a cover box, and it opens and closes by attaching and detaching the cover box with respect to the said bottom wall. Exposure prevention box as described in.   The said side wall is an exposure prevention box of any one of Claims 1-3 which has a bubble extraction window which can be inserted from a needle tip in the state which laid the syringe sideways.   The exposure prevention box according to claim 4, wherein the bottom wall has an exhaust port in a syringe insertion direction of the bubble extraction window in a plan view.   The said container holding | maintenance part is an exposure prevention box of any one of Claims 1-5 comprised so that a chemical | medical agent sealing container may be fixed to an adhesive sheet.   The said container holding | maintenance part is an exposure prevention box of any one of Claims 1-5 comprised so that a chemical | medical agent sealing container may be held with a wound spring.   The exposure prevention box according to any one of claims 1 to 7, further comprising an adapter installed in the filler insertion port so as to change an inner diameter of the filler insertion port in accordance with an outer diameter of a syringe to be used.   The said filling tool insertion port comprises a long hole shape, and the said container holding part is supported so that rocking | fluctuation is possible along the said filling tool insertion port. Exposure prevention box. In an open type safety cabinet or local exhaust device that shields the work opening with airflow by sucking external air flowing in from the work opening and air in the work room into the lower space of the work room. There,
The exposure prevention box according to any one of claims 1 to 9,
An exposure prevention box installation opening penetrating the work plate forming the bottom wall of the work chamber and communicating with the lower space; and a flat lid that closes the exposure prevention box installation opening;
The exposure prevention box is a safety cabinet or local exhaust device installed in the exposure prevention box installation opening with the flat lid open.   The safety cabinet or local exhaust device according to claim 10, comprising a plurality of the exposure prevention boxes, each of the exposure prevention boxes having a filler insertion opening having a different size.

Images