JP2019058338A - Exposure prevention box and exhauster with work stand comprising exposure prevention box - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an exposure prevention box capable of suppressing a vial bottle from being contaminated with a chemical solution. SOLUTION: The exposure prevention box 100 of the present invention is used by being connected to an exhaust device, and a syringe needle insertion hole for inserting a syringe needle C1 is provided in the center of a pressing portion 4a for pressing a sealing member of a vial B. , The structure is such that the mist and gas splashed from the place where the syringe needle C1 is pierced into the sealing member of the vial do not enter the inner box 2. Further, the mist or gas splashed inside the syringe needle insertion hole is exhausted from the exhaust port through the exhaust passages 111, 131, 141, 151 provided between the outer box 1 and the inner box 2. [Selection diagram] Fig. 5

Description

  In the present invention, for the purpose of preparation of an anticancer agent, treatment of an organic solvent and the like, a solvent such as a drug solution, physiological saline, distilled water and an organic solvent between the vial and the syringe (hereinafter simply referred to as "drug solution"). The present invention relates to an exposure prevention box for preventing exposure by a chemical solution or the like in a transfer operation.

The inventor of the present invention has previously filed a patent application (Patent Document 1) for such an exposure prevention box, although the application has not been published yet.
In the exposure prevention box of Patent Document 1, the ceiling wall is provided with an insertion port for inserting a syringe, and the operator inserts the needle of the syringe inserted from the insertion port into a vial preset in the inside of the box. The drug transfer operation can be performed between the vial and the syringe without putting your hand in the air, and the air drawn in from the insertion port is exhausted from the bottom wall exhaust port to the lower space of the safety cabinet work room Then, the vapor and mist of the drug generated inside the box are removed.

Japanese Patent Application No. 2017-092350

However, when transferring the drug solution between the vial and the syringe, the drug solution may splash from the location where the syringe is pierced by the sealing member of the vial, and the splashed drug solution is the vial in the exposure prevention box of Patent Document 1. It may adhere to the bottle, and when taking out the vial, there is a possibility that the chemical solution may adhere to the gloves of the operator.
This invention is made in view of the said subject, and even if it is a case where a chemical | medical solution splashes from a vial, it aims at provision of the exposure prevention box which can suppress that a chemical | medical solution adheres to the bottle effectively. .

  The invention made in order to solve the above-mentioned subject is an exposure prevention box which is connected to an exhaust system and used when transferring a drug solution, a solvent, etc. between a vial and a syringe, and connected to the exhaust system. Hollow outer box having an exhaust port, an inner box provided inside the outer box, an air supply path provided between the inner box and the outer box, and a vial provided inside the inner box The outer case has a syringe insertion port for inserting a syringe and communicating the outside of the outer case and the air supply passage, and the inner case includes a vial placed on the vial mounting plate It has a pressing part for pressing a sealing member, and the pressing part inserts a syringe needle of a syringe inserted into the syringe insertion port at the center and inserts the syringe needle communicating the inside of the inner box with the air supply passage. The air passage includes the hole; Di insertion opening, and is characterized by communicating with the exhaust port.

As described above, in the exposure prevention box of the present invention, since the syringe needle insertion hole for inserting the syringe needle is provided at the center of the pressing portion for pressing the sealing member of the vial, the syringe needle is pierced in the sealing member of the vial The periphery of the portion is surrounded by the portion where the sealing member and the pressing member are in close contact with each other, so that the drug solution splashed from the portion can be effectively suppressed from scattering in the inner box and adhering to the vial.
Then, an air supply path communicating with the syringe insertion port and the exhaust port is provided between the outer case and the inner case, and the syringe insertion port is communicated with the air supply chamber, so that the drug solution dispersed inside the syringe needle insertion hole Since the liquid can be discharged to the lower space of the working chamber through the air supply passage without passing through the inside of the inner box, adhesion of the drug solution to the vial can be suppressed also by this.

  The exhaust system has a workbench and is an exhaust system with a workbench configured to suck and exhaust air on the workbench to a lower space of the workbench, and the workbench communicates with the lower space. It is preferable to have an exposure prevention box installation opening, and the exhaust port is connected to the exposure prevention box installation opening. The air vents in the upper space of the work table such as safety cabinets and isolators that exhaust air from the lower space of the work room, local exhaust system, push-pull exhaust system, etc. By mounting the box, placing the exposure prevention box in the air shield provided on the workbench, and working, the double shield of the exposure prevention box and the air shield of the exhaust system with the workbench Exposure accidents can be prevented more effectively.

  It is preferable that the inner case has a discharge hole that communicates the inside with the exhaust port. When the transfer operation of the drug solution is completed and the vial is taken out from the exposure prevention box, the inside of the syringe needle insertion hole is released to the inside of the inner box, and mist or gas generated from the drug solution adhering to the syringe needle insertion hole Will contaminate the inside of the inner box. The vial is taken out by opening the open / close door, so if the inside of the inner box is filled with the mist or gas of the chemical solution, the worker may be contaminated. As described above, by communicating the inside of the inner box with the exhaust port, it is possible to discharge the mist or gas of the chemical solution generated inside the inner box from the exhaust port, so the door was opened and it was generated from the drug when taking out the vial. Contamination with mist or gas can be suppressed.

  It is preferable that the inner box includes a loading opening that is opened and closed by an opening and closing door, and the discharge hole is provided along the lower edge of the loading opening. By so doing, the inlet can be air-shielded by the air flow drawn into the discharge hole when taking out the vial.

  The pressing portion is preferably configured to be capable of coming into and coming out of contact with the sealing member of the vial. This makes it easy to mount the vial on the vial mounting table.

  It is preferable that the exposure prevention box of this invention equips the said entrance with front and back one pair. By doing this, the inside of the exposure box can be cleaned easily.

  According to the present invention, there is provided an exhaust system with a workbench including the above-described exposure prevention box and sucking and exhausting air on the workbench to a lower space of the workbench.

  As described above, according to the exposure prevention box of the present invention, when the drug solution is scattered from the location where the syringe needle pierces the sealing member of the vial, adhesion of the drug solution to the surface of the vial bottle can be suppressed .

It is the partial perspective view which showed the work stand periphery of the exhaust apparatus with a workbench (safety cabinet) which concerns on 1st Embodiment of this invention. It is a perspective view of the exposure box shown in FIG. It is the principal part perspective view which showed the opening part for exposure prevention box installation of the exhaust apparatus with a work table shown in FIG. It is (a) a partial perspective front view of the exposure prevention box shown in FIG. 2, (b) a partial perspective side view. (A) It is the YY sectional view taken on the line in FIG. 4 (b), (b) It is an XX sectional view in FIG. 4 (a). It is a top view of the exposure prevention box of FIG. 2 is a partial cross-sectional view showing how the syringe needle insertion tube of the exposure prevention box moves up and down to press the sealing member of the vial. It is an exhaust system concerning a 2nd embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail using the drawings as appropriate. The present invention is not limited to the following embodiments.
First Embodiment
FIG. 1 shows the periphery of a workbench D2 of a workbench equipped exhaust apparatus (exhaust apparatus) D according to a first embodiment of the present invention. The exhaust apparatus D with a workbench is composed of a safety cabinet configured as an open type and a full exhaust type that belongs to the class B2 of the class II cabinet for biohazard protection according to JIS K 3800, and includes a plurality of exposure prevention boxes 100. In FIG. 1, vials B of different sizes are placed in three exposure boxes.

  As shown in FIG. 1, the exhaust device D with a workbench includes a shutter D1, a workbench D2, a work opening D3 provided between them, and an exposure prevention box installation opening D6. . The work opening D3 is shielded by an air flow which is provided by suctioning the air of the work room D7 and the air flowing from the work opening D3 from the air inlet D4 provided in the grating in front of the work bench D2 .

The work bench D2 is provided with six exposure prevention box installation openings D6 aligned in the left-right direction. As shown in FIG. 3, the exposure prevention box installation opening D6 includes a cover plate D61 and a fitting receiving portion D62 formed of a substantially square through-hole in plan view penetrating the work bench D2, and the fitting receiving portion At the periphery of D62, there are provided a flange portion D62a for supporting the cover plate D61 flush with the work bench D2, and four holding members D64 extending from four side walls D62b of the fitting receiving portion D62. The holding member D64 is composed of an L-shaped metal fitting D64a and a rubber pad D64b. The lower opening of the fitting receiving portion D62 is ventilated by the punching board D63.
The number of exposure prevention boxes can be increased or decreased based on the effective space of the workbench. In some cases, only one can be attached. In this case, the size of the vial to be installed corresponds to the size of the vial to be installed by replacing the pressing portion for pressing the vial mounting table inside the inner case and the sealing member of the vial.

  The exposure prevention box 10 mainly includes an outer box 1, an inner box 2, and a vial mounting table 3 provided inside the inner box 2, as shown in FIG. The outer case 1 and the inner case 2 are substantially entirely formed of a transparent hard resin such as acrylic. In addition, depending on the kind of chemical | medical solution, an exposure prevention box can also be partially made of metals, such as stainless steel.

  The outer case 1 is formed in a rectangular box shape, and includes a top wall 11 and a bottom wall 12 substantially square in plan view, a pair of left and right side walls 13 and 14 having a rectangular shape, and a pair of front and rear doors 15 and 16 ing. The top wall of the outer box may be an openable / closable lid to facilitate cleaning and installation of the absorbent sheet.

The top wall 11 includes a syringe insertion hole 11a having a circular through hole at the center, a square frame 11b surrounding the syringe insertion hole 11a, and a flat octagonal pillar shaped syringe guide 11c placed inside the square frame 11b. Have. The syringe guide 11c has a syringe guide hole 11d penetrating in the vertical direction at the center, and is separately provided from the ceiling wall 11 in order to replace it with one having an appropriate syringe guide hole 11d according to the diameter of the syringe used. It is provided.
The top wall 11 has intake holes 11 f at the four corners inside the square frame 11 b, and the syringe guides 11 c are provided in an octagonal shape so as to displace the intake holes 11 f.

  The bottom wall 12 has an exhaust port 122 consisting of a square through hole at the center. The exhaust port 122 has a rectangular frame-like fitting portion 12a formed of four plate members hanging around the periphery.

The opening / closing doors 15 and 16 are side plates 15b and 16b vertically provided around the main plates 15a and 16a so as to be flush with the rectangular main plates 15a and 16a, the top wall 11, the bottom wall 12 and the side walls 13 and 14, respectively. And handles 15d and 16d, and is connected to the left side wall 13 by a pair of upper and lower resin hinges 5 so as to open and close in the form of an open door.
Inside the open / close doors 15 and 16, partition walls 15c and 16c having a U-shaped horizontal cross section are provided, and air supply chambers 151 and 161 are formed between the main plates 15a and 16a and the partition walls 15c and 16c.
The partition walls 15c and 16c serve as the front door and the rear door of the inner box 2, respectively.
The front and rear openings 152 and 162 of the outer case 1 opened and closed by the opening and closing doors 15 and 16 are edge plates 15f, 15g, 16f, 16g for closing the space between the outer case and the inner case up and down. have.

  The inner case 2 is formed in a box shape opened to the front and rear by the top wall 21, the bottom wall 22, and the left and right side walls 23 and 24. The top wall 21 has a substantially rectangular shape in a plan view and is vertically spaced from the top wall 11 of the outer case 1, and both left and right ends are joined to the left and right side walls 13 and 14 of the outer case 1. An intake chamber (air supply passage) 111 is formed by the top wall 11 of the outer box 1, the top wall 21 of the inner box 2, and the front and rear edge plates 15f, 16f. The top wall 21 has air holes 21a and 21a formed of rectangular notches and side walls 13 and 14 of the outer case 1 at the left and right edges.

The syringe needle insertion tube 4 is provided at the center of the top wall 21. As shown in FIG. 7, the syringe needle insertion tube 4 has an outer peripheral surface so as to be screwed into a flat cylindrical pressing portion 4a with a lid opened downward at the lower end and a female screw hole provided at the center of the top wall 21. An external thread is engraved, and it consists of the tubular part 4b which penetrates the said internal thread hole. The inside 4e of the tubular portion 4b communicates with the inside of the pressing portion 4a through a syringe insertion hole 4d consisting of a circular hole at the center of the upper wall of the pressing portion 4a. An annular packing 4 c is disposed inside the pressing portion. The pressing portion 4a slides up and down as shown by the arrow in FIG. 7 by screwing the tubular portion 4b to the female screw hole of the top wall 21. The pressing portion 4a may not have a flat cylindrical shape, and may have a disk shape having no peripheral wall.
Further, as shown in FIG. 2, a suction cloth 6 made of non-woven fabric is placed on the top wall 21. The suction cloth 6 has a circular hole 6 a at the center, through which the tubular portion 4 b of the syringe needle insertion tube 4 is inserted.

  The bottom wall 22 has a substantially rectangular shape in a plan view, and is spaced from the bottom wall 12 of the outer case 1 in the vertical direction, and both left and right ends are joined to the left and right side walls 13 and 14 of the outer case 1. An exhaust chamber (air supply passage) 121 is formed by the bottom wall 12 of the outer box 1, the bottom wall 22 of the inner box 2, and the front and rear edge plates 15g and 16g. Further, the bottom wall 22 has air vents 22a, 22a formed of rectangular notches and side walls 13, 14 of the outer box 1 at the left and right edges, and the discharge holes 22b, along the front and rear edges. 22b.

The side walls 23 and 24 have a substantially rectangular plate shape, and the upper end is joined to the top wall 21 along the inner edge of the air vent 21 a, and the lower end is an inner end of the air vent 22 a of the bottom wall 22. The air supply chamber (air supply passage) 131, 141 is connected to the bottom wall 22 along the edge and between the side wall 23 and the side wall 13 of the outer case 1 and between the side wall 24 and the side wall 14 of the outer case 1. Is formed. The air supply chambers 131 and 141 communicate with the air intake chamber 111 through the air supply holes 21a and communicate with the exhaust chamber 121 through the air supply holes 22a, and the air intake holes 11f of the top wall 11 of the outer box 1 or the syringe insertion hole 11a. The air drawn into the air intake chamber 111 from the air flow is sent to the air supply chamber 131, 141 through the air supply holes 21a, and further sent to the air discharge chamber 121 through the air discharge hole 22b. It is discharged to a space below the workbench D2 of the workbench exhaust device D.
Further, the air intake chamber 111 communicates with the air supply chambers 151 and 161 by air supply ports 21b and 21b formed of a gap provided between the lower end edges of the edge plates 15f and 16f and the upper end edges of the partition walls 15c and 16c. The air supply chambers 151 and 161 are in communication with the exhaust chamber 121 through the discharge holes 22 b and 22 b. In the state where the opening and closing doors 15 and 16 are closed and the vial B is placed on the vial mounting table 3, the discharge holes 22 b and 22 b guide the air of the air supply chambers 151 and 161 to the exhaust chamber, and the opening and closing doors 15 and 16 are When it is open and the vial mounting base 3 is empty, the air inside the inner chamber 2 is guided to the exhaust chamber 121.
In addition, it is also possible to use the exposure prevention box 100 which concerns on this embodiment for the safety cabinet which is not equipped with the opening part D6 for exposure prevention box installation, In that case, using the vacuum piping of a safety cabinet Suction the air in the air chamber. Alternatively, without using a work table exhaust system such as a safety cabinet, connect the exhaust system such as a vacuum pump or tube to the exposure prevention box, make the air supply path of the exposure prevention box negative pressure, and use the exposure prevention box alone. It is also possible to use in

  The vial mounting table 3 is formed by processing a plate material of stainless steel by sheet metal processing, and a flat plate-like substrate 31 attached to the upper surface of the bottom wall 22 and a long plate-like support hanging from the rear end edge of the substrate 31 A mounting plate 33 is provided in the form of a shelf plate at the middle in the vertical direction of the support 32. A neck support 34 is provided at the upper end of the support 32 and supports the neck of the vial. . The mounting shelf 33 and the neck support portion 34 are configured to be adjustable in height by being fixed to the support portion 32 with screws 34 a through vertically long long holes 34 b provided in the folded back portion of the rear end. The vial mounting table 3 can be replaced depending on the capacity of the attached vial.

  When installing the exposure prevention box 100 in the exhaust device D with a workbench, open the lid D61 of the opening D6 for installing the exposure prevention box of the workbench D2 and fit the fitting portion 12a of the exposure prevention box 100 Fit in the receiving part D62. At this time, four plate members around the fitting portion 12a are pierced between the holding member D64 and the peripheral wall D62b of the fitting receiving portion D62.

  Next, a method of transferring a drug solution such as a solution from a syringe C to a vial B containing an anticancer drug or the like using the workbench exhaust system D will be described. As shown in FIG. 7, the vial B is sealed by the sealing member B2, and the sealing member B2 is formed by inserting the rubber stopper B3 and the rubber stopper B3 pierced into the opening of the vial collar B1 into the vial collar B1. It consists of metal cap B4 to fix.

  In the transfer operation of the chemical solution, as shown in FIG. 1, first, the open / close door 15 on the front side of the exposure prevention box 100 is opened and the vial B is mounted on the mounting shelf 33 of the vial mounting table 3. At this time, the heights of the mounting rack 33 and the neck support 34 of the vial mounting table 3 are adjusted in accordance with the size of the vial B, as necessary. After the vial B is placed on the mounting shelf 33, as shown in FIG. 7, the syringe needle insertion tube 4 is rotated counterclockwise to lower it, and the sealing member B2 of the vial B is pressed by the pressing portion 4a. Fix and close the open / close door 15.

  In this way, when the vial B is set, as shown in FIG. 5, the syringe C having the medical fluid suctioned in advance is inserted into the syringe insertion hole 11a of the outer case 1 from the syringe needle C1 side through the syringe guide 11c. The syringe needle C1 is inserted into the tubular portion 4b of the syringe needle insertion tube 4 of the inner box 2, and the syringe needle C1 is pierced into the rubber plug B3 of the sealing member B2 of the vial B. At this time, the syringe guide 11c is replaced in accordance with the size of the syringe C to be used. When the syringe needle C1 is pierced into the rubber stopper B3, the piston of the syringe C is pushed down and the medical solution is poured out from the syringe C into the vial B.

  Even if the drug solution splashes from the location where the syringe needle C1 pierces the rubber plug B3 during pouring of the drug solution, the vial pressing portion 4a presses the sealing member B2 of the vial via the packing 4c to insert the syringe needle Since the inside 4e of the pipe 4 and the inside of the inner box 2 are airtightly isolated, it is possible to effectively suppress the mist or the vaporized chemical solution from invading the inside of the inner box 2. When a large amount of the drug solution leaks to the outside of the tubular portion 4 b of the syringe needle insertion tube 4, the drug solution can be absorbed by the sucking cloth 6.

  Then, the drug solution that has been subjected to misting and the like inside the syringe needle insertion tube 4 passes from the suction chamber 111 through the air supply chambers 113, 114, 115, 116, and the exhaust chamber 121 and It is discharged to the lower space of the work platform D2.

  When the transfer of the drug solution is completed, the syringe needle C1 is pulled out of the vial B, and the syringe C is withdrawn from the syringe insertion hole 11a. The vial B opens the open / close door 15, rotates the syringe needle insertion tube 4 to lift it, and then takes it out.

  When the transfer of the chemical solution is completed, the exposure prevention box 100 is removed from the work bench D2 of the workbench exhaust system D. The exposure prevention box installation opening B6 is closed with a cover plate B61. The removed exposure prevention box 100 is cleaned by a separately provided cleaning dedicated facility. Under the present circumstances, since the exposure prevention box 100 has the open-close doors 15 and 16 on both front and back, it is easy to wash an inside.

When not in use, remove the exposure prevention box 100 from the exhaust system D with a work table, and close the exposure prevention box installation opening D6 with the cover plate D61, and use the work table D2 widely for operations other than chemical adjustment. be able to.
Moreover, although illustration is abbreviate | omitted, you may comprise the exposure prevention box 100 so that it can be swung back and forth with the exposure prevention box by attaching a rotor. By so doing, when the solution is injected into the drug in the vial B, the vial B can be vibrated back and forth together with the exposure prevention box 100 to promote dissolution of the drug. Also, by tilting the exposure prevention box 100 backward, when inserting the syringe needle C1 into the vial B, the operator can easily visually recognize the tip of the syringe needle C1, and when returning the drug solution to the syringe C, the vial B The liquid level of the inner drug solution can be inclined to assist the suction of the drug solution from the syringe needle C1. Furthermore, when the inside of the pressing portion 4a is cleaned with tweezers and absorbent cotton etc., the inside of the pressing portion 4 can be easily recognized visually by tilting the exposure prevention box 100 to the rear side.

Second Embodiment
FIG. 8 shows a workbench equipped exhaust apparatus 2D according to a second embodiment of the present invention. The exhaust system 2D includes an exposure prevention box 100. The exhaust device 2D main body is formed of a box having a substantially square shape in plan view, and has a work bench D2 on the upper surface. The work bench D2 of the exhaust system 2D has a fitting receiving portion D62 at the center, in which the fitting portion 12a of the exposure prevention box 100 is fitted. The exhaust device main body d1 is configured to suck the inside of the exposure prevention box 100 by the pump P via the exposure prevention box installation opening D6 with the internal space.
In addition, the exhaust system 2D with a workbench is placed on the workbench of the safety cabinet that does not have the opening for exposure prevention box installation, and the air piping of the exposure prevention box is It may be aspirated.
In the second embodiment, members in common with the first embodiment are assigned the same reference numerals and explanation thereof is omitted.

  As mentioned above, the exhaust apparatus provided with the exposure prevention box of this invention is not limited to said Example, For example, an exhaust apparatus with a workbench is not restricted to said embodiment, An isolator, a local exhaust apparatus, a push pull type exhaust It may be an apparatus or the like. There should be at least one door for the exposure prevention box. The pressing portion may not be configured to be in contact with or separated from the sealing member of the vial. To that end, for example, the pressing member may be configured to press the vial with a spring or the like instead of pressing the vial with a screw. The outer box and the inner box may be made of a resin that is not transparent in whole or in part, or may be made of metal. At least one exhaust passage may be provided.

DESCRIPTION OF SYMBOLS 100 Exposure prevention box 1 Outer box 11a Syringe insertion port 111, 121, 131, 141, 151, 161 Air supply path 121 Exhaust port 152, 162 Loading port 2 Inner box 22b Discharge hole 3 Vial mounting table 4a Pressing part 4d Syringe needle insertion Hole B Vial C Syringe 1 Syringe Needle C
D, 2D exhaust system (exhaust system with work table)
D2 platform

Claims (7)

An exposure-prevention box connected to an exhaust system and used for transferring a chemical solution, a solution, etc. between a vial and a syringe,
A hollow outer box having an exhaust port connected to the exhaust device;
An inner box provided inside the outer box;
An air supply passage provided between the inner case and the outer case;
And a vial mounting table provided inside the inner box,
The outer case has a syringe insertion port through which a syringe is inserted and which communicates the outside of the outer case and the air supply passage.
The inner box has a pressing portion for pressing the sealing member of the vial placed on the vial placing table,
The pressing portion includes a syringe needle insertion hole through which a syringe needle of a syringe inserted into the syringe insertion port is inserted at the center and which communicates the air supply path with the inside of the inner box.
An exposure prevention box characterized in that the air supply passage is in communication with the syringe insertion port and the exhaust port. The exhaust apparatus with a workbench, wherein the exhaust system has a workbench and is configured to suck and exhaust air on the workbench to a lower space of the workbench,
The workbench has an opening for the installation of an exposure box that communicates with the lower space,
The exposure box according to claim 1, wherein the exhaust port is connected to the exposure box installation opening.   The exposure box according to claim 1 or 2, wherein the inner box has a discharge hole communicating the inside with the exhaust port.   The exposure control according to any one of claims 1 to 3, wherein the inner box includes a loading opening that is opened and closed by an opening and closing door, and the discharge hole is provided along the lower edge of the loading opening. box.   The said pressure part is an exposure prevention box of any one of the Claims 1-4 comprised so that contact / separation was possible with the sealing member of a vial.   The exposure box according to any one of claims 1 to 5, wherein the loading port is provided in a pair of front and back.   An exhaust system with a workbench, comprising the exposure prevention box according to claim 2, wherein the air on the workbench is sucked into the lower space of the workbench and exhausted.

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