JP2018039765A - Gel dentifrice - Google Patents

Abstract

PROBLEM TO BE SOLVED: To remove stains such as plaque and stain attached to a tooth surface without containing an abrasive, has an excellent cleaning effect, and maintains a healthy state of periodontal tissue and oral mucosa. Providing a gel-like dentifrice that has an effect of promoting recovery to a healthy state, is effective in preventing and curing periodontal disease, and is excellent in preventing and reducing bad breath. [MEANS FOR SOLVING PROBLEMS] The gel-like dentifrice of the present invention comprising a gelled product of an aqueous composition containing hydrolyzed eggshell membranes and extract of licorice in reduced water which is generated water in a cathode chamber of a three-chamber electrolyzed water generator. The said subject is solved. [Selection figure] None

Description

  The present invention relates to a gel dentifrice. More specifically, the present invention is a gel-like dentifrice which is excellent in tooth cleaning effect, periodontal disease prevention and healing effect and bad breath prevention effect, based on reduced water, and contains hydrolyzed eggshell membrane and tishima zasa extract About.

Known forms of toothpastes include toothpastes, gel dentifrices, liquid dentifrices, powder dentifrices, and the like.
Of these, gel dentifrices have a higher moisture content than toothpastes, so when applied to a toothbrush and placed in the oral cavity, they quickly disperse to every corner of the oral cavity to promote early brushing effect. Has the advantage of doing.
Gel dentifrices are generally based on purified water, which contains abrasives, wetting agents, flavoring agents, preservatives, medicinal ingredients, etc., and a binder (thickening agent). (For example, Patent Document 1).
Gel-like dentifrices for children are also known without additives, but gel-like dentifrices without additives remove stains on tooth surfaces such as plaque and stains (colored stains). Because of its low cleaning action, abrasives are generally added to gel dentifrices sold to the general public, such as adults.
Gel-like dentifrices with added abrasives are superior to gel-like dentifrices with no added abrasives, but have a better cleaning effect to remove plaque and stains attached to the tooth surface. The enamel on the tooth surface is easily damaged by the agent.

Further, a dentifrice containing a hydrolyzed eggshell membrane is known (Patent Documents 2 and 3).
A dentifrice containing hydrolyzed eggshell membrane has the effect of maintaining and restoring the health of periodontal tissues and mucous membranes in the oral cavity, restoring the periodontium itself to a strong and healthy state. Periodontal disease and reddish purple gums become healthy pink, thin and elastic, stretched, restored elasticity, tension, gloss to gums that had lost gloss, and bleeding from gums, etc. Can be eliminated. In addition, even when not suffering from periodontal disease, it has an excellent effect that the periodontal tissue is less likely to suffer from periodontal disease and the healthy state of the periodontal tissue can be maintained.
However, in the case of dentifrices containing hydrolyzed eggshell membranes, it is necessary to add abrasives in the same way as conventional gel dentifrices in order to remove stains such as plaque and stains attached to the tooth surface. There is a risk that the enamel on the tooth surface may be damaged by the blending of the abrasive.

Furthermore, toothpastes containing Sasa extract such as Kumagusu extract are known (Patent Documents 4 and 5), and toothpastes containing Sasa extract are effective in preventing and healing periodontal disease and preventing or reducing bad breath. It is said that.
However, even in the dentifrice containing Sasa extract, in order to remove plaque and stain (colored stain) adhering to the tooth surface, the above-mentioned conventional gel-like dentifrice and dentifrice containing hydrolyzed eggshell membrane Similarly, it is necessary to add an abrasive, and the addition of the abrasive tends to damage the enamel on the tooth surface.

JP-A-6-183937 JP 2001-89393 A JP 2007-197393 A JP 2001-151655 A International Publication No. 2000/67707 Japanese Patent No. 3988827 JP 2001-191076 A Japanese Patent No. 5253484

  The object of the present invention is to provide an effect of maintaining and recovering the healthy state of periodontal tissue and oral mucosa, which is contained in the dentifrice containing hydrolyzed eggshell membrane, and the periodontal of the dentifrice containing Sasa extract. While maintaining the effects of disease prevention and healing, and prevention and reduction of bad breath, it is possible to remove stains such as plaque and stains that have adhered to the tooth surface without adding abrasives. The object is to provide a gel-like dentifrice without additives, which does not cause damage to the enamel of the teeth.

  In order to achieve the above object, the present inventor has made various studies. As a result, the gel-like dentifrice contains both the hydrolyzed eggshell membrane and chicariosa extract, and as the water that forms the base material for the gel-like dentifrice, it replaces the purified water that has been widely used in gel-like dentifrices. In addition, when reducing water generated in the cathode chamber of the three-chamber water electrolysis device is used, it is possible to remove plaque and stains adhering to the tooth surface very easily without adding an abrasive, and a cleaning effect. In addition, a gel-like dentifrice that is superior in the maintenance of the periodontal tissue and oral mucosa in a healthy state and recovery to a healthy state by the inclusion of a hydrolyzed eggshell membrane. It has been found that the composition has an excellent effect of preventing and periodontal disease prevention and healing, and prevention and reduction of halitosis due to the inclusion of Chishimazasa extract.

Furthermore, the present inventor, at that time, based on the total mass of the gel dentifrice, the proportion of reduced water generated in the cathode chamber of the three-chamber water electrolysis apparatus is 20 to 90 mass%, and the hydrolyzed eggshell membrane It was found that it is preferable to make the ratio of 0.0001 to 10% by mass and the ratio of Chichimasasa extract 0.0001 to 70% by mass.
The inventor further contains the foaming agent in a ratio of 0.3 to 7% by mass based on the total mass of the gel-like dentifrice, and the diffusion of the gel-like dentifrice in the oral cavity is favorably performed. In addition, the gel-like dentifrice preferably has a pH of 5 to 8 so that it has excellent storage stability, less irritation to the mouth, and influence on the tooth enamel. It discovered that a small gel-like dentifrice was obtained and based on those knowledge, this invention was completed.

That is, the present invention
(1) A gel-like dentifrice comprising a gelled product of an aqueous composition containing hydrolyzed eggshell membranes and licorice extract in reduced water which is generated water in a cathode chamber of a three-chamber electrolyzed water generator It is.
And this invention,
(2) Based on the total mass of the gel dentifrice, the reduced water is 20 to 90% by mass, the hydrolyzed eggshell membrane is 0.0001 to 10% by mass, and the chishimasa extract is 0.0001 to 70% by mass. Containing the gel dentifrice of (1) above;
(3) The gel-like dentifrice according to (1) or (2), further containing a foaming agent in a proportion of 0.3 to 7% by mass based on the total mass of the gel-like dentifrice;
(4) The gel dentifrice of any one of the above (1) to (3) having a pH of 5 to 8; and
(5) The gel dentifrice according to any one of (1) to (4), which does not contain an abrasive;
It is.

Furthermore, the present invention provides
(6) an anode chamber provided with an anode electrode, a cathode chamber provided with a cathode electrode, an intermediate chamber provided between the anode chamber and the cathode chamber, and a diaphragm disposed between the anode chamber and the intermediate chamber; Using a three-chamber electrolyzed water generator having a diaphragm disposed between the cathode chamber and the intermediate chamber, water is supplied to each of the anode chamber and the cathode chamber, and an aqueous sodium chloride solution is supplied to the intermediate chamber. Electrolysis is performed to produce reduced water in the cathode chamber, and the reduced water produced in the cathode chamber contains a hydrolyzed eggshell membrane, chicaria extract and a gelling agent to prepare an aqueous composition. A method for producing a gel-like dentifrice, comprising gelling a composition.
And this invention,
(7) The method for producing a gel-like dentifrice according to (6) above, further comprising a foaming agent in the aqueous composition;
(8) The method for producing a gel-like dentifrice according to (6) or (7), wherein a pH adjuster is added at the time of preparation of the aqueous composition to adjust the pH of the aqueous composition to 5 to 8 to form a gel;
It is.

Since the gel-like dentifrice of the present invention uses, as a base material, reduced water generated in the cathode chamber of a three-chamber water electrolysis apparatus instead of purified water conventionally used in gel-like dentifrices, Even if it does not contain an agent, it can remove stains such as plaque and stains attached to the surface of the teeth well, has an excellent cleaning effect, and does not need to contain an abrasive. Can prevent tooth enamel damage.
Since the gel-like dentifrice of the present invention contains a hydrolyzed eggshell membrane, it has the effect of promoting the maintenance and recovery of the periodontal tissue and the oral mucosa in a healthy state.
Furthermore, since the gel-like dentifrice of the present invention contains tichimazasa extract, it is excellent in prevention and healing of periodontal disease and prevention and reduction of bad breath.

FIG. 1 is a diagram schematically showing the principle (basic structure) of a three-chamber electrolyzed water generator for producing reduced water used as a base material in the gel dentifrice of the present invention.

The present invention is described in detail below.
In the present invention, reduced water generated in the cathode chamber (negative electrode chamber) of the three-chamber electrolyzed water generating device is used as the water constituting the base material of the gel dentifrice.
A three-chamber electrolyzed water generating apparatus is conventionally known (see, for example, Patent Documents 6 to 8), and the basic structure thereof is an anode electrode (positive electrode) (1d) as shown in the schematic diagram of FIG. ) Having an anode chamber (1), a cathode chamber (2) having a cathode electrode (negative electrode) (2d), and an intermediate chamber (3) provided between the anode chamber (1) and the cathode chamber (2). And a diaphragm (such as an ion exchange membrane) (4) disposed between the anode chamber (1) and the intermediate chamber (3), and a cathode chamber (2) and the intermediate chamber (3). It consists of a diaphragm (ion exchange membrane etc.) (5).
In the three-chamber electrolyzed water generator, the anode chamber (1) has an inflow portion (1a) for water and an outflow portion (1b) for water (oxidized water) generated in the anode chamber (1). ) Has an inflow part (2a) of water and an outflow part (2b) of water (reduced water) produced in the cathode chamber (2), and the intermediate chamber (3) contains an ionic compound such as an aqueous sodium chloride solution. It has the supply part (3a) of the aqueous solution to contain, and the outflow part (3b) of aqueous solution.
Any of the conventionally known three-chamber electrolyzed water generators can be used for producing the reduced water used in the gel dentifrice of the present invention. The three-chamber electrolyzed water generating device usable in the present invention is not limited, and examples thereof include a three-chamber electrolyzed water generating system manufactured by Redox Co., Ltd. and a three-chamber double-in electrolysis manufactured by Redox Co., Ltd. System [“kreski AQUA” (Type-α4000A, C, D), etc.], “Redox R25-15 type” manufactured by Redox Technology Co., Ltd., three-room type electrolyzed water generation system and three-chamber type double-in electrolysis manufactured by Racine Co., Ltd. System, a three-chamber electrolyzed water generator manufactured by Toshiba Corporation, and the like.

  In the present invention, water (particularly pure water) is supplied to each of the anode chamber and the cathode chamber of the three-chamber electrolyzed water generator as the reducing water that forms the base material of the gel dentifrice, and an aqueous sodium chloride solution is supplied to the intermediate chamber. Reduced water produced in the cathode chamber by being supplied and electrolyzed is preferably used from the viewpoints of excellent cleaning action of dirt such as plaque and stain adhering to teeth and excellent safety.

The concentration of sodium chloride in the aqueous sodium chloride solution supplied to the intermediate chamber depends on the scale of the three-chamber electrolyzed water generating device, the electrolyzed water generating capacity, the structure, the type of model, etc. It is preferable to use the recommended concentration.
The amount of water supplied to the anode and cathode chambers and the amount of sodium chloride aqueous solution supplied to the intermediate chamber are also different depending on the scale of the three-chamber electrolyzed water generator, electrolyzed water generating capacity, structure, model type, etc. It is preferable to adopt the supply amount recommended in the three-chamber electrolyzed water generator.

By using the recommended sodium chloride concentration in each model, the amount of water supplied to the anode and cathode chambers, and the amount of sodium chloride aqueous solution supplied to the intermediate chamber, electrolysis was performed to produce acidic oxidation in the anode chamber. Water having an action (oxidized water) is generated, and water having an alkaline reducing action (reduced water) is generated in the cathode chamber.
The pH of the reduced water produced in the cathode chamber by supplying water (particularly pure water) to each of the anode chamber and the cathode chamber of the three-chamber electrolyzed water generating device and supplying the sodium chloride aqueous solution to the intermediate chamber and performing electrolysis. Is about 10-12, especially about 11-12.
In the present invention, in preparing an aqueous composition for gelling, a gel-like dentifrice having a high pH may be produced using pH 10-12 reduced water as it is without adjusting the pH, but it has excellent storage stability. Gel dentifrice by adding a pH adjuster when preparing an aqueous composition for gelling from the viewpoint of obtaining a gel-like dentifrice with less irritation to the oral cavity and less impact on the tooth enamel The pH is preferably 5 to 8, more preferably 5 to 7, and still more preferably 5 to 6.5.
Examples of the pH adjuster include organic acids such as citric acid and sodium citrate and salts thereof, sodium hydrogen carbonate, potassium hydroxide, sodium dihydrogen phosphate, sodium monohydrogen phosphate, and the like. In the gel dentifrice of the present invention, one or more of these can be used as necessary. Of these, citric acid and sodium citrate are preferably used.

In the gel-like dentifrice of the present invention, as reduced water, reduced water having an oxidation-reduction potential of -500 mV or less, more preferably -600 mV or less, particularly -750 mV or less when reduced water is produced by the three-chamber electrolyzed water generator. However, it is preferably used because it provides a gel-like dentifrice having a large reducing power and an excellent cleaning effect.
Although not limited, ultrapure water having an electric conductivity of 0.3 μS / cm (20 ° C.) is supplied to the anode chamber and the cathode chamber of the three-chamber electrolyzed water generator, and an aqueous sodium chloride solution is used as an intermediate Is supplied to the cathode chamber, it is possible to generate reduced water having a pH of 11.0 or more in the cathode chamber and an oxidation-reduction potential of −600 mV or less.

The hydrolyzed eggshell membrane used in the gel dentifrice of the present invention is a partially hydrolyzed eggshell membrane using acid, alkali, proteolytic enzyme and the like. Eggshell membranes are insoluble in water, but hydrolyzed eggshell membranes are soluble in water, and insoluble in water, but have increased hydrophilicity compared to eggshell membranes, depending on the degree of hydrolysis. In the present invention, both a hydrolysis egg shell membrane having a high degree of hydrolysis and a hydrolysis egg shell membrane having a low degree of hydrolysis can be used, and among them, a water-soluble hydrolysis egg shell membrane is preferably used. Therefore, those having a weight average molecular weight of 1,000 to 100,000, more preferably 5,000 to 50,000, particularly 10,000 to 35,000 are preferably used.
Here, “molecular weight of hydrolyzed eggshell membrane” as used herein refers to a weight average molecular weight measured by a gel permeation chromatography (GPC) method using a high performance liquid chromatograph.

Sasa is a plant belonging to the monocotyledonous subfamily, and is classified into the genus Medake, Azumazasa, Sasa, Suzutake, Yadatake, and Inochiku.
Among them, Chishimasasa (Kushima-sasa) belongs to the genus Sasa together with Kumazasa, Miyako-sasa, etc., and is a kind of large-scale cocoon, and is also referred to as Nemagari-dake (Nekyokutake), Kouraiza (Korean potato), Asahisa-sa.
The Chishimasa extract used in the gel dentifrice of the present invention is a liquid obtained by concentrating and purifying a sap produced by high-pressure pressing of fresh Chishimasa leaves and stems.
Chishimazasa extract is sold in the market. Specific examples include “Chishimasasa extract k3-C” manufactured by Nippon Haruma Co., Ltd. and Chishimasa extract concentrated “Selpure” (registered trademark) manufactured by Sano Corporation. it can.
In the gel-like dentifrice of the present invention, one or more commercially available tishima zasa extract can be used as it is.

  The gel-like dentifrice of the present invention has an effect of removing dirt such as plaque and stain attached to the tooth surface, a healing effect of wounds generated in periodontal tissues and oral mucosa, an oral cleaning effect, a tooth The total mass of gel dentifrice (and thus aqueous solution before gelation including caking agent) in order to be able to exert a balanced and effective effect on prevention and healing of peri-illness and prevention and reduction of bad breath. 20 to 90% by mass of reduced water (hereinafter sometimes referred to simply as “reduced water”) generated in the cathode chamber of the three-chamber electrolyzed water generator based on the total mass of the composition), and 0% of the hydrolysis eggshell membrane It is preferable to contain 0.0001 to 70% by mass of 0.0001 to 10% by mass and 0.0001 to 70% by mass of reduced water, 50 to 85% by mass of reduced water, 0.001 to 5% by mass of hydrolyzed eggshell membrane, and Tishimasaza extract. 0.0 It is more preferable to contain in the ratio of 1-50 mass%, 70-85 mass% of reduced water, 0.005-2 mass% of hydrolyzed eggshell membranes, and 0.005-30 mass% of Chishimasa extract (especially 0). (0.005 to 5% by mass).

The gel-like dentifrice of the present invention may or may not contain a foaming agent. However, when a foaming agent is contained, diffusion of the gel-like dentifrice in the oral cavity is promoted, and soiling is prevented. The above-described effects of the gel dentifrice of the present invention including purification can be exhibited more satisfactorily. When the foaming agent is contained, the proportion of the foaming agent is 0.3 to 7% by mass based on the total mass of the gel-like dentifrice (and thus the total mass of the aqueous composition before gelation including the binder). It is preferable to contain by 0.3-6 mass%, and it is still more preferable to contain by 0.3-5 mass%.
As the foaming agent, any foaming agent conventionally used in dentifrices can be used. Specific examples include lauryl glucoside, sodium lauryl sulfate, sapins triphoria juice extract (soap nut extract), and sucrose fatty acid. Surfactants such as esters, sodium lauroyl sarcosine, and N-lauroyl-L-glutamic acid can be used, and one or more of these can be used.

The gel-like dentifrice of the present invention contains hydrolyzed eggshell membrane and citrus extract in the reduced water produced in the cathode compartment of the three-chamber electrolyzed water generator, optionally containing a foaming agent, and if necessary, other A gelled product of an aqueous composition containing components, and the gelation of the aqueous composition is achieved by adding a binder (thickener) to the aqueous composition.
The gel-like dentifrice of the present invention may contain any of the binders conventionally used in dentifrices, and specific examples of the binder that can be used in the gel-like dentifrice of the present invention include: Examples include cellulose derivatives such as sodium carboxymethylcellulose (cellulose gum), methylcellulose, hydroxyethylcellulose, and carrageenan, alginic acid derivatives such as sodium alginate and propylene glycol alginate, and gums such as xanthan gum, gellan gum, tragacanth gum, and karaya gum. 1 type (s) or 2 or more types can be used.
The content of the binder contains reduced water, hydrolyzed eggshell membranes, chishimasa extract, and optionally foaming agents, and other components as necessary, in the cathode chamber of the three-chamber electrolyzed water generator In general, the total mass of the gel-like dentifrice so that the aqueous composition becomes a gel suitable for dentifrice, depending on the kind of ingredients constituting the aqueous composition, the ingredient composition, the kind of binder, etc. As a result, based on the total mass of the aqueous composition before gelation containing a binder, it is generally preferable to set the amount in the range of 0.05 to 5% by mass.

  Since the gel-like dentifrice of the present invention uses the above-described reduced water as a base material, its excellent cleaning action can effectively remove plaque, stains and the like without containing an abrasive. From the viewpoint of preventing damage to the enamel of the teeth, it is preferable that no abrasive is contained.

  The gel dentifrice of this invention can contain the other component conventionally used in the gel dentifrice with the above-mentioned component as needed. Examples of other components that can be contained as necessary include humectants, flavoring agents, refreshing agents, sweeteners, corrigents, colorants, emulsifiers, pH adjusters, vitamins, preservatives, preservatives, medicinal ingredients, and the like. be able to.

  Examples of the humectant include glycerin, sorbit liquid, propylene glycol, 1,3-butylene glycol, timber tuna water, nettle extract, fennel extract, chamomile extract, birch extract, sage extract, hop extract, melissa extract, rosemary extract and the like. And the gel-like dentifrice of the present invention can contain one or more of these.

  Examples of the flavoring agent and the refreshing agent include spearmint oil, peppermint type fragrance, herb type fragrance, mint oil, eucalyptus oil, menthol, bergamot type fragrance, citrus mint type fragrance, fruit type fragrance and the like. The gel dentifrice may contain one or more of these as required.

  Examples of the sweetener and flavoring agent include saccharin sodium, licorice extract, xylitol (xylitol), glycyrrhizic acid, dipotassium glycyrrhizinate, stevia extract, hamamelis extract, sodium chloride and the like. May contain one or more of these as required.

  Examples of the colorant include Blue No. 1, Yellow No. 4, Red No. 3, Red No. 102, Red No. 106, Green No. 3, Green No. 201 and the like, and the gel-like dentifrice of the present invention is necessary. Depending on the type, one or more of these may be contained.

  Examples of the emulsifier (solubilizer, solubilizer) include glyceryl caprylate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monooleate, sodium polyphosphate, soap base, polyoxyethylene alkyl ether phosphate, Examples include polyoxyethylene hydrogenated castor oil, sodium lauryl sulfate, polyglyceryl monolaurate, sodium lauroyl sarcosine, and the gel-like dentifrice of the present invention contains one or more of these as required. Can do.

  Examples of vitamins include vitamin E, vitamin C, vitamin B12, vitamin B2, and vitamin D. The gel dentifrice of the present invention contains one or more of these as required. can do.

  Examples of the preservative and preservative include p-oxybenzoate such as methyl p-oxybenzoate, ethyl p-oxybenzoate, propyl p-oxybenzoate, ethylbutyl p-oxybenzoate, and ethylethyl p-oxybenzoate. Examples thereof include acid esters, alkyldiaminoethylglycine hydrochloride, cetylpyridinium chloride and the like, and the gel-like dentifrice of the present invention can contain one or more of these as required.

  Examples of medicinal ingredients include anti-inflammatory agents and fungicides such as alkyldiaminoethylglycine hydrochloride, cetylpyridinium chloride, isopropylmethylphenol, triclosan, chlorhexidine gluconate, chlorhexidine, benzethonium chloride, benzalkonium chloride, decanium chloride, etc. , Alkali metal monofluorophosphates (sodium monofluorophosphate, potassium monofluorophosphate, etc.), fluorides such as sodium fluoride and stannous fluoride, and the like. Can contain one or more of these as required.

  The method for producing the gel-like dentifrice of the present invention is not particularly limited, and contains the hydrolyzed eggshell membrane and chicaria extract, preferably further contains a foaming agent, and is further blended as necessary together with these components. A method in which one or more of the components can produce a gel-like dentifrice uniformly mixed in a gelled product based on reduced water generated in the cathode chamber of a three-chamber electrolyzed water generator. Any method may be used. In general, an aqueous composition is prepared by blending reduced water, hydrolyzed eggshell membrane, licorice extract, binding agent and, if necessary, a foaming agent and other ingredients simultaneously or in any order. Each component in the composition can be produced by stirring and mixing well until they are uniformly mixed and gelled.

Hereinafter, the present invention will be specifically described with reference to examples and the like, but the present invention is not limited to the following examples.
Example 1
To 78.38 parts by mass of reduced water (pH 11 at a temperature of 25 ° C., oxidation-reduction potential at the time of production = −800 mV) generated in the cathode chamber of “3-chamber electrolyzer” manufactured by Redox Co., Ltd., hydrolyzed eggshell membrane ( Amounts described in Table 1 below together with 0.01 parts by mass of Cupy Co., Ltd. and 0.03 parts by mass of Chishimazasa extract (“Chishimasasa Extract K3-C” manufactured by Nippon Haruma Co., Ltd.) The gel-like dentifrice (pH = 6) based on reduced water was produced by mixing at a temperature of 25 ° C. until uniform.
The gel-like dentifrice thus obtained was filled into a tube-like container (filling amount: 100 g / 1 tube) to produce a gel-like dentifrice containing a tube.

<< Comparative Example 1 >>
In Example 1, 78.4 parts by mass of purified water was used instead of 78.38 parts by mass of reduced water, and the same procedure as in Example 1 was carried out except that citric acid and sodium citrate were not blended. A gel-like dentifrice (pH = about 7) containing a decomposed eggshell membrane and chicaria extract and based on purified water was produced.
The gel-like dentifrice thus obtained was filled into a tube-like container (filling amount: 100 g / 1 tube) to produce a gel-like dentifrice containing a tube.

<< Test Example 1 >>
(1) 6 monitors A, B, C, D, E, F [Monitor A = 25 years old (female), Monitor B = 27 years old (male), Monitor C = 36 years old (female), Monitor D = 40 Age (male), monitor E = 60 years old (female), monitor F = 58 years old (male)], after lunch, using about 1.5 g of the gel dentifrice of Example 1 for 5 minutes. After rinsing the mouth 5 times with water, clean the plaque stain on the upper and lower teeth, gums and teeth with a cotton swab impregnated with plaque stain ("Prospec stain" manufactured by GC Corporation). It was applied to the entire border and rinsed once with water.
(2) The same observer visually observes the mouth of each monitor, and the remaining state of the dental stain is evaluated according to the evaluation criteria shown in Table 2 below. It was as follows.

<< Comparative Test Example 1 >>
(1) On the day following the test 1 above, about 6 g of the above-mentioned six monitors A to F, after lunch, about 1.5 g of the gel dentifrice of Comparative Example 1 was used. Brush your teeth for 5 minutes and rinse your mouth 5 times with water, then use a cotton swab impregnated with the same plaque stain used in Test 1 to place the plaque stain up and down. It was applied to the entire tooth and gum-to-teeth boundary, and the mouth was rinsed once with water.
(2) When the same observer as in Test Example 1 visually observed the mouth of each monitor and evaluated the remaining state of the dental stain according to the evaluation criteria shown in Table 2 below, As shown in Table 3.

From the results of Test 1 and Comparative Test 1 described above, the gel-like dentifrice of Example 1 based on reduced water produced in the cathode chamber of the three-chamber electrolyzed water generator is free from abrasives. It can be seen that the cleaning effect of dental dirt such as dental plaque is excellent.
On the other hand, the gel-like dentifrice of Comparative Example 1 based on purified water is inferior in the cleaning effect of dental stains such as dental plaque, and is a conventional gel-like dentifrice for removing tooth stains. It turns out that it is necessary to mix | blend an abrasive etc. similarly to.

<< Test Example 2 >>
10 monitors (aged 36-72 years old, 5 males, 5 females) who feel the gums are thin and have no elasticity and tension, the color of the gums is a little reddish purple and have bad breath. Using the gel dentifrice obtained in Example 1 three times a day (after breakfast, after lunch and before going to bed), the amount of gel dentifrice used once is about 1.5 g for 14 days (2 weeks) ) The teeth were brushed over and evaluated according to the evaluation contents shown in Table 4 below, and as shown in Table 4 below.

  From the results of Table 4 above, the gel-like dentifrice of the present invention, which uses reduced water produced in the cathode chamber of a three-chamber water electrolysis apparatus as a base material and contains a hydrolyzed eggshell membrane and tishimasa extract, is an abrasive. Even if it does not contain, it is possible to remove stains such as plaque and stains attached to the surface of the teeth, and it is excellent in cleaning effect, while maintaining the healthy state of the periodontal tissue and oral mucosa and the healthy state It can be seen that it has the effect of promoting the recovery of the skin, is effective in the prevention and cure of periodontal disease, and is further excellent in the prevention and reduction of bad breath.

DESCRIPTION OF SYMBOLS 1 Anode chamber 1a Water inflow part 1b Oxidized water outflow part 1d Anode electrode (positive electrode)
2 Cathode chamber 2a Water inflow part 2b Reduction water outflow part 2d Cathode electrode (negative electrode)
3 Intermediate chamber 3a Supply part of aqueous solution containing ionic compound (sodium chloride, etc.) 3b Outflow part of aqueous solution 4 Diaphragm 5 Diaphragm

Claims (8)

  A gel-like dentifrice comprising a gelled product of an aqueous composition containing hydrolyzed eggshell membranes and licorice extract in reduced water which is generated water in a cathode chamber of a three-chamber electrolyzed water generator.   Based on the total mass of the gel dentifrice, the reduced water is contained in an amount of 20 to 90% by mass, the hydrolyzed eggshell membrane in an amount of 0.0001 to 10% by mass, and the tishima zasa extract in a proportion of 0.0001 to 70% by mass. Item 2. A gel dentifrice according to Item 1.   The gel dentifrice of Claim 1 or 2 which contains a foaming agent in the ratio of 0.3-7 mass% further based on the total mass of a gel dentifrice.   The gel dentifrice according to any one of claims 1 to 3, which has a pH of 5 to 8.   The gel-like dentifrice of any one of Claims 1-4 which does not contain an abrasive | polishing agent.   An anode chamber having an anode electrode; a cathode chamber having a cathode electrode; an intermediate chamber provided between the anode chamber and the cathode chamber; a diaphragm disposed between the anode chamber and the intermediate chamber; Using a three-chamber electrolyzed water generating device having a diaphragm disposed between the intermediate chamber, water is supplied to each of the anode chamber and the cathode chamber, and an aqueous sodium chloride solution is supplied to the intermediate chamber for electrolysis. To produce reduced water in the cathode chamber, and the reduced water produced in the cathode chamber contains a hydrolyzed eggshell membrane, chicaria extract and a gelling agent to prepare an aqueous composition. The manufacturing method of the gel-like dentifrice characterized by making into a gel.   The method for producing a gel dentifrice according to claim 6, wherein a foaming agent is further contained during preparation of the aqueous composition.   The method for producing a gel-like dentifrice according to claim 6 or 7, wherein a pH adjusting agent is added at the time of preparation of the aqueous composition to adjust the pH of the aqueous composition to 5 to 8 to form a gel.

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