JP2018050808A - Chemical solution administration device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a chemical solution administration device capable of preventing the component of a chemical solution from being deposited into a distribution part serving as a liquid sending pipe due to removal of the distribution part from a puncture part serving as a cannula.SOLUTION: An insulin administration device 100 according to this invention comprises a first control unit 134 which controls a drive mechanism 131 to operate so as to keep a liquid sending pipe 142 moist when separation of the liquid sending pipe 142 from a cannula 113 is detected.SELECTED DRAWING: Figure 9

Description

  The present invention relates to a chemical solution administration device used for administering a chemical solution into a living body.

  2. Description of the Related Art Conventionally, as a device for administering a drug solution such as insulin, a portable administration device that continuously administers a drug solution while being attached to the skin of a patient or subject to be administered is known.

  In the conventional technology related to a chemical solution administration device, a component group that is attached to the patient's skin surface and a component equipped with a chemical solution such as insulin are detachable so that refilling of insulin and the like can be performed. Yes (see Patent Document 1). In Patent Document 1, a part attached to the skin surface is called a cradle unit, and a part group including a container for storing insulin is called a patch unit. The cradle unit is provided with a cannula (referred to as a puncture unit) corresponding to the puncture needle, and the patch unit is provided with a CPU for controlling the apparatus.

European Patent No. 2185218

  As described above, the chemical solution administration device is used by being affixed to a user's living body. However, when the user takes a bath, the patch unit is attached to the cradle unit in order to protect the patch unit including an electronic device such as a CPU. It is necessary to remove from. The liquid feeding pipe (referred to as a circulation part) is included in the patch unit, but remains in the liquid feeding pipe if the patch unit including the liquid feeding pipe is removed from the cradle unit including the cannula and left for a relatively long time. There is a possibility that components other than moisture may deposit due to evaporation of the moisture in the chemical solution. If the deposit clogs the liquid delivery tube, or if the patch unit and cradle unit are connected with the deposit on the liquid delivery tube, the deposit moves to the cradle unit and clogs the cannula. There is a fear.

  An object of this invention is to provide the chemical | medical solution administration apparatus which can prevent that the component of a chemical | medical solution precipitates in a distribution part by removing the distribution | circulation part which corresponds to a liquid feeding tube from the puncture part which corresponds to a cannula.

  A medicinal-solution administration device according to the present invention includes a puncturing unit including a first channel that can be punctured into a living body and can circulate the medicinal solution, a medicinal solution storage unit that stores a medicinal solution that circulates in the first channel, a medicinal solution storage unit, and a puncture A second flow channel that is disposed between the first flow channel and the second flow channel, and is configured to be separable from the puncture unit, and a chemical solution stored in the chemical solution storage unit is sent to the second flow channel. A driving mechanism that generates a driving force; a detection unit that detects connection and separation between the puncture unit and the circulation unit; and a control unit that operates the driving mechanism. The control unit operates the drive mechanism so that the second flow path is kept wet when the detection unit detects the separation of the circulation unit from the puncture unit.

  According to the drug solution administration device of the present invention, the control unit operates the drive mechanism to feed the drug solution to the second channel so that the second channel in the circulation unit is kept wet. Therefore, even when the flow part is separated from the puncture part, it is possible to prevent the chemical component from being deposited in the second flow path of the flow part.

It is the schematic which shows the chemical | medical solution administration apparatus which concerns on embodiment of this invention. It is a disassembled perspective view which shows the liquid feeding main-body part of a chemical | medical solution administration apparatus. It is a top view which shows the injection | pouring part of a chemical | medical solution administration apparatus. 4A and 4B are enlarged cross-sectional views taken along line 4-4 of FIG. 3, in which FIG. 4A shows a state before the cannula is introduced into the living body, and FIG. It is a figure which shows a mode that it introduced. FIG. 4C is a view showing a state where the puncture device is removed and the cannula is left in the living body. It is a schematic plan view which shows the structure of each part in the liquid feeding main-body part of the chemical | medical solution administration apparatus which concerns on embodiment. It is a perspective view which shows the interruption | blocking member which comprises the rotation detection part which detects rotation of the motor which comprises a drive mechanism. FIGS. 7A and 7B are cross-sectional views taken along line 7-7 in FIG. 5, in which FIG. 7A shows a state before connecting the injection portion and the liquid feeding portion, and FIG. It is a figure which shows the state which connected the part. It is a block diagram explaining the structure of the control system of a chemical | medical solution administration apparatus. It is a flowchart shown about supply of the fluid to a liquid feeding pipe.

  Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings. In addition, the following description does not limit the technical scope and terms used in the claims. In addition, the dimensional ratios in the drawings are exaggerated for convenience of explanation, and may differ from actual ratios.

  Hereinafter, with reference to FIGS. 1-9, the chemical | medical solution administration apparatus which concerns on this embodiment is explained in full detail. FIGS. 1-8 is a figure where it uses for description of a structure of each part of the chemical | medical solution administration apparatus which concerns on this embodiment.

  The drug administration device according to the present embodiment is configured as a portable insulin administration device 100 that delivers insulin as a drug solution into the living body of a diabetic patient who is a user. In the following description, the drug administration device is described as the insulin administration device 100.

  As shown in FIG. 1, the insulin administration device 100 performs a liquid feeding main body 10 that performs a liquid feeding operation for feeding insulin, which is a drug solution, into a living body, and gives various operation instructions to the liquid feeding main body 10. A remote controller 20. Hereinafter, the configuration of each part of the insulin administration device 100 will be described in detail.

  As shown in FIG. 2, the liquid feeding main body unit 10 includes a cannula 113 or the like placed in the user's living body, and drives the injection unit 11 attached to the user's living body and members necessary for the liquid feeding operation. A liquid feed reuse unit 13 including a drive mechanism 131 that generates a driving force, a drug solution storage unit 141 filled with insulin, and an extrusion mechanism 143 that is used when a drug solution filled in the drug solution storage unit 141 is sent out. And a liquid feeding section 12 including a liquid feeding disposable section 14 that includes the liquid feeding disposable section 14.

  The injection unit 11 and the liquid feeding unit 12 are configured to be connected and separated. For example, when the user takes a bath or the like, while the injection unit 11 is attached to a living body, the drug solution storage unit 141 filled with insulin or the liquid feeding unit 12 including an electrical / mechanical mechanism is removed from the injection unit 11. To separate. By performing this operation, it is possible to prevent the insulin in the drug solution storage unit 141 from being heated and the liquid from adhering to the electrical / mechanical mechanism in the liquid feeding unit 12 to get wet.

  Moreover, the liquid feeding reuse part 13 and the liquid feeding disposable part 14 are comprised so that connection separation is possible. When the insulin or the like in the drug solution storage unit 141 has been used up after a predetermined period of time, the liquid supply reuse unit 13 and the liquid supply disposable unit 14 are separated, and the liquid supply disposable unit 14 is made disposable (disposable) to be new. Can be exchanged for something. On the other hand, the liquid supply reuse unit 13 is mounted with relatively expensive components such as a motor 136 and a gear group 137, which will be described later, which are less expensive to replace than components mounted on the liquid supply disposable unit 14. In this way, a component member discarded after use for a predetermined period and a relatively expensive component member are mounted in different housings, respectively, and the relatively expensive component member is mounted in the liquid feeding reuse unit 13 and can be reused. By doing so, it is possible to reduce the manufacturing cost of the apparatus and the cost associated with use. Each configuration will be described below.

  First, the injection part 11 will be described. As shown in FIG. 2 and the like, the injection part 11 includes an injection main body part (also referred to as a cradle) 111, a sticking part 112 for attaching the injection main body part 111 to the living body of the user, and protrudes from the injection main body part 111. A cannula 113 placed on the injection body 111, a support member 114 mounted on the injection main body 111 and supporting the cannula 113, and a magnet 115 used to detect the connection between the injection part 11 and the liquid feeding part 12 (see FIG. 3). ) And. The cannula 113 and the support member 114 correspond to a puncture portion.

  As shown in FIG. 2, the injection main body 111 includes a flat plate-like placement portion 111 a and a vertical wall portion 111 b that rises a part of the outer peripheral edge of the placement portion 111 a. As shown in FIGS. 4A to 4C, the mounting portion 111a is formed with an insertion hole 111c through which the cannula 113 can be inserted.

  In addition, as shown in FIG. 2, the vertical wall portion 111b has an engagement portion for maintaining a mechanical connection state with a second housing 145 of a liquid delivery disposable portion 14 to be described later, toward the opposing surface. A protruding projection 111d and a through hole 111e are formed. When the second housing 145 of the liquid delivery disposable part 14 is slid and connected to the injection main body 111, the protrusion 111 d is fitted into a groove 145 c formed on the outer side of the second housing 145. Further, the hooking portion 145d formed in the second housing 145 is hooked in the through hole 111e. Note that the shape of the engaging portion is not limited to the above shape as long as the injection main body portion 111 and the second housing 145 of the liquid delivery disposable portion 14 can be connected and separated.

  As shown in FIG. 3 and FIGS. 4A to 4C, the pasting portion 112 is configured by a substantially rectangular sheet-like member. Adhesiveness of the pasting portion 112 is added to the surface opposite to the surface on which the vertical wall portion 111b rises in the placement portion 111a of the injection main body portion 111. Using the adhesiveness of the sticking part 112, the injection part 11 can be stuck to the living body of the user. In addition, the sticking part 112 may be inadvertently attached to the surface of the sticking part 112 having adhesiveness by using a removable release paper that covers and protects the sticking part 112. May be prevented.

  The cannula 113 is punctured into the living body and used to introduce a medical solution such as insulin from the medical solution storage unit 141 into the living body. As shown in FIG. 4A, the cannula 113 has a cylindrical portion and a truncated cone-shaped portion that is formed continuously with the cylindrical portion, and the cylindrical portion and the truncated cone-shaped portion. Has a continuous lumen (corresponding to the first flow path) through which insulin is circulated. The cannula 113 is configured to have a so-called funnel-like shape by having the above-described shape.

  As shown in FIG. 4, the support member 114 includes a base 114 a that supports the cannula 113, a connection port 114 b that includes a lumen into which the liquid feeding pipe 142 (see FIG. 7) of the liquid feeding disposable part 14 is inserted, A cap 114c attached so as to cover the connection port 114b; a lid member 114d attached to the upper surface of the base 114a (the surface opposite to the mounting surface on the injection main body 111); the base 114a and the lid member 114d; And a seal member 114e provided between the two.

  The base 114a is a part that becomes a base of the support member 114, and is configured in a substantially cylindrical shape in the present embodiment. As shown in FIG. 4C and the like, the base 114a includes an internal space 114f in which the cannula 113 is installed. The internal space 114f has a funnel shape in accordance with the shape of the cannula 113 so that the cannula 113 can be supported. It is configured as follows. The internal space 114f corresponds to a first flow path through which insulin from the liquid feeding tube 142 flows.

  As shown in FIG. 4A and the like, the connection port 114b extends in a direction intersecting the cylindrical axis of the cannula 113 at the base 114a. The lumen of the connection port 114b communicates with the internal space 114f of the base 114a.

  The cap 114c is formed of a material that can insert a liquid feeding pipe 142 of the liquid feeding disposable section 14 to be described later, and can keep liquid tight between the liquid feeding pipe 142 and the connection port 114b. The material is preferably rubber.

  As shown in FIG. 4C, the lid member 114d has a function of pressing the seal member 114e. A through hole into which a needle N of a puncture tool M, which will be described later, can be inserted is formed in the lid member 114d coaxially with the axial direction of the cannula 113.

  The seal member 114e is configured so that the needle N of the puncture device M can be inserted, and prevents insulin from leaking out from the through hole of the lid member 114d after the puncture device M is removed. Examples of the material of the seal member 114e include rubber. Note that the puncture tool M shown in FIGS. 4A and 4B is not shown in detail.

  The indwelling of the cannula 113 in the living body is supported, for example, in the direction in which the needle N and the cannula 113 protrude from the placement portion 111a, and the needle N that can be inserted into the lumen of the cannula 113 supported by the support member 114. It can be performed by a puncture device M including a biasing member (not shown) that applies a biasing force to the member 114 and the needle N.

  Specifically, first, the user attaches the injection main body 111 to the body surface of the user using the attaching portion 112. Next, the needle N is inserted from the through hole formed in the lid member 114 d of the support member 114, and the support member 114 is attached to the puncture tool M so that the needle N passes through the lumen of the cannula 113. Next, as shown in FIG. 4A, the puncture tool M is attached on the placement portion 111a. Next, as shown in FIG. 4B, the support member 114 and the needle N are moved toward the direction in which the needle N and the cannula 113 protrude from the placement portion 111a by the urging force of the urging member included in the puncture tool M. Eject. At this time, the support member 114 is fixed to the placement portion 111a by a not-shown hanging mechanism. Next, as shown in FIG. 4C, the puncture tool M including the needle N is removed from the placement portion 111a with the support member 114 attached to the placement portion 111a. As a result, the cannula 113 is placed in the living body.

  The magnet 115 is used to detect that the liquid feeding unit 12 is connected to the injection unit 11. As will be described later, the liquid feeding reuse unit 13 constituting the liquid feeding unit 12 is provided with a mounting detection unit 139 (corresponding to a detection unit) used for detecting the connection between the liquid feeding unit 12 and the injection unit 11 together with the magnet 115. ing. In the present embodiment, the mounting detection unit 139 is configured by a reed switch and is installed in the first housing 135 of the liquid feeding reuse unit 13 described later. The reed switch is disposed so as to be located above the magnet 115 when the liquid feeding part 12 is attached to the injection part 11. In the reed switch, the metal plates are arranged apart from each other inside the glass tube, and the metal plates are brought into contact with each other by arranging the magnet 115 on the head in the vicinity of the reed switch. Since the mounting detection unit 139 is electrically connected to a first control unit 134 described later, the liquid feeding unit 12 is attached to the injection unit 11 by detecting the presence or absence of contact of the metal plate of the mounting detection unit 139. It can be detected whether or not.

  Next, the liquid feeding reuse unit 13 will be described. As shown in FIGS. 2 and 5, the liquid supply reuse unit 13 includes a drive mechanism 131 that drives a member necessary for performing the liquid supply operation, a rotation detection unit 132 that detects a rotation operation of the drive mechanism 131, and A first communication unit 133 that communicates with the remote controller 20, a first control unit 134 (corresponding to a control unit) that controls the drive mechanism 131, the first communication unit 133, and the like, a first housing 135 that holds these, a transmission unit A state detection unit 138 (corresponding to a temperature detection unit) that detects the state of the liquid dispensing unit 14 in the vicinity of the liquid supply pipe 142, and a mounting detection unit 139 that is used when detecting the mounting of the liquid supply unit 12 to the injection unit 11. And having. In FIG. 5, a part surrounded by a dotted line X represents a part attached to the liquid feeding reuse part 13, and a part surrounded by a one-dot chain line Y represents a part attached to the liquid feeding disposable part 14. In FIG. 5, the first housing 135 is omitted for easy understanding.

  As shown in FIG. 5 and the like, the drive mechanism 131 decelerates the rotation generated by the motor 136 having an output shaft that generates rotation by the electric power from the battery 144 of the liquid supply disposable unit 14 and supplies the liquid. And a gear group 137 that transmits to the extrusion mechanism 143 of the disposable unit 14.

  The motor 136 generates a driving force necessary for moving the slide portion 146 of the push-out mechanism 143 on the output shaft as a rotational motion. The motor 136 uses a stepping motor in this embodiment. The stepping motor is preferable from the viewpoint of safety because the rotation of the motor is stopped at the time of a short circuit. However, the specific mode of the motor 136 is not limited to this as long as it can generate a driving force by rotation and can be mounted on the portable insulin administration device 100. The motor 136 may be, for example, a DC motor, an AC motor, or the like other than the stepping motor.

  The gear group 137 is used to transmit the rotational power generated from the motor 136 to the extrusion mechanism 143 that presses the chemical solution storage unit 141. In the present embodiment, the gear group 137 includes a first gear 137a connected to the motor 136, a second gear 137b meshing with an adjacent gear, a third gear 137c, and a fourth gear 137d, as shown in FIG.

  The first gear 137a includes one type of tooth that meshes with an adjacent gear. In contrast, the second gear 137b, the third gear 137c, and the fourth gear 137d are provided with two types of teeth that mesh with adjacent gears in the axial direction in which the gear rotates.

  The second gear 137b is disposed adjacent to the first gear 137a and the third gear 137c in the direction intersecting with the rotation axis of the first gear 137a (the vertical direction in FIG. 5).

  The third gear 137c is disposed adjacent to the second gear 137b and the fourth gear 137d in the direction intersecting the rotation axis of the first gear 137a (the vertical direction in FIG. 5).

  The fourth gear 137d is disposed adjacent to the third gear 137c and the fifth gear 148 of the liquid delivery disposable unit 14 in the direction intersecting the rotation axis of the first gear 137a (the vertical direction in FIG. 5).

  The gear group 137 and the fifth gear 148 are constituted by spur gears. However, the number of gears is not limited to the above as long as the power generated by the rotation from the motor 136 can be transmitted to the extrusion mechanism 143. The gear group 137 and the fifth gear 148 set the number of gears and the number of teeth so that the torque from the motor 136 can be reduced to a set value. However, specifications such as the number of gears and the number of teeth are not limited to the above as long as a desired reduction ratio can be realized in a given space. In the present embodiment, the rotation direction of the input gear corresponding to the first gear 137a and the rotation direction of the output gear corresponding to the fifth gear 148 may be the same or different. The material of the gear group 137 is not particularly limited as long as the output from the output shaft 136a of the motor 136 can be transmitted to the extrusion mechanism 143, and examples thereof include resin materials such as metal and plastic.

  The motor 136 is connected to the first gear 137a of the gear group 137 via a coil spring (not shown).

  As shown in FIG. 5, the rotation detecting unit 132 includes a blocking member 132a provided on the motor 136 side of the first gear 137a, a light emitting unit 132b disposed so as to face the blocking member 132a, and a light receiving unit 132b. And an optical sensor including the portion 132c.

  As shown in FIG. 6, the blocking member 132a is provided with a plurality of substantially fan-shaped shapes such as fan blades at regular angular intervals in the circumferential direction of the first gear 137a. When the detection light S emitted from the light emitting unit 132b of the optical sensor passes through a portion of the blocking member 132a where the blade shape is not provided, the light receiving unit 132c receives the detection light S. Conversely, when the detection light S from the light emitting unit 132b is blocked by the blade shape of the blocking member 132a, the light receiving unit 132c does not receive the detection light S. Since the blade shape of the blocking member 132a is provided at regular intervals, the rotation speed of the output shaft of the motor 136 is detected based on the time interval (frequency) at which the detection light S is received. Since the reduction ratio by the gear group 137 and the fifth gear 148 and the screw pitch of the feed screw 147 of the extrusion mechanism 143 are fixed (not variable), the chemical solution is detected by detecting the rotation speed of the output shaft 136a of the motor 136. Can be detected.

  The blocking member 132a is configured by providing three fan-shaped blade shapes in FIG. 6 and the like. However, as long as the blocking and passing of the detection light S can be switched, the blade shape, the number of the blade shapes, and the like are not illustrated. It is not limited to 6. In the present embodiment, the rotation detector 132 detects the number of rotations of the output shaft of the motor 136 to determine the amount of liquid to be fed. However, the method for detecting the amount of liquid to be fed is not limited to this. For example, it is also possible to obtain the liquid feeding amount from a control signal sent to the motor 136. In addition, although an optical sensor is used for detecting the rotation speed, a magnetic sensor or the like may be used in addition to the above as long as the rotation amount of the motor can be detected.

  The first communication unit 133 includes electronic devices necessary for communication with the remote controller 20. The remote controller 20 is provided with a second communication unit 202 as will be described later, and uses the BLE (Bluetooth (registered trademark) Low Energy) communication that is short-range wireless communication with the first communication unit 133 of the liquid-feeding reuse unit 13. Thus, information can be transmitted and received between each other.

  As illustrated in FIG. 8, the first control unit 134 includes a processing unit 134a and a storage unit 134b. The first control unit 134 is configured by a known microcomputer, and controls the entire components that operate in the liquid feeding unit 12.

  The processing unit 134a executes calculations and instructions necessary for the operation of the motor 136, the first communication unit 133, the rotation detection unit 132, and the like that constitute the drive mechanism 131. The processing unit 134a is configured by a CPU or the like.

  The storage unit 134b stores the output of the number of rotations of the motor 136 from the rotation detection unit 132, and stores information about whether the liquid feeding unit 12 is removed from the injection unit 11. The storage unit 134b is configured by a RAM, a ROM, or the like.

  As shown in FIG. 2, the first housing 135 has a top surface 135 a that covers the configuration of the drive mechanism 131, the rotation detection unit 132, the first communication unit 133, the processing unit 134 a, and a part of the outer periphery of the top surface 135 a. And a raised side wall 135b. A drive mechanism 131, a rotation detection unit 132, a first communication unit 133, a processing unit 134a, and the like are operatively attached to the upper surface 135a.

  Moreover, the 1st housing 135 has a convex part (not shown) which protrudes inward from the inner surface of the side wall 135b as a structure which can connect and separate the liquid feeding reuse part 13 with the liquid feeding disposable part 14. As shown in FIG. In the present embodiment, the first housing 135 is made of resin parts such as plastic, but is not limited to this as long as it has a certain degree of strength.

  The state detection unit 138 detects the state of the liquid supply tube 142 that corresponds to the flow path of the chemical solution between the chemical solution storage unit 141 and the cannula 113. The state detection unit 138 is configured by a temperature sensor in the present embodiment. The state detection unit 138 is installed in the first housing 135 in the vicinity of the liquid supply pipe 142 and in the liquid supply reuse unit 13. If the state in the vicinity of the liquid supply pipe 142 can be detected, the state detection unit 138 is disposed in the liquid supply disposable unit 14. May be. The state detection unit 138 is disposed around the liquid feeding pipe 142. The first control unit 134 operates the drive mechanism 131 under a certain condition based on the temperature detected by the state detection unit 138 and instructs to send a small amount of chemical solution to the liquid feeding tube 142. Details will be described later.

  Since the mounting detection unit 139 has been described above, a detailed description thereof is omitted here.

  Next, the liquid delivery disposable part 14 will be described. As shown in FIG. 5, the liquid delivery disposable unit 14 includes a liquid delivery pipe 142 (distribution) that communicates the drug solution storage unit 141 filled with insulin with the lumen of the connection port 114 b provided in the injection unit 11 and the drug solution storage unit 141. An extrusion mechanism 143 that is mechanically connected to the drive mechanism 131 and pushes the insulin in the drug solution storage section 141 to the liquid feeding tube 142, a battery 144 that supplies power to the drive mechanism 131, and the like. And a second housing 145 for holding.

  The chemical solution storage unit 141 has a cylindrical shape. A liquid feeding pipe 142 is connected to one end of the chemical liquid storage unit 141. An opening 141 a is formed at the other end of the chemical solution storage unit 141. A slide part 146 of an extrusion mechanism 143, which will be described later, is inserted into the drug solution storage part 141 from the opening 141a, and insulin is stored in a space partitioned by the drug solution storage part 141 and the slide part 146.

  As shown in FIGS. 7A and 7B, in this embodiment, the liquid feeding tube 142 is constituted by a metal thin tube having a sharp tip shape. As shown in FIG. 7A, when the liquid feeding section 12 is connected to the injection section 11 while being slid, the sharp tip of the liquid feeding pipe 142 is connected to the injection section 11 as shown in FIG. It penetrates the cap 114c and is inserted into the lumen of the connection port 114b. The liquid feeding tube 142 is disposed between the chemical liquid storage unit 141, the cannula 113 and the support member 114. The liquid feeding pipe 142 is provided with a flow path (corresponding to the second flow path) for circulating insulin.

  As shown in FIG. 5, the push-out mechanism 143 meshes with a slide portion 146 that can move forward and backward in the internal space of the chemical solution storage portion 141 and a female screw portion 146 d formed on the slide portion 146 to move the slide portion 146 forward and backward. A feed screw 147 and a fifth gear 148 engaged with the fourth gear 137 d of the drive mechanism 131 and connected to the feed screw 147 are provided.

  As shown in FIG. 5, the slide portion 146 includes an extruding member 146 a that can move forward and backward in the chemical solution storage portion 141 while maintaining a sealing property so that the chemical solution does not leak to the slide portion 146 side, and a female screw that meshes with the feed screw 147. It has a feed plate 146b in which a portion 146d is formed, and a connecting plate 146c that connects the push member 146a and the feed plate 146b.

  The pushing member 146a is inserted from the opening 141a of the chemical solution storage unit 141 in order to form a space for storing the chemical solution in the internal space of the chemical solution storage unit 141. The push-out member 146a is fitted to the cylindrical inner wall surface so that the chemical solution does not leak from the boundary between the push-out member 146a and the cylindrical inner wall surface of the chemical solution storage unit 141, and the inner wall surface is moved in the horizontal direction of FIG. Move forward and backward. The size (volume) of the storage space (the internal space of the chemical solution storage unit 141) that stores the chemical solution varies depending on the position of the pushing member 146a in the chemical solution storage unit 141. The pushing member 146a is sometimes called a pusher or a pusher.

  The feed plate 146b is configured by forming a hole in the plate shape and forming a female screw portion 146d that meshes with the male screw portion 147a of the feed screw 147 in the hole.

  The connecting plate 146c connects the push member 146a and the feed plate 146b using two plates. However, the shape of the connection plate 146c is not limited to this as long as the push member 146a and the feed plate 146b can be connected and operated together. In addition to the above, the connecting plate 146c may be configured in a hollow shape that fits around the cylindrical inner wall surface of the chemical solution storage unit 141, for example.

  The feed screw 147 has a general male screw shape, and a part of the feed screw 147 is engaged with the female screw portion 146d of the feed plate 146b. The head of the feed screw 147 is provided with a cross groove, for example, and meshes with a part of a fifth gear 148 described later.

  The fifth gear 148 is disposed in the second housing 145 at a position that meshes with the fourth gear 137d in a state where the liquid feeding reuse portion 13 and the liquid feeding disposable portion 14 are connected.

  As shown in FIG. 5, the fifth gear 148 meshes with (engages with) the gear teeth and the groove of the screw head of the feed screw 147 provided at the end of the rotation shaft serving as the rotation center of the gear. And a bit.

  The bit of the fifth gear 148 is configured in the same manner as the tip shape of a driver (also called a screw driver, screwdriver, etc.) that tightens a general screw. By configuring the bit of the fifth gear 148 as described above, the bit engages with the concave groove of the screw head of the feed screw 147, and transmits the power generated by the rotation of the fifth gear 148.

  Moreover, since the tooth | gear and rotating shaft of the 5th gear 148 are the same as that of a well-known shape, description is abbreviate | omitted.

  The feed screw 147 and the fifth gear 148 are rotatably attached to the second housing 145.

  When the fifth gear 148 rotates with the rotation of the fourth gear 137d constituting the drive mechanism 131, the feed screw 147 rotates. The feed plate 146b is restricted from rotating in the rotational direction of the feed screw 147, and the feed plate 146b moves along the helical axis of the male screw portion of the feed screw 147 as the feed screw 147 rotates. The pushing member 146a connected to the feed plate 146b via the connecting plate 146c moves in the chemical solution storage unit 141 as the feed plate 146b moves. When the extruding member 146a moves in the direction in which the extruding member 146a is pushed into the medicinal solution storage unit 141 (the direction in which the volume of the accommodating space decreases), insulin in the accommodating space formed by the medicinal solution storing unit 141 and the extruding member 146a enters the liquid feeding tube 142. The liquid is sent.

  The battery 144 is electrically connected to the motor 136, the rotation detection unit 132, the first communication unit 133, and the first control unit 134 in the liquid supply reuse unit 13 when the liquid supply reuse unit 13 and the liquid supply disposable unit 14 are connected. Connected to each other to supply power. In the present embodiment, the battery 144 is configured by connecting two batteries in series. However, the number of batteries and the connection method such as series or parallel are not particularly limited as long as power can be supplied to each unit.

  As shown in FIG. 2, the second housing 145 has a bottom surface 145 a on which components such as a chemical solution storage unit 141, a liquid feeding pipe 142, an extrusion mechanism 143, and a battery 144 are placed, and an outer peripheral edge portion of the bottom surface 145 a. And a side wall 145b.

  The second housing 145 is configured to be connected to and separated from the injection main body 111. Specifically, in the present embodiment, the side wall 145b has a groove 145c that can be fitted to the protrusion 111d formed on the injection main body 111 and a through hole formed in the injection main body 111 as shown in FIG. A hooking portion 145d that hooks on 111e is formed. When the second housing 145 is slid to the injection main body 111, the projection 111 d of the injection main body 111 and the groove 145 c of the second housing 145 are fitted, and the through hole 111 e of the injection main body 111 is inserted into the through hole 111 e of the second housing 145. The hooking portion 145d is hooked. As a result, the second housing 145 is connected to the injection main body 111.

  The second housing 145 has a concave portion (not shown) that meshes with a convex portion provided on the side wall 135 b of the first housing 135, so that the second housing 145 can be connected to and separated from the first housing 135. By connecting the first housing 135 and the second housing 145, the drive mechanism 131 mounted on the first housing 135 and the push-out mechanism 143 mounted on the second housing 145 are mechanically connected. In addition, the motor 136, the rotation detection unit 132, the first communication unit 133, and the first control unit 134 mounted on the first housing 135 are electrically connected to the battery 144 mounted on the second housing 145.

  In the present embodiment, the second housing 145 is made of resin parts such as plastic, but the material is not limited to this as long as the first housing 135 has a certain degree of strength.

  Next, the remote controller 20 will be described. As shown in FIG. 1, the remote controller 20 includes a remote controller body 201, a second communication unit 202 that can wirelessly communicate with the first communication unit 133, and a second control unit 203 that controls the insulin administration device 100 in an integrated manner. The remote control main body 201 has a monitor 204, a button 205 that can accept instructions from the user, and a battery 206 that supplies power to each part of the remote control 20.

  The remote control main body 201 is configured to have a size that can be held by a user with one hand, and is configured by a relatively lightweight resin component such as plastic.

  The second communication unit 202 includes an electronic device necessary for communication with the first communication unit 133 of the liquid feeding main body unit 10. The second communication unit 202 uses the BLE (Bluetooth (registered trademark) Low Energy) communication, which is a short-range wireless communication technology capable of performing low-power communication in the present embodiment, to communicate with the liquid feeding main body unit 10. It is configured to send and receive information between them. However, the communication method is not limited to BLE as long as wireless communication can be performed with the liquid feeding main body unit 10.

  As shown in FIG. 8, the second control unit 203 includes a processing unit 203a and a storage unit 203b. The second control unit 203 is configured by a known microcomputer and controls the entire components that operate in the remote controller 20. The processing unit 203a executes calculations and instructions necessary for the operation of the second communication unit 202, the monitor 204, and the like. The processing unit 203a is configured by a CPU or the like.

  The storage unit 203b stores a program and the like necessary for controlling the second communication unit 202 and the monitor 204. The storage unit 203b is configured by a RAM, a ROM, or the like. For example, when the storage unit 203b includes a RAM and a ROM, the processing unit 203a reads various programs stored in advance in the ROM into the RAM and executes them to perform operations such as a liquid feeding operation. Note that the monitor 204, the button 205, and the battery 206 have the same configurations as those known in the art, and thus illustration and description in FIG.

  Next, a usage example of the insulin administration device 100 will be described.

  First, prior to the use of the insulin administration device 100, the user attaches the injection unit 11 to the living body, and performs the treatment of placing the cannula 113 in the living body using the puncture tool M as described above.

  In addition, prior to the use of the insulin administration device 100, the user connects and integrates the liquid feeding reuse unit 13 and the liquid feeding disposable unit 14 to form the liquid feeding unit 12. Then, the user operates the remote controller 20 to give an instruction for priming (first priming) for filling the liquid feeding tube 142 of the liquid feeding disposable part 14 with insulin. In response to the instruction from the remote controller 20, the first control unit 134 operates the drive mechanism 131 to move the slide unit 146 of the extrusion mechanism 143 by a predetermined amount. Thereby, the insulin accommodated in the chemical solution storage unit 141 is fed to the liquid feeding tube 142, and the liquid feeding tube 142 is filled with insulin.

  Next, the liquid feeding part 12 is connected to the injection part 11.

  Next, the user operates the remote controller 20 to instruct priming (second priming) so that the lumen of the cannula 113 is filled with insulin.

  Next, the user operates the remote controller 20 to perform a basal mode in which insulin is continuously delivered at a constant amount, a bolus mode in which the amount of insulin delivered per unit time is temporarily increased, and the like. The liquid feeding mode is appropriately selected to deliver insulin into the living body.

  Next, the operation when the liquid feeding part 12 is removed from the injection part 11 will be described. FIG. 9 is a flowchart showing the operation when the liquid feeding unit according to this embodiment is removed from the injection unit.

  First, the first control unit 134 checks whether or not the metal plate is in contact with the mounting detection unit 139, and checks whether the liquid feeding unit 12 is removed from the injection unit 11 (ST1). When the liquid delivery part 12 is removed from the injection | pouring part 11 (ST1: YES), the 1st control part 134 acquires the atmospheric temperature of the liquid delivery pipe 142 detected by the state detection part 138 (ST2).

  If the liquid feeding part 12 is left for a long time in a state where it is removed from the injection part 11, there is a possibility that the chemical solution remaining on the inner wall surface of the liquid feeding pipe 142 will precipitate and affect the subsequent liquid feeding.

  Therefore, the first control unit 134 instructs the drive mechanism 131 to perform the liquid feeding operation based on the temperature acquired from the state detection unit 138 to the extent that the inside of the liquid feeding tube 142 is not dried (ST3). The liquid feeding amount at this time is less than the basic dose (basal) of the chemical solution when the insulin administration device 100 is used, and is controlled based on the ambient temperature. The higher the atmospheric temperature is, the larger the liquid feeding amount is, and the lower the atmospheric temperature is, the smaller the liquid feeding amount is controlled. By storing the output of the number of rotations of the motor 136 from the rotation detection unit 132 at this time in the storage unit 134b, the liquid feeding amount during this time is obtained. Therefore, it is possible to determine the amount of the chemical solution that was not actually administered to the living body, and by actually subtracting the amount of the chemical solution that was not actually administered to the living body from the amount of the chemical solution that was delivered by the chemical solution administration device, It is possible to accurately know the amount of the medicinal solution. In addition, the liquid feeding operation may be performed by operating the driving mechanism 131 to continuously feed a predetermined chemical liquid or discretely (intermittently) liquid feeding. The liquid feeding is performed as long as the state where the liquid feeding section 12 is removed from the injection section 11 continues (ST4: NO) (ST2, ST3).

  When the attachment detector 139 detects that the liquid delivery part 12 is attached to the injection part 11 (ST4: YES), the first controller 134 controls the drive mechanism 131 to temporarily stop the liquid delivery operation. (ST5). Thereafter, liquid feeding in the basal mode or the bolus mode is performed by the user's operation through the remote controller 20.

  Next, the effect of this embodiment is demonstrated. The insulin administration device 100 according to the present embodiment is configured such that the first control unit 134 operates the driving mechanism 131 so that the liquid feeding tube 142 is kept wet by operating the driving mechanism 131. Therefore, even when the liquid feeding pipe 142 is separated from the cannula 113 and the support member 114, the inside of the liquid feeding pipe 142 can be prevented from being dried and the chemical liquid can be prevented from being deposited.

  In addition, when the liquid feeding pipe 142 is not liquid feeding and is separated from the cannula 113, the chemical liquid is likely to be deposited. Therefore, contrary to the above, when it is detected that the liquid feeding part 12 including the liquid feeding pipe 142 is attached to the injection part 11 including the cannula 113, the liquid feeding is stopped, so that unnecessary chemical liquid is introduced into the body. In addition, it is possible to save the chemical solution necessary for liquid feeding.

  Further, the first control unit 134 is configured to control the amount of the chemical solution fed to the liquid feeding tube 142 based on the atmospheric temperature of the liquid feeding tube 142 detected by the state detection unit 138. Therefore, based on the most recent state of the liquid feeding pipe 142, the chemical liquid necessary for preventing the chemical liquid from being precipitated can be more accurately delivered.

  In addition, the first control unit 134 may control the drive mechanism 131 to feed a predetermined amount of chemical liquid continuously or intermittently to the liquid feeding pipe 142 to prevent the chemical liquid from depositing inside the liquid feeding pipe 142. it can.

  The present invention is not limited to the above-described embodiment, and various modifications can be made within the scope of the claims.

  Although it has been described above that the state detection unit 138 detects the ambient temperature of the liquid supply pipe 142 and determines the amount of liquid supplied to the liquid supply pipe 142, the present invention is not limited to this. In addition to the above, the state detection unit may be configured to arrange a humidity sensor around the liquid feeding pipe 142 and determine the liquid feeding amount based on the humidity around the liquid feeding pipe 142.

  Moreover, although the 5th gear 148 which comprises the extrusion mechanism 143 demonstrated the embodiment operatively hold | maintained in the 2nd housing 145 which comprises the liquid feeding disposable part 14, it is not limited to this. The fifth gear 148 may be operatively held in the first housing 135 that constitutes the liquid-feeding reuse unit 13 in the same way as the gear group 137, as long as a frequently exchanged member can be easily replaced. Moreover, although embodiment mentioned above demonstrated the chemical | medical solution administration apparatus which administers insulin as an example, it is not limited to this. As the drug solution to be administered, various other drug solutions such as analgesics, anticancer therapeutic agents, HIV drugs, iron chelating agents, pulmonary hypertension therapeutic agents and the like may be used.

10 Liquid feeding body,
11 injection part,
113 cannula (puncture part provided with the 1st channel),
114 support member (puncture part provided with the 1st channel),
114f internal space (first flow path),
12 Liquid feeding part,
13 Liquid Reuse Department,
14 Liquid delivery disposable part,
100 insulin administration device (medical solution administration device),
131 drive mechanism,
132 rotation detector,
134 1st control part (control part),
135 first housing,
136 motor,
138 State detector (temperature detector),
139 wearing detection unit (detection unit),
141 chemical storage part,
142 Liquid feeding pipe (circulation part provided with the second flow path).

Claims (4)

A puncture unit provided with a first flow path that is punctured into a living body and capable of circulating a chemical solution;
A chemical storage part for storing a chemical flowing through the first flow path;
A circulation part that is arranged between the medicinal solution storage part and the puncture part and that constitutes a second flow path that communicates with the first flow path and is configured to be separable from the puncture part;
A driving mechanism for generating a driving force for sending the chemical stored in the chemical storage to the second flow path;
A detection unit for detecting connection and separation between the puncture unit and the circulation unit;
A control unit for operating the drive mechanism,
The said control part is a chemical | medical solution administration apparatus which operates the said drive mechanism so that the said 2nd flow path may be maintained when the said detection part detects that the said distribution | circulation part isolate | separated from the said puncture part.   The control unit is in a state of controlling the drive mechanism so as to send the liquid to the second channel, and when the flow unit is connected to the puncture unit, The medicinal-solution administration device according to claim 1, wherein the driving mechanism is operated so as to stop liquid feeding. A temperature detection unit that detects an ambient temperature around the circulation unit;
3. The chemical solution administration according to claim 1, wherein the control unit controls the drive mechanism so as to increase or decrease a chemical solution to be circulated through the second flow path based on the ambient temperature detected by the temperature detection unit. apparatus.   The said control part is a chemical | medical solution administration apparatus of any one of Claims 1-3 which controls the said drive mechanism so that a chemical | medical solution may distribute | circulate the said 2nd flow path continuously or intermittently.