JP2012031169A - Lice eliminator - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a lice eliminator which has a high insecticidal effect on lice such as Pediculus humanus, Pediculus humanus corporis, and Phthirus pubis, particularly even lice on which a pyrethroid-based insecticide does not exhibit an effect and is highly safe for the human body.SOLUTION: The lice eliminator includes at least one of a higher alcohol and a fatty acid and the higher alcohol has 9-24 carbon atoms, and the fatty acid has 1-22 carbon atoms.

Description

The present invention relates to a lice control composition that is highly safe, has an effect on normal lice, and further has an effect on drug-resistant lice.

  In recent years, many infections of head lice (scientific name: Pediculus humanus humanus) have been reported among kindergarten, preschool and elementary school children. Head lice once ceased due to post-war DDT treatment, etc., but with the ban on the use of DDT in 1971, outbreaks of head lice began to occur again in children and children. In 1982, the number of head lice reports reached a peak, but the number of patients decreased again with the advent of pyrethroid insecticides. However, in the 1990s, it showed an increasing trend again and has reached the present. The causes of head lice increased due to changes in Japanese lifestyle and behavior, lack of knowledge due to the fact that generations who do not know head lice are guardians of kindergarten and elementary school children, and the rapid increase in overseas visitors Along with this, there are cases where it is brought into Japan from overseas, but the matter that should be particularly noted is the appearance of head lice that are resistant to drugs.

  Conventionally, a method for controlling lice with a pyrethroid insecticide has been generally used, but lice resistant to these insecticides has also been reported, and Takashi Hamada et al. According to the “2009 Survey Results on Resistance” (the 62nd Annual Meeting of the Japan Society for Hygienic Zoology, published on April 3, 2010), out of 110 colonies analyzed in 2009, 11 colonies possessing the resistance gene (10%), and it is reported that the annual increase tendency of the resistance rate was recognized from the survey results (8.5%) for the past four years. Since more than 90% of colonies have already become drug resistant in the United States and Denmark, it is predicted that drug-resistant head lice will increase in Japan. Therefore, it is necessary to develop a pesticide against these head lice. .

  In addition, there is a possibility that the body lice (scientific name: Pediculus humanus corporis) and the pheasant lice (scientific name: Phthirus pubis) may increase drug resistance in the future. There is no need to use different types depending on the type, which is convenient.

  The only drug that can be used in the human body in Japan is the pyrethroid insecticide phenothrin, which has a certain level of safety, and therefore some measures are necessary for the development of drug resistance. Need to be at least as safe as

  Furthermore, since drug-resistant head lice cannot be expected to be controlled by nerve action, different actions are required.

  For example, as a lice insecticide having different activities, Patent Document 1 discloses an insecticide containing isopropanol and isopropyl myristate as main components. Patent Document 2 describes an insecticide mainly composed of isopropyl alcohol.

JP-A-53-94034 JP 2008-143851 A

  In the specification of the insecticide described in the above-mentioned Patent Document 1, “It is to provide a safe and effective new insecticide, and it is safe and effective to kill an extracorporeal parasite such as an insect. Is to provide a method, "(page 3, upper right 9-12 lines) and the object of the invention is described.

  However, this specification does not specify whether it is effective against lice having resistance to the pyrethroid insecticides described above, that is, lice that are difficult to control even with pyrethroid insecticides.

  Further, in the specification of the insecticide described in the above-mentioned Patent Document 2, “the isopropanol concentration is effective when the concentration is 70 V / V% or more. If the concentration is lower than 70 V / V%, the effect is difficult. “It is 90 V / V% or more” (paragraph 0016), which describes that there is no effect unless the concentration is high.

  However, isopropanol is a volatile liquid, and even if it is a food additive, if it is used in a closed space such as a bathroom, there is a risk of inhaling a high concentration of vapor and causing acute poisoning, which is not always safe. It can not be said.

  Therefore, in the present invention, the insecticidal effect is high against lice that exhibits efficacy with pyrethroid insecticides, as well as lice that do not exhibit efficacy with pyrethroid insecticides. It aims at providing the lice control agent with high property.

  That is, the lice control agent according to the present invention is a lice control agent characterized by containing at least one of a higher alcohol and a fatty acid.

  If it is such, there exist the following effects.

  In other words, since at least one of higher alcohol and fatty acid is used, it can be killed by the action of suffocation of lice by sealing the louse's air gate, and it is resistant to pyrethroids that are killed by nerve action. It has an insecticidal effect against so-called drug-resistant lice.

  And since at least any one of a higher alcohol or a fatty acid is used, the safety | security with respect to a human body is high. That is, higher alcohols are generally produced by reducing fatty acids obtained by decomposing natural fats and oils and are less toxic to the human body, and fatty acids are generally produced by degrading natural fats and oils and are also less toxic to the human body. It is. Also, since higher alcohols and fatty acids are less likely to volatilize, they are safe with little risk of inhaling vapors and causing acute poisoning.

  In order to improve the insecticidal effect of lice, the fatty acid preferably has 1 to 22 carbon atoms, and the higher alcohol preferably has 9 to 24 carbon atoms.

  Contains a pyrethroid insecticide that is an insecticide component in order to enhance the insecticidal effect against both lice with and without pyrethroid insecticide, synergistically with at least one of higher alcohols and fatty acids You can also

  As described above, according to the lice control agent according to the present invention, since at least one of the higher alcohol and the fatty acid is used, the lice are killed by the action of suffocation of the lice by sealing the airways of the lice. It has an insecticidal effect against so-called drug-resistant lice that are resistant to pyrethroid drugs that have the effect of being killed by nerve action.

  And since at least any one of a higher alcohol or a fatty acid is used, the safety | security with respect to a human body is high. That is, higher alcohols are generally produced by reducing fatty acids obtained by decomposing natural fats and oils and are less toxic. Fatty acids are generally produced by degrading natural fats and oils and are also less toxic. Also, since higher alcohols and fatty acids are less likely to volatilize, they are safe with little risk of inhaling vapors and causing acute poisoning.

  Hereinafter, the embodiment regarding the lice control agent which concerns on this invention is described in detail.

  The higher alcohol used in the present invention is an aliphatic primary alcohol having 6 or more carbon atoms, has a linear or branched structure, and has a saturated or unsaturated structure, and the type is not particularly limited.

  Examples include 1-hexanol, capryl alcohol, 2-ethylhexanol, decyl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, linolyl alcohol, and behenyl alcohol. Preferably, higher alcohols having 9 to 24 carbon atoms are used because they are general-purpose and easily available. More preferably, a higher alcohol having 10 to 22 carbon atoms is used because it is inexpensive and easily available. In addition, the above higher alcohols can be used alone or in combination of two or more.

  The content of the higher alcohol is 1 to 50% by weight, more preferably 2 to 40% by weight, and most preferably 3 to 20% by weight.

  The fatty acid used in the present invention is a monovalent carboxylic acid composed of hydrocarbons and represented by the general formula CnHmCOOH, where n is an integer of 0 or more, and has a linear or branched structure, Moreover, it has a saturated or unsaturated structure, and the type is not particularly limited.

  For example, formic acid, acetic acid, butyric acid, valeric acid, caproic acid, enanthic acid, caprylic acid, pelargonic acid, capric acid, 2-ethylhexanoic acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, margaric acid, stearic acid, Examples include oleic acid, vaccenic acid, linoleic acid, linolenic acid, araginic acid, eicosenoic acid, eicosapentaenoic acid, behenic acid, docosahexaenoic acid, lignoceric acid, serotic acid, montanic acid, and melicic acid. Coconut oil fatty acid, beef tallow fatty acid and the like. Preferably, a fatty acid having 1 to 22 carbon atoms is used because it is universal and easily available. More preferably, a fatty acid having 8 to 20 carbon atoms is used because it is inexpensive and easily available. The above fatty acids can be used alone or in combination of two or more.

  Moreover, the content rate of the said fatty acid is 1-50 weight%, Preferably it is 2-40 weight%, More preferably, it is 3-20 weight%.

  In the present invention, the higher alcohol or the fatty acid is used alone or in combination. Although each of them exhibits an insecticidal effect against lice, the insecticidal effect is synergistically expressed when mixed.

  As the solvent for the higher alcohol or the fatty acid, a solvent capable of dissolving them is used.

  For example, water, dihydric or higher liquid polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butanediol, glycerin, aliphatic hydrocarbons such as liquid paraffin and light liquid paraffin, silicone oil such as dimethyl silicone Natural oils such as vegetable oils and animal oils are used. Moreover, the said solvent can be used only in 1 type, or in combination of 2 or more types.

  In addition, the content of the solvent is a residual amount with respect to the amount of the component containing at least one of the higher alcohol or the fatty acid, and when there are other compounds to be added, the amount including those additives There is no particular limitation on the remaining amount.

  In addition, a surfactant can be added to improve the storage stability of each component, that is, to prevent separation of each component after the composition is prepared. Examples of the surfactant include a cationic surfactant, an anionic surfactant, an amphoteric surfactant, and a nonionic surfactant.

  Among the above types of surfactants, those having an HLB of 3 to 11 calculated from the Griffin equation are preferable as the nonionic surfactant. For example, polyoxyethylene alkyl ethers such as fatty acid sorbitan ester, fatty acid glycerin ester, fatty acid polyglycerin ester, polyoxyethylene stearyl ether (EO average added mole number 20, HLB = 4.9), triolein Acid polyoxyethylene sorbitan (EO average addition mole number 20, HLB = 10.9), polyoxyethylene alkyl ester such as polyoxyethylene fatty acid sorbitan ester, polyoxyethylene fatty acid glycerin ester, polyoxyethylene fatty acid polyglycerin ester, etc. Is used.

Moreover, the content rate of the said surfactant is 0.1 to 60 weight%. The surfactant can be used alone or in combination of two or more.

  Furthermore, pyrethroid insecticides such as phenothrin can be added in order to synergistically improve the insecticidal effect on both lices with and without pyrethroid insecticides.

  Specific examples of the pyrethroid insecticide include allethrin, tetramethrin, praretrin, phenothrin, resmethrin, ciphenothrin, permethrin, cypermethrin, deltamethrin, tralomethrin, cyfluthrin, framethrin, imiprotolin, etofenprox, fenvalerate, It includes fenpropraslin, silafluophene, teraretrin, bifenthrin, empentrin, pyrethrin and the like.

  In addition, vitamin C (ascorbic acid), vitamin E (tocophenol), BHT (dibutylhydroxytoluene), BHA (butylhydroxyanisole), sorbic acid, potassium sorbate, sodium sulfite, etc. to prevent deterioration of the composition due to oxidation An antioxidant can be added.

  Further, a surfactant such as polyoxyethylene sorbine monooleate (HLB = 15.8) having an HLB of 12 to 20 calculated from the Griffin equation can be added in order to improve the flushability after washing. .

  Furthermore, various fragrance | flavors can be added in order to scent l-menthol and a composition in order to provide a refreshing feeling.

  According to the lice control agent according to the present invention, head lice and lice that adhere to the hair by diluting with water or hot water at the time of bathing, washing, etc. The body is covered with lice such as body lice attached to clothes by thoroughly accustoming to the clothes when washing, etc., thereby eradicating them by killing them by closing the airways of the lice and suffocating. be able to.

Examples of the present invention will be specifically described below. In addition, this invention is not limited to a following example.

<Example 1>
In a 200 ml Griffin beaker, 15 g of decyl alcohol (trade name “Calcoal 1098” manufactured by Kao Corporation) and 85 g of 1,3-butylene glycol (trade name “1,3 butylene glycol” manufactured by Daicel Chemical Industries, Ltd.) The mixture was stirred and mixed until it became uniform while indirectly heating with a 40 ° C. water bath.

  About the evaluation method of efficacy, it confirmed with the following method. That is, 20 body lice were put into a petri dish, the composition according to Example 1 was added thereto, the lice were immersed for 5 minutes and then treated, and the state after 24 hours was observed. Observed after 24 hours, the number of surviving animals (survival number) and the number of dead and dead or similar animals (number of dead insects) were counted, and efficacy (%) = {number of dead insects / (survival number) Number + dead insect count)} × 100, and the efficacy was calculated as a percentage. When the efficacy was 70% or more, it was judged that there was a lice control effect. The results are shown in Table 1.

  According to “Urban Pest Encyclopedia” by Sawako Matsuzaki and Kazuo Takee (Asakura Shoten, published in June 1993, pages 34-36), head lice are taxonomically called human lice (scientific name: Pediculus humanus) and hair. It is divided into head lice that parasitize and body lice that parasitize clothes, but they are treated as the same species in taxonomy, and head lice are described as variants of human lice. Therefore, the test was conducted using a body lice. This body lice is not resistant to pyrethroid insecticides.

<Examples 2 to 18>
Except that 15 g of decyl alcohol in Example 1 was replaced with at least one of the other higher alcohols and fatty acids described in the formulation examples in Table 1 to obtain the compounding amounts described in the same manner as in Example 1. After obtaining the drug, an efficacy evaluation test was conducted. The results are also shown in Table 1.

<Example 19>
A uniform composition containing 15 g of decyl alcohol (trade name “Calcoal 1098” manufactured by Kao Corporation) and 85 g of 1,3-butylene glycol (trade name “1,3 butylene glycol” manufactured by Daicel Chemical Industries, Ltd.) In a petri dish containing 5 head lice having resistance to a pyrethroid insecticide, the potency was measured. Moreover, it was confirmed by genetic analysis that the head lice used had resistance to pyrethroid insecticides.

  About the evaluation method of efficacy, it confirmed with the following method. That is, the composition according to Example 19 was added, the head lice were immersed for 5 minutes, treated, and then pulled up, and the state after 24 hours was observed. Observed after 24 hours, the number of surviving animals (survival number) and the number of dead and dead or similar animals (number of dead insects) were counted, and efficacy (%) = {number of dead insects / (survival number) Number + dead insect count)} × 100, and the efficacy was calculated as a percentage. When the efficacy was 70% or more, it was judged that there was a lice control effect. The results are shown in Table 2.

<Examples 20 to 36>
Except that 15 g of decyl alcohol of Example 19 was replaced with at least one of the other higher alcohols or fatty acids described in the formulation examples of Table 2 to obtain the indicated blending amounts, the same procedure as in Example 19 was performed. After obtaining the drug, an efficacy evaluation test was conducted. The results are also shown in Table 2.

<Comparative Examples 1-4>
As described in the formulation examples in Table 3, without using any higher alcohol or fatty acid, only various solvents are used, and it has resistance to a pyrethroid insecticide in the same manner as in Examples 1-18. Efficacy evaluation test against no body lice was conducted. The results are shown in Table 3.

<Comparative Example 5>
As described in the formulation examples in Table 3, without using any higher alcohol or fatty acid, only various solvents are used, and head lice having resistance to a pyrethroid insecticide in the same manner as in Examples 19 to 36. The evaluation test of the efficacy against was conducted. The results are shown in Table 3.

Claims (3)

A lice control agent comprising at least one of a higher alcohol and a fatty acid. The lice control agent according to claim 1, wherein the higher alcohol has 9 to 24 carbon atoms. The lice control agent according to claim 1 or 2, wherein the fatty acid has 1 to 22 carbon atoms.