JP2010532340A5 - - Google Patents
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- JP2010532340A5 JP2010532340A5 JP2010514144A JP2010514144A JP2010532340A5 JP 2010532340 A5 JP2010532340 A5 JP 2010532340A5 JP 2010514144 A JP2010514144 A JP 2010514144A JP 2010514144 A JP2010514144 A JP 2010514144A JP 2010532340 A5 JP2010532340 A5 JP 2010532340A5
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- JP
- Japan
- Prior art keywords
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- compound
- compounds
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- examples
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 description 7
- 238000000034 method Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000007257 deesterification reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Description
本発明の化合物は、下記実施例に示す方法に従い製造できる。あるいは、本化合物はエナンチオマーの混合物として製造でき、それを次いで当分野で既知の技術を使用して、例えばクロマトグラフィーを使用して、分離および精製して、純粋なまたは実質的に純粋な(Ｓ)異性体を得ることができる。さらなる別法として、化合物(１ｆ)のような中間体化合物の異性体を、脱エステル化前に分離できる。本明細書の実施例中に定義する式(１ａ)、(１ｃ)、(１ｄ)および(１ｆ)の中間体化合物は新規であり、そして各々本発明の態様を構成する。さらなる局面において、本発明は式(Ｉ)の化合物の製造方法であって：
式(１ｄ)：
の化合物と式(１ｅ)：
〔式中、Ｒはエステル形成基である。〕
の化合物を反応させ、続いて得られた誘導体を脱エステル化し、そして所望により薬学的に許容される塩、溶媒和物または塩の溶媒和物を形成することを含む、方法を提供する。エステル形成基Ｒは、典型的にＣ１−６アルキル、好ましくはメチルである。本反応は、適当な溶媒中、高温で、一つの態様において本明細書の実施例に具体化した条件を使用して行うのが適切である。
式(１ｄ)：
の化合物を反応させ、続いて得られた誘導体を脱エステル化し、そして所望により薬学的に許容される塩、溶媒和物または塩の溶媒和物を形成することを含む、方法を提供する。エステル形成基Ｒは、典型的にＣ１−６アルキル、好ましくはメチルである。本反応は、適当な溶媒中、高温で、一つの態様において本明細書の実施例に具体化した条件を使用して行うのが適切である。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94801207P | 2007-07-05 | 2007-07-05 | |
| US60/948,012 | 2007-07-05 | ||
| PCT/GB2008/050525 WO2009004379A1 (en) | 2007-07-05 | 2008-07-01 | Novel compounds 951: a biphenyloxypropanoic acid as crth2 modulator and intermediates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010532340A JP2010532340A (ja) | 2010-10-07 |
| JP2010532340A5 true JP2010532340A5 (ja) | 2011-07-28 |
| JP5368438B2 JP5368438B2 (ja) | 2013-12-18 |
Family
ID=39942682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010514144A Expired - Fee Related JP5368438B2 (ja) | 2007-07-05 | 2008-07-01 | 新規化合物９５１：ｃｒｔｈ２モジュレーターとしてのビフェニルオキシプロパン酸および中間体 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8507544B2 (ja) |
| EP (1) | EP2173730B1 (ja) |
| JP (1) | JP5368438B2 (ja) |
| KR (1) | KR20100039326A (ja) |
| CN (1) | CN101796042B (ja) |
| AR (1) | AR067461A1 (ja) |
| AU (1) | AU2008272690B2 (ja) |
| BR (1) | BRPI0813992A2 (ja) |
| CA (1) | CA2691615A1 (ja) |
| CL (1) | CL2008001982A1 (ja) |
| CO (1) | CO6270211A2 (ja) |
| CY (1) | CY1114804T1 (ja) |
| DK (1) | DK2173730T3 (ja) |
| EC (1) | ECSP109848A (ja) |
| ES (1) | ES2442523T3 (ja) |
| HR (1) | HRP20140004T1 (ja) |
| MY (1) | MY153957A (ja) |
| NZ (1) | NZ582192A (ja) |
| PE (2) | PE20121515A1 (ja) |
| PL (1) | PL2173730T3 (ja) |
| PT (1) | PT2173730E (ja) |
| RS (1) | RS53129B (ja) |
| SA (1) | SA08290406B1 (ja) |
| SI (1) | SI2173730T1 (ja) |
| TW (1) | TWI453017B (ja) |
| UA (1) | UA100983C2 (ja) |
| UY (1) | UY31208A1 (ja) |
| WO (1) | WO2009004379A1 (ja) |
| ZA (1) | ZA200909226B (ja) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0301010D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301009D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SA04250253B1 (ar) * | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| GB0415320D0 (en) * | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) * | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| UY29223A1 (es) | 2004-11-23 | 2006-06-30 | Astrazeneca Ab | Ácidos fenoxiacéticos sustituidos, composiciones farmacéuticas que los contienen y procesos para su preparación |
| TW200745003A (en) * | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| US8148572B2 (en) | 2005-10-06 | 2012-04-03 | Astrazeneca Ab | Compounds |
| WO2007052023A2 (en) * | 2005-11-05 | 2007-05-10 | Astrazeneca Ab | Novel compounds |
| ES2380683T3 (es) * | 2005-12-15 | 2012-05-17 | Astrazeneca Ab | Difenil-éteres, -amidas, -sulfuros y - metanos sustituidos para el tratamiento de la enfermedad respiratoria |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| WO2009099902A1 (en) | 2008-02-01 | 2009-08-13 | Amira Pharmaceuticals, Inc. | N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors |
| EP2245022A4 (en) | 2008-02-25 | 2012-02-22 | Panmira Pharmaceuticals Llc | ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS |
| GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| US8378107B2 (en) | 2008-10-01 | 2013-02-19 | Panmira Pharmaceuticals, Llc | Heteroaryl antagonists of prostaglandin D2 receptors |
| WO2010042652A2 (en) | 2008-10-08 | 2010-04-15 | Amira Pharmaceuticals, Inc. | Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors |
| GB2465062B (en) | 2008-11-06 | 2011-04-13 | Amira Pharmaceuticals Inc | Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors |
| CA2768492A1 (en) | 2009-07-31 | 2011-02-03 | Panmira Pharmaceuticals, Llc | Ophthalmic pharmaceutical compositions of dp2 receptor antagonists |
| WO2011017201A2 (en) | 2009-08-05 | 2011-02-10 | Amira Pharmaceuticals, Inc. | Dp2 antagonist and uses thereof |
| BR112013000254A2 (pt) | 2010-07-05 | 2016-05-24 | Actelion Pharmaceuticals Ltd | derivados heterocíclicos 1-fenil-substituídos e seu uso como moduladores do receptor de prostaglandina d2 |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| EP2526945A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | New CRTH2 Antagonists |
| EP2548863A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists. |
| EP2548876A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists |
| WO2013093842A1 (en) | 2011-12-21 | 2013-06-27 | Actelion Pharmaceuticals Ltd | Heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
| CN104428305A (zh) | 2012-07-05 | 2015-03-18 | 埃科特莱茵药品有限公司 | 1-苯基-取代的杂环衍生物及其作为前列腺素d2受体调节剂的用途 |
| KR101538846B1 (ko) | 2013-07-30 | 2015-07-22 | 동아에스티 주식회사 | 신규한 바이페닐 유도체 및 그의 제조방법 |
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| CH432119A (de) | 1963-02-22 | 1967-03-15 | Geigy Ag J R | Verwendung von Halogen-o-hydroxy-diphenyläthern als antimikrobielle Mittel |
| BE790679A (fr) | 1971-11-03 | 1973-04-27 | Ici Ltd | Derives de l'indole |
| DD113545A5 (ja) | 1973-03-30 | 1975-06-12 | ||
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| GB1585963A (en) | 1976-10-14 | 1981-03-11 | Lilly Industries Ltd | Aryl sulphur compounds |
| JPS5951943B2 (ja) | 1978-08-21 | 1984-12-17 | キツセイ薬品工業株式会社 | 新規なイミダゾ−ル誘導体 |
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| US4670566A (en) | 1979-07-12 | 1987-06-02 | A. H. Robins Company, Incorporated | 3-methyl-hio-4-(5-, 6-, or 7-)phenylindolindolin-2-ones |
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| BR0210391A (pt) | 2001-06-12 | 2004-06-15 | Elan Pharm Inc | Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto |
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| SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
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| SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
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| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301009D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
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| JP2008500991A (ja) | 2004-05-29 | 2008-01-17 | ７ティーエム ファーマ エイ／エス | 医学的使用のためのｃｒｔｈ２レセプターリガンド |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| GB0422057D0 (en) | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| UY29223A1 (es) | 2004-11-23 | 2006-06-30 | Astrazeneca Ab | Ácidos fenoxiacéticos sustituidos, composiciones farmacéuticas que los contienen y procesos para su preparación |
| GB0510584D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
| US8148572B2 (en) | 2005-10-06 | 2012-04-03 | Astrazeneca Ab | Compounds |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| WO2007052023A2 (en) | 2005-11-05 | 2007-05-10 | Astrazeneca Ab | Novel compounds |
| ES2380683T3 (es) | 2005-12-15 | 2012-05-17 | Astrazeneca Ab | Difenil-éteres, -amidas, -sulfuros y - metanos sustituidos para el tratamiento de la enfermedad respiratoria |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
-
2008
- 2008-01-07 UA UAA200913443A patent/UA100983C2/ru unknown
- 2008-07-01 JP JP2010514144A patent/JP5368438B2/ja not_active Expired - Fee Related
- 2008-07-01 DK DK08776164.9T patent/DK2173730T3/da active
- 2008-07-01 NZ NZ582192A patent/NZ582192A/en not_active IP Right Cessation
- 2008-07-01 HR HRP20140004AT patent/HRP20140004T1/hr unknown
- 2008-07-01 RS RS20140008A patent/RS53129B/sr unknown
- 2008-07-01 PL PL08776164T patent/PL2173730T3/pl unknown
- 2008-07-01 MY MYPI2010000009A patent/MY153957A/en unknown
- 2008-07-01 CA CA002691615A patent/CA2691615A1/en not_active Abandoned
- 2008-07-01 BR BRPI0813992A patent/BRPI0813992A2/pt not_active IP Right Cessation
- 2008-07-01 EP EP08776164.9A patent/EP2173730B1/en active Active
- 2008-07-01 PT PT87761649T patent/PT2173730E/pt unknown
- 2008-07-01 CN CN2008801056933A patent/CN101796042B/zh not_active Expired - Fee Related
- 2008-07-01 SI SI200831132T patent/SI2173730T1/sl unknown
- 2008-07-01 KR KR1020107000017A patent/KR20100039326A/ko not_active Abandoned
- 2008-07-01 AU AU2008272690A patent/AU2008272690B2/en not_active Ceased
- 2008-07-01 ES ES08776164.9T patent/ES2442523T3/es active Active
- 2008-07-01 WO PCT/GB2008/050525 patent/WO2009004379A1/en not_active Ceased
- 2008-07-03 US US12/167,513 patent/US8507544B2/en not_active Expired - Fee Related
- 2008-07-04 PE PE2012000994A patent/PE20121515A1/es not_active Application Discontinuation
- 2008-07-04 TW TW097125273A patent/TWI453017B/zh not_active IP Right Cessation
- 2008-07-04 CL CL2008001982A patent/CL2008001982A1/es unknown
- 2008-07-04 UY UY31208A patent/UY31208A1/es not_active Application Discontinuation
- 2008-07-04 PE PE2008001135A patent/PE20090475A1/es not_active Application Discontinuation
- 2008-07-05 SA SA8290406A patent/SA08290406B1/ar unknown
- 2008-07-07 AR ARP080102918A patent/AR067461A1/es unknown
-
2009
- 2009-12-23 ZA ZA2009/09226A patent/ZA200909226B/en unknown
-
2010
- 2010-01-05 EC EC2010009848A patent/ECSP109848A/es unknown
- 2010-01-06 CO CO10001081A patent/CO6270211A2/es active IP Right Grant
-
2014
- 2014-01-15 CY CY20141100033T patent/CY1114804T1/el unknown
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