JP2008150314A - Bleaching agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a bleaching agent having melanin formation-inhibiting activities. <P>SOLUTION: The bleaching agent contains an extract of one or more kinds of plants selected from the group consisting of Physalis divaricata of Solanaceae, Senecio chrysanthemoides of Compositae, Rabdosia coetsa of Labiatae, Cyperus sp. of Cyperaceae (local name in Nepal: Namiramjan), Leontopodium jacotianum of Compositae, Swertia alata of Gentianaceae, Artemisia roxburghiana of Compositae and Callistemon lanceolatus of Myrtaceae. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a whitening agent containing a specific plant extract.

It is thought that pigmentation such as skin spots and freckles causes excessive melanin formation due to hormonal abnormalities, ultraviolet rays, and local inflammation of the skin, which deposits in the skin. This melanin, which causes skin pigmentation, is produced in organelles called melanosomes in pigment cells (melanocytes) in the basal layer of the epidermis, and the produced melanin is taken up by surrounding keratinocytes (keratinocytes). Melanin in the melanocytes is produced by converting tyrosine into black melanin through an enzymatic or non-enzymatic oxidation reaction via dopaquinone by the action of the enzyme tyrosinase. Therefore, it is important to suppress the activity of tyrosinase, which is the first stage reaction, in order to suppress the production of melanin.
Substances having a whitening effect for the purpose of preventing or improving pigment abnormalities as described above, that is, substances that suppress melanin production are mainly used. For example, a method of orally administering vitamin C in large amounts, glutathione, etc. A method of injection or a method of locally applying kojic acid, vitamin C and its derivatives, cysteine, etc. in the form of an ointment, cream, lotion or the like is known.
However, the compounds that suppress the activity of tyrosinase exhibit very slow effects except for hydroquinone, and thus the effect of improving skin pigmentation is not sufficient. On the other hand, hydroquinone has an effect, but its general use is limited because of its sensitization. In order to improve the safety, attempts have been made to use higher fatty acid monoesters and alkyl monoethers (see Patent Document 1).
However, such monoesters of higher fatty acids are not necessarily safe because they are degraded by hydrolyzing enzymes in the body, and ethers are not sufficiently satisfactory in terms of safety. .

JP 58-154507 A

  Therefore, as a result of examining the melanin production inhibitory effect of various plant extracts, the present inventors have found that a specific plant extract that has not been known to have such an effect has an excellent melanin production inhibitory action. As a result, the present invention has been completed.

  The present invention relates to the physalis divaricata (Solanaceae) plant (synonyms Physalis minima, Japanese name Nepalese physalis, English name ground cherry, Nepal local name isamgoli, jangali mewa, patpate, golbhede jhar), Compositae ) The plant Senecio chrysanthemoides (synonymous Senecio laetus, Nepal local name bijauri phul), Labiatae plant Rabdosia coetsa (Nepal local name Thamo sing, jwahane, mirre, mirre, mirre, mirre , surchendro), Cyperaceae plant Cyperus sp. (Cyperus sp.) (Nepal local name: Namiramjan), Compositae plant, Leontopodium jacotianum (Nepal local name: Taa), Gentianaceae plant, Sertia alata (Swertia alata) (Nepal) One selected from the group consisting of the local name Tikta), Artemisia roxburghiana (Compositae) plant, Artemisia roxburghiana (Nepal local name Patse), and the callistemon lanceolatus (Callistemon lanceolatus). A whitening agent comprising an extract of two or more kinds of plants.

  The present invention is a whitening method characterized in that skin whitening is performed using the above-described whitening agent.

  The present invention is a method for producing a whitening skin external preparation, wherein the above-described whitening agent is added to an aqueous phase or an oil phase to produce a whitening skin external preparation.

  The whitening agent of the present invention has an excellent inhibitory action on melanin production, and has excellent effects on lightening and whitening of pigmentation, stains, freckles, and liver spots after sunburn.

  Further, according to the present invention, there is provided a whitening method having effects excellent in lightening and whitening of pigmentation / stain / freckle / liver spots after sunburn, and also in safety.

  Furthermore, according to the method for producing a skin whitening preparation for skin whitening according to the present invention, it has a melanin production inhibitory effect, and has excellent effects on lightening whitening, such as pigmentation, stains, freckles, and liver spots after sunburn. It is possible to produce a skin whitening preparation for skin whitening that is excellent in safety.

The best mode of the present invention will be described below.
Physalis divaricata of Solanaceae plant, Senecio chrysanthemoides of Compositae plant, Rabdosia coetsa of Labiatae plant, Cyperus sp. Of Cyperaceae plant used for whitening agent of the present invention The local name Namiramjan), Leontopodium jacotianum of the Compositae plant, Swertia alata of the Gentianaceae plant, Artemisia roxburghiana of the Compositae plant, and Callistemon lanceolatus of the Myrtaceae plant are detailed below. To do. These plants are all plants that grow in Nepal.
The whitening agent of the present invention preferably consists essentially of the above plant extract, but may contain other components.

Physalis divaricata, a solanaceae plant, is a physalis plant, and its Chinese name is Huang Xiao daughter. In China, the whole plant or fruit (Temago) is used for anthelmintic, jaundice, diuresis and asthma. The whole plant is used for fractures, artifacts, ulcers and the like.
Senecio chrysanthemoides, a compositae plant, is a genus of the genus Sioncio and its Chinese name is called Chisato Kikuba. A large perennial plant with a height of 60-180 cm, distributed in the Himalayas (Pakistan to Assam) Mountains, southern Nepal, and southwestern China. It contains alkaloids (seneciophylline) and is toxic to livestock. Then it is medicinal.
Rabdosia coetsa, a Labiatae plant, is a dicotyledonous plant that is recently classified into the genus Isodon. Used for eye diseases.
Cyperus sp. (Nepalese local name Namiramjan), a family of Cyperaceae, is a genus of genus Cyperaceae and is a monocotyledonous plant.

The Compositae plant, Leontopodium jacotianum, is a plant belonging to the genus Pleurotus, distributed in the alpine belts of Kashmir to Bhutan, south and southeast of Nepal, and grows in grassy and gravel areas exposed to wind. The genus name was given, as if the stem and leaves were covered with white fluff. Several to ten or more buds are developed at the base of the inflorescence, and these buds are covered with white fluff and are arranged in a radial pattern, so they look like flowers as a whole.
The Gentianaceae plant Swertia alata is a genus plant and a dicotyledonous perennial plant.
The Compositae plant Artemisia roxburghiana is a Artemisia plant and a dicotyledonous plant. Leaves are alternating, finely cut, flowers are airborne flowers, head flowers are small, bloom downwards, pollen bites are round and low.

  Callistemon lanceolatus, a myrtaceae plant, is called Hanamaki, Buttercup, and is an evergreen shrub or tree that is slightly weak in cold weather and distributed on the Australian continent and Tasmania Island. It is known as the bottle brush tree in English because only the stamens, like the plum blossom core, have developed and the inflorescences look like brushes for washing bottles and test tubes. The tree height is about 2 to 10 m, and the leaves are needle-shaped and closely attached to the branches. The leaves contain essential oils and some are fragrant. The flowers bloom in early summer and the inflorescences are cylindrical and are about 5-10 cm long. There are beautiful stamens and relatively sparse ones. The flower color is red or yellow, but some are reddish-purple and some are yellow-green, which is rare for ornamental flowers.

  The plant extract used in the present invention is obtained by immersing or heating and refluxing the above-mentioned plant leaves, stems including root stems, roots, fruits, whole plant plants and the like together with an extraction solvent, followed by filtration and concentration. The extraction solvent used in the present invention is not particularly limited as long as it is usually used for extraction, and in particular, organic solvents such as alcohols such as methanol and ethanol, hydrous alcohols, acetone and ethyl acetate are used alone or in combination. Can do. The whitening agent of the present invention preferably comprises the above plant extract, and may be a plant extract using the above plant alone or a plant extract using a mixture.

The physalis divaricata used in the present invention preferably uses the above-ground part, but other parts can also be used.
Senecio chrysanthemoides used in the present invention is preferably whole plant, but other sites can also be used.
Rabdosia coetsa used in the present invention preferably uses the above-ground part, but other parts can also be used.
Cyperus sp. (Nepal local name: Namiramjan) used in the present invention is preferably whole plant, but other parts can also be used.
Leontopodium jacotianum used in the present invention preferably uses whole grass, but other parts can also be used.
Swertia alata used in the present invention preferably uses the above-ground part, but other parts can also be used.
Artemisia roxburghiana used in the present invention is preferably whole plant, but other sites can be used.
The Callistemon lanceolatus used in the present invention preferably uses the above-ground part, but other parts can also be used.

  In this invention, what was obtained by either self-growth or cultivation can be used, and the said plant extract may mix and use 2 or more types.

  Any of the above-mentioned plants or extracts thereof thus obtained has an excellent melanin production inhibitory effect. By adding such a plant or an extract thereof to an aqueous phase or an oil phase, it is possible to produce a skin whitening external preparation that exhibits an excellent whitening effect.

  When the above-mentioned plant or extract thereof is blended and used in a skin external preparation, it is preferably blended in the total amount of the external preparation in a dry weight of 0.0005 to 20% by mass, more preferably 0.001 to 10% by mass. . If it is less than 0.0005% by mass, the melanin production inhibitory effect of the present invention is not sufficiently exerted. Moreover, even if it mixes exceeding 10 mass%, the improvement of the big effect is not recognized.

  In addition to the above essential components, the above-mentioned skin external preparations are usually used in skin external preparations such as cosmetics and pharmaceuticals, for example, other whitening agents, moisturizers, antioxidants, oily components, ultraviolet absorbers, interfaces. Activators, thickeners, alcohols, powder components, color materials, aqueous components, water, various skin nutrients, and the like can be appropriately blended as necessary.

  Others, disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, sequestering agents such as gluconic acid, caffeine, tannin, verapamil, tranexamic acid and its derivatives, licorice extract, grabrizine , Hot water extract of fire thorn fruit, various herbal medicines, drugs such as tocopherol acetate, glycyrrhizic acid and its derivatives or salts thereof, vitamin C, magnesium ascorbate phosphate, glucoside ascorbate, arbutin, kojic acid, lucinol, ellag Other whitening agents such as acid and chamomile, and sugars such as glucose, fructose, mannose, sucrose, and trehalose can be appropriately blended.

  The topical skin preparation containing the whitening agent of the present invention refers to those usually used in the fields of pharmaceuticals, quasi drugs, cosmetics, etc., and the dosage form is particularly limited as long as the effect of the present invention is exhibited. It is not something. For example, any ointment, cream, milky lotion, lotion, pack, bath preparation and the like conventionally used for external preparations for skin may be used.

EXAMPLES Next, an Example is given and this invention is demonstrated further in detail. Here, a compounding quantity is the mass%.
Prior to the examples, the test method and the results regarding the melanin production inhibitory effect and the whitening effect of the plant extract of the present invention will be described.

(Test method and results)
1. Preparation of sample Hereinafter, the preparation method of the plant extract used in this example will be described, and all of these plant materials used Nepalese plants.
(1) Physalis divaricata extract
0.629 g of the above-ground part of Physalis divaricata was immersed in 20 mL of methanol for 1 week at room temperature, the extract was filtered and the solvent was distilled off to obtain 0.078 g of methanol extract. This extract was dissolved in 1% by mass in DMSO, and this solution was diluted to adjust the concentration. Using this, the following experiment was conducted.

(2) Senecio chrysanthemoides extract
4.194 g of whole plant of Senecio chrysanthemoides was immersed in 30 mL of methanol at room temperature for 1 week, the extract was filtered and the solvent was distilled off to obtain 0.583 g of methanol extract. The extract was dissolved in 1% by mass in DMSO, the solution was diluted to adjust the concentration, and the following experiment was performed using this.

(3) Rabdosia coetsa extract
20.0 g of the above-ground part of Rabdosia coetsa was immersed in 200 mL of methanol at room temperature for 1 week, the extract was filtered and the solvent was distilled off to obtain 1.136 g of methanol extract. This extract was dissolved in 1% by mass in DMSO, and this solution was diluted to adjust the concentration. Using this, the following experiment was conducted.

(4) Cyperus sp. (Nepal local name: Namiramjan) extract
1.289 g of whole plant of Cyperus sp. (Nepal local name Namiramjan) was immersed in 20 mL of methanol for 1 week at room temperature, the extract was filtered and the solvent was distilled off to obtain 0.068 g of methanol extract. This extract was dissolved in 1% by mass in DMSO, and this solution was diluted to adjust the concentration. Using this, the following experiment was conducted.

(5) Leontopodium jacotianum extract
0.735 g of whole plant of Leontopodium jacotianum was immersed in 20 mL of methanol at room temperature for 1 week, the extract was filtered and the solvent was distilled off to obtain 0.029 g of methanol extract. This extract was dissolved in 1% by mass in DMSO, and this solution was diluted to adjust the concentration. Using this, the following experiment was conducted.

(6) Swertia alata extract
0.330 g of the above-ground part of Swertia alata was immersed in 20 mL of methanol for 1 week at room temperature, the extract was filtered and the solvent was distilled off to obtain 0.063 g of methanol extract. This extract was dissolved in 1% by mass in DMSO, and this solution was diluted to adjust the concentration. Using this, the following experiment was conducted.

(7) Artemisia roxburghiana extract
3.970 g of whole plant of Artemisia roxburghiana was immersed in 50 mL of methanol for 1 week at room temperature, the extract was filtered and the solvent was distilled off to obtain 0.325 g of methanol extract. This extract was dissolved in 1% by mass in DMSO, and this solution was diluted to adjust the concentration. Using this, the following experiment was conducted.

(8) Callistemon lanceolatus extract
2.53 g of the above-ground part of Callistemon lanceolatus was immersed in 20 mL of methanol for 1 week at room temperature, the extract was filtered and the solvent was distilled off to obtain 0.23 g of methanol extract. The extract was dissolved in 2% by mass in DMSO, this solution was diluted to adjust the concentration, and the following experiment was performed using this.

2. Cell culture method Mouse B16 melanoma cells were used. A medium containing Eagle's MEM containing FBS (10%) and αMSH (10 ng / mL) was used as a test medium. The cells were grown in a CO ₂ incubator using Eagle's MEM medium containing FBS (10%) in a 75 cm ² flask. The cells were detached with a trypsin solution, Eagle MEM medium containing FBS (10%) was added, and the cells were collected by centrifugation at 1,100 rpm. Cells were seeded at 300,000 in a dish (100 × 20 mm), cultured for 1 day in Eagle's MEM medium containing 5 mL of FBS (10%), and then cultured for 3 days in the test medium containing each concentration of the test sample. The amount of melanin per cell was measured by the following method.

3. Measurement of the amount of melanin Cells were detached with 5 mL of trypsin solution and transferred to a 15 mL centrifuge tube. 5 mL of PBS was added to the dish and transferred to the same centrifuge tube. After measuring the cell number with Coulter Z1, the cells were collected by centrifugation at 1,100 rpm. After air drying, 2M sodium hydroxide solution was added to 100 μL / 10,000 cells, warmed at 60 ° C. for 3 minutes, and stirred to dissolve melanin. 50 μL of this was diluted with 150 μL of water, and the absorbance at 500 nm was measured with a microplate reader. The result was calculated | required by the suppression rate (%) with respect to a test plant extract no addition group. The results are shown in Table 1. As a reference example, arbutin, which is already known to have a melanin production inhibitory effect, was also tested in the same manner as described above. The results are also shown in Table 1. Cell proliferation was a “no suppression” result in all samples tested.

  From the results in Table 1, the extract of Physalis divaricata, Senecio chrysanthemoides, Rabdosia coetsa, Cyperus sp. (Nepal local name Namiramjan), Leontopodium jacotianum, Swertia alata, Artemisia roxburghiana, Callistemon lanceolatus has no effect on cell proliferation. It was found that it suppresses the production of melanin, and has an excellent inhibitory effect on melanin production like arbutin.

4). Whitening effect test (4-1) Preparation of whitening agent-containing skin external preparation A whitening agent was prepared for each sample as follows. The preparation method was carried out by preparing an alcohol phase and an aqueous phase according to a conventional method.
(Alcohol phase)
99% ethanol 70.0 mass%
Whitening agent described in “Table 2” Amount described in “Table 2” (aqueous phase)
Glycerin 5.0
Ion exchange water

(4-2) Test Method For each skin of the panel (n = 5) exposed to ultraviolet rays, each prescription solution was applied once a day for 8 weeks from 14 days after the day of exposure to ultraviolet rays. After the application was completed, whether or not there was an inhibitory effect on the pigmentation induced by ultraviolet irradiation was examined at the end of the test using four evaluation criteria. The results are shown in Table 2.
(Evaluation criteria)
4: Excellent effect 3: Effective 2: Slightly effective 1: No effect

  As can be seen from Table 2, whitening effect is applied to the prescription solution containing Physalis divaricata, Senecio chrysanthemoides, Rabdosia coetsa, Cyperus sp. Was recognized.

  Examples of the external preparation for skin containing the whitening agent of the present invention will be given below. The whitening agent used was the one prepared above. A compounding quantity represents the mass%. The skin external preparations obtained in Examples 1 to 16 were all effective in the whitening effect test.

Example 1 Cream (Prescription)
Stearic acid 5.0% by mass
Stearyl alcohol 4.0
Isopropyl myristate 18.0
Glycerol monostearate 3.0
Propylene glycol 10.0
Physalis divaricata ethanol extract 0.01
Caustic potash 0.2
Sodium bisulfite 0.01
Preservative Appropriate amount Perfume Appropriate amount Ion-exchange water Residue
Propylene glycol and Physalis divaricata ethanol extract are added to ion-exchanged water, dissolved in ethanol extract and caustic potash, and heated to 70 ° C. (aqueous phase). The other ingredients are mixed, heated and melted, and kept at 70 ° C. (oil phase). The oil phase is gradually added to the aqueous phase, and after the addition is complete, the temperature is maintained for a while to cause the reaction. Thereafter, the mixture is uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well.

Example 2 Cream (Prescription)
Stearic acid 2.0% by mass
Stearyl alcohol 7.0
Hydrogenated Lanolin 2.0
Squalane 5.0
2-Octyldodecyl alcohol 6.0
Polyoxyethylene (25 mol) cetyl alcohol ether 3.0
Glycerin monostearate ester 2.0
Propylene glycol 5.0
Senecio chrysanthemoides hexane extract 0.05
Sodium bisulfite 0.03
Ethylparaben 0.3
Perfume Appropriate amount Ion exchange water Residue
Propylene glycol is added to ion-exchanged water and heated to 70 ° C. (aqueous phase). The other ingredients are mixed, heated and melted, and kept at 70 ° C. (oil phase). Preliminarily emulsify by adding an oil phase to the aqueous phase, uniformly emulsify with a homomixer, and then cool to 30 ° C. while stirring well.

Example 3 Cream (Prescription)
Solid paraffin 5.0% by mass
Beeswax 10.0
Vaseline 15.0
Liquid paraffin 41.0
Glycerin monostearate ester 2.0
Polyoxyethylene (20 mol) sorbitan monolaurate 2.0
Soap powder 0.1
Borax 0.2
Rabdosia coetsa acetone extract 0.05
Sodium bisulfite 0.03
Ethylparaben 0.3
Perfume Appropriate amount Ion exchange water Residue
Add soap powder and borax to ion-exchanged water, dissolve by heating and maintain at 70 ° C. (aqueous phase). The other ingredients are mixed, heated and melted, and kept at 70 ° C. (oil phase). The reaction is gradually added while stirring the oil phase in the aqueous phase. After completion of the reaction, the mixture is uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well after emulsification.

Example 4 Latex (Prescription)
Stearic acid 2.5% by mass
Cetyl alcohol 1.5
Vaseline 5.0
Liquid paraffin 10.0
Polyoxyethylene (10 mol) monooleate 2.0
Polyethylene glycol 1500 3.0
Triethanolamine 1.0
Carboxyvinyl polymer 0.05
Cyperus sp. (Nepal local name Namiramjan) Acetic acid ethyl ester extract 0.01
Sodium bisulfite 0.01
Ethylparaben 0.3
Perfume Appropriate amount Ion exchange water Residue
Dissolve the carboxyvinyl polymer in a small amount of ion-exchanged water (A phase). Polyethylene glycol 1500 and triethanolamine are added to the remaining ion-exchanged water, dissolved by heating and maintained at 70 ° C. (aqueous phase). The other ingredients are mixed, heated and melted, and kept at 70 ° C. (oil phase). Add the oil phase to the water phase, preliminarily emulsify, add the A phase, uniformly emulsify with a homomixer, and cool to 30 ° C. while stirring well after emulsification.

Example 5 Latex (Prescription)
Microcrystalline wax 1.0% by mass
Beeswax 2.0
Lanolin 20.0
Liquid paraffin 10.0
Squalane 5.0
Sorbitan sesquioleate ester 4.0
Polyoxyethylene (20 mol) sorbitan monooleate 1.0
Propylene glycol 7.0
Leontopodium jacotianum water extract 10.0
Sodium bisulfite 0.01
Ethylparaben 0.3
Perfume Appropriate amount Ion exchange water Residue
Propylene glycol is added to ion-exchanged water and heated to 70 ° C. (aqueous phase). The other ingredients are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added thereto and uniformly emulsified with a homomixer. Cool to 30 ° C. while stirring well after emulsification.

Example 6 Jelly (Prescription)
95% ethyl alcohol 10.0% by mass
Dipropylene glycol 15.0
Polyoxyethylene (50 mol) oleyl alcohol ether 2.0
Carboxyvinyl polymer 1.0
Caustic soda 0.15
L-Arginine 0.1
Swertia alata 50% aqueous ethanol extract 7.0
Sodium 2-hydroxy-4-methoxybenzophenone sulfonate 0.05
Ethylenediaminetetraacetate, 3 sodium, 2 water 0.05
Methylparaben 0.2
Perfume Appropriate amount Ion exchange water Residue
Dissolve the carboxyvinyl polymer uniformly in ion-exchanged water, while dissolving the Swertia alata 50% aqueous ethanol extract, polyoxyethylene (50 mol) oleyl alcohol ether in 95% ethanol and add to the aqueous phase. Next, after adding other components, the mixture is neutralized and thickened with caustic soda and L-arginine.

Example 7 Cosmetic liquid (prescription)
(Phase A)
Ethyl alcohol (95%) 10.0% by mass
Polyoxyethylene (20 mol) octyldodecanol 1.0
Pantotenyl ethyl ether 0.1
Artemisia roxburghiana ethanol extract 1.5
Methylparaben 0.15
(Phase B)
Potassium hydroxide 0.1
(Phase C)
Glycerin 5.0
Dipropylene glycol 10.0
Sodium bisulfite 0.03
Carboxyvinyl polymer 0.2
Purified water residue (production method)
A phase and C phase are uniformly dissolved, and A phase is added to C phase to solubilize. Next, filling is performed after adding phase B.

Example 8 Pack (Prescription)
(Phase A)
Dipropylene glycol 5.0% by mass
Polyoxyethylene (60 mol) hydrogenated castor oil 5.0
(Phase B)
Callistemon lanceolatus ethanol extract 0.01
Olive oil 5.0
Tocopherol acetate 0.2
Ethylparaben 0.2
Fragrance 0.2
(Phase C)
Sodium bisulfite 0.03
Polyvinyl alcohol 13.0
(Saponification degree 90, polymerization degree 2,000)
Ethanol 7.0
Purified water residue (production method)
A phase, B phase, and C phase are uniformly dissolved, and B phase is added to A phase to solubilize. Next, this is added to phase C and then filled.

Example 9 Solid Foundation (Prescription)
Talc 43.1% by mass
Kaolin 15.0
Sericite 10.0
Zinc flower 7.0
Titanium dioxide 3.8
Yellow iron oxide 2.9
Black iron oxide 0.2
Squalane 8.0
Isostearic acid 4.0
Monooleic acid POE sorbitan 3.0
Isocetyl octoate 2.0
Physalis divaricata ethanol extract 1.0
Preservative appropriate amount perfume appropriate amount (production method)
A powder component of talc to black iron oxide is sufficiently mixed with a blender, and an oily component of squalane to isocetyl octanoate, a Physalis divaricata ethanol extract, a preservative, and a fragrance are added and kneaded well, and then filled into a container and molded.

Example 10 Emulsification Foundation (Cream Type)
(Prescription)
(Powder part)
Titanium dioxide 10.3% by mass
Sericite 5.4
Kaolin 3.0
Yellow iron oxide 0.8
Bengala 0.3
Black iron oxide 0.2
(Oil phase)
Decamethylcyclopentasiloxane 11.5
Liquid paraffin 4.5
Polyoxyethylene-modified dimethylpolysiloxane 4.0
(Water phase)
Purified water 50.0
1,3-butylene glycol 4.5
Senecio chrysanthemoides ethanol extract 1.5
Sorbitan sesquioleate 3.0
Preservative appropriate amount perfume appropriate amount (production method)
After the aqueous phase is heated and stirred, the powder part sufficiently mixed and pulverized is added and homomixed. Furthermore, after adding the heat-mixed oil phase and carrying out a homomixer process, a fragrance | flavor is added, stirring, and it cools to room temperature.

Example 11 Cream (Prescription)
Stearic acid 5.0% by mass
Stearyl alcohol 4.0
Isopropyl myristate 18.0
Glycerol monostearate 3.0
Propylene glycol 10.0
Rabdosia coetsa ethanol extract 0.01
Caustic potash 0.2
Sodium bisulfite 0.01
Preservative Appropriate amount Perfume Appropriate amount Ion-exchange water Residue
Propylene glycol, Rabdosia coetsa ethanol extract and caustic potash are added to ion-exchanged water, dissolved, heated and maintained at 70 ° C. (aqueous phase). The other ingredients are mixed, heated and melted, and kept at 70 ° C. (oil phase). The oil phase is gradually added to the aqueous phase, and after the addition is complete, the temperature is maintained for a while to cause the reaction. Thereafter, the mixture is uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well.

Example 12 Cream (Prescription)
Stearic acid 2.0% by mass
Stearyl alcohol 7.0
Hydrogenated Lanolin 2.0
Squalane 5.0
2-Octyldodecyl alcohol 6.0
Polyoxyethylene (25 mol) cetyl alcohol ether 3.0
Glycerin monostearate ester 2.0
Propylene glycol 5.0
Cyperus sp. Hexane extract 0.05
Sodium bisulfite 0.03
Ethylparaben 0.3
Perfume Appropriate amount Ion exchange water Residue
Propylene glycol is added to ion-exchanged water and heated to 70 ° C. (aqueous phase). The other ingredients are mixed, heated and melted, and kept at 70 ° C. (oil phase). Preliminarily emulsify by adding an oil phase to the aqueous phase, uniformly emulsify with a homomixer, and then cool to 30 ° C. while stirring well.

Example 13 Cream (Prescription)
Solid paraffin 5.0% by mass
Beeswax 10.0
Vaseline 15.0
Liquid paraffin 41.0
Glycerin monostearate ester 2.0
Polyoxyethylene (20 mol) sorbitan monolaurate 2.0
Soap powder 0.1
Borax 0.2
Leontopodium jacotianum acetone extract 0.05
Sodium bisulfite 0.03
Ethylparaben 0.3
Perfume Appropriate amount Ion exchange water Residue
Add soap powder and borax to ion-exchanged water, dissolve by heating and maintain at 70 ° C. (aqueous phase). The other ingredients are mixed, heated and melted, and kept at 70 ° C. (oil phase). The reaction is gradually added while stirring the oil phase in the aqueous phase. After completion of the reaction, the mixture is uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well after emulsification.

Example 14 Emulsion (Prescription)
Stearic acid 2.5% by mass
Cetyl alcohol 1.5
Vaseline 5.0
Liquid paraffin 10.0
Polyoxyethylene (10 mol) monooleate 2.0
Polyethylene glycol 1500 3.0
Triethanolamine 1.0
Carboxyvinyl polymer 0.05
Swertia alata ethyl ester extract 0.01
Sodium bisulfite 0.01
Ethylparaben 0.3
Perfume Appropriate amount Ion exchange water Residue
Dissolve the carboxyvinyl polymer in a small amount of ion-exchanged water (A phase). Polyethylene glycol 1500 and triethanolamine are added to the remaining ion-exchanged water, dissolved by heating and maintained at 70 ° C. (aqueous phase). The other ingredients are mixed, heated and melted, and kept at 70 ° C. (oil phase). Add the oil phase to the water phase, preliminarily emulsify, add the A phase, uniformly emulsify with a homomixer, and cool to 30 ° C. while stirring well after emulsification.

Example 15 Emulsion (Prescription)
Microcrystalline wax 1.0% by mass
Beeswax 2.0
Lanolin 20.0
Liquid paraffin 10.0
Squalane 5.0
Sorbitan sesquioleate ester 4.0
Polyoxyethylene (20 mol) sorbitan monooleate 1.0
Propylene glycol 7.0
Artemisia roxburghiana extract 10.0
Sodium bisulfite 0.01
Ethylparaben 0.3
Perfume Appropriate amount Ion exchange water Residue
Propylene glycol is added to ion-exchanged water and heated to 70 ° C. (aqueous phase). The other ingredients are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added thereto and uniformly emulsified with a homomixer. Cool to 30 ° C. while stirring well after emulsification.

Example 16 Jelly (Prescription)
95% ethyl alcohol 10.0% by mass
Dipropylene glycol 15.0
Polyoxyethylene (50 mol) oleyl alcohol ether 2.0
Carboxyvinyl polymer 1.0
Caustic soda 0.15
L-Arginine 0.1
Callistemon lanceolatus 50% aqueous ethanol extract 7.0
Sodium 2-hydroxy-4-methoxybenzophenone sulfonate 0.05
Ethylenediaminetetraacetate, 3 sodium, 2 water 0.05
Methylparaben 0.2
Perfume Appropriate amount Ion exchange water Residue
Carbopol 940 is uniformly dissolved in ion-exchanged water, while Callistemon lanceolatus 50% aqueous ethanol extract, polyoxyethylene (50 mol) oleyl alcohol ether is dissolved in 95% ethanol and added to the aqueous phase. Next, after adding other components, the mixture is neutralized and thickened with caustic soda and L-arginine.

Claims (3)

  Solanaceae plant Physalis divaricata, Compositae plant Senecio chrysanthemoides, Labiatae plant Rabdosia coetsa, Rabdosia coetsa Plant Cyperus sp. (Cyperus sp.) (Nepalese local name Namiramjan), Leontopodium jacotianum of the Compositae plant, Leontopodium jacotianum, Gentianaceae plant Swertia alata, Compositae plant A whitening agent comprising an extract of one or more plants selected from the group consisting of Artemisia roxburghiana and Callistemon lanceolatus, a myrtaceae plant, Callistemon lanceolatus.   A whitening method comprising whitening the skin using the whitening agent according to claim 1. A method for producing a whitening skin external preparation, which comprises adding the whitening agent according to claim 1 to an aqueous phase or an oil phase to produce a whitening skin external preparation.