JP2010222273A - Hair nourishing composition - Google Patents

Abstract

An unprecedented novel hair papilla cell growth promoter and hair matrix cell growth promoter, which exhibit excellent hair nourishing (hair growth / hair growth) effects, and a hair nourishing composition containing them.
The hair nourishing composition comprises an extract of at least one plant selected from the group consisting of Indian Jacoboku, Alstonia scholaris, Tinospora cordifolia, Carotropis gigantea, Ceylon pine, Togoma and Bandate Serata. Hair matrix cell growth promoter containing as an active ingredient, and / or hair papilla cell growth promoter containing as an active ingredient at least one plant extract selected from the group consisting of nutmeg, chilettaso, ceylon pine, sesame, and Indian salsaparilla contains.
[Selection figure] None

Description

  The present invention relates to a hair nourishing composition that promotes hair growth and hair growth.

  The hair grows and falls off and repeats a certain cycle (hereinafter referred to as the hair cycle) in which new hair grows again. However, due to aging and changes in hormonal balance, the hair cycle is not performed normally, and alopecia and Thinning occurs.

  By the way, the hair is divided into a hair shaft protruding above the skin and a hair root buried in the skin, and the hair root is surrounded by a tissue layer called a hair follicle. The spherically bulging portion of the hair follicle base located at the bottom of the hair root is called a “hair bulb” and is known to be an important part for hair growth and hair growth. The bottom of the hair bulb is recessed, and a tissue called the hair papilla enters the portion. In this, "hair papilla cells" are densely packed and capillaries are stretched, and nutrients and oxygen for growing hair are carried from the capillaries. The cells dividing by the nutrients are "hair matrix cells" that surround the hair papilla (the hair papilla cells and the hair matrix cells may be collectively referred to as hair bulb cells). ). Hair matrix and inner root sheath are generated from the hair matrix cells, and they grow upward with the proliferation of the hair matrix cells. In addition, dermal papilla cells give instructions on hair growth and rest to hair matrix cells and are deeply involved in the growth of hair matrix cells.

  For this reason, in order to normalize the hair cycle, attempts have been made to promote the proliferation of hair papilla cells and hair matrix cells. For example, as a hair papilla cell proliferation promoter, a substance containing a specific seaweed extract such as a seaweed extract of the family Kombuaceae as an active ingredient (Patent Document 1), or as a hair matrix cell proliferation promoter, water extraction of ougon The thing (patent document 2) which contains a thing as an active ingredient is proposed, These are mix | blended with the hair nourishing (hair growth and hair growth) agent composition (it may only be called a hair nourishing agent composition hereafter). .

JP 2007-131571 A Japanese Patent Laid-Open No. 9-216827

  However, some of the active ingredients blended in the hair nourishing compositions described in Patent Documents 1 and 2 are not always sufficient in hair restoration (hair growth / hair growth) effect, and natural products are used as raw materials. Therefore, there was a problem that it might interfere with the acquisition. For this reason, the present condition is that the new hair papilla cell proliferation promoter and the hair matrix cell growth promoter are always calculated | required.

  Accordingly, the present invention provides an unprecedented novel hair dermal papilla cell proliferation promoter and hair matrix cell proliferation promoter that exhibits an excellent hair restoration (hair growth / hair growth) effect, and a hair nourishing composition containing them. With the goal.

  In view of the above object, the present inventors have extensively searched for plant-derived components, and as a result, specific plant extracts that were not known at all for excellent proliferation activity against hair bulb cells are excellent hair bulbs. It has been found that it has a partial cell growth promoting effect, that is, a hair matrix cell growth promoting effect or a hair papilla cell growth promoting effect and is highly safe against the skin, and has completed the present invention.

That is, the present invention relates to Nycanthes arborristis, Alstonia scholaris, Tinospora cordifolia, Caltropis gigante, Hair matrix growth promoter containing at least one plant extract selected from the group consisting of Ricinus communis and Vanda roxburghii as an active ingredient, and / or Myristica fragrances, Swartia chirata, Ceylon pine (Plumbago z a hair nourishing composition comprising a hair papilla cell growth promoter containing, as an active ingredient, at least one plant extract selected from the group consisting of eylanica), sesame indicum, and Indian salsa parilla (Hemidesmus indicus). Offer things. Moreover, the cosmetic method characterized by applying this hair nourishing agent composition to a scalp is provided.

  Further, the present invention provides, as an active ingredient, an extract of at least one plant selected from the group consisting of the above-mentioned Indian cedar, Alstonian cholaria, Tinospora cordifolia, Carotropis gigantea, Ceylon pine, Togoma and Bandate serrata. The present invention provides a hair matrix cell growth promoter characterized by containing.

  Furthermore, the present invention provides a dermal papilla cell proliferation promoter characterized by containing, as an active ingredient, at least one plant extract selected from the group consisting of the above-mentioned nutmeg, chilettaso, ceylon pine, sesame, and Indian salsaparilla. provide.

  The hair matrix cell growth promoter or hair papilla cell growth promoter contained in the hair nourishing composition of the present invention contains an extract of at least one plant selected from a specific plant group. This extract is highly safe to the skin and has a growth promoting effect on hair matrix cells or hair papilla cells. Therefore, by applying the hair nourishing composition of the present invention to the scalp, the hair growth promoting effect, the hair loss preventing effect, and the hair growth promoting effect can be achieved, and the hair cycle can be normalized. In addition, the hair nourishing composition of the present invention can be expected to normalize the scalp metabolic function and to exhibit an anti-dandruff effect.

  The hair nourishing composition of the present invention contains at least one of a hair matrix cell growth promoter and a hair papilla cell growth promoter, preferably both. Here, the hair matrix cell growth promoter is an extract of at least one plant selected from the group consisting of Indian Jacoboku, Alstonian Polaris, Tinospora cordifolia, Carotropis gigantea, Ceylon pine, Togoma and Bandate Serata. On the other hand, the hair papilla cell proliferation promoter contains as an active ingredient at least one plant extract selected from the group consisting of nutmeg, chilettaso, ceylon pine, sesame and Indian salsaparilla. Therefore, the hair nourishing agent composition of the present invention can contain these plants alone or in combination.

  Ceylon pine has the effect of promoting the growth of both hair matrix cells and hair papilla cells. Therefore, when the hair nourishing composition of the present invention contains an extract of Ceylon pine, it contains a hair matrix cell growth promoter and a hair papilla cell growth promoter. Hereinafter, although the plant mentioned above which characterizes the present invention is explained, the locality of these plants is not particularly limited.

Indian mussel is a plant of the family Asteraceae;
Alstonia polaris is a oleander Takagi;
Tinospora cordifolia is a plant belonging to the genus Tinospora in the family Rhododendronaceae;
Carotropis gigantea is an evergreen shrub of the scallop family, native to India;
Ceylon pine is an evergreen shrub of the family Pinaceae, often a vine plant that grows to 2 m. Native to South India and Malaysia;
Castor is an evergreen shrub (wild) of Euphorbiaceae, native to South Africa;
Bandanteserata is a plant belonging to the genus Banda genus;
Nutzuku is an evergreen tree of the family Nymphalidae, native to Indonesia and currently widely cultivated;
Cireetta is a traditional Ayurvedic herbal medicine in the perennial family of Gentianaceae. The place of origin is north India and Nepal. In India, it is prescribed for fever and liver disease including malaria, gallstones, indigestion, etc .;
Sesame is an annual plant of the sesame family and is native to Africa; and Indian Sarsaparilla is a plant of the genus Hemidesmus, with approximately 350 species distributed throughout the world.

  As the plant extract characterizing the present invention, any part of a plant body such as leaves, stems, trunks, bark, buds, flowers, fruits, seeds, roots, etc. It is possible to use the one extracted from the above, but preferably the leaf bark is used in the case of Indian mussel, the bark is used in the case of Alstonia cholaria, and the trunk is used in the case of Tinospora cordifolia. In the case of Carotropis gigantea, the stem and bark are used, in the case of Ceylon pine, the root is used, in the case of castor bean, the bark is used, in the case of Bandate Serata, the root is used, Seeds are used, leaves are used in the case of Cireetta, seeds are used in the case of sesame, and whole plants are used in the case of Indian Sarsaparilla.

  When obtaining extracts from these plants, each part may be used as it is, but after appropriate pretreatment such as drying, shredding, crushing, pressing or fermentation, the solvent is used at low or warm temperature. It is preferable to extract using. Although the extraction method is not specifically limited, For example, the method of immersing one site | part of the said plant body, or 2 or more types of site | parts in the solvent under low temperature or room temperature-heating is mention | raise | lifted. The extraction time is set according to the type of extraction solvent and the extraction temperature, but is preferably about 1 to 2 weeks.

  Examples of the extraction solvent include water, lower monohydric alcohols (methyl alcohol, ethyl alcohol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid polyhydric alcohols (glycerin, propylene glycol, dipropylene glycol). 1,3-butylene glycol etc.), lower esters (ethyl acetate, butyl acetate etc.), hydrocarbons (benzene, hexane, pentane etc.), ketones (acetone, methyl ethyl ketone etc.), ethers (diethyl ether, tetrahydrofuran, di Propyl ether, etc.), acetonitrile and the like, and one or more of them can be used. Further, physiological saline, phosphate buffer, phosphate buffered saline, or the like may be used. If necessary, purification treatment such as deodorization and decolorization may be performed within a range not impairing the effects of the present invention. Further, if necessary, an antiseptic / antifungal agent (phenoxyethanol, paraoxybenzoic acid ester, etc.) may be added and then stored at a low temperature for 1 to 2 days, followed by filtration.

  As an example of a preferable method for extracting a plant that characterizes the present invention, water-containing ethyl alcohol or 1,3-butylene glycol having a concentration of 0 to 100 vol% is used, and after extraction at room temperature or 1 to 10 days after heating. There is a method in which the mixture is filtered, and the filtrate obtained is left to mature for about one week at a low temperature to room temperature, and then filtered again.

  In the hair matrix cell growth promoter that can be contained in the hair nourishing composition of the present invention, the total content of Indian pearl moth, Alstonia cholaris, Tinospora cordifolia, Carotropis gigantea, Ceylon pine, Togoma and Bandate serrata is In order to achieve a good balance between the safety to the scalp and the effect of promoting hair matrix growth, the dry solid content is preferably 0.000001 to 10% by mass, more preferably 0.00001 to 2% by mass.

  On the other hand, the total content of nutmeg, chiletta, sesame, ceylon pine, and Indian salsaparilla in the hair papilla cell growth promoter that can be contained in the hair nourishing composition of the present invention is also related to the safety to the scalp and hair matrix growth. The dry solid content is preferably 0.000001 to 10% by mass, more preferably 0.00001 to 2% by mass in order to achieve a good balance between the promoting effect.

  If the total amount of the hair matrix cell proliferation promoter and the hair papilla cell proliferation promoter in the hair nourishing composition of the present invention is too small, the desired effect of the present invention will not be sufficiently exhibited, and if it is too large, a formulation will be obtained. However, the improvement in the effect commensurate with the increase in the blending amount is not recognized, so that the dry solid content is preferably 0.000001 mass% to 10 mass%, more preferably 0.00001 mass% to 2% by mass.

  Further, the hair nourishing agent composition, hair matrix cell growth promoter or hair papilla cell growth promoter of the present invention has various medicinal components that are usually used, such as other hair growth / hair nourishing agents, moisturizers, anti-inflammatory agents, antioxidants. It can be used in combination with one or more medicinal agents selected from agents, cell activators, UV protection agents, blood circulation promoters, and the like. Thereby, the effect of the present invention can be further enhanced.

  Examples of hair growth and nourishing agents include, for example, vitamin E and derivatives thereof, assembly extract, garlic extract, cephalanthin, γ-oryzanol, carpronium chloride, acetylcholine, capsicum tincture, cantalis tincture, ginger tincture, nonyl acid vanillamide, salicylic acid, resorcin, lactic acid , Placenta extract, pentadecanoic acid glyceride, pantothenic acid, pantothenyl ethyl ether, biotin, hinokitiol, allantoin, glycyrrhizic acid, glycyrrhetinic acid, isopropylmethylphenol, triclosan, zinc pyrithione, hinokitiol, menthol, camphor, photosensitizer 301, adenosine, cordyceps Extract, benzyl nicotinate, trans-3,4, -dimethyl-3-hydroxyflavanone, Western Hypericum , Mention may be made of the Netherlands mustard extract, Clara extract, wheat germ extract, pepper extract, the other female hormone, and the like.

  Examples of humectants include aspartic acid, aspartate, alanine, arginine, alginic acid, sodium alginate, xylitol, glycine, glucose, cystine, cysteine, serine, polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, polyglycerin, 1 , 3-butylene glycol, 1,2-pentanediol, hexylene glycol, xylitol, sorbitol, POE methylglucoside, maltitol, maltose, mannitol, lysine, honey, royal jelly, chondroitin sulfate, chondroitin sulfate, hyaluronic acid, hyaluronic acid Sodium, sodium acetyl hyaluronate, mucoitin sulfate, caronic acid, tranexamic acid, betaine, trehalose, chito , Urea, ceramide, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salt, dl-pyrrolidone carboxylate, soluble collagen, diglycerin (EO) PO adduct, ashitaba extract, asparagus extract , Izayoi rose extract, quince seed extract, guava leaf extract, yarrow extract, merirot extract and the like.

  Anti-inflammatory agents include, for example, aminocaproic acid, allantoin, indomethacin, bisabolol, saponin, lysothium chloride, azulene, guaiazulene, guaiazulene sulfonate, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, salicylic acid and its derivatives, hinokitiol, photosensitivity Examples thereof include elemental, tranexamic acid and derivatives thereof, zinc oxide, turmeric extract, ganoderma extract, button extract, litchi extract, and bitumen extract.

  As an antioxidant, for example, astaxanthin, β-carotene, γ-oryzanol, kinetin, tocopherol, dibutylhydroxytoluene, flavonoid, SOD, catalase, fullerene, phytic acid, ferulic acid, chlorogenic acid, propyl gallate, green tea extract, Rosemary extract, Rosehip extract, Shobu extract, Horsetail extract, Hamamelis extract, Parsley extract, Loquat leaf extract, Grapefruit extract, Citrus extract, Lychee extract, Artemisia extract, Peach leaf extract Products, mango extract, button pi extract, pine bark extract, platinum, ubiquinone, α-lipoic acid and the like.

  Examples of cell activators include, for example, aminobutyric acid, ginkgo biloba extract, fennel extract, Dutch mustard extract, carrot extract, clara extract, chlorella extract, saffron extract, soybean extract, tiso extract, nicotinic acid, Examples thereof include nicotinamide, pantothenic acid and derivatives thereof, biotin, retinol, leucine, photosensitizer, riboflavin and derivatives thereof, pyridoxine and derivatives thereof, and the like.

  As a blood circulation promoter, for example, salamander extract, ginger extract, gypsum extract, chimpi extract, pepper extract, ginger extract, button extract, nonyl acid valenylamide, nicotinic acid benzyl ester, nicotinic acid β- Examples include butoxyethyl ester, capsaicin, cantalis tincture, ictamol, caffeine, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, acetylcholine, cephalanthin, and γ-oryzanol.

  Further, the hair nourishing composition, hair matrix cell growth promoter or hair papilla cell growth promoter of the present invention is water that is a component usually used for external preparations within the range not impairing the effects of the present invention, in addition to the above components. , Oils and fats, waxes, hydrocarbons, fatty acids, higher alcohols, esters, plant extracts, vitamins, water-soluble polymers, surfactants, metal soaps, alcohol, polyhydric alcohols, pH adjusters , Ingredients such as preservatives, fragrances, powders, thickeners, pigments, chelating agents, and the like can be appropriately blended.

  The dosage form of the hair nourishing composition, hair matrix cell growth promoter or hair papilla cell growth promoter of the present invention is not particularly limited, and examples thereof include low viscosity liquids, pastes, creams, foams, emulsions, packs, ointments, powders, Examples include aerosols and patches. The present invention can be applied to any of cosmetics, quasi drugs, and pharmaceuticals. Specifically, for example, it can be applied to hair growth / hair nourishing agents, hair nick, hair liquid, head lotion, head emulsion, head cream, head mousse, shampoo, rinse, hair treatment, etc. .

The hair nourishing composition of the present invention can be preferably used in a cosmetic method in which it is applied to the scalp and massaged as necessary. Moreover, the usage of the hair matrix cell growth promoter or hair papilla cell growth promoter of the present invention can be the same as that of the hair nourishing composition of the present invention. Here, if the amount of the hair nourishing composition of the present invention, or the hair matrix cell growth promoter or hair papilla cell growth promoter applied to the scalp is too small, the effect of the invention cannot be obtained, and even if it is too large, it corresponds to the added amount. Therefore, in terms of plant extract (dry solid content), per scalp unit area (1 cm ² ), preferably 0.0002 to 1340 μg / cm ² · day, more preferably 0.0002 to 270 μg / It is preferable to use cm ² · day.

  Next, the hair nourishing agent composition, hair matrix cell growth promoter, and hair papilla cell growth promoter of the present invention will be described more specifically with reference to preparation examples, test examples, and examples, but the present invention is not limited to these. Is not to be done.

<Preparation example of plant extract>
Tinospora cordifolia stem site, Carotropis gigantea stem and bark site, Ceylon pine root site, Sesame bark site, Bandate serrata root site, nutmeg seed plant site, Chileta Sato leaf site, Sesame seed site, and With respect to the whole plant of Indian Salsaparilla, 100 g of each was pulverized, and 1 kg of a 50% aqueous ethanol solution was separately added and mixed. Let stand at room temperature for 7 days, filter to remove insolubles, extract of Indian mussel extract, Alstonia choralis extract, Tinospora cordifolia extract, Carotropis gigantea extract, Ceylon pine extract, A castor bean extract, a bandate serrata extract, a nutmeg extract, a chiletta extract, a sesame extract, and an Indian salsaparilla extract were obtained. These extracts were used as plant extract samples in the following test examples and examples.

<Test example: Maternal cell proliferation promoting effect>
Each plant extract sample prepared as described above was tested and evaluated for its growth promoting effect on hair matrix cells as described below.

1 × 10 ⁴ hair matrix cells are seeded in a 60 mm petri dish (collagen coat), FBS (5%), MSC growth supplement (1%), Penicillin / streptomycin (1%) in Mesenchymal Stem Cell Medium (ScienCell Research Laboratories) ) Was added at 37 ° C. in the presence of 5 vol% CO ₂ in a CO ₂ incubator. The plant extract diluted 1000 times the day after sowing was added to the medium in an amount of 1% by mass. As a control, 50% ethanol was added to the medium in an amount of 1% by mass. The medium was changed every 4 days and the same amount of plant extract or 50% ethanol was added each time. The proliferation effect was determined by counting the number of cells on the 14th day. The number of cells when no plant extract as a control was added was defined as 100, and the cell growth rate when each specific plant extract was added was determined. The results of cell proliferation rate are shown in Table 1.

  From Table 1, it can be seen that by adding the plant extract characterizing the present invention, a growth promoting action on the hair matrix cells is recognized, and each plant extract in Table 1 is an effective hair matrix growth promoter. .

<Test example: dermal papilla cell proliferation promoting effect>
The samples (each plant extract) obtained in the production example were tested and evaluated as described below for the growth promoting effect on the hair papilla cells.

A 60 mm petri dish (coated with poly-L-lysine) is seeded with 1 × 10 ⁴ papilla cells, and FCS (1%), ITT (0.5%), BPE (1%) on Papilla Cell Growth Medium (Toyobo) , Cyp (0.5%) was added, and the cells were cultured at 37 ° C. in the presence of 5 vol% CO ₂ in a CO ₂ incubator. The plant extract diluted 1000 times the day after sowing was added to the medium in an amount of 1% by mass. As a control, 50% ethanol was added to the medium in an amount of 1% by mass. The medium was changed every 4 days and the same amount of plant extract or 50% ethanol was added each time. The proliferation effect was determined by counting the number of cells on the 14th day. The number of cells when no plant extract as a control was added was defined as 100, and the cell growth rate when each specific plant extract was added was determined. The results of cell proliferation rate are shown in Table 2.

  From Table 2, it can be seen that by adding the plant extract characterizing the present invention, a growth promoting effect on hair papilla cells is recognized, and each plant extract in Table 2 is an effective hair papilla cell growth promoter. .

Examples 1 and 2 (test example: actual use test)
According to the formulation shown in Table 3, hair nicks of Examples 1 and 2 corresponding to the hair nourishing agent composition of the present invention were prepared by a conventional method. Using these, actual use tests were conducted to examine the effects on hair growth and hair loss symptoms.

  An actual use test was carried out using the obtained hair tonics of Examples 1 and 2, and the effects on hair growth and hair loss were examined. Specifically, 20 males (27 to 60 years old) are divided into two groups, and each one of the hair artnics of Example 1 or 2 is once or twice a day, and the appropriate amount is set to 4 months. The hair growth promoting effect and the hair loss preventing effect were evaluated according to the following evaluation criteria. Table 4 shows the obtained results.

<Evaluation criteria>
(1) Hair growth promoting effect test evaluation rank: <Contents>
Remarkable effect Hair has grown in the hair removal part.
Effective New hair formation was observed in more than half of the hair loss area.
Invalid No improvement is seen.

(2) Hair removal prevention effect test evaluation rank: <Contents>
Remarkable effect Hair loss stopped.
Effective Progression of hair loss decreased.
Invalid No improvement is seen.

  As is apparent from Table 4, it can be seen that the hair artnics of Examples 1 and 2 containing the plant extract characterizing the present invention have excellent effects on hair growth promotion and hair loss prevention. In addition, even in the group using hair artnics of Examples 1 and 2, no subject complained of skin disorders such as skin irritation and allergic reaction.

Examples 3 to 13 (preparation of hair art)
Among the blending components in Table 5, components (1) to (3) were added to ethanol and dissolved by stirring. Next, components (4) and (6) were added and dissolved uniformly to obtain the hair artnic of Example 3. In addition, as an ingredient (4), instead of the extract of Indian pearl millet, Alstonia cholaris extract (Example 4), Tinospora cordifolia extract (Example 5), Carotropis gigantea extract (Example) 6), Ceylon pine extract (Example 7), castor bean extract (Example 8), Bandate Serata extract (Example 9), nutmeg extract (Example 10), Chileta extract (Example 11), sesame The hair artnics of Examples 3 to 13 were similarly prepared using the extract (Example 12) and the Indian Sarsaparilla extract (Example 13), respectively.

  About the hair technic of each Example, when the same test as Example 1 and 2 was done, the hair growth promotion effect and the hair loss prevention effect which were excellent also about any hair technic were shown. Moreover, no subject complained of skin disorders such as skin irritation or allergic reaction in any hair artnic group.

Examples 14-20 (preparation of hair art)
Among the blending components in Table 6, components (1) to (3) were added to ethanol and dissolved by stirring. Next, components (5) to (7) were added and dissolved uniformly to obtain the hair artnic of Example 14. Further, as the component (5), instead of the extract of Indian pearl millet extract, Alstonian Chloralis extract (Example 15), Tinospora cordifolia extract (Example 16), Carotropis gigantea extract (Example) 17), Ceylon pine extract (Example 18), castor bean extract (Example 19), Bandate serrata extract (Example 20), component (6), Chileta extract (Example) 17), hairy nicks of Example 14 to Example 20 were prepared in the same manner using Ceylon pine extract (Example 18), sesame extract (Example 19) and Indian Sarsaparilla extract (Example 20), respectively. did.

  About the hair technic of each Example, when the same test as Example 1 and 2 was done, the hair growth promotion effect and the hair loss prevention effect which were excellent also about any hair technic were shown. Moreover, no subject complained of skin disorders such as skin irritation or allergic reaction in any hair artnic group.

Examples 21-31 (Preparation of head cream)
Among the blending components in Table 7, components (1) to (6) are heated and mixed to prepare a mixture A at 75 ° C. Separately, components (7) to (10) are added to component (12). The mixture B was prepared by heating and mixing at 75 ° C. The resulting mixture A and mixture B were mixed and emulsified using a homomixer and allowed to cool to room temperature to prepare mixture C. To the obtained mixture C, the component (11) was uniformly mixed to obtain the head cream of Example 21. As the component (11), instead of the extract of Indian pearl millet extract, Alstonia cholaris extract (Example 22), Tinospora cordifolia extract (Example 23), Carotropis gigantea extract (Example 24) , Ceylon pine extract (Example 25), castor bean extract (Example 26), Bandate serrata extract (Example 27), nutmeg extract (Example 28), chiletta extract (Example 29), sesame extract (Example 30) Indosarsaparilla extract (Example 31) was used to prepare head creams of Examples 21 to 31 in the same manner.

  About the head cream of each Example, when the same test as Example 1 and 2 was done, the hair growth promotion effect and the hair loss prevention effect which were excellent also about any head cream were shown. Moreover, no subject complained of skin disorders such as skin irritation or allergic reaction in any of the groups using head cream.

Example 32 (Preparation of head lotion)
Among the blending components in Table 8, components (1) to (6) are mixed and dissolved at room temperature to prepare mixture A. Separately, components (7) to (19) are mixed and dissolved at room temperature. Mixture B was prepared. The obtained mixture A and mixture B were uniformly mixed using a stirrer to obtain a head lotion.

  About the head lotion of the present Example, when the same test as Example 1 and 2 was done, the outstanding hair growth promotion effect and the hair loss prevention effect were shown. In any group, no subject complained of skin disorders such as skin irritation or allergic reaction.

Example 33 (Preparation of head emulsion)
Among the blending components in Table 9, components (1) to (8) are heated and mixed to prepare a mixture A at 75 ° C. Separately, components (9) to (13) are added to component (19). The mixture B was prepared by heating and mixing at 75 ° C. The resulting mixture A and mixture B were mixed and emulsified using a homomixer and allowed to cool to room temperature to prepare mixture C. Components (14) to (18) were uniformly mixed with the obtained mixture C to obtain a head emulsion.

  When the same tests as in Examples 1 and 2 were performed on the head emulsion of this example, excellent hair growth promoting effects and hair loss preventing effects were exhibited. In any group, no subject complained of skin disorders such as skin irritation or allergic reaction.

Example 34 (Preparation of shampoo)
Among the blended components in Table 10, the components (1) to (8) and (15) were mixed and heated to 70 ° C while mixing, then cooled and added with components (9) to (14) at 40 ° C. After uniformly dissolving, it was cooled to room temperature to obtain a shampoo.

  About the shampoo of a present Example, when the test similar to Example 1 and 2 was done, the outstanding hair growth promotion effect and the hair loss prevention effect were shown. In any group, no subject complained of skin disorders such as skin irritation or allergic reaction.

Example 35 (Preparation of rinse)
Among the blending components of Table 11, components (1), (4), (5), (11) are heated and mixed to prepare a mixture A at 75 ° C. Separately, components (2), (3) Were mixed by heating to prepare a mixture B at 75 ° C. The resulting mixture A and mixture B were mixed and emulsified using a homomixer and cooled to 40 ° C. to prepare mixture C. Components (6) to (10) were uniformly mixed with the obtained mixture C, and then cooled to room temperature to obtain a rinse.

  About the rinse of a present Example, when the same test as Example 1 and 2 was done, the outstanding hair growth promotion effect and the hair loss prevention effect were shown. In any group, no subject complained of skin disorders such as skin irritation or allergic reaction.

  The hair nourishing agent composition, hair matrix cell growth promoter, and hair papilla cell growth promoter of the present invention are highly safe for the skin and have a good growth promoting effect on the hair matrix cells or hair papilla cells. (Hair growth and hair growth), exerts hair loss prevention effect. Moreover, in the cosmetic method of this invention, the hair-care agent composition of the above-mentioned this invention is applied to a scalp, and the hair growth promotion effect and the hair loss prevention effect are expressed. Therefore, the present invention is useful in the medical field or the cosmetic field.

Claims (7)

Nycanthes arborristis, Alstonia scholaris, Tinospora cordifolia, icola y, cinnamon Hair matrix growth promoter containing, as an active ingredient, an extract of at least one plant selected from the group consisting of Vanda roxburghii, and / or Myrtica fragrans, Swirtia chirata, Ceylon pine (Plumbergoz) ), Sesame (Sesum indicum) and Indian salsaparilla (Hemidesmus indicus) at least one plant extract selected from the group consisting of a hair papilla cell growth promoter containing as an active ingredient .   The hair nourishing composition according to claim 1, wherein the total content of the hair matrix cell growth promoter and the hair papilla cell growth promoter is 0.000001 mass% to 10 mass% in terms of dry solid content.   A cosmetic method comprising applying the hair nourishing composition according to claim 1 or 2 to the scalp.   Nycanthes arborristis, Alstonia scholaris, Tinospora cordifolia, icola y, cinnamon A hair matrix cell growth promoter comprising, as an active ingredient, an extract of at least one plant selected from the group consisting of Vanda roxburghii).   The total content of Indian Jacoboku, Alstonia Polaris, Tinospora cordifolia, Carotropis gigantea, Ceylon pine, Togoma and Bandate Serata in the hair matrix growth promoter is 0.000001-10 mass as dry solids The hair matrix cell growth promoter according to claim 4, which is%.   An extract of at least one selected from the group consisting of myrtica fragrans, Sirettia chirata, Ceylon pine (Plumbago zeylica), sesame (Sesum indicum), and Indian salsaparilla (Hemidesmus indicus) A dermal papilla cell growth promoter characterized by that.   The dermal papilla cell proliferation promoter according to claim 6, wherein the total content of nutmeg, chiletta, sesame, ceylon pine and Indian salsaparilla in the dermal papilla cell proliferation promoter is 0.000001 to 10% by mass as a dry solid content. .