JP2006241062A - Cosmetic composition and beauty / health food composition - Google Patents

Abstract

[PROBLEMS] To develop a safe glutamate decarboxylase activator and glutathione production promoter using plant components and to combine them to promote the production of γ-aminobutyric acid in vivo, as well as to improve rough skin, hair growth effect, skin A cosmetic composition with excellent cosmetic effects such as anti-aging effects, skin turnover promoting effects and the like, and in addition to such cosmetic effects, it maintains normal levels of neutral lipids and cholesterol in the blood to prevent obesity and arteriosclerosis Providing beauty and health-oriented food compositions useful for prevention.
A glutamic acid decarboxylase activator or glutathione production promoter comprising one or two plant extracts selected from bilberry and walnut as an active ingredient, and a cosmetic composition comprising these and a cosmetic / health product Oriented food composition.
[Selection figure] None

Description

  The present invention relates to a glutamate decarboxylase (GAD) activator comprising a plant extract as an active ingredient, or a glutathione production promoter and a cosmetic composition or beauty / health food composition containing the same. More specifically, a safe GAD activator with specific plant components and it are combined to promote the production of γ-aminobutyric acid (GABA) in the body, skin aging prevention effect (improved rough skin, keratin improvement effect, turnover speed) Cosmetic composition excellent in effect of speeding up skin, effect of beautifying skin, promotion of glutathione production), hair growth effect (blood vessel dilation effect, hair matrix activation effect), and whitening effect (effect of increasing turnover speed), and such beauty In addition to the effects, the present invention provides a beauty / health food composition excellent in blood pressure lowering, tranquilizing action, colon cancer suppressing action, liver function improvement, renal function activation, obesity prevention, and arteriosclerosis prevention effects.

GABA has been known to have cosmetic effects such as skin aging prevention effect (Patent Document 1), collagen production promotion effect (Non-Patent Document 1), hair growth effect (Patent Document 2) and whitening effect (Patent Document 3). It was done. In addition, when applied as a food, excellent effects such as blood pressure lowering, tranquilizing action, colon cancer suppressing action, liver function improvement, renal function activation, obesity prevention effect and the like were recognized (Non-patent Document 2). Furthermore, the healing effect with respect to gum diseases, such as gingivitis, was also known (patent document 4).
JP 51-148041 A. Scutt, Boichem. Pharmacolgy, (36) 8, P1333-1335 (1987) JP-A-62-255409 JP 03-63211 A Food and Development, (36) 6, P4-18 (2001) Japanese Patent Laid-Open No. 03-59754

  However, these were all intended for direct application or administration of GABA. GABA is expressed in vivo in various fibroblasts in addition to brain and pancreatic β cells, and GAD is known to be a synthase thereof. In the present invention, paying attention to the in-vivo natural synthesis system of GABA by activation of GAD, development of a GAD activator with a highly safe natural component, and using it, beauty and biological homeostasis by the natural action of the living body The composition which leads to a maintenance of property is provided.

  The present invention relates to a glutamic acid decarboxylase (GAD) activator, a glutathione production promoter, and a cosmetic composition and beauty / health food composition, each of which contains a specific plant extract.

As a result of screening many natural components useful as GAD activators, the present inventors have obtained knowledge that a plant extract selected from bilberry and walnut is extremely effective. In addition, they were simultaneously observed to promote glutathione production. Bilberry (also known as cypress) is Vaccinum myrtillus, and Walnut is Juglas regia. These plants can be used if they are available as herbal medicines.

  In the extraction from these plants, the leaves of the plant body are extracted as they are or after being pulverized, and then extracted with a solvent from room temperature to the boiling point of the solvent. Usable solvents are water, alcohols (for example, lower alcohols such as methanol, ethanol and butanol, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin), ketones such as acetone, ethyl ether, Esters such as dioxane, acetonitrile, and ethyl acetate, and organic solvents such as xylene, benzene, and chloroform can be used alone or in any combination of two or more. However, the specific plant used in the present invention is preferably extracted with a polar solvent in the screening process, because a higher GAD activity effect and glutathione production promoting action were observed. Therefore, water, ethanol, 1,3 -It is good to use the liquid mixture with water of polar organic solvents, such as butylene glycol.

  In the extraction method, the solvent 1 to 20 is usually used for the plant 1, and the immersion extraction is performed for 1 hour to 1 week at room temperature to the boiling point of the solvent under normal pressure. Further, not only normal pressure but also high pressure or supercritical fluid can be used. After extraction, the solution is recovered by filtration, and purification such as deodorization and decolorization is performed as necessary. The extract thus obtained can be used as it is as a GAD activator and as a glutathione production promoter. However, depending on the purpose of use, it can be diluted or evaporated to a paste or dried. You may process into.

  The cosmetic composition according to the present invention includes 1) topical or systemic skin cleanser or skin cosmetics, 2) medicinal and / or cosmetic preparations applied to the scalp and hair, and 3) bathing in bath water. 4) Deodorant / deodorant for human body, 5) Oral agents such as mouthwash, gargle, etc., 6) Sheet for skin application, cosmetic sheet, cosmetic cotton, hygiene product, hygiene It means cotton, wet tissue, etc., and can be in a suitable form such as ampoule, capsule, powder (powder), granule, solid, solution, gel, bubble, emulsion, sheet, mist, spray.

  Specifically, basic cosmetics such as lotion, milky lotion, cream, ointment, gel, lotion, oil, pack, mist, facial cosmetic sheet, shaving agent, facial cleanser, skin cleanser (including soaps) ), Shampoos, rinses, hair treatments, hair conditioners, permanents, hair nickings, hair dyes, hair cosmetics such as hair growth and hair restorer, makeup cosmetics such as foundation, lipstick, blusher, eye shadow, eyeliner, mascara, etc. , Perfumes, skin deodorants, antiperspirants, bathing agents, mouthwashes, toothpastes, mouth fresheners, and the like.

  Further, the beauty / health food composition according to the present invention means beauty and health-oriented foods, beverages, and oral preparations in general, and in terms of form, ampoules, capsules, pills, tablets (pellets), powders, granules, Solid, liquid, jelly (gel), air bubbles, etc. may be arbitrary. Specifically, nutritional supplementation, nourishing tonic, fatigue recovery, physical condition improvement, whitening, skin beautification, hair cleansing, hair growth / hair growth, slimming, mental stability, and other beauty / health-oriented foods and beverages, gums, candy, yogurt Favorable foods or beverages such as soft drinks are raised.

  The GAD activator and glutathione production promoter comprising the plant extract according to the present invention as an active ingredient means a form containing 0.001 to 100% of a plant-derived active ingredient, and the GAD activator and glutathione production promotion When blended into a cosmetic composition, the active ingredient concentration is about 0.001 to 5%. When blended into a beauty / health food, the daily intake of the active ingredient is 50 mg to 20 g. It is good to adjust so that it may become.

  The specific plant extract according to the present invention is excellent in glutamate decarboxylase (GAD) activation action and is safe. In addition to promoting the production of γ-aminobutyric acid (GABA) and glutathione in vivo, it also has excellent cosmetic effects such as skin roughening improvement, hair growth effect, skin aging prevention effect, skin turnover promotion effect, etc. The effect of maintaining normal levels of neutral lipids and cholesterol is observed. Therefore, the GAD activator of the present invention has a high utility value as a cosmetic composition useful for maintaining beauty and homeostasis, and a beauty / health-oriented food composition.

  EXAMPLES Hereinafter, an Example is shown and this invention is explained in full detail.

(Manufacture of plant extracts)
After the plant (100 g) is pulverized, a solvent (1 kg) is added, soaked and extracted at room temperature to warm, and then suction filtered to obtain an extract (about 1 kg). By this operation, plant extracts (samples 1 to 18) as shown in Table 1 were obtained.

(Measurement of GAD67 expression promoting action)
Normal human skin fibroblasts (NB1RGB Riken Cell Bank) were cultured in a DMEM medium (Sigma) containing 5% fetal calf serum (Thermo Trace) under conditions of 5% CO ₂ and 37 ° C. Cells were seeded at 1 × 10 ⁵ cells / ML in a 60 mm dish and cultured at about 37 ° C. for about 72 hours until confluent. Each plant extract (samples 1 to 18 produced in Example 1) was added to the culture solution to a final concentration of 20 ppm and incubated at 37 ° C. for 24 hours. As a control, an extract containing only the extraction solvent was also incubated. After 24 hours, intracellular proteins were extracted from the cells using RIPA buffer (50 mM Tris-HCl, pH 7.5, 1% -Nonident P-40, 150 mM NaCl, 0.1% SDS), and the protein amount was determined by the Bradford method. Was measured. GAD67 in the extracted protein (10 ug) was detected by Western blotting. The expression level of GAD67 protein was quantified with a densitometer, and the expression ratio with the control was calculated.

Table 1 shows the results.

(Measurement of glutathionic acid production promoting effect)
In normal human skin fibroblasts, the final concentration of solids was 20 ppm and each plant extract (samples 1, 3, 5, 7, 9, 10, 12, 14, 16, 18 produced in Example 1) was used. Each was processed. After 24 hours, the total amount of glutathione in the cells was measured using a Total Glutathione Quantification kit (manufactured by DOJINDO) and compared with the control.

Table 2 shows the results.

(Skin roughening action)
In order to evaluate the improvement effect of the GAD activator according to the present invention on rough skin, a sample application test was performed using a guinea pig on which a rough skin model was created. The sample was prepared by drying the plant extract prepared in Example 1 and re-dissolving the obtained solid in purified water so as to have the same concentration. Moreover, it implemented also only about the purified water as a comparison object.

(Method) A Hartley guinea pig (female, 5 weeks old, 3 per group) with hair removed on the back was applied to 3% by weight of white petrolatum for 3 days. Created rough skin. The skin roughness preparation site was divided into 4 minutes, each sample (1.0 mL) was applied 3 times / day, and the degree of skin roughness was evaluated according to the criteria (score) determined by observation after 3 days.
(Criteria) 1 point with almost no erythema or desquamation
2 mild desquamation without erythema
3 moderate desquamation without erythema
4 pieces of desquamation with weak erythema
5 desquamation with moderate erythema
6 debris with significant erythema

The results are shown in Table 3. The sample was found to be effective in improving rough skin.

(Hair growth action)
About 8 cm ² (length 2 cm, width 4 cm) of the back of the C3H mouse was removed with an electric clipper and an electric shaver. Next, the sample hair tonic (Table 4) was applied once a day, about 0.2 mL 5 days a week for 20 days on the back from which hair had been removed (the test animals consisted of 3 animals in 1 group, the back was the left side, the right side) And apply sample hair tonic and control hair tonic respectively). Judgment was made by measuring the area ratio (%) at which hair regeneration was observed with respect to the hair removal area on the 12th and 20th day after application, and comparing it with the control group (test method of Ogawa et al. (See Fragrance Journal, Vol. 17, No. 5, pages 20-29 (1989)). As a result (FIG. 1), the hair-growth action was recognized by applying the sample hair tonic.

  As experimental animals, 8-week-old male C3H mice were used. These animals were kept in an environment of 20 to 24 ° C., humidity of 35 to 65%, all fresh ventilation 15 times / hour, and lighting 9 hours / day. The animals had a solid feed MF (Oriental Yeast Industry) and tap water ad libitum.

(Skin anti-aging effect)
Irradiate the back of hairless mice 3 times a week (36 to 216 mJ / cm ^{2 each time} ) with a total amount of 4 J / cm ² ultraviolet rays (using 6 FL20S-E lamps and 3 FL20SBLB lamps manufactured by Toshiba) for 10 weeks did. A sample (plant extract prepared according to Example 1) was applied to the back by 100 μL one hour before ultraviolet irradiation. The animals were divided into 3 groups per group, and a group not irradiated with ultraviolet rays was also provided as a control. After the ultraviolet irradiation for 10 weeks, in order to measure the viscoelasticity of the back skin, it was measured with a skin viscoelasticity measuring instrument (CUTOMETER SEM474 manufactured by Eurotech Japan).

The measurement principle is as follows. Aspirate the skin at the measurement site and then release the negative pressure. Waveform processing is performed on the skin return that occurs at this time. FIG. 2 shows a typical waveform measured with CUTOMETER SEM474. The upward waveform is when negative pressure is applied, and the downward waveform is when negative pressure is released. The Uv value is a plastic part of skin viscoelasticity, and in the case of a highly elastic body, there is almost no plastic part and the value is extremely small. Middle-aged skin has an extremely high Uv value. The degree of plasticity was obtained from the following equation.

Plasticity = Uv value / Ue value

  The Uf value indicates the maximum suction value. The Ur value indicates the waveform that returns after the negative pressure is released and the suction is completed. In the case of a highly elastic body, Uf value = Ur value. Two waveforms are observed in the case of a highly viscous body. The elastic portion Ur is directed vertically, and the viscoelastic plastic portion Ua is directed horizontally. If the skin is rich in elasticity, Uf value = Ur value. The degree of elasticity was obtained from the following equation.

Elasticity = Ur value / Uf value

  The results are shown in Table 5. By applying the sample to the skin, the skin elasticity improving action is significantly improved. Therefore, application of the GAD activator of the present invention to the skin is considered to be a particularly effective means for preventing skin aging by ultraviolet rays.

(Skin stratum corneum turnover promoting action)
In order to examine the effect of the sample application on the turnover rate of the stratum corneum, the disappearance rate of the dye adsorbed on the skin was measured. In this test, the method using dansyl chloride (J. Soc. Cosmet. Japan, Vol. 20, No. 3, P. 186 (1986)) was used. The normal skin stratum corneum turnover is 14 to 16 days, and the aged skin stratum corneum is about 18 days.

  In the test, dansyl chloride, a fluorescent labeling reagent for amino acids, was applied to and stained on the inside of the forearm of both hands and on each of the two skins (four places in total) for 24 hours, and then samples were placed on three places. Purified water was applied twice in the morning and evening as a control (using the plant extract prepared according to the above example). An ultraviolet lamp was irradiated to the site stained with dansyl chloride, and the daily change in which the fluorescence due to each dansyl chloride disappeared was visually confirmed and compared with a control to determine the average number of days lost. Table 6 shows the results. The sample application site was found to have a skin stratum corneum turnover promoting effect as compared with the control. No one complained of skin abnormalities during the period of use.

(Prevention of obesity and arteriosclerosis)
In order to examine the effects of GAD activator intake and the amount of neutral lipids and cholesterol in the blood, 6-week-old male Wistar rats (7 rats per group) were allowed to use the diet shown in Table 7 The animals were fed and reared for about 7 weeks, and changes in body weight, serum neutral fat (triglyceride), and total cholesterol were examined. The results were as shown in FIG. That is, as apparent from Table 8, the serum total cholesterol was not significantly different among the four groups by administration of the GAD activator, but it was recognized that the serum neutral lipid decreased. Moreover, from FIG. 3, since the tendency to suppress weight gain was also observed, it was suggested that the GAD activator according to the present invention has an obesity and arteriosclerosis-preventing action.

  For the cosmetic composition and beauty / health food of the present invention, in addition to the GAD activator containing a specific plant extract as an active ingredient, the ingredients and additives exemplified below are optionally selected as necessary Can be blended.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber oil, safflower oil , Shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, palm Oil, beef tallow, pork tallow, squalene, squalane, pristane or hydrogenated products of these oils (hardened oil, etc.).

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax and the like.

(3) Mineral oils Liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax, etc.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid Synthetic fatty acids such as natural fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) Alcohols: natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol .

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate, Diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) gum, sugar or water-soluble polymer compound gum arabic, benzoin rubber, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose or ester thereof, Trehalose or its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C ₂ -C ₄ ) chitin or chitosan to which alkylene (C ₂ -C ₄ ) oxide such as ethylene oxide is added Low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethylcellulose, methylcellulose, cal Polymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide, polypropylene oxide, etc. Alkylene oxide or its crosslinked polymer, carboxyvinyl polymer, polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt), amphoteric Surfactant: Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant ( Ether type nonionic surfactant, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other surfactants ( Natural surfactants, protein hydrolyzate derivatives, polymer surfactants, surfactants containing titanium and silicon, fluorocarbons System surfactant), and the like.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), Riboflavin (vitamin B2), pyridoxine (vitamin B6),
Cyanocobalamin (vitamin B12), folic acids, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol ( Vitamin D3), dihydrotaxol, vitamin E group: vitamin E or derivatives thereof, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), others Essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U and the like.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine , Arginine, ornithine, histidine and the like, and their amino acid derivatives such as sulfate, phosphate, nitrate, citrate or pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, fermentation, purification) , Compression, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc., arbitrarily selected and combined), arbitrarily selected from various materials You can use it.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol 1 type selected from various organic solvents such as lower alcohols such as isobutanol or hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or hydrous polyhydric alcohols, acetone and ethyl acetate Alternatively, it is desirable to use a mixture of two or more. However, when it is not preferable to contain an organic solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. The thing extracted and extracted may be sufficient.

  In addition, when using additives derived from plant or animal-based ingredients for systemic or topical external preparations and cosmetics, it protects skin and hair, moisturizes, improves touch and texture, imparts flexibility, and stimulates Relieving stress, relieving stress due to fragrance, cell activation (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, preventing hair loss, imparting luster, cleansing effect, In addition to cosmetic effects such as fatigue relief, blood flow promotion, and bathing effects, effects such as flavoring, deodorization, thickening, antiseptic, and buffering can also be expected.

  In addition, in food and drink, nutritional supplementation, fatigue recovery, tonicity, cell activation (cell aging prevention) and other healthy and cosmetic effects, as well as improved taste, color tone, aroma, gloss, stabilization, thickening, It can be used for antiseptic purposes. In addition to this, we expect various cosmetic and pharmaceutical effects of each of the raw materials known so far, and by combining these, we aim to enhance the target effect or to have a multifunctional effect It is also possible to make a product that expects

Specific plants (herbal medicines) as raw materials include, for example, almonds (toen), ai (indigo leaves), aokazura (Keifu Fuji), Aoki (Aoki), Aogiri or Kenashia Ogiri (Ao Tung), Aotsu Samurai (wooden candy) , Aotenma, acacia, red ginseng, red spruce `` fruit '', red clover, red grapes, red ginseng (logwood), red wrinkles (red buds), red crested or red crested or reddish (root), red crested or reddish (ground yellow), Agi (Aki), Aki larch, Akinire (crusted skin), Aguay Guassou, Aguahe (Omiten coconut palm), Akebi (Kitsu), Asa (Asakojin), Maruba morning glory or morning glory (Chicken), Hydrangea (hydrangea), Ashitaba (Tomorrow), Azuki (Red Azuki), Asunaro, Acerola, Asenyaku (Asenyaku), Athira (Shokuyokanna), Anise, Abiyu, A Biurana, oilseed rape, Abemaki `` fruit '', avocado, ama, achacha (Amacha), Achacharu, Amadokoro (Jade bamboo), Amana (a light-hearted), amaranth (Hyuyu, Hagatetou, Himogeito, Senninkoku, Sugimorigateto, Hosoaogeito, Hasoagoito Aozulan, Amaranthus hypochondriacus), Amigasayuri or Baimo (shellfish mother), Aristolomeria (Yurizuisen), Arcana (Alcanna), Algarrobo (Cabe), Altea, Arnica, Alpinia or Katsumadai (Suzukuku), Aloe (蘆薈), Aloe vera, angelica, apricot or honanzu (Anzujin), Ansokkou (benzoic incense), yellow support, igakozolina (geo-biliary head), licorice or gecko licorice (indian oyster), rush (light heart grass), itadori (tiger cane root), yew (one Place), Strawberry, fig (no flower `` fruit, leaf ''), Ichihatsu (first), Ichibi (winter lion), Ichiyakusou (one medicinal herb), ginkgo (Ginkgo `` seed, leaves ''), Japanese yellow peas (distant), carob, Japanese beetle ( Taillexi), Inubiyu (Honagainubiyu), Rice `` Seeds, Seed coat '', Inondo `` Seeds '', Ibuki-so-sou, Nettle, Ylang-ylang, Iwa-tobacco (Iwabuchi), Iwahiba or Iwamatsu (rolling mushroom), kidney beans, oolong tea, fennel (mustard) , Wheat (Chibusanoki), Ukiyara (Sanryo), Uguisukagura `` Fruit '', Himewikyo, Turmeric (Urban), Duckweed, Usubasaishin or Keirinsaishin or Oshusaishin (spicy), Usvenia Oy, Usbeni Hollyhock, phalaenopsis, weevil (summer hay), udo or shishiudo (gung, alone, tangy), unyadegato (unkari) A, Cat's Claw), Uba tea, Ume (Japanese apricot `` seed, pulp ''), Japanese white beetle, Uwaurushi (Kusako-kemomo), Unshuumika (Chen), Unboku, Estragon, Ezoukogi (Tomogoka), Ezo-suzuran, Echinashi (Hosobamurasaki Barengiku) , Enishida, Enokitake (榎 茸), Ebisugusa or Cassia Tora (Keiko), El Campre, Elderberry “fruit”, Elemi, Elingi or Pre-Lotus Elinji, Enju (Safflower, Camellia rice), Pea, Ogi or Kibanaogi (Yellow Twilight), Naruko Yuri or Kagura-mabanaru Koyuri (Yellow), Ohisasa Yuki or Sasano Yuki, Ouren (Yo Ren), Ogata Houken, Okarasuri (Karokon), Oguruma (Civil Works Incense), Otsu Samurai (Prevention), Psyllium , Car forage), toucan thistle (Zhengzhou leakage, bald eagle), toucan Mi (coconut palm), Toucan cactus, Ovana okera or okera (white moth), Osara squirrel (Banaba), Ooyabaya shabushi "fruit", Oohashigusa (cereal sperm), Omia catechu, Oomihasa or hawthorn (Mountain vegetation), Omiyashi, Omiji Barley), Oka, Okazeri (snake bed), Okra `` fruit '', Oguruma (overturn), Oguri higotai (Zhengzhou leakage, indigo head), Panax ginseng or Tochibaninjin (Ginseng), Hypericum pertussis or Pterotus pertussis or Hypericum perforatum (Brother cut grass), Odorikosou (continuous), Onamomi (Circle ear), Onigomi, Onikoro or Tokoro or Nagadokoro (Hikai), Oninoyara (Tempa), Onyuri or Sasayuri or Hakatayuri (Yuri), Onoelan, Ononis, Halibut楡), Ominae (losing sauce), Yuuko, Dutch mustard (watercress), Ora Dazelli, Dutch beech, Dutch bees, olives `` fruit, seeds, leaves '', oregano, orange `` fruits, peels '', silkworm (ripe yellow), cacao `` fruits, peels, seeds '', oysters (bamboo `` leaves ''), Kagi-Kazura (Katsufuji), Kakidooshi or Kantorisou (Lotus), Kakiran, Gaku Hydrangea, Cassia, Casinoki (fruit berries), Gadju (Kashiwa), Kashiwa (Kashiwagi, Kashiwa), Cascarilla, Cascala Sagrada, gypsophila, gypsophila, cynomolgus (Kinshato), kaniwa, carnation, valerian (valerian), hippopotamus, birch or fern birch (white birch), gerbera, pumpkin, kapokoki `` seed '', kahoku salamander (蜀椒), gama Yellow), chamomile or roman chamomile, chamomile (weed), cam cam (camo duck), collar, chrysanthemum, calla or cinnamon , Oat biscak (half summer), oats, guarana `` seed '', carahoo (kokubaku), karaya, galyu, karin (garden), garcinia, kawamidori, kawara-saiko (reeled rape, white millet), kawajisha, kawaratake, kawaranadeshiko ( (Stone bamboo) or Ezokawaranadeshiko (buckwheat noodles, buckwheat), Chinese carrot (blue potatoes), Chinese mugwort (bamboo chin mackerel), kansui (kansui), licorice (licorice), kantarasa, candelilla, kanto, canna, kanran, raspberry (ezo strawberry) , Dutch Strawberry, Shrimp Strawberry, Nawashiro Strawberry, Momiji Strawberry, European Raspberry Strawberry), Kiwi `` Fruits, Leaves '', Kikarasuuri (Gurone), Chrysanthemum (Kikyo, Kikyo-root), Chrysanthemum (Chrysanthemum, Chrysanthemum, Datura), Kikutanigiku, Kisage (Salmon), Gigigishi (sheep hooves), pheasant (salmon), Kizuta, Kidachi aloe, Kidachi mint , Quina, linden (shinkona, red linden), quinoa (quinoa), yellowfin (yellow tuna), bean, gymnema sylvester, kimenkaku, cabbage, cabbage `` unripe fruit '', caraway, cucumber, gyory (Nishikawa willow, tail willow), Kiraja saponaria, Kiraya, Kiransou (Kinza small grass), Kumquat `` fruit '', Kinkiju, Ginseikai, Kimbusen, Kinma, Kinkihiki (Sentsukusa), Kinlan, Ginlan, Ginryohen, Guapeba Vermela, Guava `` Fruit '', Guayule, Quercus・ Infectria (garlic pods), kukui nuts, kugenumaran, wolfberry (bamboo shoots, coconut palm leaves, cocoon leaves, ground bone skin), cedar casserole (Tenmon winter), kudu (kudzu), camphor tree, gooseberry `` fruit '', ginseng (yellow flower candy) ), Kutiti River, Gardenia (Yamako), Kunigi (Kusou), Kupu , Kubeba, Kumazasa, Kuma-tsutsura (horse whip grass), Clara (bitter), cranberry `` fruit '', chestnut `` seed, fruit, astringent skin '', curcumigo latifolia `` fruit '', grapefruit `` fruit and leaf '', buckthorn, kuroganemochi ( Rescue), Kamehiba Kokoshi or Kurobana Hikikoshi or Hikiokoshi (prolonging grass), Clove (clove, clove), Gumbai Tuna (Sekimei, Sekimeishi), Keigai (Kashiwa, Hakuho), Celosia (Chicken flower, Chicken crown), Gekkavidin, Gecko (Laurel Tree), Kenashi Sartoribaira (Dogo, Mountain Return), Gentiana, Gennoshouko (Old Grass), Kemponashi (Kigushi), Kokisekoku, Kishimizukan (Koji, Tachibana, Obenimikan, Fukurimikan, Sagamikouji, Ponkan, Santara Skin) ), Koshinbara (monthly flower), Koiusui mint, Kozo `` Fruit '', kocha (tea), kohone (river bone), koh hong (Tsubakimoto, Karamotomoto), Kouriang, Kouryokyo (Koryo), cilantro `` fruit '', Koouren (Huo Ren), Koganebana (Yellow Gon), cowberry (Etsu) Tachibana), Coco `` fruit '', Goshuyu (Kurei), Gosho strawberry (Golden bonsai), Pepper (Pepper), Cosmos, Copaiba balsam, Coffee `` Seeds, leaves '', Kobushi or magnolia (hot pepper), Burdock (Beef bowl, Gyudon) ), Coconut lees, sesame (sesame seeds), sesame seeds (genus ginseng), trash (goji), saneka or binankazura or pine bush, wheat (wheat), rice or rice bran `` red potato, white birch '', rice oil, cola acminata `` seed '' , Cola Bella "Seeds", Colony Lilla, Koroha "Fruits", Colombo, Conzurango, Kombu, Konjac, Comfrey (Chang Zhang grass), Sisal (Sisal Asa), Cy Hailan Sakaneran (Ezosakaneran), Sasima button eel or Sina button eel or Cinnamon ginseng (weikensen), Sakura (Ooshima cherry, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyazakura, Someiyoshino, Takanezakura, Kasamikan, Sakura, Sakura, Sakura Fruit, bark (cherry bark) ''), cherry, pomegranate, sasa, sababagin orchid, sasanqua, sardine sardine (salmon), sweet potato, sugar cane, sugar beet, sunflower jujube (saccharin), saffron (bancho flower, west safflower), sapodilla, sapotea mariyo , Pomelo `` fruit '', savonso, salmon berry `` fruit '', salamander (sasma), salamander (sand indigo sashimi), salvia (sage), scallops (bamboo rape), sawagurumi (wild walnuts), sankaku cactus, sangre Degrad ( Loton), Salamander, Sansino Ginseng (37 ginseng), Sanshuyu (Yamamuro), Sansho (Yamamuro), Sandskon (Yamazune), Shea (Kalite), Cyano `` fruit '', Shiitake mushroom (Shitake), Sion (Purple spider), winged bean, jikitarisu, shikunshi (messenger), perilla or ajizo or chimmentiso or catamenzo (purple leaf, shisoko), rosewood, linden tree, red-faced syringae, renilla (ream), shimeji (hinshimeji, shakashimeji, hatake-shimeji (Shimeji, Beechhimeji, Honjimeshi, Shirotamogitake), Shimokuren (hot pepper), Shimosukeso, potato, peonies (shakuyaku), shajin (shasan), jasmine (matsurika), janohige (barley winter), shrimp scorpion, shukukonka miso, Shukushamitsu (sand, crushed sand), Juzdama, Shul "fruit" Oyashi, Ginger (Ginger), Zouzan Hydrangea (Tsuneyama), Shobu (Bamboo, Sone), Shozu "Fruits", Shirakashi "Seeds", Silane (Biacyu), White Rooster "Seeds", White Clover (Clover), White Clover (chicken) Bone grass), White squirrels (Nioiris), Shirobanatsuta "flowers", Shirobana rupin, Shirominanten (Nan Tenshin), Cinchona sylbula, Ginkgo biloba (Mizuka, Mizuka flower, Shencho flower), Cinnamon, Cinnamum cassia (cinnamon), watermelon (Saijo), Honeysuckle (Silver flower, Shinobu), Sorrel (Acami), Swimberry `` Fruit '', Star Apple, Stevia, Strawberry `` Fruit '', Suzu-Psycho (Xucho), Sugina (Question), Suburihiyu (Horse tooth soap, (Horse teeth), plum (fruit), sulgaran (oran), Japanese red pine cone, Japanese larch, Japanese pine Ukizuta, Japanese walnut, Japanese hawthorn, Japanese cypress, Japanese dandelion, Japanese horse chestnut (Maroni), Japanese pear `` fruit '', Japanese cypress, Japanese elder (Elder), Japanese squirrel (Juniper, Juniper), Japanese yarrow (Milfoil), Japanese cypress Roses, pearl butterflies, mistletoe, Atlantic mint or wild mint (Dendrobium, sarcophagus), Cedron (Boshushuboku), Zeniaoi, Hiroha Senega, Senega, Seri, Celery, Senkyu (river cucumber), Senshinren (Pureshinren), Sendan, Se Ninja cactus, senna `` fruit, leaf '', ginseng (daikon), senburi (medication), senboku, soka (grass), elephant clover, soshinwaby, buckwheat `` seed '', potato monogram, broad bean, daiou (daihuang), radish, Soybean, Daidai (orange peel, fruit), Takasago Gurihigotai (southeast indigo sashimi), Takasaburo (Cirrus lotus), Takatodai (Daisatsu), Takaharabi (Cirrus), Dark sweet cherry `` fruit '', hollyhock (Thyme, Hyorika), Tachidokoro (Hikai), Tachiyanagi, Tamarind `` Seeds '', Onion, Tamshiba (hot pepper), Taranoki `` Fruits, leaves, root bark '', Tarayo (Large winter blue, Ichiha tea, bitter tea, bitter tea ), Dahlia (Tenji button), Tarwi, Tankimi, Tanshichiwa, Tanjin, Dandelion, Shirobana Dandelion or Mouko Dandelion, Damma , Cherry `` fruit '', chigaya `` fruit, root, sprout '', chiketsu carrot (bamboo carrot), chicory, champaedera (tufted licorice), tulip, choco no stay, datura (artichoke), ginkgo biloba (large yellow), Korean senile (mushrooms), Korean mugwort (mushroom leaves), choreimaitake mushrooms (mushrooms), chorogi, camellia, tsukushikaneran, tsukuritake (mushrooms), azalea, camellia, camellia, tsumeksaku (lacquered licorice), camellia (duck moth grass) ), Tsuruzuki (Red Azuki), Tsurutsuchiakebi, Tsurudokudami (What Noodles), Tsuruna (Apricot), Tsuruninjin (Yotsuba Ginseng), Tsurume, Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruits '', Tengusa, Tencha (Salmon Tea), Tendai Yaku (Samurai) (Medicine), red pepper (winter lion), red pepper, red pepper (banban), red pepper ), Pearl millet (marigold), red horned beetle, tounabena (river cut), corn or corn hair (southern cocoon), gerbil mochi (sadako), turpentine or ginseng (dragon gall), toxa (wood bandits), doddam (Medicine), tokon (root), toshishi or bean pod or pear pod, eucommia (bark, `` bark, leaf, root ''), ash (crust), tomato, tragacanth, triacanthos `` seed '', turkish leopard, tormentilla, dronoki, trorooi Ton bean, Niseria berry `` fruit '', Chinese yam or yam (Yakuyaku), Nagii kada (Bucher bloom), Naginata Kouji, Nazuna, Rapeseed, Solid bean or Vertical bean (Sword bean), Natsumikan, Jujube (Otsuchi), Naniwaibara ), Navena (continuous), Nameko, peanut (peanut), Nanten (Nami Tenmi), Nan Carambola (Hemp), Japanese violet, Nigaki (Nagi), Nigorimogi (bitter), Nikuzuku, Kay or Nikkei or Ceylon Nikkei or Yab Nikkei (Kinshikashi) or Keishi (Katsura), Nyo-bachidori, Nira (coconut), Niwatoko (Bone, fruit, flower, stem, leaf)), garlic (large cocoon), nulde (pentapod), leek, nemkin or nebu or nebi or nemlinoki or zigokubana (community), white thistle (large cocoon), noibara (fruit), nozenkazura (Lingen Flower), Nogateto, Yarrow, Nodake (Plum), Novara, Peach, Pineapple `` Fruit '', Hibiscus (Bussouge, Furiinbusouge, Roselle), Hirindo, Hauchiwa, Pau Dorse, Hakamau Labosi (Bone Fracture), Hakukayuto , Hummingbird, Huxen (Ringworm skin), Hackleberry "fruit", Jacobe (traditional), Hazel (coconut), Hasiliko (Roth root), basil, lotus (lotus, lotus meat, lotus), parsley (holland jellied), hadakamugi, batata, wasp or mushroom (bamboo bamboo), patchouli, mint (light load, light load leaf), yellow pea, pearl barley (yokuinin) ), Hanasuge (my mother), Banana, Hanahaku, Hanabishi (Sitoshi, Shishitsuri), Vanilla bins, Papaya, Hakogakusa (Paso), Pahalobo, Hub "whole grass, stem, leaf", paprika, Hamakakiran, Hamago or Mitsubahamago (Vulgaris), Hamasuge (Kosuke), Habishi (Shitsuko), Hamanasu (Maika Flower), Hamaboufu (Hamaboshi), Hamamelis, Palm, Rose (Rose), Balata, Balata rubber, Agaric (Agaricus, White-faced agaric), Usukimori no Kasa), Haran, Pariurus (Hana Natsume), Parietalia, Harkanran, Balsamina (Turureishi, Niga) (Uri), Harunire (crusted bark, whitened bark, coral leaves), Barbasco, Harlindow, Handaikai (Cotton Ocean), Panoki, Hagigi (Ganoderma), Hikagetsu Carrot (Ginseng), Pecan nuts, Higanbana (Ishibuchi, vine pearl) Shahua), Higuramidaria, Higotai, Hishi (Hishimi), Pistachio, Beet, Hitotsuba (Ishizuchi), Hitotsubuenishiida, Daisies (Daisy), Hinata Taikozuchi (cow knee), Daisies, Hinoki, Hiba, Castor, Sunflower, Peppers, Himeuzu (Tengu), Himegama (Kaori), Himematsutake (Kawariharatake, Hiromatsutake), Himemuyoran, Pimenta "Fruits", Bikushi, Bikkyu, Hiyu "Fruits", Chickpeas, Flounder, Bellows Aoi , Loquat “fruits, leaves, stems”, betel wax (large clothes skin, coconut), puer tea (fuyu tea), peas (south wicker), Japanese cypress, Japanese dandelion (Fuji winter flower, Japanese winter leaf), Fujibakama (Orchid grass), Fuji bean (Tsuname), Fujimodoki (Chujizakura, Camellia flower), Grape `` Fruits, pericarp, seeds, leaves '', Beech, Fuyumushinatsusatake (Cycium summer grass), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant coconut, black currant `` fruit '', blackberry, buranyen, plum `` fruit '', fullcellaria, blueberry (Prunus japonica), prunes, floral blanka, blond psyllium, bundo ( Mung beans), hazelnuts, loofah, hetsukaran, safflower (safflower), heneken, belladonna, berries `` fruit '', persair, pervianburg, pereschia grandifolia, crabs or duckweed (scenic sky), boysenberry `` fruit '', scallop or narcissus Or Nendo or Hahagigi / Kokia (Golden), Hosairan, Hosenka (Akansen, Acute Child, Pelvic grass), Pouteria sapota, Pouteria rukuma, Honoki, Bofu (windproof), Spinach, Physalis (Torune), Honoki (Japanese thickness) (Park, Park), Bokeh (Bamboo Tree), Hosoba Abraciku (Bitterwheat), Hosobaa Guruma, Hosobanaokera (Bamboo Tree), Hosoba Kirinso (Keiten Sanshichi), Hosobabarengiku, Bodaiju (Bamboo Tree), Button (Peonies `` Flowers, Leaves, `` Stem, bark ''), button pi (peony skin), hop, jojoba, borage (Lulichisha), Bordeaux, white berry `` fruit '', hononiku (meat juju, large art), honsekkok (iron crust stone sparrow, sparrow mountain sarcophagus) , Mizul Tennan Show (Tennan Star), Maitake (Maiko), Maou (Mao), Maca, Macadamia Nuts, Margaret (Mokushungiku), Macri (Seaman Grass), Muwa (Mulberry White Bark `` Bark, Leaf ), Magnolia splengeri, Massaran cuba, Masaransuba de Cearár, Masheira de Boi, Mashua (Tamanosen Hallen, Kyukonkinrenka), Matatabi (wood tengu), Matsukasa, pine `` leaves, bark, root '', matta・ Ohryo, Matsuhodo (茯苓), Matico (Cordon Shijo), Mayoram (Hanahakka), Malvanojadin (Bitter), Mulberry `` Fruit '', Quince, Malene (Biloud Mozuika), Mango, Mangosteen, Manzanya (Andesukamite), Manshu Gurumi, Mandarin `` Fruit '', Mannentake (Ganoderma biloba), Pheasant (fruit `` fruit ''), Mishima Saiko (Shibahu), Mizuoobako or Mizuasagao (Dragongrass), Mizokakushi (Half-sided lotus), Misohagi Japanese willow or elder willow (Henpo), Mitsugashi, Mitsuba, Midorisapote, Midorihakka Mimosa, mioga, miracle fruit `` fruit '', myrrh, milobaran, wheat straw, mugweed, mugwort, mugwort (prolonged skin), munya, murasaki (purple root), murasakikib or omurasakikib (purple pearl), murasaki corn, murasaki natsu Fuji (Kunming chicken blood wisteria), Megakansa Opuntica, Mehajiki (beneficial mother grass), Mebougi, Melaroika, Melissa, Merirot, Melon `` Fruit '', Moukomugigi, Mosouchiku, Mokkirin, Mogi (Pepper), Mochinoki, Mokko (wooden incense), Japanese maple peach, peach (peach `` leaves, seeds, flowers, fruit ''), coconut palm, morero cherry `` fruit '', morohaya (burlap), yakawa potato, yakuchi (masutachi), cornflower (cornflower), cornflower mint, Yacon, Yashabushi (Yowa), Himeya Sabushi or Oobaya Sabushi Fruit, pericarp, spikelet '', willow willow, starfish (octagonal gold plate), mistletoe (willow infestation), willow (kawayanagi, tachiyanagi, weeping willow, red willow, cat willow, incolyana, kinuyanagi, koryanagi, unagi willow, willow, willow , Tairikunu willow, fox willow, dronoki), willow tree `` leaves, stems '', jabgarashi, yabukouji (purple gold beef), yab tobacco (crane tsumugi, Tenmeisei), pokeweed (shoku land), yamahanoki (yamabuchi), bayberry (bamboo ume) Skin), wormwood, eucalyptus, yukinoshita (tiger ear grass), yucca or flevifolia, yuzu `` fruit '', lily, crocodile, mugwort (carp leaves), ligan (Raimaru), lime `` fruit '', rye, lacanca `` fruit '', Raspberry `` leaves, fruits '', latania (chlamelia), raccoon or shallot (薤White), lavender, longan (longan), agave (Aonu agave, fuchlin agave), ryokucha (green tea), apple `` fruit, seed, leaf, root '', gentian, lubas or suabisimus (cool), rulitama thisami (urajiro higotai, Xinjiang indigo sashimi), litchi (toothpick, toothpick core), lettuce (chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or syringae (ream), forsythia, wintersweet ), Wax palm, locon (Yoshi, Sone), Loganberry “fruit”, rosemary (Mannenrou), rosehip (Nobara), wasabi, cotton-butterfly (Ming Mongolia), bituminous (land).

  As seaweeds, seaweed [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (usba aonori, Sugiaonori, Hiraaoori, Boaonori, Hosoeda Aonori), seaweed [Brown algae] (Macombu, Resilibu, Hosocome, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis Integrifolia, Neocitus Ruetkeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Umiuchiwa, Akaba Umiuchiwa, Konami Uchiwa, Okinawa Uchiwa, Usuki Uchiwa, Etuki Umi Uchiwa], seaweed [Red Algae: Hijirimen, Maca (Tengusa), Hiluxa, Syria, Oaxa Caterpillar, Yatabegusa, Yuukiri, Shimatengusa, Tosakanori, Togekirinsai, Amakusakirinsai, Giraffe, Juniper ginkgo rhinoceros, Tsunomata, Totsuka (Yahazutsu notamata), Ezotsunotamata, Togetu no Takita , Yaleus banori, Kagius banori, Susius banori, Haius banori, Akamo mizunori] and the like.

  In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Anemone: Quanomomo, Volbox: Ougenmawari, Volbox, Palmera, Yotsumeo, Aomido: Chrysanthemum, Aoumidro, Tirguimidro, Hibidoro: Hibidoro, Aosa: Anaaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Friccella, Shiogusa Magama genus: Magamata, Iwagata: Fusaikawa, Surichogata, Heraiwata, Kurokita, Hanemo, Genus: Mill, Chromel, Sakibutimil, Nagamil, Hira Lemon, Casanori genus: Casanori, Jusmo genus: Jujusmo, Tamajusmo, Mizojuzumo, Mika ヅ kimo, Korekaete, Tsutsumimo genus: Kyukougusa, Hitogususa genus: Humanegusa, Hirohatohigususa, Umushihimoe, Sakikimoe Sumiremo: Sumiremo, Hoshimamidro, Fushinashimidoro etc.).

  Cyanobacteria (Suizenjinori genus: Suizenjinori, Aoko genus, Nenjumo genus: Kawatake, Ishijelly, Hassai, Yuremo, Rasenmo (Spirulina): Spirulina, Trichodesmium (Iaciasio), etc.).

  Brown alga Sanadagusa: Sanadagusa, Fukurimamiji, Commongusa: Commongusa, Yahazugusa: Ezoyahaz, Yahazugusa, Uraboshiyahaz, Jigamusa: Jigmygusa, Umichiwagusa, Umamisakugakua, Hakusou : Navarimo, Chasomen genus: Motsuki Chasomen, Matsumo genus: Matsumo, Nagamatsumo genus: Nagamatsumo, Okinawa mozuku: Okinawa mozuku, fake Tomozuku: Niseft Mozuku, Futomozuku: Futomozuku, Ishimozuku: Ishimozuku, Kuromo: Kuromo, Nisemozuku: Nisemozu, Mozuku: Mozuku, Ishige: Ishige, Iroro, Ichimosa: Ichimegasa Umibosu, Urushigusu: Urushigusa, Keurushigusa, Tobaccogusa, Composita: Composita, Haberodomo: Haberodoki, Havanori: Habanori, Habanori: Habanori, Commonbukuro, Ezobukuro, Ezobukuro Chishima fukuronori genus: Chishima fukuronori, Kagomenori genus: Kagomenori, Muraridori genus: Murachidori, shark genus: shark zusa, genus genus: iwahige, yokojimamanori: Ganoderma genus: cynomolgus, fennel spider: fennel spider, vine genus: turmo, turtle genus: sea turtle, scorpion genus: sujime, misji kumbu genus: misji kumbu, atsuba misji kumbu, kumbu genus: tsutsugara kumbu, oyster kumbu, onikombu, gakonbubu Barracuda, Trollocombu: Trollocombu, Antokume: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikombu: Kikuishicombu, Nejikcombu: Nejicombu, Kuroshiome: Kuroshiome, Nekoshikonbu, Aramei Genus: Ainuwakame, Chigaiso, Oniwakame Ezoi Shige: Ezoi Shige, Yabane Moku: Yabane Moku, Rappa Moku: Rappa Moku, Joromoku: Ugano Moku, Jo Lomoku, Hiemoku, Honda Walla: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yatsumata Moku, Umitora no Moku, Fushishimoku, Mohmokumoku, Hahamokumoku , Genus Ukimo: Ouokimo, genus Burukimo: burukimo, genus Kayamonori, etc.).

Red algae Genus: Sea urchins, Tsukumonori, Anemone crickets, Astragalus, Amaranthus, Amaranthus, Agaricata Genus: Tamaitadaki, Kaikekenori Genus: Kaginori, Kaikekenori, Tengusa: Himetengususa, Hytengususa, Oobusa, Nambugu , Kohira, Yohira, Kinukusa, Hibirodo: Hibirodo, Himebiro, Isomumedo: Isommedo, Aedes: Rhizome, Ryumons: Ryumon, Ranunculaceae, Nisekare Naminohana: Hosobanaminohana, Naminohana, Sangomodoki: Ragaramomodoki, Shiogusagoromo: Shiogusagoromo, Iwanokawa: Etsukiiwanawa, Kinokawa: Kinokawa, Kanonote, Sangori Kyono Shiro, Sakuranori, Nikumukade, Tambanori, Tsurutsuru, Fudarak, Marubahdarak, Isonohana: Nurakusa, Ronulaksa, Oomkadenori, Hirakintoki: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Rice, Tokamatsu, Hitomatsu, Fushikintoki, Tsunomude, Nagakinito, Crayfish Nagaobane: Naganobane, Funori genus: Hanafonori, Fukurofunori, Mafunori, Karekigusa: Karekigusa, Tosakamodoki: Hosobanatosakamodoki, Hironotosakamodoki, Yatsudegatatosakamodoki, Kurotosakamodokisane, Zotosofomoza Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hana Tacarimenia, Hoonoo: Honoo, Hikagenoit: Hikagenoit, Usuginu, Nikuhounoo: Nikuhounoo, Venus nago, Venus nago, Susca veni: Suscabeni, Okarugusa: Yamadagusa, Mirin: Mirin, Hosokamiso , Isomocca genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagibaranori, Kojinoo: Kizino-o, Isodantsu: Isodantsu, Atsubanori: Atsubanori, Ogonori, Ogonori, Ogori Mizo-okonori, birch, beniogonori, fukureshinori, purple birch, shinkaibanori, spruce birch, kataogonori, ryukyuogono Li, Atlantic scorpion, Ivy genus, Yumigataonori, Kubireogonori, Mosagogonori, Kinubanori, Amanita genus: Hachijotensamodoki, Fushikenori genus: Fushikenori, Namiiwatake, Nymphalanthus Itagususa, Saimi, Hari, Lotus Jigusa: Lotus Jigusa, Sugi nori: Ikanoashi, Hosoibonori, Nobonori, Black Haginansou Genus: gourd, cherries, octopus: octopus, sedge, genus: genus, genus: goat, dals : Dulse, Scorpionus, Anadalus, Weibusa: Uebusca, Benifronori: Benifuronori, Fusunagi: Futsutsunagi, Himefusunagi, Hirohafushitsugi, Otsunagisou, Hirawatagigi, Usuwasugi , Egonori: Egonori, Futogigi, Saeda: Saeda, Chirimomiji: Chirimomiji, Konohori family: Habutaenori, Konohori, Suzuronori, Usubeni: Genus: Kagios banori, Yareus banori, Susius banori, Heius banori, Usubanorimodoki: Usubanorimodoki, Ayanishiki genus: Ayani Genus: Aeginu, Dadia: Enasidadia, Shimadadia: Isohagi, Shimadadia, Dajimodoki: Dajimodoki, Euglena: Morayogusa, Fuyugusa, Makuri: Makri, Yanaginogi, Yuna, Yukinagina , Sasabayanaginori, Sozo genus: Kurosozo, Kobsozo, Hanesozo, Sozonohana, Hanegusa genus: Hananegusa, Hananegusa, Kozanemo genus: Kozanemo, Isomurasaki, Hosozozanemo, Himegoshigusu, Giant genus Isomagusa, Suginasugusa: Suginasusa, Isobashou: Isobasho, Fujimatsumo: Fujimatsumo, Sawweed: Haeshinosakiba, Kawamoku : Kawamoku, Aokawa Mozuku, Himekawa Mozuku, Ideyugogome: Ideyugogome, Okichimozuku: Okimozu, Otosa, Chinomo: Chinomo, Chisujinori, Chisujinori, etc.).

  Axial algae (Shajikumo, Shiratamamo, Hoshitsurimo: Hoshitsurimo, Rikunotamnus, Flaskmo: Himebumo, Chaboflasmo, Tripera, etc.), yellow algae (Hikarimo: Hikarimo, etc.), etc.

  In addition, the materials derived from animal materials include chicken crown extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposition product thereof, cow or pig brain tissue Extracts, cattle / pig or fish collagen hydrolyzate (acid, alkali, enzyme etc.) degradation products, water-soluble collagen or collagen derivatives such as acylated collagen, cow or pig elastin or elastin hydrolyzate (acid, alkali, Enzymes etc.) or water-soluble elastin derivatives, keratin and its degradation products or their derivatives, silk proteins and their degradation products or their derivatives, porcine or bovine blood cell protein degradation products (globin peptides), cattle or porcine hemoglobin degradation products (Hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its degradation products or their derivatives, skim milk powder and their degradation products or their inducements Body, lactoferrin or decomposed product thereof, egg ingredients, fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.

  In addition, as a material derived from a plant or animal material, any site, cell, tissue, organ, metabolite, etc. derived from a gene recombinant or a cell fusion can be used. Furthermore, for example, an undifferentiated cell group, a cell group in the middle of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can also be used.

(14) Marine components Seawater such as deep seawater, for example, sea salt, dried seawater, inorganic salt (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (from the Dead Sea or Atlantic Ocean) Fango), for example, Italian mud, German fungo, Eifelfango, Freiburg fungo, etc. Sea mud or mud from various locations (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, Magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, etc.

(15) Microbial culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, rice fermentation extract , Fermented rice bran (red rice bran, white birch) extract, Euglena extract or decomposition product thereof or water-soluble derivative thereof, trehalose or derivative thereof, lactic acid fermentation product of raw milk or skim milk powder, fermented lactic acid bacteria of legumes, coconut plant Lactic acid bacteria fermented products.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, Bengala, black iron oxide, gunjo, chromium oxide, chromium hydroxide, carbon black, calamine, etc.

(18) UV absorber / blocker benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxy Dimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, Octyl paradimethylaminobenzoate), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxycinnamic acid cinnamate) Til, sodium paramethoxycinnamate, potassium paramethoxycinnamate, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, Methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives , Camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative Body, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, talc, kaolin etc.

(19) Whitening agent Paraaminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative, Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, Shikonin, baicalin, baicalein, berberine, placenta extract, ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, vitamin E or a derivative thereof, N-acetyltyrosine or its derivatives, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camille, mulberry, gardenia, pearl oyster, clam, clam, mugwort, honeysuckle) , Kihada, dokudami, matsuhod, pearl barley, nettle, hop, hawthorn, eucalyptus, yarrow, saw Tsu, Psycho, storm, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.

(21) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether).

(22) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, ganoderma extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe, Ogon, Japanese horsetail, Gentiana, Burdock, Sikon, Carrot, Camelis, Hop, Yokuinin, Odori-so, Semburi, Toki, Kinkakusen, Achacha, Hypericum, Cucumber, Tachytrum, Rosemary, Parsley).

(23) Astringents Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds) and the like.

(24) Active oxygen scavenger
SOD, catalase, glutathione peroxidase and the like.

(25) Antioxidants Vitamin C or salts thereof, stearic acid ester, vitamin E or derivatives thereof, nordihydrogua cetelenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole , Propyl gallate, sesamol, sesamorin, gossypol, propolis, etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame culture cell, hamcha, hypericum, hamamelis, clove, melissa, birch, birch, salvia, rosemary, minamitenji, jitsu, ginkgo, green tea).

(27) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or its Salt, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract, propolis, etc.

(28) Antibacterial / bactericidal / disinfectant Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, Sarashi flour, iodine compound, iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p -Chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ester Tanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether, Polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkco chloride) Nium, benzethonium chloride, methyl rosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal bio Tsu DOO, Jamaru photosensitive No. 101-containing, photosensitizer No. 201, photosensitizer No. 401, N- long chain acyl basic amino acid derivative and its acid shark salts, zinc oxide, hinokitiol, Sophora root, propolis, and the like.

(29) Moisturizer Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, mini Sasanishiki extract, natto metabolite, natto extract, loofah water, birch (white birch) or red pine sap

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (eg, gongoid, hypericum, clara, mulberry leaves, keihi, genokosho, comfrey, salvia, elderberry, bodaiju, button pie), seaweed extract and the like.

(31) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castari tincture, pepper tincture, pepper tincture, quinine hydrochloride, strong ammonia water, potassium bromate, sodium bromate, thio Glycolic acid and the like.

(32) Antiandrogens Follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone, etc.

(33) Peripheral vascular blood flow promoter Vitamin E or derivatives thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitive element 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.

(36) Antiseborrheic agent Pyridoxine or a derivative thereof, sulfur, vitamin B6 and the like.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea and the like.

(38) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, Sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(39) Hair remover Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate) Strontium thioglycolate) and the like.

(40) Hair swelling agents such as ethanolamine, urea and guanidine.

(41) Dye agent
5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, para Nitroorthophenylenediamine, paraphenylenediamine, paramethylamino Phenol, picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N -Phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diamino sulfate Diphenylamine, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, parasulfate sulfate Methylaminophenol, metaaminosulfate Diol, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfone Sodium acid, hematein, etc.

(42) Fragrance Natural animal fragrance such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, Cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, Otsuka perfume essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, trout balsam essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, persimmon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot Spirit , Peru balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, Japanese mint essential oil, and other synthetic flavors Fragrance etc.

(43) Dye and Colorant Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye, Krill Dye, Amber Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye, Onion Dye , Tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin etc.

(44) Sweeteners Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monelin, licorice extract and the like.

(45) Nutrient enhancer Shell calcined calcium, cyanocobalamin, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.

(46) Dairy products Milk, cheese, fresh cream, butter, margarine, powdered milk, whey, condensed milk, etc.

(47) Others Hormones, sequestering agents, pH adjusters, chelating agents, antiseptic and antifungal agents, cooling agents, stabilizers, emulsifiers, animal and vegetable proteins and their degradation products, animal and vegetable polysaccharides And its degradation products, animal and plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound treatment agents, foam increasing agents, thickeners, enzymes, purified water (electronic Water, small clustering, etc.), oral preparations, deodorants / deodorants, bittering agents, seasonings, etc. are raised, and in combination with these, the effects of the present invention or other cosmetic effects are added Or a synergistic improvement can be expected.

(Manufacture of various preparations)
Various cosmetic compositions and beauty / health foods were produced using GAD activators. Although the formulation example is shown below, this invention is not limited to these.

1) Production Example of Lotion A whitening lotion was produced according to the following formulation.
weight%
1. Sorbit 2
2. 1,3-butylene glycol 2
3. Polyoxyethylene oleyl ether (25E.O.) 2
4). Ethanol 20
5. Soybean extract (containing 0.1% isoflavone) 2
6). Yokuinin hot water extract (solid content 1.4%) 2
7). Bilberry 30% ethanol extract (solid content 1.4%) 2
8). pH adjuster appropriate amount 9. Preservative (methylparaben) appropriate amount 10. Residue with 100 purified water

2) Example of production of emulsion An emollient emulsion was produced according to the following formulation.
weight%
1. Squalane 3
2. Vaseline 1
3. Stearyl alcohol 0.3
4). Sorbitan monostearate 1.5
5. Polyoxyethylene (20) sorbitan monooleate 3
6. 1,3-Butylene glycol 10
7). Bilberry 30% 1,3-BG extract (containing 1.3% solids) 5
8). Ascorbic acid phosphate magnesium salt 0.1
9. Sodium hyaluronate 0.0005
10. Preservative (phenoxyethanol) appropriate amount 11. Residue with 100 purified water

3) Production Example of Hair Shampoo A hair shampoo was produced according to the following formulation.
weight%
1. Lauryl sulfate triethanolamine 5
2. Polyoxyethylene lauryl ether sulfate Na 12
3. 1,3-Butylene glycol 4
4). Lauric acid diethanolamide 2
5. Edetate disodium 0.1
6). Walnut water extract (solid content 1.2%) 2
7). Bilberry water extract (solid content 1.2%) 1
8). Arginine or its salt 0.2
9. Preservative (Ethylparaben) Appropriate amount Residue with 100 purified water

4) Production Example of Body Soap A body soap was produced according to the following formulation.
weight%
1. Potassium laurate 15
2. Potassium myristate 5
3. Propylene glycol 5
4). Bilberry 30% -1,3-BG extract (solid content 1.3%) 3
5. Walnut 30% 1,3-BG extract (solid content 1.4%) 1
6). Luteolin 0.001
7). Sodium lactate 0.1
8). pH adjuster appropriate amount 9. Preservative appropriate amount 10. Residue with 100 purified water

5) Production example of hair rinse A hair rinse was produced according to the following formulation.
weight%
1. Stearyltrimethylammonium chloride 2
2. Cetostearyl alcohol 2
3. Polyoxyethylene lanolin ether 3
4). Propylene glycol 5
5. Bilberry 50% 1,3-BG extract (solid content 1.4%) 5
6). pH adjuster appropriate amount 7. Residue with 100 purified water

6) Production example of hair liquid A hair liquid was produced according to the following formulation.
weight%
1. Ethanol 29
2. Polyoxypropylene butyl ether phosphate 10
3. Polyoxypropylene monobutyl ether 5
4). Triethanolamine 1
5. Bilberry 50% ethanol extract (solid content 1.4%) 5
6). Residue with 100 purified water

7) Granule bath preparation
weight%
1. Sodium bicarbonate 60
2. Anhydrous sodium sulfate 32
3. Borax 3
4). Walnut 50% ethanol extraction powder 5

8) Health foods (tablets)
The composition containing the following additives was compressed into tablets.
weight%
1. Bilberry 50% ethanol extract powder 5
2. Walnut hot water extraction powder 5
3. Plant extract powder (Chlorella, Blueberry, Ginkgo) 30
4). Royal jelly powder 5
5. Collagen powder 5
6). Lactose 25
7). Corn starch 20
8). Hydroxypropyl cellulose 4
9. Magnesium stearate 1

9) Health drinks Health drinks were made according to the following prescription.
weight%
1. Bilberry water extract (solid content 1.1%) 20
2. Walnut hot water extract (solid content 1.2) 20
3. Honey 15
4). Citric acid 0.1
5. dl-malic acid 0.1
6). D-sorbitol solution (70%) 10
7). Sodium benzoate 0.05
8). Fragrance
Appropriate amount 9. Residue with 100 purified water

The hair regeneration area ratio (%) of the C3H mouse | mouth performed in the Example (hair growth action) is represented. The general waveform measured with the skin viscoelasticity measuring device (Japan Eurotech CUTOMETER SEM474) used by the Example (skin anti-aging effect) is represented. The change in the body weight of the Wistar male rat carried out in the examples (obesity and arteriosclerosis-preventing action) in 7 weeks of breeding is shown.

Claims (4)

A glutamate decarboxylase activator comprising as an active ingredient one or two kinds of plant extracts selected from bilberry and walnut. A glutathione production promoter comprising as an active ingredient one or two plant extracts selected from bilberry and walnut. A cosmetic composition comprising the glutamate decarboxylase activator according to claim 1 or the glutathione production promoter according to claim 2 containing a plant extract as an active ingredient. A beauty / health food composition comprising the glutamic acid decarboxylase activator according to claim 1 or the glutathione production promoter according to claim 2 containing a plant extract as an active ingredient.

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