JP2006160650A - Anti-aging cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an anti-aging cosmetic having excellent stability of the cosmetic, exhibiting sufficient anti-aging effects and having slight irritation. <P>SOLUTION: The anti-aging cosmetic is characterized as comprising a multi-chain and multi-hydrophilic group type compound having &ge;2 long-chain hydrophobic groups and &ge;2 hydrophilic groups in the molecule, respectively and an anti-aging ingredient. <P>COPYRIGHT: (C)2006,JPO&amp;NCIPI

Description

  The present invention relates to an anti-aging cosmetic comprising a multi-chain polyhydrophilic group type compound.

Conventionally, anti-aging cosmetics have been formulated with retinol, retinoic acid, carotenoids, hormones, collagen, saponin, tocopherol, hyaluronic acid, pyrrolidone carboxylic acid, ceramide and the like (for example, Patent Document 1 and Patent Document 2). , Patent Document 3 and Patent Document 4).
However, these ingredients do not have surface activity, so it is difficult to mix them stably in cosmetics such as lotions, emulsions, creams, etc. is not. Thus, anti-aging cosmetics that are excellent in cosmetic stability, exhibit sufficient anti-aging effects, and have little irritation have been eagerly desired.

Japanese Patent Laid-Open No. 10-218729 JP 2003-095913 A JP 2004-002219 A JP 2004-175731 A

  An object of the present invention is to provide an anti-aging cosmetic that is excellent in the stability of cosmetics, exhibits a sufficient anti-aging effect, and has little irritation.

As a result of intensive studies to solve the above problems, the present inventor has obtained a specific compound, that is, a compound having two or more long-chain hydrophobic groups and hydrophilic groups in the molecule (that is, a multi-chain poly-hydrophilic group). In particular, it has been found that by combining this compound with an anti-aging component, the cosmetic has excellent stability, exhibits a sufficient anti-aging effect, and is an anti-aging cosmetic with little irritation. The present invention has been completed.
That is, the present invention is as follows.
1. Component (A): An anti-aging cosmetic comprising at least one of a multi-chain polyhydrophilic group type compound having two or more long-chain hydrophobic groups and hydrophilic groups in the molecule.
2. At least one of the multi-chain poly-hydrophilic group type compound, the long-chain hydrophobic group is a long-chain acyl group, and the hydrophilic group is a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group or a salt thereof 1. An anionic surfactant as described above Anti-aging cosmetics described in 1.
3. At least one of the multi-chain polyhydrophilic group type compounds has an amino acid residue in the molecule. Or 2. Anti-aging cosmetics described in 1.
4). At least one of the multi-chain polyhydrophilic group-type compounds is a compound represented by the general formula (1). ~ 3. The anti-aging cosmetic according to any one of the above.

〔一般式（１）中、Ｘはｍ個の官能基、およびそれ以外の置換基を有していてもよい分子量１００万以下の直鎖または分枝鎖または環状鎖または芳香族炭化水素鎖であるスペーサーを示す。Ｘに結合しているｎ（ｍ≧ｎ）個のＱは、次の一般式（２）で表される置換基であり、それぞれ互いに同一でも異なっていてもよい。

（一般式（２）において、ＺはＸの有する官能基に由来する結合部であり、Ｒ¹ＣＯは炭素数８〜２０の飽和または不飽和の脂肪酸から誘導される長鎖アシル基を示し、Ｒ²は水素であるか、またはヒドロキシル基またはカルボキシル基が置換していてもよい炭素原子数１〜３の低級アルキル基を示し、Ｙはカルボキシル基、スルホン酸基、硫酸エステル基、リン酸エステル基またはそれらの塩の内のいずれかを示す。ｊ、ｋはそれぞれ独立に０，１，２のいずれかであり、かつｊ、ｋは同時に０ではない。ｎは２〜２０の整数を示す。また、ｍはｍ≧ｎである整数を示す。）〕

[In General Formula (1), X is a linear, branched, cyclic, or aromatic hydrocarbon chain having a molecular weight of 1 million or less, which may have m functional groups and other substituents. A spacer is shown. N (m ≧ n) Qs bonded to X are substituents represented by the following general formula (2), and may be the same as or different from each other.

(In General Formula (2), Z is a bond part derived from the functional group of X, R ¹ CO represents a long-chain acyl group derived from a saturated or unsaturated fatty acid having 8 to 20 carbon atoms, R ² is hydrogen, or a lower alkyl group having 1 to 3 carbon atoms which may be substituted by a hydroxyl group or a carboxyl group, and Y is a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester Represents a group or a salt thereof, j and k are each independently 0, 1, or 2 and j and k are not simultaneously 0. n represents an integer of 2 to 20 M represents an integer where m ≧ n.)]

5. At least one of the multi-chain polyhydrophilic group type compounds is a compound represented by the general formula (1), and in the general formula (1), X may have a substituent other than the functional group 1 1. A spacer which is a straight chain, branched chain, cyclic chain or aromatic hydrocarbon chain of ˜40. ~ 4. The anti-aging cosmetic according to any one of the above.
6). Furthermore, it contains at least one component (B): an anti-aging component. ~ 5. The anti-aging cosmetic according to any one of the above.
7). 5. The anti-aging component is at least one selected from a wrinkle-preventing component, an antioxidant component, and a moisturizing agent. Anti-aging cosmetics described in 1.
8). At least one of wrinkle prevention component, antioxidant component, moisturizer is retinol, retinoic acid, carotenoid, ubiquinone, hormones, collagen, anthocyanin, magnesium, saponin, unsaturated fatty acid, tocopherol, hyaluronic acid, trimethylglycine, urea, 6. At least one selected from pyrrolidone carboxylic acid, saponin, and ceramide. Anti-aging cosmetics described in 1.
9. Furthermore, it contains at least one selected from component (C): anionic surfactant, nonionic surfactant, amphoteric surfactant, and cationic surfactant. ~ 8. The anti-aging cosmetic according to any one of the above.
10. Furthermore, it contains at least one component (D): polyhydroxyl compound. ~ 9. The anti-aging cosmetic according to any one of the above.
11. Above 1. -10. An anti-aging method characterized by using the anti-aging cosmetic according to any one of the above.

  The present invention has an effect of providing an anti-aging cosmetic that is excellent in the stability of cosmetics, exhibits a sufficient anti-aging effect, and has little irritation.

Hereinafter, the present invention will be specifically described.
The anti-aging cosmetic composition of the present invention is structurally a composition comprising at least one multi-chain polyhydrophilic group type compound having two or more long-chain hydrophobic groups and hydrophilic groups in the molecule, This structure may be used, and a compound that has been publicly known may be used.
In the anti-aging cosmetic composition of the present invention, as the multi-chain poly-hydrophilic group type compound, the long-chain hydrophobic group is independently a saturated or unsaturated linear, branched, or cyclic chain having 8 to 20 carbon atoms. Each having a hydrophobic group consisting of a carboxyl group, a sulfonic acid group, a sulfuric acid residue, a phosphoric acid residue or a salt thereof, an oxyalkylene group, a polyethylene glycol group, or the like, or an amino group A compound having a quaternary ammonium group, a pyridinium group, a sulfonium group, or a salt thereof is exemplified, and the anionic surfactant having these groups.
Examples of the long-chain hydrophobic group of the polychain polyhydrophilic group compound include n-octyl, n-nonyl, n-decyl, n-undecyl, n-dodecyl, n-tridecyl, n-tetradecyl, n-pentadecyl, n- Each residue such as hexadecyl, n-heptadecyl, n-octadecyl, n-nonadecyl, n-eicosyl, etc. and their branched isomers, and corresponding one, two or three unsaturated moieties And unsaturated residues.
In addition, the long-chain hydrophobic group of the multi-chain polyhydrophilic group type compound is a long-chain acyl group derived from a saturated or unsaturated fatty acid having 8 to 20 carbon atoms. That is, they may be different or the same.

For example, linear fatty acids such as caprylic acid, pelargonic acid, capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, stearic acid, nonadecanoic acid, arachidic acid;
2-butyl-5-methylpentanoic acid, 2-isobutyl-5-methylpentanoic acid, dimethyloctanoic acid, dimethylnonanoic acid, 2-butyl-5-methylhexanoic acid, methylundecanoic acid, dimethyldecanoic acid, 2-ethyl- 3-methylnonanoic acid, 2,2-dimethyl-4-ethyloctanoic acid, methyldocosanoic acid, 2-propyl-3-methylnonanoic acid, methyltridecanoic acid, dimethyldodecanoic acid, 2-butyl-3-methylnonanoic acid, methyltetradecanoic acid , Ethyltridecanoic acid, propyldodecanoic acid, butylundecanoic acid, pentyldecanoic acid, hexylnonanoic acid, 2- (3-methylbutyl) -3-methylnonanoic acid, 2- (2-methylbutyl) -3-methylnonanoic acid, butylethylnonane Acid, methylpentadecanoic acid, ethyltetradecanoic acid, propyltri Canic acid, butyldodecanoic acid, pentylundecanoic acid, hexyldecanoic acid, heptylnonanoic acid, dimethyltetradecanoic acid, butylpentylheptanoic acid, trimethyltridecanoic acid, methylhexadecanoic acid, ethylpentadecanoic acid, propyltetradecanoic acid, butyltridecanoic acid, pentyldodecane Acid, hexylundecanoic acid, heptyldecanoic acid, methylheptylnonanoic acid, dipentylheptanoic acid, methylheptadecanoic acid, ethylhexadecanoic acid, ethylhexadecanoic acid, propylpentadecanoic acid, butyltetradecanoic acid, pentyltridecanoic acid, hexyldodecanoic acid, heptyl Undecanoic acid, octyldecanoic acid, dimethylhexadecanoic acid, methyloctylnonanoic acid, methyloctadecanoic acid, ethylheptadecanoic acid, dimethylheptadecanoic acid, Octyl decanoic acid, Mechirunonadekan acid, Mechirunonadekan acid, dimethyl octadecanoic acid, branched fatty acids such as butyl heptyl nonanoic acid;
Octenoic acid, nonenoic acid, decenoic acid, caproleic acid, undecylenic acid, Lindelic acid, touric acid, lauroleic acid, tridecenoic acid, tuzuic acid, myristoleic acid, pentadecenoic acid, hexedenoic acid, palmitoleic acid, heptadecenoic acid, octadecenoic acid, Linear monoenoic acids such as oleic acid, nonadecenoic acid, gondoic acid;
Such as methylheptenoic acid, methylnonenoic acid, methylundecenoic acid, dimethyldecenoic acid, methyldodecenoic acid, methyltridecenoic acid, dimethyldodecenoic acid, dimethyltridecenoic acid, methyloctadecenoic acid, dimethylheptadecenoic acid, ethyloctadecenoic acid Branched monoenoic acid;
Di- or trienoic acids such as linoleic acid, linoleic acid, eleostearic acid, linolenic acid, linolenic elaidic acid, pseudoeleostearic acid, parinaric acid, arachidonic acid;
Acetylene acids such as octinoic acid, nonic acid, decinic acid, undecinic acid, dodecinic acid, tridecinic acid, tetradecinic acid, pentadecinic acid, heptadesinic acid, octadecinic acid, nonadesinic acid, dimethyloctadesinic acid;
Of methyleneoctadecenoic acid, methyleneoctadecanoic acid, aleprolic acid, alepresinic acid, allepuric acid, alepuric acid, hydnocarpic acid, shoulmuric acid, gorulic acid, α-cyclopentylic acid, α-cyclohexylic acid, α-cyclopentylethylic acid Cyclic acids such as;
An acyl group derived from is mentioned.

Moreover, the acyl group derived from the fatty acid obtained from natural fats and oils may be sufficient, and the acyl group derived from the mixed fatty acid containing 80% or more of the above saturated or unsaturated fatty acid having 8 to 20 carbon atoms is preferable. For example, acyl groups derived from coconut oil fatty acid, palm oil fatty acid, linseed oil fatty acid, sunflower oil fatty acid, soybean oil fatty acid, sesame oil fatty acid, castor oil fatty acid, olive oil fatty acid, camellia oil fatty acid, rapeseed oil fatty acid, palm kernel oil fatty acid, etc. Etc. Two or more of these acyl compounds may be used in combination.
When using a multi-chain polyhydrophilic group-type compound as a salt, examples of the salt include alkali metal salts, alkaline earth metal salts, ammonium salts, organic amine salts, basic amino acid salts, and the like. Alkali metals such as sodium, potassium and lithium, alkaline earth metals such as calcium and magnesium, metals such as aluminum and zinc, organic amines such as ammonia, monoethanolamine, diethanolamine, triethanolamine and triisopropanolamine, arginine, It is a salt with one or more kinds arbitrarily selected from basic amino acids such as lysine. Among these, sodium salts, potassium salts, organic amine salts, and basic amino acid salts are particularly preferable.

In the present invention, it is preferable that at least one of the multi-chain polyhydrophilic group compounds contained in the anti-aging cosmetic is an acyl compound represented by the general formulas (1) and (2).
The term “acyl compound” as used herein refers to a structure in which compounds having at least one acyl group and a hydrophilic group in the molecule are linked with an appropriate spacer as shown in the general formulas (1) and (2). It is a compound of this.
In general formula (2), the acyl groups represented by R ¹ CO may be independent, that is, they may be different or the same, and as described above, from a saturated or unsaturated fatty acid having 8 to 20 carbon atoms. Any material can be used as long as it is induced, and it may be linear, branched or cyclic.
In general formula (2), R ² is hydrogen, or a hydroxyl group or a carboxyl group, a sulfonic acid group, a sulfuric ester group, a phosphoric ester group or a salt thereof, which may be substituted, 3 lower alkyl groups, for example, methyl group, ethyl group, propyl group, isopropyl group, hydroxymethyl group, hydroxyethyl group, hydroxy (iso) propyl group, dihydroxy (iso) propyl group, carboxymethyl group, carboxyethyl Group, carboxypropyl group, sulfoethyl group and the like.

In the general formula (1), n substituents Q (formula (2)) bonded to X may be different from each other or the same. In addition, the group represented by the formula (2) represents a group in which a so-called acidic amino acid is N-acylated, and it does not matter whether they are optical isomers such as D-form, L-form, and racemate. Absent.
The acidic amino acid is a monoaminodicarboxylic acid having 2 and 1 carboxyl groups and 1 amino group, respectively, in the molecule, and the amino group may be an N-methyl group or an N-ethyl group. It does not matter whether it is an optical isomer, for example, a D-form, an L-form, or a racemate. Examples of acidic amino acids include glutamic acid, aspartic acid, lanthionine, β-methyllanthionine, cystathionine, diencholic acid, ferrinin, aminomalonic acid, β-oxyaspartic acid, α-amino-α-methylsuccinic acid, β-oxy Glutamic acid, γ-oxyglutamic acid, γ-methylglutamic acid, γ-methyleneglutamic acid, γ-methyl-γ-oxyglutamic acid, α-aminoadipic acid, α-amino-γ-oxyadipic acid, α-aminopimelic acid, α-amino -Γ-oxypimelic acid, β-aminopimelic acid, α-aminosuberic acid, α-amino sebacic acid, pantothenic acid and the like.
The n substituents (formula (2)) attached to X are preferable because the acidic amino acid is an L-acidic amino acid molecule because it is excellent in biodegradability.

In the general formula (2), Z is a bonding part (—O) derived from m functional groups (hydroxyl group, amino group, thiol group) substituted with X (m ≧ n and an integer of 2 to 20). -, -NR < ³ >-, -S-). Here, R ³ is hydrogen, an alkyl group having 1 to 10 carbon atoms, an alkenyl group, an aryl group, or an alkylaryl group.
In general formula (1), X is a linear or branched or cyclic chain having a molecular weight of 1 million or less and having m functional groups consisting of one or more selected from a hydroxyl group, an amino group and a thiol group. It is a spacer which is an aromatic hydrocarbon chain, and X may have a substituent other than the hydroxyl group, amino group and thiol group.
In the general formula (1), X is preferably a residue of an m-valent compound having a molecular weight of 1 million or less and having m functional groups of one kind or two or more kinds selected from a hydroxyl group, an amino group and a thiol group. , A compound residue that may have a substituent other than a hydroxyl group, an amino group, or a thiol group. Here, the m-valent compound means that a bond derived from m functional groups can be formed. It does not matter whether they are optical isomers such as D-form, L-form, and racemate.

Examples of such m-valent compounds include amino acids such as serine, threonine, cysteine, cystine, cystine disulfoxide, cystathionine, methionine, arginine, lysine, tyrosine, histidine, tryptophan, and oxyproline;
Aminoethanol, aminopropanol, aminobutanol, aminopentanol, aminohexanol, aminopropanediol, aminoethylethanolamine, aminoethylaminoethanol, aminocresol, aminonaphthol, aminonaphtholsulfonic acid, aminohydroxybenzoic acid, aminohydroxybutanoic acid Compounds having an amino group and a hydroxyl group in the molecule such as aminophenol, aminophenethyl alcohol, glucosamine;
Compounds having a thiol group and a hydroxyl group in the molecule such as mercaptoethanol, mercaptophenol, mercaptopropanediol, glucothiose;
Compounds having a thiol group and an amino group in the molecule such as aminothiophenol and aminotriazole thiol;
Is mentioned.
Further, proteins, peptides, etc., or those obtained by hydrolyzing them may be used.

In the general formula (1), X is preferably an m-valent (m ≧ n) polyhydroxyl compound residue having a molecular weight of 1,000,000 or less, which may have a substituent other than a hydroxyl group. Here, the m-valent polyhydroxyl compound means that m ester bonds can be formed. It does not matter whether they are optical isomers, for example, D-form, L-form, or racemate.
Examples of such m-valent polyhydroxyl compounds include ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, and 1,4-butane. Diol, pentanediol, 1,6-hexanediol, cyclohexanediol, dimethylolcyclohexane, neopentyl glycol, 1,8-octanediol: 2,2,4-trimethyl-1,3-pentanediol, isoprene glycol, 3 -Methyl-1,5-pentanediol, sorbite, catechol, resorcin, hydroquinone, bisphenol A, bisphenol F, hydrogenated bisphenol A, hydrogenated bisphenol F: dimer diol, dimethylolpropionic acid, dimethylolbutanoic acid, tartaric acid, The Dorokishi tartaric, mevalonate, 3,4-dihydroxy cinnamic acid, 3,4-dihydroxy-hydro cinnamic acid, hydroxy benzoic acid, dihydroxy stearic acid, dihydroxyphenylalanine, and the like, and divalent hydroxyl compounds such as isomers thereof;
Glycerin, trioxyisobutane, 1,2,3-butanetriol, 1,2,3-pentanetriol, 2-methyl-1,2,3-propanetriol, 2-methyl-2,3,4-butanetriol, 2-ethyl-1,2,3-butanetriol, 2,3,4-pentanetriol: 2,3,4-hexanetriol, 4-propyl-3,4,5-heptanetriol, 2,4-dimethyl Trivalents such as -2,3,4-pentanetriol, 1,2,4-butanetriol, 1,2,4-pentanetriol, trimethylolethane, trimethylolpropane, diethanolamine, triethanolamine, trihydroxystearic acid Polyhydroxyl compounds;
Pentaerythritol, erythritol, 1,2,3,4-pentanetetrol, 2,3,4,5-hexanetetrol, 1,2,4,5-pentanetetrol, 1,3,4,5-hexane Tetravalent polyhydroxyl compounds such as tetrol, diglycerin and sorbitan; pentavalent polyhydroxyl compounds such as adonitol, arabitol, xylitol and triglycerin;
Hexavalent polyhydroxyl compounds such as dipentaerythritol, sorbitol, mannitol, iditol, inositol, dulcitol, talose, allose;
Or these dehydration condensates, polyglycerol, etc. are mentioned.

Sugars such as tetroses such as erythrose, sreose, erythrulose;
Pentose such as ribose, arabinose, xylose, lyxose, xylulose, ribulose; monosaccharides such as hexose such as allose, altrose, glucose, mannose, guylose, idose, galactose, talose, fructose, sorbose, psicose, tagatose;
And oligosaccharides such as maltose, isomaltose, cellobiose, gentiobiose, melibiose, lactose, turranose, trehalose, saccharose, mannitolose, cellotriose, gentianose, raffinose, meretitose, cellotetorose, stachyose and the like.
In addition, other saccharides such as heptose, deoxy sugar, amino sugar, thio sugar, seleno sugar, aldone sugar, uronic acid, sugar acid, ketoaldonic acid, anhydro sugar, unsaturated sugar, sugar ester, sugar ether, glycoside, etc. It may be a residue, and may be a polysaccharide such as starch, glycogen, cellulose, chitin, or chitosan, or a hydrolyzed product thereof.

In general formula (1), X is preferably an m-valent polyamino compound residue having a molecular weight of 1,000,000 or less, which may have a substituent other than an amino group. Here, an m-valent polyamino compound means that m acid amide bonds can be formed. It does not matter whether they are optical isomers, for example, D-form, L-form, or racemate.
Examples of such m-valent polyamino compounds include N, N′-dimethylhydrazine, ethylenediamine, N, N′-dimethylethylenediamine, diaminopropane, diaminobutane, diaminopentane, diaminohexane, diaminoheptane, diaminooctane, and diaminononane. , Aliphatic diamines such as diaminodecane, diaminododecane, diaminoadipic acid, diaminopropanoic acid, diaminobutanoic acid and isomers thereof;
Diethylenetriamine, triaminohexane, triaminododecane, 1,8-diamino-4-aminomethyl-octane, 2,6-diaminocapric acid-2-aminoethyl ester, 1,3,6-triaminohexane, 1,6 , 11-triaminoundecane, aliphatic triamines such as di (aminoethyl) amine and isomers thereof;
Alicyclic polyamines such as diaminocyclobutane, diaminocyclohexane, 3-aminomethyl-3,5,5-trimethylcyclohexylamine, triaminocyclohexane;
Aromatic polyamines such as diaminobenzene, diaminotoluene, diaminobenzoic acid, diaminoanthraquinone, diaminobenzenesulfonic acid, diaminobenzoic acid, and their respective isomers;
Araliphatic polyamines such as diaminoxylene, di (aminomethyl) benzene, di (aminomethyl) pyridine, di (aminomethyl) naphthalene, and their isomers;
And polyamines substituted with hydroxyl groups such as diaminohydroxypropane and isomers thereof.

In the general formula (1), X is preferably an m-valent polythiol compound residue having a molecular weight of 1,000,000 or less, which may have a substituent other than a thiol group. Here, an m-valent polythiol compound means that m thioester bonds can be formed. It does not matter whether they are optical isomers, for example, D-form, L-form, or racemate.
Examples of such m-valent polythiol compounds include dithiol compounds such as dithioethylene glycol, dithioerythritol, and dithiothreitol.
X is preferably a group having 1 to 40 carbon atoms among the residues of the compounds listed above, and more preferably X has 1 to 20 carbon atoms. X is preferably a naturally occurring type from the viewpoint of excellent biodegradability.
In general formula (2), the carboxyl group, sulfonic acid group, sulfate ester group, phosphate ester group represented by Y and the carboxyl group, sulfonate group, sulfate ester group, phosphate ester group, etc. that can be contained in X are: Salts can be formed with various basic substances.
Examples of such salts include alkali metal salts, alkaline earth metal salts, ammonium salts, organic amine salts, basic amino acid salts, polyvalent metal salts, and the like. Specific examples include sodium, potassium, lithium, and the like. Alkaline metals, alkaline earth metals such as calcium and magnesium, metals such as aluminum, zinc, iron, cobalt, titanium and zirconium, organic amines such as ammonia, monoethanolamine, diethanolamine, triethanolamine and triisopropanolamine, arginine, It is a salt with one or more kinds arbitrarily selected from basic amino acids such as lysine.

（式（３）中、Ｒ¹ ＣＯ、Ｒ² 、ｋ、ｊは、式（２）中のものと同じである。） The method for producing the acyl compound represented by the general formula (1) is selected from an N-acyl acidic amino acid anhydride represented by the following general formula (3) and a hydroxyl group, an amino group, and a thiol group in the molecule. By reacting the compound having one or more kinds of m functional groups in water and / or a mixed solvent of water and an organic solvent, or tetrahydrofuran, benzene, toluene, xylene, carbon tetrachloride It can be obtained by using an inert solvent such as chloroform or acetone, or by mixing and reacting at -5 ° C to 200 ° C at a temperature equal to or higher than any melting point without solvent.

(In formula (3), R ¹ CO, R ² , k, and j are the same as those in formula (2).)

Alternatively, the acyl compound represented by the general formula (1) includes an N-acyl acidic amino acid mono-lower ester (for example, methyl ester, ethyl ester) and a polyhydroxyl compound, a polyamino compound, or a polythiol compound, or a hydroxyl group or an amino group in the molecule. , A compound having any two or three of the thiol groups is dissolved in a suitable solvent such as dimethylformamide, a catalyst such as potassium carbonate is added, and the reaction is performed at −5 ° C. to 250 ° C. under reduced pressure. Thereafter, it can be obtained by removing the reaction solvent. Alternatively, the acyl compound can be obtained by melting with heating without a solvent, adding a catalyst such as sodium hydroxide, and performing a transesterification reaction at room temperature to 250 ° C.
The blending amount of the anti-aging cosmetic composition of the present invention is not particularly limited, but the content of the multi-chain polyhydrophilic group compound is preferably 0.001 to 20% by weight, and can be adjusted according to the purpose. More preferably, it is 0.01 to 10 weight% in a composition, More preferably, it is 0.01 to 5 weight%. If the content of the multi-chain polyhydrophilic group type compound is less than the above range, the cosmetic stability and anti-aging effect may not be sufficient. Further, when the amount is larger than the above range, stickiness or the like may occur.

As the anti-aging component of the component (B) blended in the anti-aging cosmetic of the present invention, at least one anti-aging component selected from a wrinkle-preventing component, an antioxidant component, and a moisturizing agent is desirable. Is mentioned.
For example, retinol, retinoic acid, carotenoid (α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, rhodoxanthine, crocetin, etc.), ubiquinone, hormones (estradiol, etenyl estradiol, etc.), Collagen, anthocyanin, magnesium, saponin, unsaturated fatty acid (linoleic acid, linolenic acid, etc.), tocopherol (α-tocopherol, β-tocopherol, γ-tocopherol, d-tocopherol, tocopherol acetate, DL-α-tocopherol nicotinate, etc.) , At least one selected from hyaluronic acid, trimethylglycine, urea, pyrrolidone carboxylic acid, ceramide and the like can be used. In addition, as an anti-aging component used for this invention, it is not restricted to what was shown here, The thing well-known by a publication etc. is also contained.

Examples of the component (C) anionic surfactant blended in the anti-aging cosmetic composition of the present invention include the following carboxyl group-containing ones.
For example, higher fatty acid salts (soaps); higher fatty acids having 8 to 20 carbon atoms in the hydrophobic group or salts thereof are also used as mixed fatty acids.
N-acyl amino acid type anionic surfactants; examples of acyl groups include those having 8 to 20 carbon atoms as described above, and examples of constituent amino acids include the above-mentioned acidic amino acids such as glutamic acid and aspartic acid Or glycine, alanine, valine, leucine, isoleucine, proline, methionine, cysteine, tryptophan, tyrosine, phenylalanine, asparagine, glutamine, serine, threonine, oxyproline, β-aminopropionic acid, γ-aminobutyric acid, anthranilic acid, m -Aminobenzoic acid, amino acids such as p-aminobenzoic acid, and the like.
Or alkyl ether carboxylate, amide ether carboxylate, etc. are mentioned.

Moreover, as an anionic surfactant of components (C) other than the component (A) blended in the anti-aging cosmetic composition of the present invention, the following non-carboxyl group-containing ones can be mentioned.
For example, alkane sulfonate, α-olefin sulfonate (AOS), alkylbenzene sulfonate, alkyl naphthalene sulfonate, alkyl sulfonate (SAS), sulfonate of higher fatty acid ester, α-sulfonated fatty acid salt Sulfonates of higher fatty acid amides, N-acyl-N-alkyl taurates, dialkyl sulfosuccinates, sulfated oils and fats, alkyl sulfates (AS), alkyl ether sulfates, sulfates of higher fatty acid esters, higher fatty acids Alkylolamide sulfate, polyoxyalkylene alkyl ether sulfate (AES), polyoxyalkylene styrenated phenyl ether sulfate, alkyl phosphate, alkyl ether phosphate, polyoxyethylene alkyl ether phosphate, polyoxyethylene Examples include lenalkylphenyl ether phosphate and naphthalene sulfonate formalin condensate. Here, the counter ions of the salts of these anionic surfactants are arbitrarily selected from alkali metals, alkaline earth metals, ammonium ions, and organic ammonium ions. In the anti-aging cosmetic composition of the present invention, the anionic surfactant is preferably blended in an amount of 0.01 to 5% by weight, and two or more kinds may be mixed and used. Among these, soaps, N-acyl amino acid salts, N-acyl alkyl taurine salts, sulfosuccinates, and polyoxyethylene alkyl ether sulfates are preferably blended.

Examples of the nonionic surfactant of component (C) to be blended in the anti-aging cosmetic composition of the present invention include alkyl polyglucoside, (poly) glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, and fatty acid ester such as sho. Hydric alcohol ester, polyoxyethylene alkyl ether (AE), polyoxyalkylene fatty acid ester, polyoxyalkylene sorbitan fatty acid ester, polyoxyalkylene fatty acid alkanolamide, polyoxyalkylene alkyl glucoside, polyoxyalkylene hydrogenated castor oil, polyoxyalkylene alkylamine , Polyoxyalkylene alkyl phenyl ether, polyoxyethylene polystyryl phenyl ether, polyoxyethylene polyoxypropylene al Ether, polyoxyethylene polyoxypropylene glycol, ethylene oxide condensation type, fatty acid alkanolamides and the like, sugars Amin'ashiru products, triethanolamine fatty acid partial esters, alkyl amine oxides, and the like. In the anti-aging cosmetic composition of the present invention, the nonionic surfactant is preferably blended in an amount of 0.01 to 5% by weight, and two or more kinds may be mixed and used.
In the anti-aging cosmetic composition of the present invention, examples of the amphoteric surfactant blended as the component (C) include alkylbetaines, alkylamidobetaines, alkylsulfobetaines, imidazolinium betaines, and lecithins. Specific examples include amidopropyl betaine laurate. In the anti-aging cosmetic composition of the present invention, the amphoteric surfactant is preferably blended in an amount of 0.01 to 5% by weight, and two or more kinds may be mixed and used.

As the cationic surfactant of component (C) to be blended in the anti-aging cosmetic composition of the present invention, primary to tertiary fatty amine salts, alkylammonium chloride salts, tetraalkylammonium salts, trialkylbenzylammonium salts, alkyls Examples include pyridinium salts, alkylhydroxyethyl imidazolinium salts, dialkylmorpholinium salts, alkylisoquinolinium salts, benzethonium salts, benzalkonium salts, and the like. Halogen ions such as chlorine, iodine, bromine, etc. , Organic anions such as methosulphate, ethosulphate, methophosphate and ethfophosphate. In the anti-aging cosmetic composition of the present invention, the cationic surfactant is preferably blended in an amount of 0.01 to 5% by weight, and two or more kinds may be mixed and used.
Examples of the component (D) polyhydroxyl compound to be blended in the anti-aging cosmetic composition of the present invention include bivalent or higher polyhydroxyl compounds as described above. These polyhydroxyl compounds are preferably blended in an amount of 0.1 to 30% by weight in anti-aging cosmetics, and may be used in combination of two or more.
The anti-aging cosmetic of the present invention can be used in a wide pH range of preferably 3 to 12, more preferably by adjusting the neutralization rate with a basic substance, more preferably pH 4.5 to 5 of the composition. 11 can be used. More preferably, it can be used at pH 5-8.
The anti-aging cosmetic of the present invention can be produced by a method using an apparatus equipped with a normal stirrer, mixer, disperser and the like.
Moreover, in the anti-aging cosmetics of this invention, unless the objective of this invention is impaired, it can be used together with various base materials according to a use and the objective.

Specifically, natural rubbers such as gum arabic and tragacanth, glucosides, cellulose derivatives such as methylcellulose, carboxycellulose, and hydroxymethylcellulose, natural polymers such as lignin sulfonate and shellac, polyacrylate, styrene-acrylic Salt of acid copolymer, salt of vinyl naphthalene-maleic acid copolymer, sodium salt of β-naphthalene sulfonic acid formalin condensate, anionic polymer such as phosphate, polyvinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol, etc. Dispersants such as nonionic polymers of
Polymeric surfactants such as sodium alginate, starch derivatives, tragacanth gum;
Natural surfactants such as phospholipids, lecithin, lanolin, cholesterol;
Avocado oil, almond oil, olive oil, cacao oil, sesame oil, safflower oil, soybean oil, camellia oil, persic oil, castor oil, mink oil, cottonseed oil, owl, palm oil, egg yolk oil, palm oil, palm kernel oil, synthetic triglyceride, Fats and oils such as jojoba oil;
Hydrocarbons such as liquid paraffin, petrolatum, ceresin, microcrystalline wax, isoparaffin;
Waxes such as beeswax, whale wax, lanolin, carnauba wax, candelilla wax and derivatives thereof;
Higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, behenic acid, undecylenic acid, lanolin fatty acid, hard lanolin fatty acid, soft lanolin fatty acid;

Higher alcohols such as lauryl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, lanolin alcohol, hydrogenated lanolin alcohol, hexyldecanol, octyldodecanol;
Other ester oils such as isopropyl myristate and butyl stearate;
Metal soap, dimethylpolysiloxane, polyether-modified silicone, alcohol-modified silicone, methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alkyl-modified silicone, alkoxy-modified silicone, amino-modified silicone, volatile silicone and other silicones Volatile and non-volatile oils;
Cationized cellulose derivative, cationic starch, cationized guar gum derivative, diallyl quaternary ammonium salt / acrylamide copolymer, quaternized polyvinylpyrrolidone derivative, quaternized vinylpyrrolidone / vinylimidazole polymer, polyglycol / amine condensate, Cationic compounds such as quaternized collagen polypeptides, polyethyleneimine, cationic silicone polymers, adipic acid / dimethylaminohydroxypropyldiethylenetriamine copolymers, polyaminopolyamides, cationic chitin derivatives, cationic polymers such as quaternized polymers;

Hydroxyethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose hydroxypropyl trimethyl ammonium chloride ether, methyl cellulose, ethyl cellulose, hydroxypropyl cellulose, methyl hydroxypropyl cellulose, soluble starch, carboxymethyl starch, methyl starch, propylene glycol alginate, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl Methyl ether, carboxyvinyl polymer, polyacrylate, guar gum, locust bin gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, dextran, succinoglucan, curdlan, gelatin, casein, albumin, Highly water-soluble and oil-soluble, such as toxiethylene maleic anhydride copolymer, amphoteric methacrylate copolymer, polydimethylmethylenepiperidinium chloride, polyacrylate copolymer, polyvinyl acetate, nitrocellulose, silicone resin molecule;
Thickening and foam increasing components such as polyethylene glycol fatty acid ester, polyoxyethylene fatty acid ester methyl glycoside, tetradecene sulfonate;
Sequestering agents such as ethylenediaminetetraacetic acid and its salts, hydroxyethylenediaminetriacetic acid and its salts, phosphoric acid, ascorbic acid, succinic acid, gluconic acid, polyphosphates, metaphosphates, hinokitiles;
Preservatives such as paraoxybenzoates, benzoic acid and its salts, phenoxyethanol, hinokitile;

PH adjusters such as citric acid, malic acid, adipic acid, glutamic acid, aspartic acid;
Other anti-dandruff and itching agents such as trichlorocarbanilide, salicylic acid, zinc pyrithione, isopropylmethylphenol;
Benzophenone derivatives, paraaminobenzoic acid derivatives, paramethoxycinnamic acid derivatives, salicylic acid derivatives and other UV absorbers;
Blood circulation promoters such as assembly extract, cephalanthin, gamma oryzanol;
Local stimulants such as pepper tincture, ginger tincture, cantharis tincture, nicotinic acid benzyl ester;
Nutrients such as various vitamins and amino acids;
Hair root activator;
Anti-inflammatory agents such as glycyrrhetinic acid, glycyrrhizic acid derivatives, allantoin, azulene, aminocaproic acid, hydrocortisone;
Astringents such as zinc oxide, zinc sulfate, allantoin hydroxyaluminum, aluminum chloride, zinc sulfocolate, tannic acid;
Refreshing agents such as menthol and camphor;
Antihistamines;
Silicone materials such as high molecular silicones and cyclic silicones;
Antioxidants such as tocopherols, BHA, BHT, gallic acid, NDGA;
Sebum inhibitors such as estradiol, estrone, ethinyl estradiol;
Exfoliating / dissolving agents such as sulfur, salicylic acid, resorcin;

Organic synthetic pigments (dyes, lakes, organic pigments), natural pigments, inorganic pigments (external pigments, colored pigments, white pigments), pearlescent pigments, polymer powders, functional pigments It can be used without being limited to the shape of needles, etc., the particle size of fumes, fine particles, pigment grades, etc., and the structure of particles such as porous and nonporous. For example, talc, kaolin, sericite, calcium carbonate, zinc oxide, aluminum oxide, magnesium oxide, zirconium oxide, magnesium carbonate, calcium carbonate, barium sulfate, chromium oxide, chromium hydroxide, tar dyes, mica, (synthetic) seric Site, silicon carbide, boron nitride, titanium dioxide, black titanium oxide, conger, red iron oxide, black iron oxide, yellow iron oxide, ultramarine, titanium coated mica, bismuth oxychloride, bengara, caking pigment, gunjo pink, gun Zou violet, chromium hydroxide, mica titanium, chromium oxide, aluminum cobalt oxide, carbon black, anhydrous silicic acid, magnesium silicate, bentonite, (synthetic) mica, zirconium oxide, magnesium (meth) silicate aluminate, aluminum silicate Calcium oxide, Liethylene powder, nylon powder, polymethyl methacrylate, polyethylene terephthalate-polymethyl methacrylate laminate powder, acrylonitrile-methacrylic acid copolymer powder, vinylidene chloride-methacrylic acid copolymer powder, wool powder, silk powder, crystalline cellulose, N-acyl lysine, poly Methyl silsesquioxane powder, plant fruit and skin powder, bismuth oxychloride, mica titanium, iron oxide coated mica, iron oxide mica titanium, organic pigment treated mica titanium, aluminum powder, fine particle titanium oxide, Fine zinc oxide, fine titanium oxide coated mica titanium, fine zinc oxide coated mica titanium, barium sulfate coated mica titanium, carmine, β-carotene, chlorophyll, sunset yellow FCF, Ponceau SX, eosin YS, TE Trabromofluorescein, rhodamine B, quinoline yellow SS, quinoline yellow WS, alizanin cyanine green, quinizarin green, resolbin BCA, resolbin BCA, permaton red, herringdon pink CN, phthalocyanine blue, β-apo-8-carotenal , Capsanthin, lylopine, bixin, crocin, canthaxanthin, shisonin, raphanin, ninocyanin, calsamine, safrole yellow, rutin, quercetin, cacao dye, lipoflavin, lacaic acid, carminic acid, kermesic acid, alizanin, shikonin, alkanine, niquinochrome, blood dye , Curcumin, betanin, and other cosmetic colorants;

Purified water, others, oyster extract, N-methyl-L-serine, whey, nicotinamide, diisopropylamine dichloroacetic acid, mevalonic acid, γ-aminobutyric acid (including γ-amino-β-hydroxybutyric acid), altea extract, Aloe extract, apricot kernel extract, turmeric extract, oolong tea extract, dried sea water, hydrolyzed wheat powder, hydrolyzed silk, carrot extract, cucumber extract, gentian extract, yeast extract, rice germ oil, comfrey extract, savonso extract, Giant extract, lion extract, birch extract, Atlantic mint extract, assembly extract, bisabolol, propolis, loofah extract, bodaiju extract, hop extract, marronnier extract, muroji extract, melissa extract, eucalyptus extract, yukinoshita extract, rosemary It may include; kiss, Roman chamomile extract, royal jelly extract, seaweed, rice bran, licorice, citrus unshiu peel, angelica, pulverized Momonoha, sphingolipids, guaiazulene, vitamin C and the like.
In particular, combined use with fatty acid diethanolamide, polyoxyethylene dioleic acid methyl glucoside, polyethylene glycol distearate, tetradecene sulfonate, myristic acid salts, myristyl dimethylamine is useful in terms of increasing viscosity and foaming power. Also, the combined use with each amphoteric surfactant is extremely useful in that the irritation is further reduced.
The anti-aging cosmetic composition of the present invention includes all cosmetics and detergents applied to the outer skin, and the forms thereof are aqueous solutions, solubilizing systems such as skin lotions, emulsion systems such as emulsions and creams, powder systems, and oil solutions. It can take a wide variety of forms such as a system, gel system, ointment system, water-oil two-layer system, water-oil-powder three-layer system.
Hereinafter, the present invention will be described more specifically using examples and the like, but the present invention is not limited to these examples and the like.

The evaluation means used in the examples of the present invention are as follows.
(Skin irritation test)
After applying 0.1 g of the sample to the forearm flexion skin of 5 healthy male panelists for 3 days, the presence or absence of skin irritation was evaluated. The determination result is indicated by a case where the average score of the following evaluation points is 0 point or more and less than 1 point: ◯, when 1 point or more and less than 2 points: Δ, when 2 points or more: ×.
Judgment criteria and score Erythema, edema, blisters (4 points)
Erythema, edema (3 points)
Erythema (2 points)
Minor erythema (1 point)
No erythema, no edema (0 points)
(Storage stability)
Stability over time (1): After the sample was stored at 40 ° C. for 1 month, the appearance was visually observed and evaluated according to the following criteria. Judgment criteria are shown as follows.
Good (O): Aggregation is not recognized for 3 months or more.
Slightly poor (Δ): Aggregation was observed from 1 month to 3 months.
Poor (x): Aggregation was observed in less than 1 month.
(Anti-aging property)
Eight girls aged 35 to 55 years old were panelists and applied the test cosmetics twice daily in the morning and evening for 10 weeks. After 10 weeks, the wrinkle improvement effect was evaluated according to the following criteria. The determination result is indicated by ○ when the average score of the following evaluation points is 1 or more: ◯, when 0.5 or more and less than 1: Δ, when 0 or more and less than 0.5: x.
Judgment criteria and evaluation scores Wrinkles were improved (2 points)
Wrinkles were slightly improved (1 point)
No change from before use (0 points)

（式４中、Ｘは、各々独立にＨまたはＮａである。）
〔アシル化合物の製造例２〕
製造例１において、Ｎ−ラウロイル−Ｌ−グルタミン酸無水物３１．１ｇをＮ−ココイル−Ｌ−グルタミン酸無水物（０．１ｍｏｌ）とし、それ以外は、製造例１の方法と同じ条件で実施し、アシル化合物を含有する組成物を得た。 [Production Example 1 of acyl compound]
9.1 g (0.05 mol) of L-lysine hydrochloride was mixed with 57 g of water. While this solution was adjusted to a pH range of 10 to 11 with a 25% aqueous sodium hydroxide solution and the reaction temperature was maintained at 5 ° C., 31.1 g of N-lauroyl-L-glutamic anhydride (0. 1 mol) was added over 2 hours to carry out the reaction. After further stirring for 2 hours, tertiary butanol was added to a concentration of 20% by weight in the liquid, 75% sulfuric acid was added dropwise to bring the pH value of the liquid to 2, and the liquid temperature to 65 ° C. It was adjusted. After completion of the dropwise addition, stirring was stopped and the mixture was allowed to stand at 65 ° C. for 20 minutes, so that the organic layer and the aqueous layer were separated, and the organic layer was separated therefrom. Tertiary butanol and water were added to the separated organic layer, the temperature was raised to 65 ° C., and the mixture was stirred for 20 minutes. After the stirring was stopped, the mixture was allowed to stand to separate into an organic layer and an aqueous layer. After repeating the same water washing operation on the obtained organic layer, the solvent was removed from the obtained organic layer, and the resulting solution was made into an aqueous solution having a solid content of 30 wt% and a pH value of 6.5 (25 ° C.) with sodium hydroxide. After neutralization and preparation, this was dried to obtain a composition containing an acyl compound represented by the following formula (4).

(In formula 4, each X is independently H or Na.)
[Production Example 2 of acyl compound]
In Production Example 1, 31.1 g of N-lauroyl-L-glutamic anhydride was changed to N-cocoyl-L-glutamic anhydride (0.1 mol), and the other conditions were carried out under the same conditions as in Production Example 1. A composition containing an acyl compound was obtained.

[Examples 1-10, Comparative Examples 1-2]
Each component shown in Table 1 was used in the blending amount shown in Table 1 to prepare an anti-aging cosmetic. The results of evaluation for each anti-aging cosmetic are shown in Table 1.

[Example 11]
The following anti-aging cream was prepared. The results of evaluation of the cosmetic stability, skin irritation and anti-aging effects were all good.
(Composition) (Parts by weight)
(1) Stearic acid 4
(2) Stearyl alcohol 4
(3) Butyl stearate 6
(4) Propylene glycol 5
(5) Glycerol monostearate 2
(6) Potassium hydroxide 0.2
(7) Acyl compound 1 of Production Example 1
(8) Sodium pyrrolidonecarboxylate 1
(9) Perfume appropriate amount (10) Preservative appropriate amount (11) Purified water 76

[Example 12]
The following anti-aging cream was prepared. The results of evaluation of the cosmetic stability, skin irritation and anti-aging effects were all good.
(Composition) (Parts by weight)
(1) Stearic acid 2
(2) Stearyl alcohol 5
(3) Hydrogenated lanolin 5
(4) Squalane 9
(5) Octyldodecanol 10
(6) 1,3-butylene glycol 5
(7) Polyethylene glycol (Mw 1500) 5
(8) Acyl compound 1 of Production Example 2
(9) Sodium hyaluronate 0.2
(10) Perfume appropriate amount (11) Preservative appropriate amount (12) Purified water 57

[Example 13]
The following anti-aging lotions were created. The results of evaluation of the cosmetic stability, skin irritation and anti-aging effects were all good.
(Composition) (Parts by weight)
(1) Stearic acid 2
(2) Cetyl alcohol 1.5
(3) Vaseline 4
(4) Squalane 4
(5) Glycerol tri-2-ethylhexanoate 2
(6) Dipropylene glycol 5
(7) Polyethylene glycol (Mw1500) 3
(8) Acyl compound 1 of Production Example 1
(9) β-carotene 0.2
(10) Sodium hyaluronate 0.1
(11) Perfume appropriate amount (12) Preservative appropriate amount (13) Purified water 77

[Example 14]
The following anti-aging emulsion was prepared. The results of evaluation of the cosmetic stability, skin irritation and anti-aging effects were all good.
(Composition) (Parts by weight)
(1) Ethanol 15
(2) Glycerin 2
(3) Liquid paraffin 3
(4) Dimeryl silicone (20 cSt) 2
(5) Carboxyvinyl polymer 0.3
(6) Propylene glycol 5
(7) Hydroxypropyl cellulose 0.1
(8) Acyl compound 1 of Production Example 1
(9) Ubiquinone 0.2
(10) Perfume appropriate amount (11) Preservative appropriate amount (12) Purified water 71

[Example 15]
The following anti-aging gel was prepared. The results of evaluation of the cosmetic stability, skin irritation and anti-aging effects were all good.
(Composition) (Parts by weight)
(1) Polyethylene glycol (Mw 1500) 10
(2) Dipropylene glycol 5
(3) Methylcellulose 0.2
(4) Carboxyvinyl polymer 0.4
(5) Acyl compound 1 of Production Example 1
(6) Potassium hydroxide 0.1
(7) Linoleic acid 1
(8) Perfume appropriate amount (9) Preservative appropriate amount (10) Chelating agent appropriate amount (11) Purified water 82

  INDUSTRIAL APPLICABILITY The present invention can be suitably used as an anti-aging cosmetic that is excellent in cosmetic stability, exhibits a sufficient anti-aging effect, and has little irritation.

Claims (11)

  Component (A): An anti-aging cosmetic comprising at least one multi-chain polyhydrophilic group compound having two or more long-chain hydrophobic groups and hydrophilic groups in the molecule.   At least one of the multi-chain poly-hydrophilic group type compound, the long-chain hydrophobic group is a long-chain acyl group, and the hydrophilic group is a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group or a salt thereof The anti-aging cosmetic according to claim 1, which is an anionic surfactant.   The anti-aging cosmetic according to claim 1 or 2, wherein at least one of the multi-chain polyhydrophilic group type compound has an amino acid residue in the molecule. The anti-aging cosmetic according to any one of claims 1 to 3, wherein at least one of the multi-chain polyhydrophilic group type compound is a compound represented by the following general formula (1).

[In General Formula (1), X is a linear, branched, cyclic, or aromatic hydrocarbon chain having a molecular weight of 1 million or less, which may have m functional groups and other substituents. A spacer is shown. N (m ≧ n) Qs bonded to X are substituents represented by the following general formula (2), and may be the same as or different from each other.

(In General Formula (2), Z is a bond derived from a functional group of X, R ¹ CO represents a long-chain acyl group derived from a saturated or unsaturated fatty acid having 8 to 20 carbon atoms, R ² is hydrogen, or a lower alkyl group having 1 to 3 carbon atoms which may be substituted by a hydroxyl group or a carboxyl group, and Y is a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester Represents any of a group or a salt thereof, j and k are each independently 0, 1, or 2 and j and k are not simultaneously 0. n represents an integer of 2 to 20 M represents an integer where m ≧ n.)]   At least one of the multi-chain polyhydrophilic group type compound is a compound represented by the general formula (1), and in the general formula (1), X may have a substituent other than the functional group. The anti-aging cosmetic composition according to any one of claims 1 to 4, wherein the cosmetic composition is a spacer of 1 to 40 linear, branched, cyclic, or aromatic hydrocarbon chains.   Furthermore, anti-aging cosmetics in any one of Claims 1-5 containing at least 1 sort (s) of component (B): anti-aging component.   The anti-aging cosmetic according to claim 6, wherein the anti-aging component is at least one selected from an anti-wrinkle component, an antioxidant component, and a moisturizing agent.   At least one selected from a wrinkle prevention component, an antioxidant component, and a moisturizer is retinol, retinoic acid, carotenoid, ubiquinone, hormones, collagen, anthocyanin, magnesium, saponin, unsaturated fatty acid, tocopherol, hyaluronic acid, trimethylglycine, The anti-aging cosmetic according to claim 7, which is at least one selected from urea, pyrrolidone carboxylic acid, saponin, and ceramide.   Furthermore, at least 1 sort (s) chosen from component (C): anionic surfactant, nonionic surfactant, amphoteric surfactant, and cationic surfactant is contained, The one in any one of Claims 1-8 characterized by the above-mentioned. Anti-aging cosmetics.   Furthermore, anti-aging cosmetics in any one of Claims 1-9 containing at least 1 sort (s) of component (D): a polyhydroxyl compound.   An anti-aging method using the anti-aging cosmetic composition according to claim 1.