JP2005200390A - Endurance promoter and anti-fatigue agent - Google Patents
Endurance promoter and anti-fatigue agent Download PDFInfo
- Publication number
- JP2005200390A JP2005200390A JP2004035731A JP2004035731A JP2005200390A JP 2005200390 A JP2005200390 A JP 2005200390A JP 2004035731 A JP2004035731 A JP 2004035731A JP 2004035731 A JP2004035731 A JP 2004035731A JP 2005200390 A JP2005200390 A JP 2005200390A
- Authority
- JP
- Japan
- Prior art keywords
- endurance
- fatigue
- gold wire
- lotus
- promoter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002929 anti-fatigue Effects 0.000 title claims abstract description 21
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- 240000002853 Nelumbo nucifera Species 0.000 claims description 22
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims description 22
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims description 22
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 22
- 239000003623 enhancer Substances 0.000 claims description 7
- 235000013376 functional food Nutrition 0.000 abstract description 11
- 239000000843 powder Substances 0.000 abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 6
- 239000003814 drug Substances 0.000 abstract description 4
- 241000196324 Embryophyta Species 0.000 abstract description 3
- 241000719836 Anoectochilus formosanus Species 0.000 abstract description 2
- 239000003960 organic solvent Substances 0.000 abstract description 2
- 238000000605 extraction Methods 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 235000013305 food Nutrition 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 230000037396 body weight Effects 0.000 description 6
- 230000002708 enhancing effect Effects 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 235000013402 health food Nutrition 0.000 description 6
- 235000016709 nutrition Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 239000010931 gold Substances 0.000 description 3
- 229910052737 gold Inorganic materials 0.000 description 3
- 230000009182 swimming Effects 0.000 description 3
- 241000719837 Anoectochilus Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- -1 hot water extraction Substances 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241001418093 Anoectochilus koshunensis Species 0.000 description 1
- 241000934230 Anoectochilus roxburghii Species 0.000 description 1
- 241000777300 Congiopodidae Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 229940050526 hydroxyethylstarch Drugs 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 235000008476 powdered milk Nutrition 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
人間および動物の持久力増強および抗疲労作用を目的とした医薬品、栄養機能食品、又は健康食品に関する。 The present invention relates to a pharmaceutical, a nutritional functional food, or a health food for the purpose of enhancing endurance and anti-fatigue action in humans and animals.
健康志向が高まっている現在、スポーツと栄養・生理機能との関係についての認識が深まっている。このような中で、エネルギー補給、疲労回復、さらに瞬発力や持久力増強、身体作りなど様々な場面でスポーツフーズが利用されている。中でも、持久力増強剤および抗疲労剤は、スポーツ選手の成績向上のためのみならず、ふつうの人が仕事をする上での持久力維持や、活力あふれる生活を送るためのものとして多く使用されている。これら持久力増強剤および抗疲労剤の多くは、ビタミン類と生薬から成り、科学的根拠のない古来からの伝承により効果を謳っているものや、カフェインやエチルアルコールを含有し、興奮、不眠などを伴うことも多く、真に健康を目的としたものとは言い難いものもあるのが実情である。このような中で、持久力増強剤および抗疲労剤は、はっきりとした有効性が認められ、科学的根拠のあるものが求められている。また、動物においても同様であり、競走馬などのレース用の動物から家畜、動物園などの施設で飼育されている動物、ペットなどの動物においても持久力増強、抗疲労作用のあるものが求められている。 Now that health consciousness is increasing, there is a growing awareness of the relationship between sports and nutrition / physiology. Under such circumstances, sports foods are used in various situations such as energy supply, fatigue recovery, instantaneous power and endurance enhancement, and body building. Among them, endurance enhancers and anti-fatigue agents are often used not only to improve athletes' performance, but also to maintain endurance when ordinary people work, and to lead a lively life. ing. Many of these endurance enhancers and anti-fatigue agents are made of vitamins and herbal medicines, and have been effective since ancient times without scientific evidence. They contain caffeine and ethyl alcohol, and are excited and insomnia. In many cases, there are some things that are not really aimed at health. Under such circumstances, endurance enhancers and anti-fatigue agents have been found to be clearly effective and have a scientific basis. The same applies to animals. From animals for racing such as racehorses to animals bred in facilities such as livestock, zoos, and animals such as pets, those with increased endurance and anti-fatigue are required. ing.
金線蓮は、台湾において薬王と呼ばれ、古くから珍重されているラン科の多年生薬用植物である。高血圧、解熱、小児の発育不良、肺病、喉の痛み、糖尿病、肝臓病、腎臓病などに効果があると言われている（Ｋａｎ，Ｗ．Ｓ．１９７９．Ｎａｔｉｏｎａｌ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ ｏｆ Ｍｅｄｉｃｉｎｅ）。しかし、金線蓮が持久力増強および抗疲労作用に有効であるという報告は全くない。 The gold line lotus is a perennial medicinal plant of Orchidaceae, which is called Yakuo in Taiwan. It is said to be effective for high blood pressure, antipyretic, poor growth of children, lung disease, sore throat, diabetes, liver disease, kidney disease, and the like (Kan, WS 1979. National Research Institute of Medicine). However, there is no report that gold wire lotus is effective for endurance enhancement and anti-fatigue action.
人間および動物に対して、持久力増強作用および抗疲労作用を有する医薬品、栄養機能食品、又は健康食品を提供することにある。 The object is to provide pharmaceuticals, nutritionally functional foods, or health foods having endurance enhancing action and anti-fatigue action for humans and animals.
上記の課題を解決するために鋭意検討を重ねた結果、金線蓮に、顕著な持久力増強および抗疲労作用効果があることを見出した。すなわち、本発明は、人間および動物に対して、金線蓮を有効成分とする持久力増強および抗疲労作用を有する医薬品、栄養機能食品、又は健康食品を提供する。 As a result of intensive studies to solve the above problems, it was found that the gold wire lotus has a remarkable endurance enhancement and anti-fatigue effect. That is, the present invention provides pharmaceuticals, nutritional functional foods, or health foods with endurance enhancement and anti-fatigue action, which use gold wire lotus as an active ingredient, for humans and animals.
金線蓮の投与により持久力増強および抗疲労作用効果があることが明らかとなった。従って、本発明により、金線蓮を有効成分とする持久力増強および抗疲労作用を有する医薬品、栄養機能食品、又は健康食品を提供することができる。 It has been clarified that administration of gold wire lotus has the effect of enhancing endurance and anti-fatigue. Therefore, according to the present invention, it is possible to provide a pharmaceutical, a nutritionally functional food, or a health food having an endurance enhancement and an anti-fatigue action using gold wire lotus as an active ingredient.
本発明に関わる「金線蓮」とは、金線蓮および近縁種とされているＡｎｏｅｃｔｏｃｈｉｌｕｓ ｆｏｒｍｏｓａｎｕｓ、Ａｎｏｅｃｔｏｃｈｉｌｕｓ ｒｅｉｎｗａｒｄｉｉ、Ａｎｏｅｃｔｏｃｈｉｌｕｓ ｋｏｓｈｕｎｅｎｓｉｓ、Ａｎｏｅｃｔｏｃｈｉｌｕｓ ｒｏｘｂｕｒｇｈｉｉ Ｌｉｎｄｌｙ、Ａｎｏｅｃｔｏｃｈｉｌｕｓ Ｂｌｕｍｅ Ｏｄｏｎｔｃｈｉｌｕｓ ｉｎａｂａｉ Ｈａｙａｔａ、Ｏｄｏｎｔｃｈｉｌｕｓ ｂｉｓａｃｃａｔｕｓ Ｈａｙａｔａなどをさす。 The according to the present invention "gold lotus" refers Anoectochilus formosanus being a gold lotus and Kin'enshu, Anoectochilus reinwardii, Anoectochilus koshunensis, Anoectochilus roxburghii Lindly, Anoectochilus Blume Odontchilus inabai Hayata, etc. Odontchilus bisaccatus Hayata.
本発明に関わる金線蓮は、生のまま使用することができ、乾燥、もしくは乾燥後粉砕した粉末としても使用することができる。また、熱水抽出、エタノール、又は酢酸エチル等有機溶媒で抽出した抽出物としても使用できる。 The gold wire lotus according to the present invention can be used as it is, and can also be used as a dried or pulverized powder after drying. It can also be used as an extract extracted with an organic solvent such as hot water extraction, ethanol, or ethyl acetate.
本発明に関わる「持久力」とは、ある一定の運動状態を継続して行うことができる能力をいう。「疲労」とは、生体がある機能を発揮した結果、その機能が低下する現象をいう。これらに限定されるものではないが例えば、「長時間水泳をし続けることができる」「長く仕事をしていても疲れない」「毎日の生活で疲れが残らない」等を挙げることができる。 “Endurance” according to the present invention refers to the ability to continuously perform a certain exercise state. “Fatigue” refers to a phenomenon in which the function of a living body is reduced as a result of exerting a function. Examples include, but are not limited to, “I can continue swimming for a long time”, “I don't get tired even if I work for a long time”, “I don't get tired in my daily life”, and the like.
本発明に関わる持久力増強剤および抗疲労剤を製造するには、上記の方法で製造した金線蓮粉末もしくは抽出物を用いることができ、常法に従って公知の医薬用無毒性担体と組み合わせて製剤化すればよい。本発明に関わる持久力増強剤および抗疲労剤は、種々の剤型での投与が可能であり、例えば、経口投与剤としては錠剤、顆粒剤、散剤、カプセル剤、ソフトカプセル剤等の固形剤、溶液剤、懸濁剤、乳剤等の液剤、凍結乾燥製剤等が挙げられ、非経口投与剤としては、注射剤のほか、坐剤、噴霧剤、経皮吸収剤等が挙げられ、これらの製剤は製剤上の常套手段により調整することができる。上記の医薬用無毒性担体としては、例えば、グルコース、乳糖、ショ糖、澱粉、マンニトール、デキストリン、脂肪酸グリセリド、ポリエチレングリコール、ヒドロキシエチルデンプン、エチレングリコール、ポリオキシエチレンソルビタン脂肪酸エステル、アミノ酸、アルブミン、水、生理食塩水等が挙げられる。また、必要に応じて、安定化剤、滑剤、湿潤剤、乳化剤、結合剤等の慣用の添加剤を適宜添加することができる。本発明に関わる持久力増強剤および抗疲労剤において、金線蓮粉末もしくは抽出物の投与量は、患者の年齢、体重、症状、疾患の程度、投与スケジュール、製剤形態などにより、適宜選択・決定されるが、例えば、一日あたり０．０１〜１０ｇ／ｋｇ体重程度とされ、一日数回に分けて投与してもよい。動物においても同様に製剤化すればよい。動物の年齢、体重、症状、疾患の程度、投与スケジュール、製剤形態などにより、適宜選択・決定されるが、例えば、一日あたり０．０１〜１０ｇ／ｋｇ体重程度とされ、一日数回に分けて投与してもよい。 In order to produce the endurance enhancer and anti-fatigue agent according to the present invention, the gold wire lotus powder or extract produced by the above method can be used in combination with a known non-toxic pharmaceutical carrier according to a conventional method. What is necessary is just to formulate. The endurance enhancer and anti-fatigue agent according to the present invention can be administered in various dosage forms, for example, as oral administration agents, solid agents such as tablets, granules, powders, capsules, soft capsules, Solutions, suspensions, emulsions and other solutions, lyophilized preparations and the like are included. Parenteral administration agents include injections, suppositories, sprays, transdermal absorption agents, etc., and these preparations Can be adjusted by conventional means on formulations. Examples of the non-toxic pharmaceutical carrier include glucose, lactose, sucrose, starch, mannitol, dextrin, fatty acid glyceride, polyethylene glycol, hydroxyethyl starch, ethylene glycol, polyoxyethylene sorbitan fatty acid ester, amino acid, albumin, water And physiological saline. If necessary, conventional additives such as stabilizers, lubricants, wetting agents, emulsifiers, binders and the like can be appropriately added. In the endurance enhancer and anti-fatigue agent according to the present invention, the dose of gold wire lotus powder or extract is appropriately selected and determined according to the patient's age, weight, symptoms, degree of disease, administration schedule, formulation form, etc. However, for example, the daily dose is about 0.01 to 10 g / kg body weight, and the dose may be divided into several times a day. A similar formulation may be used for animals. It is appropriately selected and determined according to the age, body weight, symptoms, degree of disease, administration schedule, formulation form, etc. of the animal. For example, it is about 0.01 to 10 g / kg body weight per day and divided into several times a day. May be administered.
また、本発明に関わる金線蓮は、食経験も豊富なことから安全性が高いと考えられ、持久力増強および抗疲労作用を目的として、機能性食品として摂取することもできる。本発明に関わる金線蓮（生のまま、乾燥粉末もしくは抽出物）を含有することを特徴とする機能性食品は、特定保険用食品、栄養機能性食品、又は健康食品として位置づけることができる。機能性食品としては、例えば、金線蓮（生のまま、乾燥粉末もしくは抽出物）に適当な助剤を添加した後、慣用の手段を用いて、食用に適した形態、例えば、顆粒状、粒状、錠剤、カプセル剤、ペースト状等に形成したものを用いることができる。この機能性食品は、そのまま食用に供してもよく、また種々の食品（例えばハム、ソーセージ、かまぼこ、ちくわ、パン、バター、粉乳、菓子など）に添加して使用したり、水、酒類、果汁、牛乳、清涼飲料水等の飲物に添加して使用してもよい。かかる食品の形態における本発明の金線蓮（生のまま、乾燥粉末もしくは抽出物）の摂取量は、対象の年齢、体重、症状、摂取スケジュール、製剤形態などにより、適宜選択・決定されるが、例えば、一日あたり００１〜１０ｇ／ｋｇ体重程度とされる。動物においても同様に金線蓮（生のまま、乾燥粉末もしくは抽出物）に適当な助剤を添加した後、慣用の手段を用いて、食用に適した形態、例えば、顆粒状、粒状、錠剤、カプセル剤、ペースト状等に形成したものを用いることができる。また、飼料およびペットフードに添加して使用したり、水などの飲料水に添加してもよい。かかる食品の形態における本発明の金線蓮（生のまま、乾燥粉末もしくは抽出物）の摂取量は、動物の年齢、体重、症状、摂取スケジュール、製剤形態などにより、適宜選択・決定されるが、例えば、一日あたり０．０１〜１０ｇ／ｋｇ体重程度とされる。 In addition, the gold wire lotus according to the present invention is considered to be highly safe because it has abundant eating experience, and can be taken as a functional food for the purpose of enhancing endurance and anti-fatigue action. The functional food characterized by containing the gold wire lotus (raw, dry powder or extract) according to the present invention can be positioned as a food for specific insurance, a nutritional functional food, or a health food. As a functional food, for example, after adding an appropriate auxiliary agent to gold wire lotus (raw, dry powder or extract), using a conventional means, a form suitable for food, for example, granular, Those formed into granules, tablets, capsules, pastes and the like can be used. This functional food may be used as it is, or added to various foods (eg, ham, sausage, kamaboko, chikuwa, bread, butter, powdered milk, confectionery, etc.), water, alcoholic beverages, fruit juice It may be used by adding to drinks such as milk and soft drinks. The intake amount of the gold wire lotus (raw, dry powder or extract) of the present invention in the form of such food is appropriately selected and determined according to the age, weight, symptoms, intake schedule, formulation form, etc. of the subject. For example, it is set to about 001 to 10 g / kg body weight per day. Similarly in animals, after adding a suitable auxiliary agent to gold wire lotus (raw, dry powder or extract), it is used in a conventional manner and is in an edible form, for example, granular, granular, tablet , Capsules, pastes and the like can be used. Moreover, you may add and use for feed and pet food, or may add to drinking water, such as water. The intake amount of the gold wire lotus (raw, dry powder or extract) of the present invention in the form of such food is appropriately selected and determined according to the age, weight, symptoms, intake schedule, formulation form, etc. of the animal. For example, about 0.01 to 10 g / kg body weight per day.
以下に本発明をより詳細に説明するために実施例を挙げるが、本発明はこれらによって何ら限定されるものではない。 Examples are given below to describe the present invention in more detail, but the present invention is not limited by these.
実施例 金線蓮の持久力増強および抗疲労作用の効果
生の金線蓮に、エタノールを１：２の割合で入れ、粉砕を行なった後、２４時間抽出し、減圧濾過を行った。得られた濾液を減圧下で濃縮後、凍結乾燥を行ったところ、濃赤色粉末が得られた。４週齢の雄性ｄｄＹマウスを用い、５日間の予備飼育後、１群１０匹で２群に分けた。群構成は、対照群（水投与群）と、上記方法にて抽出した金線蓮抽出物１０００ｍｇ／ｋｇを投与群とし、週５日間経口投与を行った。投与後１週目からマウスに体重の１０％の重りを付加して強制水泳させ、疲労困憊し頭部が完全に５秒間水中に沈むまでの時間を測定した。その結果を表１に示す。平均値（ｓｅｃ．）±標準誤差を示した。＊：ｐ＜０．０５ｖｓ投与群、Ｓｔｕｄｅｎｔのｔ−ｔｅｓｔによって検定した。Example Effect of Enhancing Endurance and Anti-Fatigue Action of Gold Wire Lotus After putting ethanol in a ratio of 1: 2 into a raw wire wire lotus and grinding, it was extracted for 24 hours and filtered under reduced pressure. The obtained filtrate was concentrated under reduced pressure and then freeze-dried to obtain a dark red powder. Four-week-old male ddY mice were used, and after preliminary breeding for 5 days, 10 mice were divided into 2 groups. The group composition was the control group (water administration group) and the gold wire lotus extract 1000 mg / kg extracted by the above method as the administration group, and oral administration was performed for 5 days a week. From the first week after the administration, a weight of 10% of the body weight was added to the mouse and forced swimming was performed, and the time until the head was completely tired and submerged in water for 5 seconds was measured. The results are shown in Table 1. Average value (sec.) ± standard error was shown. *: P <0.05 vs administration group, tested by Student's t-test.
この結果より、金線蓮投与群において遊泳時間の顕著な延長効果が認められた。 From this result, the remarkable effect of extending swimming time was recognized in the gold wire lotus administration group.
本発明により、金線蓮を有効成分とする持久力増強作用および抗疲労作用を目的とした医薬品、栄養機能食品、又は健康食品を人間および動物に提供することができる。INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide humans and animals with pharmaceuticals, nutritional functional foods, or health foods that have endurance enhancing action and anti-fatigue action using gold wire lotus as an active ingredient.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004035731A JP2005200390A (en) | 2004-01-14 | 2004-01-14 | Endurance promoter and anti-fatigue agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004035731A JP2005200390A (en) | 2004-01-14 | 2004-01-14 | Endurance promoter and anti-fatigue agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2005200390A true JP2005200390A (en) | 2005-07-28 |
Family
ID=34824354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004035731A Pending JP2005200390A (en) | 2004-01-14 | 2004-01-14 | Endurance promoter and anti-fatigue agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2005200390A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011079809A (en) * | 2009-10-05 | 2011-04-21 | China Medical Univ | Polysaccharide extract of anoectochilus spp for promoting growth of useful bacterium, and release of granulocyte-colony stimulating factor, and regulating t helper cell type i and/or t helper cell type ii, and pharmaceutical composition, and method of preparation thereof |
| CN107337741A (en) * | 2017-06-17 | 2017-11-10 | 福建中医药大学 | A kind of preparation method and application of beautiful flower bud Shorthairy Antenoron polyoses extract |
| CN107823450A (en) * | 2017-12-25 | 2018-03-23 | 云南保山嘉宏农业开发（集团）有限公司 | Roxburgh anoectochilus terminal bud tea and manufacture craft |
| CN108721236A (en) * | 2018-06-12 | 2018-11-02 | 贡享本草（永泰）生物科技有限公司 | A kind of roxburgh anoectochilus terminal bud chewable tablets and preparation method thereof |
-
2004
- 2004-01-14 JP JP2004035731A patent/JP2005200390A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011079809A (en) * | 2009-10-05 | 2011-04-21 | China Medical Univ | Polysaccharide extract of anoectochilus spp for promoting growth of useful bacterium, and release of granulocyte-colony stimulating factor, and regulating t helper cell type i and/or t helper cell type ii, and pharmaceutical composition, and method of preparation thereof |
| CN107337741A (en) * | 2017-06-17 | 2017-11-10 | 福建中医药大学 | A kind of preparation method and application of beautiful flower bud Shorthairy Antenoron polyoses extract |
| CN107823450A (en) * | 2017-12-25 | 2018-03-23 | 云南保山嘉宏农业开发（集团）有限公司 | Roxburgh anoectochilus terminal bud tea and manufacture craft |
| CN108721236A (en) * | 2018-06-12 | 2018-11-02 | 贡享本草（永泰）生物科技有限公司 | A kind of roxburgh anoectochilus terminal bud chewable tablets and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI407963B (en) | Contains the composition of riboflavin and sesamin | |
| WO1997014422A1 (en) | Multiple vitamin supplement composition | |
| KR20150101458A (en) | Synergistic dietary supplement for enhancing physical performance | |
| CN104664168B (en) | A kind of piglet specific complex vitamin microemulsion preparation and its preparation method and application | |
| JP2008516998A5 (en) | ||
| JP2009051775A (en) | Endurance-enhancing agent and anti-fatigue agent | |
| WO2012137953A1 (en) | Animal nutrient composition | |
| EP2956013B1 (en) | Horse supplement | |
| JP2005312365A (en) | Lysine-containing antiobesity or antilipemic food, feed and supplement | |
| JP2005200390A (en) | Endurance promoter and anti-fatigue agent | |
| CN101284061B (en) | Chinese herbal medicine formulations for promoting the yellow catfish growing | |
| JP2007230989A (en) | Endurance enhancing and anti-fatigue agent | |
| TW200908992A (en) | Anti-fatigue agent | |
| JP2006197911A (en) | Health food using bee larva | |
| JP2005112831A (en) | Endurance enhancer and anti-fatigue agent | |
| JP2005255574A (en) | IgA-PRODUCTION-LEVELING AGENT AND STRESS DISEASE-PREVENTING AND/OR TREATING COMPOSITION CONTAINING THE SAME | |
| JP2019041687A (en) | Composition for eating and drinking | |
| KR20190063536A (en) | Composition for preventing or treating acute radiation syndrome comprising 1-palmitoyl-2-linoleoyl-3-acetylglycerol | |
| JP2007230987A (en) | Anti-obestic agent | |
| JP2008266278A (en) | Endurance promoter and anti-fatigue agent | |
| KR20160148205A (en) | Capsule with bee pollen and bee venom as active ingredients | |
| JP2007161703A (en) | Anti-fatigue compound, endurance enhancing compound, and food and drink containing the same | |
| JP2012077010A (en) | Composition for building muscle | |
| JP2008067637A (en) | Health supplement | |
| JP4714438B2 (en) | Anti-fatigue agent and food and drink containing the same |