JP2012077010A - Composition for building muscle - Google Patents

Abstract

[PROBLEMS] To prevent muscular weakness in children and young people who have the effect of strengthening muscles without increasing fat and are suffering from muscular weakness, such as elderly people and bed rest persons, muscle and body development. Provision of a highly safe composition that can be used for muscle strengthening in humans or animals such as healthy animals and athletes who want to increase muscle strength and animals, and animals such as livestock that are desired to promote growth or improve meat quality .
SOLUTION: A composition for enhancing muscle containing wheat germ such as bread wheat, durum wheat, club wheat, spelled wheat, enma wheat, etc. belonging to the family Gramineae, talho wheat, wedge-wheat, etc. belonging to the genus Aegilops.
[Selection figure] None

Description

  The present invention relates to a composition for strengthening muscles that can strengthen muscles without increasing fat in the body and is highly safe for living bodies.

  In recent years, the problem of decreased physical strength has surfaced, and the decrease in basic physical strength of young people, particularly children, has been greatly highlighted in conjunction with the problem of declining birthrate. Physical strength is closely related to the body muscle mass. Growth is an important time to form the body such as the skeleton and muscles, but in recent years, children and young people have become normal to take sweets such as confectionery instead of meals. As a result, the necessary skeleton and muscles are not sufficiently formed, resulting in a decrease in physical strength. In recent years, the movement of the body in daily life is becoming less and more due to the development of mechanized moving means such as elevators and the decrease in opportunities and places to exercise. This decrease in muscle mass due to chronic lack of exercise also causes a decline in physical fitness.

  In recent years, the proportion of the population with obesity has been increasing due to changes in lifestyle and diversification of food. Obesity in growing children and young people impairs the formation of necessary muscles and skeletons, impairs healthy physical development and adversely affects health after adulthood. Also, obesity in the elderly can have an immediate adverse effect on health. As the body's fat percentage increases and the proportion of muscle decreases due to obesity, it becomes increasingly troublesome to move the body, and the vigorous cycle of obesity and muscle loss progresses, so the physical strength decreases further.

  One of the main causes of obesity is the calorie intake exceeds the calorie consumption. If you increase muscle mass by exercise and raise basal metabolism, you can improve obesity because calorie consumption increases. However, it is not easy to strengthen muscles by exercising, coupled with the recent tendency to decrease physical strength. In particular, it is difficult for elderly people who have weak muscle strength and basal metabolism. Therefore, there is a demand for means for strengthening muscles without increasing fat by ingesting drugs, foods and drinks, etc. in daily life without performing special training or the like.

  In addition, from the viewpoint of livestock production, it is desired to grow an individual having many muscles and no excess fat in order to obtain good quality meat storage. Furthermore, it would be more desirable if the feed can be efficiently replaced with muscles because cost effectiveness increases.

  Patent Document 1 discloses that a composition obtained by hydrolyzing whey protein under specific conditions exhibits muscle strengthening action. However, the only thing that can be confirmed in Patent Document 1 is to recover a contracted muscle, and has been confirmed to have an effect of enhancing normal muscle and an effect of strengthening muscle without increasing fat. There was no actual situation.

JP 2010-150160 A

  In view of such a conventional situation, an object of the present invention is to provide a material that has an action of strengthening muscles without increasing fat in the body and is highly safe for a living body.

  As a result of intensive studies to solve the above-mentioned problems, the present inventors have found that wheat germ has a strong muscle enhancing action and a lipid metabolism improving action, and can strengthen muscles without increasing body fat. The present invention has been completed by finding out what can be done.

That is, this invention solves the said subject by providing the composition for muscle enhancement which contains wheat germ as an active ingredient.
Moreover, this invention solves the said subject by providing the method of strengthening a muscle, without increasing fat mass by ingesting wheat germ.

  The composition for strengthening muscles of the present invention can strengthen muscles without increasing fat in the body, and has high safety without causing side effects even when taken for a long time. Therefore, the composition for strengthening muscles of the present invention can be used for drugs for improving obesity, muscle strengthening or improving physical strength, functional foods and drinks, feeds, and the like.

The graph which shows the amount of weight gain during a breeding period. The graph which shows the amount of visceral fat after a test. The graph which shows the feed efficiency in a breeding period. The graph which shows the amount of weight gain during a breeding period. The graph which shows the feed efficiency in a breeding period. The graph which shows the amount of visceral fat in each site | part in the body after a test.

  The wheat germ contained in the composition for enhancing muscles of the present invention refers to a germ portion contained in wheat seeds that becomes a radicle or cotyledon during germination. Therefore, the composition for muscle enhancement of the present invention may contain wheat seeds containing a germ portion as it is, but is commercially available as wheat germ (for example, “Wheat Germ” manufactured by Nisshin Pharma), etc. It is preferable that a germ separated from wheat seeds is contained.

  Of the components contained in the wheat germ, the wheat germ oil has no muscle-enhancing effect, and the wheat germ may be altered by the oxidation or rot of the oil, so that it is preferably removed. Therefore, defatted wheat germ is more desirable as the wheat germ. As the defatted wheat germ, those produced from wheat germ by a known method such as a pressing method or an extraction method may be used, or commercially available defatted wheat germ (for example, “Higie B” manufactured by Nisshin Flour Milling) ) Can also be used.

  Any wheat can be used as the wheat germ material as long as it is available. Preferable examples include bread wheat, durum wheat, club wheat, spelled wheat, enma wheat, etc., Gramineae Aegilops talho wheat, wedge wheat, and the like.

  The wheat seed including the germ part, the germ separated from the seed, and the defatted wheat germ may be in any form such as crushing, pulverizing, granulating, powdering, and drying, roasting, heating, dissolving Or the like. In the composition for enhancing muscles of the present invention, the wheat seed containing the above-mentioned germ portion, the germ separated from the seed, or the defatted wheat germ may each be contained alone, or any two or more of them may be used in combination. May be.

  As shown in Examples described later, by ingesting wheat germ, muscles can be strengthened without increasing body fat. Therefore, the composition for strengthening muscles of the present invention containing wheat germ is useful for the elderly and bed resters who suffer from muscle weakness; children and young people who need muscle and body development; It can be used for muscle strengthening in humans or animals such as healthy individuals and athletes who desire muscle strength enhancement; and animals such as domestic animals where growth promotion or meat quality improvement is desired.

  In addition, as shown in Examples below, when wheat germ is ingested, the rate of increase in muscle with respect to food intake is improved. Therefore, the composition for strengthening muscles of the present invention containing wheat germ can efficiently strengthen muscles without the need for ingesting a large amount of food, so that it can be applied to elderly people and sick people with reduced appetite. As well as cost-effective improvement in livestock.

  The wheat germ contained in the composition for muscle enhancement of the present invention is a substance that has been conventionally used as a food, and there is no side effect even if taken for a long time. It can be used safely for the elderly and the sick. Accordingly, the muscle building composition of the present invention can be used as a pharmaceutical product, food or drink, feed, etc. for muscle building for humans or animals, or for producing them.

When the muscle building composition of the present invention is a pharmaceutical product, the composition can be administered in any dosage form including oral and parenteral administration.
Dosage forms for oral administration include solid preparations such as tablets, coated tablets, granules, powders, capsules, or liquid preparations such as elixirol, syrups and suspensions. Examples of the dosage form for parenteral administration include injection, infusion, transdermal, transmucosal, nasal, enteral, inhalation, suppository, bolus and the like.

When the composition for enhancing muscles of the present invention is a food or drink or a feed, the composition is based on the concept of a muscle enhancing effect, and a functional food or drink, a food or drink for the sick, or a food or drink for specified health that indicates that effect. It can be used for livestock feed, pet food and the like.
The form of the food or drink or feed is not particularly limited. For example, the drink form includes fruit juice drinks, carbonated drinks, tea drinks, milk drinks, alcoholic drinks, soft drinks, and the like. It can be solid, semi-solid or liquid, and includes tablet form, pill form, capsule form, liquid form, syrup form, powder form, granule form and the like. Specific food forms include breads, noodles, jelly-like foods and various snacks, baked goods, cakes, chocolate, gum, candy, tablets, capsules, soups, dairy products, frozen foods, instant foods, Examples include supplements, other processed foods, seasonings and raw materials thereof.

The composition for enhancing muscles of the present invention may contain other components other than wheat germ, for example, other active ingredients and / or additives or carriers that are usually used, as necessary.
When the muscle building composition of the present invention is a pharmaceutical product, other ingredients other than wheat germ include, for example, other medicinal ingredients, cosmetic ingredients, nutrition ingredients, excipients, disintegrants, binders, lubricants. Agent, surfactant, water-soluble polymer, diluent, osmotic pressure adjuster, pH adjuster, emulsifier, preservative, buffer, stabilizer, antioxidant, thickener, UV absorber, activity enhancer , Coloring agents, sweeteners, flavoring agents, flavoring agents, acidulants and the like, and these are used in appropriate combinations.
When the composition for enhancing muscles of the present invention is a food or drink or feed, examples of other ingredients other than wheat germ include other nutritional ingredients, cosmetic ingredients, and solvents, oils, softeners, emulsifiers, preservatives, Stabilizers, antioxidants, colorants, ultraviolet absorbers, humectants, thickeners, brighteners, sweeteners, fragrances and the like can be used, and these are used in appropriate combinations.

The content of wheat germ in the composition for enhancing muscles of the present invention varies depending on the dosage form and form thereof, but in terms of dry wheat germ, usually, in the case of a pharmaceutical, It is 90 mass%, Preferably it is 5-70 mass%, and in the case of food-drinks or feed, it is 5-100 mass%, Preferably it is 10-90 mass%. In terms of dry defatted wheat germ, it is usually 1 to 90% by mass, preferably 20 to 60% by mass in the case of pharmaceuticals, and 1 to 100% by mass in the case of food and drink or feed, with respect to the total mass of the composition. Preferably it is 5-95 mass%.
The administration or intake of the composition for enhancing muscle according to the present invention is usually 2 to 30 g, preferably 6 to 30 g per day in terms of the amount of wheat germ. It is 2 to 27 g per day, preferably 6 to 27 g. The administration or intake amount can be appropriately adjusted according to the usage and application target.

  EXAMPLES Next, although an Example is shown and this invention is demonstrated further in detail, this invention is not limited to a following example.

Test example 1
Rats (male Wistar, 5 weeks old) were subjected to the test after 1 week of preliminary breeding. The control group, the wheat germ oil group, and the wheat germ group were divided into 5 groups per group, fed with the composition shown in Table 1, and reared for 2 weeks with free intake and free water absorption. During the breeding, the food intake of each individual was measured. After the breeding, each individual was weighed and then sacrificed under ether anesthesia to remove visceral fat (mesenteric fat, testicular fat and perirenal fat), and the total weight was measured.

The results are shown in Table 2 and FIGS. In the wheat germ group, the body weight increased more than in the control group (Table 2 and FIG. 1). On the other hand, in the wheat germ group, the visceral fat amount decreased (Table 2 and FIG. 2) and the fecal amount increased (data not shown) as compared to the control group. It was suggested that it was not caused by an increase in body fat but was caused by an increase in muscle mass. That is, by ingesting wheat germ, muscles can be strengthened without increasing the amount of fat in the body.
Furthermore, in the wheat germ group, feed efficiency (weight gain per 100 g of food intake) was improved compared to the control group (Table 2 and FIG. 3). It was found that muscles were strengthened even when a large amount of sample was ingested.
In animals fed wheat germ oil, the amount of visceral fat decreased compared to the control group, but no effect of increasing body weight or improving feed efficiency was confirmed.

Test example 2
Rats (male Wistar, 5 weeks old) were subjected to the test after 1 week of preliminary breeding. The control group and the wheat germ group were divided into 5 groups per group, fed with the composition shown in Table 1, and reared for 2 weeks with free intake and free water absorption. During the breeding, the food intake of each individual was measured. After completion of the breeding, each individual was weighed and then sacrificed under ether anesthesia, and the mesenteric fat, testicular fat and kidney fat were peeled off, and each weight was measured.

  The results are shown in Tables 3 to 4 and FIGS. Animals fed wheat germ gained more weight (Table 3 and FIG. 4) and improved feed efficiency (Table 3 and FIG. 5) compared to controls. Further, in the animals fed with wheat germ, the visceral fat mass, particularly the perirenal fat mass, decreased compared to the control (Table 4 and FIG. 6).

Claims (6)

  A composition for enhancing muscles, comprising wheat germ.   The composition for enhancing muscles according to claim 1, wherein the wheat germ is defatted wheat germ.   The composition for enhancing muscles according to claim 1 or 2, wherein the composition is a food or drink.   The composition for enhancing muscles according to claim 1 or 2, wherein the composition is a feed.   The composition for enhancing muscles according to claim 1 or 2, wherein the composition is a medicine.   A method of strengthening muscles without increasing fat mass by ingesting wheat germ.

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