JP2002284690A - Melanin formation inhibitor and whitening agent including ganoderod b and composition containing ganoderol b - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a substance effective for preventing, improving and treating skin pigmentation such as whitening of tanned skin after irradiating ultraviolet rays, and spots, freckles and liver spots due to tanning, and a composition containing the same. Providing things. SOLUTION: The following formula (1): A melanin production inhibitor and a whitening agent comprising ganoderol B represented by the formula: A melanin production inhibitor and a whitening agent containing ganoderol B represented by Chemical Formula 4. A composition for suppressing melanin production and a composition for whitening containing ganoderol B represented by Chemical Formula 4. A cosmetic, a medicine, and a skin external preparation containing ganoderol B represented by Chemical Formula 4. Ganoderol B represented by Chemical Formula 4
A food for inhibiting melanin production and a food for whitening, containing.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a melanin production inhibitor and a whitening agent comprising ganoderol B, and a composition containing ganoderol B, particularly a cosmetic, a medicine, an external preparation for skin and a food. More specifically, melanin which suppresses melanin production in melanocytes and can prevent, improve and treat skin pigmentation such as whitening of tanned skin after ultraviolet irradiation, and spots, freckles, and melasma due to tanning. The present invention relates to a production inhibitor and a whitening agent, and a composition, particularly a cosmetic, a medicine, a skin external preparation, and a food.

[0002]

2. Description of the Related Art Skin pigmentation such as spots, freckles and liver spots due to sunburn, etc., occurs with aging and increases or hardly disappears with aging. ing. Although the mechanism of the onset of these pigmentations has not yet been clarified, melanin pigments are produced in melanin-producing granules called melanosomes in melanocytes present in epidermal cells due to sunburn (especially ultraviolet rays) and the like. melanin pigment is thought to be caused by spreading to adjacent cells.

[0003] There is a strong demand for the development of substances capable of restoring such pigmentation to normal skin color, and many substances have been commercialized so far. For example,
L-ascorbic acid, kojic acid, hydroquinone and the like are known.

[0004] However, L- ascorbic acid is the flame stability, but Kojic acid has been found prima facie effect,
The effect is weak. On the other hand, although hydroquinone has also been recognized as having an effect, it is irritating and allergic, has a problem in safety, and has a problem in being formulated as a drug. Therefore, a substance having a sufficient pigmentation preventing and improving effect has not yet been known.

[0005]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and has as its object the whitening of tanned skin after irradiation with ultraviolet rays, and the pigmentation of skin such as spots, freckles, and liver spots due to tanning. An object of the present invention is to provide a substance effective for prevention, improvement and treatment of deposition and a composition containing the same.

[0006]

Means for Solving the Problems The present inventors have conducted intensive studies in order to solve the above-mentioned problems, and as a result, have found that the extract of Ganoderma lucidum has an inhibitory effect on melanin production. The present inventors have found that ganoderol B having a specific structure, obtained by fractionating a product using a separation and purification means, has a strong melanin production inhibitory action and a whitening action, and solves the above-mentioned problems, and has completed the present invention. Reached.

That is, the present invention provides the following formula (1)

Embedded image A melanin production inhibitor and a whitening agent comprising ganoderol B represented by the formula:

Further, the present invention is a melanin production inhibitor and a whitening agent containing ganoderol B represented by the above formula (2).

Further, the present invention is a composition for suppressing melanin production and a whitening composition containing ganoderol B represented by the above formula (2).

[0010] The present invention is also a cosmetic containing ganoderol B represented by Chemical Formula 2, and this cosmetic can be used for inhibiting melanin production and whitening.

Further, the present invention is a pharmaceutical comprising the Ganoderoru B represented by Formula 2, the medicament can be used for and whitening inhibition of melanin production.

Further, the present invention is a skin external preparation containing ganoderol B represented by Chemical Formula 2, and this skin external preparation can be used for inhibiting melanin production and whitening.

Further, the present invention is a food for suppressing melanin production and a food for whitening, containing ganoderol B represented by the above formula (2).

[0014]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of the present invention will be described in detail.

The following formula (1) used in the present invention:

Embedded image Ganoderol B represented by is a known substance. However, it is not known that ganoderol B represented by Chemical Formula 3 (hereinafter simply referred to as ganoderol B) has an effect of suppressing melanin production and has a skin whitening effect.

Ganoderol B can be isolated from fungi, and any fungus including ganoderol B can be used for the production of ganoderol B. For example, Lingzhi is conveniently used. It can also be prepared by chemical synthesis. Ganoderol B can be isolated from a fungus containing ganoderol B as follows. That is, the fungal fruit body or the mycelium, a part of the spores and the like are preferably ground, and then immersed in an extraction solvent or heated to reflux in the extraction solvent, and then filtered, centrifuged to remove insoluble matter. The obtained extract solution is concentrated in some cases, and then isolated by a known separation and purification means.

The solvent used for the extraction may be a solvent usually used for the extraction of fungi, plants and the like. For example, alcohols such as methanol and ethanol, organic solvents such as acetone and ethyl acetate, and water may be used alone or in combination. Can be. The extraction method may be a conventional one. Generally, the extraction temperature is in the range of 0 to 100 ° C, preferably 40 to 70 ° C, and the extraction time is 1 to 168 hours, preferably 2 to
4 to 72 hours. Isolation from the extraction solution is, for example,
It can be performed by chromatography such as reverse phase chromatography, gel filtration column chromatography, and liquid chromatography.

Hereinafter, specific examples of the extraction of fungi and the isolation of ganoderol B will be described. [Purification Example] The cultivated ganoderma ginseng was pulverized, immersed in methanol, and extracted at 40 ° C for 72 hours. Next, insoluble materials were removed by filtration, and the obtained extract was concentrated, and then purified by reverse phase chromatography. The structure of the purified product was determined by mass spectrometry gas chromatography and NM.
It was determined by R. The compound was Ganoderol B shown in the formula (1) and was a derivative of ergosterol.

The ganoderol B of the present invention has a melanin production inhibitory action and a whitening action, as described later. Therefore, it can be used as a melanin production inhibitor and a whitening agent. Further, as a composition containing ganoderol B, a composition for suppressing melanin production and a composition for whitening, that is, a composition for preventing and treating melanin production suppression and symptoms related to whitening, specifically, cosmetics, It can be applied to various cosmetics, pharmaceuticals, foods and the like in the field of pharmaceuticals and foods.

The composition of the present invention can take both oral (internal) and parenteral (external) forms. For oral use, the compositions of the present invention are prepared, for example, in the form of a medicament or food. In the case of parenteral use, it can be prepared in the form of cosmetics, quasi-drugs, medicaments, skin external preparations and the like.

When compounding ganoderol B with the composition of the present invention, a pure product of ganoderol B is compounded, but it may also be compounded in the form of an extract or extract of a plant or fungus containing ganoderol B. I do not care.

Hereinafter, specific compositions of the present invention containing ganoderol B will be described in more detail according to their uses. Cosmetics which are the first use of the present invention include, for example, ointments, solutions, creams, emulsions, lotions, lotions, gels, essences (essences), foundations, pack masks, lipsticks, sticks, bath agents, etc. It can be applied in a wide range including quasi-drugs as an external preparation for skin.

[0023] The form of the cosmetic is also a solution type, a solubilizing type, an emulsifying type, a powder type, a powder dispersing type, an oil liquid type, a gel type, an ointment type, an aerosol type, a water-oil two-layer type, a water type. A wide range of dosage forms, such as an oil-powder three-layer system, can be employed.

The compounding amount of ganoderol B in the cosmetic of the present invention is preferably 0.001 to 20% by weight, more preferably 0.01 to 16% by weight, and still more preferably 0.1 to 12% by weight based on the total amount of the cosmetic. % By weight. Most preferred is 1 to 10% by weight. Since the cosmetic of the present invention has a melanin production inhibitory action and a whitening action, it is used as a melanin production inhibitory cosmetic and a whitening cosmetic. In addition, the cosmetic of the present invention can be preferably used particularly as an external preparation for skin, and is therefore used as a skin external preparation for suppressing melanin production and a skin external preparation for whitening.

The medicament which is the second use of the present invention can be administered by oral administration or parenteral administration, and can be in the form of a pharmaceutical preparation suitable for each. Pharmaceutical preparations include, for example, liquids, syrups, injections, inhalants, liquids such as emulsions, tablets, powders, granules,
Capsules, solid preparations such as inhalants, skin external preparations such as ointments,
External preparations such as suppositories can be given.

The compounding amount of ganoderol B in the pharmaceutical preparation is preferably 0.001 to 30% by weight based on the total amount of the pharmaceutical preparation. More preferably, it is 0.01 to 20% by weight, most preferably 0.1 to 10% by weight. The dose may be suitably varied based on the age and weight of the patient, the route of application, the degree of progression of the disease, and the concurrent treatment, and is not specified, but is generally, The dose can be administered once or twice or three times a day in about 4 to 10 ml, but is not limited thereto. Since the medicament of the present invention has a melanin production inhibitory action and a whitening action,
It is used as a melanin production inhibitor and whitening agent. In addition, the medicament of the present invention can be preferably used particularly as an external preparation for skin, and thus is used as a skin external preparation for suppressing melanin production and a skin external preparation for whitening.

The food which is the third use of the present invention is useful as a so-called health food.
Beverages such as soft drinks, vegetables or fruit processed products, meat products, can be widely applied as a seasoning or the like. As the form,
Powders, solid products, solutions and the like. The compounding amount of ganoderol B in food can be appropriately changed depending on the purpose, product form and the like. Generally, in the case of a solution such as a drink,
For example, the amount is 0.001 to 10 mg, preferably 0.01 to 5 mg, more preferably 0.15 to 1 mg in 30 ml. In the case of a powdered solid product such as a tablet, the content is, for example, 0.001 to 10 mg, preferably 0.1 to 300 mg.
The amount is from 01 to 5 mg, more preferably from 0.1 to 1 mg. Since the food of the present invention has a melanin production inhibitory action and a whitening action, it is used as a melanin production inhibitory food and a whitening food.

In the composition of the present invention such as cosmetics, medicines and foods, in addition to the above-mentioned ganoderol B, other components usually used in cosmetics, medicines and foods, etc. as long as the effects of the present invention are not impaired. Can be blended.

For example, cosmetics include oily components, powders, surfactants, humectants, thickeners, lower alcohols, film agents, ultraviolet absorbers, sequestering agents, organic amines, pH adjusters, and medicinal effects. Ingredients include sugars, preservatives, vitamins, other whitening agents, antioxidants, fragrances, water and the like.

Examples of the oily component include jojoba oil, olive oil, avocado oil, castor oil, coconut oil, tallow, hardened oil,
Natural oils and fats such as liquid lanolin and derivatives thereof, carnauba wax, beeswax, waxes such as lanolin, liquid paraffin,
Hydrocarbons such as microcrystalline wax, squalane, petrolatum, higher fatty acids such as stearic acid, higher alcohols such as cetyl alcohol and stearyl alcohol, glycerin monostearate, glyceryl trioctanoate, glycerin monooleate, isopropyl myristate, Diisostearyl malate, di-2
Esters such as glycerin heptylundecanoate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane trioctanoate, di-2-ethylhexyl sebacate, essential oils such as peppermint oil, rose oil and citronellal, dimethylpolysiloxane And silicone oils such as decamethylcyclopentasiloxane. The amount of these oily components in the cosmetic is appropriately selected depending on the form, dosage form, and the like of the cosmetic, but can be usually 0.1 to 95% of the total amount of the cosmetic.

Examples of the powder include talc, mica, kaolin, silica, zinc white, titanium mica, titanium oxide, iron oxide, nylon powder and the like.

Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester,
Nonionic surfactants such as glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitol fatty acid ester, polyoxyalkylene-modified polysiloxane, anionic surfactant such as sodium palmitate, and cationic interface such as stearyltrimethylammonium chloride Surfactants and amphoteric surfactants such as sulfobetaine.

Examples of humectants include glycerin, 1,3
-Butylene glycol, polyethylene glycol, dipropylene glycol, sorbitol and the like.

Examples of the thickener include water-soluble polymers such as carboxyvinyl polymer, carboxymethylcellulose and polyvinyl alcohol, and clay minerals such as bentonite.

Examples of the ultraviolet absorber include para-aminobenzoic acid (hereinafter abbreviated as PABA), glyceryl PABA,
Ethyl dihydroxypropyl PABA, octyl methoxycinnamate, 2-ethoxyethyl-p-methoxycinnamate, 2,4-dihydroxybenzophenone,
-Hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4-methylbenzophenone, 2
-Hydroxy-4-methoxy-4-methylbenzophenone sulfonate, urocanic acid ethyl ester, 2-phenyl-5-methylbenzoxazole, 4-methoxy-
4-t-butyldibenzoylmethane, ethylhexyl paramethoxycinnamate and the like.

Examples of sequestering agents include tetrasodium edetate, citric acid and the like. Examples of lower alcohols include ethanol and the like. Examples of organic amines include monoethanolamine, triethanolamine and the like. Examples of pH adjusters include:
Buffers such as lactic acid-sodium lactate and citric acid-sodium citrate are exemplified.

Examples of the medicinal component include pantothenyl ethyl ether, glycyrrhizinate and the like. Examples of vitamins include vitamin C or a derivative thereof, vitamin E or a derivative thereof, and the like. Examples of antioxidants include tocopherols, dibutylhydroxytoluene, propyl gallate and the like.

Examples of sugars include erythritol, sucrose, hyaluronic acid and the like. Examples of preservatives include ethyl paraben, butyl paraben, sodium benzoate and the like. Examples of whitening agents include ascorbic acid or its derivatives, kojic acid or its derivatives, licorice extract, hydroquinone derivatives, glutathione and the like.

Next, pharmaceuticals include excipients, stabilizers, wetting agents, emulsifiers, absorption enhancers, pH adjusters, surfactants,
Various additional components such as diluents and carriers can be blended. Specific examples of these additional components include, for example, starch, sugars such as lactose, magnesium sulfate, talc, gelatin, cellulose derivatives such as hydroxypropylcellulose, soybean oil, vegetable oils such as sesame oil, animal oils or synthetic oils, Examples thereof include water such as rubber and physiological saline, and alcohols such as ethanol, 1,3-butylene glycol, and polyalkylene glycol. In addition, it can also be selected and blended from the components that can be blended in the cosmetic.

Next, foods include sweeteners, acidulants, preservatives, flavors, colorants, excipients, stabilizers, wetting agents, emulsifiers, absorption enhancers, pH adjusters, surfactants, and diluents. Various additional components such as a carrier and the like can be blended. Specific examples of these additional components include, for example, mushroom extract,
Ginseng extract, ginger extract, various food extract extracts such as honey, liquid foods, and saccharides include cyclic oligosaccharides, reduced maltose, trehalose, lactose, sucrose fatty acid esters, and the like. In addition, the cosmetics,
It can also be selected from components that can be blended with a medicine and blended.

The composition of the present invention can be prepared in any form and dosage form by mixing the essential components of the present invention and one or more of the above optional components, by a conventional method.

[0042]

The present invention will be specifically described below with reference to examples. In the compounding amounts of the composition, those not particularly described are% by weight.

Example 1 Melanin Production Inhibitory Effect [Melanin Production Inhibitory Effect on B16 Melanoma Cells] Melanin production inhibitory effect was measured by B16 10F7 melanoma cells, which are mouse-derived melanocytes (available from Akita Prefectural Food Research Institute) Using a solution obtained by diluting ganoderol B purified in the above purification example with a culture solution, and then applying the solution to cells to observe and evaluate melanin production. B-
For 16 cells, 70% confluent cells were washed with PBS, and trypsin was added to detach the cells. The same amount of serum-containing medium (E-MEM + 10% FBS) as trypsin was added, and the cells were collected and centrifuged (800 rpm, 5 min.). The number of cells is counted and about 10 ⁴ cells / ml (E-MEM + 10% FBS)
Was adjusted. Ganoderol B solution was diluted by dispensing 20 μL of sterile PBS into a cell culture plate (for adherent cells), taking 20 μL of Ganoderol B solution, and diluting it twice (final concentration in culture solution: 100 μg / mL to 0.0012 μg / mL). .
Arbutin as a control (final concentration 1 in culture solution)
40 μg / mL to 0.22 μg / mL), and methanol was similarly diluted.

The cell suspension was dispensed at 80 μL each onto a plate containing the diluted solution. Furthermore, 37 ° C., and 72 hours of culture at a CO ₂ incubator, a microscope, and observed melanin production in the cell. Furthermore, when melanin is produced, 300 μL of 1N, NaO
In H, dissolved melanin was evaluated melanin production amount by measuring the ultraviolet absorption of 470 nm. Ganoderol B and arbutin were dose-changed with the value obtained by reacting the solvent methanol as 100%, and the concentration showing melanin synthesis inhibition at the lowest concentration was determined. Table 1 shows the results. In addition, in the case of ganoderol B, even in the case of arbutin, the blackness of B-16 cells was suppressed to the same extent as in the case of arbutin, and it was confirmed that Ganoderol B had excellent melanin production inhibitory effect and whitening effect.

[0045]

[Table 1]

As can be seen from Table 1, ganoderol B has a melanoma B16 cell activity similar to that of arbutin, which is a melanin production inhibitor, and is useful as a melanin production inhibitor and whitening agent. It is clear that.

Examples 2-3, Comparative Examples 1-2 Measurement of Whitening Effect Ingredients Amount (wt%) (Alcohol Phase) Ethyl Alcohol 25.0 Polyoxyethylene (25 mol) Hardened Castor Oil 2.0 Oxidation Inhibitors Appropriate Preservatives Appropriate Perfume Appropriate Amount Test Compound (described in Table 2) Amount described in Table 2 (aqueous phase) Glycerin 5.0 Sodium hexametaphosphate Appropriate amount Ion-exchanged water Residue (Preparation method) After preparing an alcohol phase, the two were mixed and solubilized to obtain a composition (lotion).

(Test Method) Twenty panelists were exposed to sunlight for a total of four hours during a period from 11:00 am to 1:00 pm in the summer in two days. The above composition (lotion) was applied once a day in the morning and evening for 5 weeks from 5 days after the sun was exposed to the exposed inner skin of the upper arm of the panelists.

(Evaluation Method) The test results after use were evaluated according to the following criteria.

(Judgment criteria) Significant effect: Pigmentation became almost inconspicuous. Effective: Pigmentation was very light. Somewhat effective: Pigmentation became light. Invalid: No change.

(Judgment) ：: 16 or more of the panelists showed an effect that was more than effective. ：: 11 to 15 panelists showed an effect more than effective. △: 6~10 people out of panelists showed an effective or more effective. X: Five or less panelists showed the effect more than effective.

Table 2 shows the evaluation results.

[0053]

[Table 2]

As is clear from Table 2, Ganoderol B
The composition containing (a lotion) prevented the deposition of melanin pigment and exhibited a whitening effect. On the other hand, when no test compound was added (Comparative Example 1) and when hydroquinone was added (Comparative Example 2), no effect was observed.

Examples of the present invention in which various formulations were prepared by a conventional method are shown below. In all Examples, excellent melanin production inhibitory effect and whitening effect were observed.

[0056] [Example 4] Cream Ingredients Amounts (wt%) Stearic acid 6.0 glyceryl monostearate 2.0 polyoxyethylene (20 mol) Soruhi Keypad monostearate 2.0 1,3-butylene glycol 10.0 Ganoderol B 5.0 Isopropyl myristate 12.0 Squalane 5.0 Liquid paraffin 3.0 Vitamin E 0.05 Sodium bisulfite qs Preservative qs Perfume qs Ion exchange water residue

Example 5 Emulsion Ingredients Compounding Amount (% by Weight) Stearyl Alcohol 2.0 Squalane 5.0 Liquid Lanolin 3.0 Trimethylolpropane Trioctanoate 2.0 Glyceryl Trioctanoate 5.0 Glycerin Monooleate 2.0 Polyoxyethylene (20 mol) sorbitan monooleate 1.0 Vitamin C 0.1 Preservatives Appropriate Ganoderol B 8.0 Paraaminobenzoic acid 0.1 Fragrance Appropriate Sodium bisulfite Appropriate glycerin 5.0 Carboxyvinyl polymer 0.2 Triethanolamine 1.0 Purified water residue

Example 6 Gel Component Compounding Amount (% by weight) Dipropylene glycol 10.0 PEG 1500 5.0 Carboxyvinyl polymer 1.0 Ethyl alcohol 2.0 Polyoxyethylene (50 mol) Oleyl ether 2.0 Water Potassium oxide 0.15 Ganoderol B 1.0 Sodium 2-human peroxy-4-methoxybenzosophenonesulfonate 0.05 Preservatives proper amount EDTA ・ 3Na proper amount Fragrance proper amount Deionized water residue

[Example 7] Essence component blending amount (% by weight) Glycerin 5.0 Dipropylene glycol 10.0 Ethanol 10.0 Carboxyvinyl polymer 0.2 Sodium hyaluronate 0.5 Potassium hydroxide 0.1 Polyoxy Ethylene (20 mol) sorbitan monooleate 0.5 Polyoxyethylene (20 mol) octyl decyl ether 1.0 Olive oil 0.15 Vitamin E acetate 0.1 Ganodelol B 3.0 Appropriate sodium bisulfite Preservative Appropriate EDTA 3Na qs perfume qs Purified water residue

Example 8 Pack Ingredients Compounding Amount (% by Weight) Polyvinyl Acetate Emulsion 15.0 Polyvinyl Alcohol 10.0 Dipropylene Glycol 5.0 Sorbitol 5.0 Tocopherol Acetate 0.2 Olive Oil 1.0 Squalane 3. 0 Polyoxyethylene (20 mol) sorbitan monooleate 1.5 Titanium oxide 5.0 Talc 10.0 Ethanol 7.0 Ganoderol B 3.0 Preservatives Appropriate amount Perfume Appropriate amount Purified water residue

[Example 9] Lotion component amount (% by weight) 1,3-butylene glycol 6.0 glycerin 5.0 sodium hyaluronate 0.3 polyoxyethylene (20 mol) sorbitan monostearate 5 Polyoxyethylene (20 mol) octyl decyl ether 0.5 Ethanol 15.0 Ganoderol B 4.0 Preservatives Appropriate perfume Appropriate amount Purified water Residue

Example 10 Ointment Ingredients Compounding amount (% by weight) Polyoxyethylene (30 mol) hydrogenated castor oil 2.0 Glyceryl monostearate 10.0 Squalane 10.0 Vaseline 40.0 Cetanol 6.0 Ganoderol B 5.0 1,3-butylene glycol 10.0 Ion-exchanged water Residual Preservatives Appropriate perfume Appropriate amount

Example 11 Foundation Component Compounding Amount (% by Weight) Talc 3.0 Titanium Oxide 5.0 Bengala 0.5 Iron Oxide Yellow 1.5 Iron Oxide Black 0.1 Bentonite 0.5 Polyoxyethylene (20 Mol) sorbitan monostearate 1.0 triethanolamine 1.0 glycerin 5.0 propylene glycol 5.0 stearic acid 2.0 glycerin monostearate 10.0 liquid paraffin 10.0 dimethylpolysiloxane 5.0 polyoxy Alkylene-modified polysiloxane 3.0 Ganoderol B 3.0 Purified water Remaining amount Preservative appropriate amount Perfume appropriate amount

Example 12 Healthy Drink Ingredients (30 mL) Ganoderol B 0.085 mg Ginseng extract 50 mg Cordyceps sinensis extract 100 mg Ginger extract 300 mg Honey 150 mg Cyclic oligosaccharide 300 mg Sweetener Suitable amount Acidulant Suitable amount Preservative Suitable amount Flavoring agent Appropriate amount

Example 13 Healthy Drink Ingredients Amount (in 30 mL) Ganoderol B 0.5 mg Ginseng extract 50 mg Cordyceps sinensis extract 100 mg Ginger extract 300 mg Honey 150 mg Cyclic oligosaccharide 300 mg Sweetener Appropriate acidulant Appropriate preservative Appropriate flavor Appropriate amount

Example 14 Healthy Food Tablet Ingredients Ingredients (in 300 mg) Ganoderol B 0.025 mg Reduced maltose 87.8 mg Trehalose 41.2 mg Lactose 16.5 mg Sucrose fatty acid ester 6.2 mg Dextrin 148.275 mg

Example 15 Healthy Food Tablet Ingredients Ingredients (in 300 mg) Ganoderol B 0.5 mg Reduced maltose 87.8 mg Trehalose 41.2 mg Lactose 16.5 mg Sucrose fatty acid ester 6.2 mg Dextrin 147.8 mg

[0068]

As described in detail above, according to the present invention,
A novel melanin production inhibitor, whitening agent, and a composition having a melanin production inhibitory action and a whitening action can be obtained. In addition, it has a melanin production inhibitory action and whitening effect, whitening of tanned skin after ultraviolet irradiation, and stains due to sunburn,
The present invention provides cosmetics, medicines, external preparations for skin, and foods having excellent effects on prevention, improvement and treatment of skin pigmentation such as freckles and liver spots.

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (reference) A61K 7/00 A61K 7/00 NRUX 7/021 7/021 7/48 7/48 A61P 17/16 A61P 17 / 16 43/00 111 43/00 111 C07J 13/00 // C07J 13/00 A23L 2/00 F (72) Inventor Keiji Hata 3-1-45 Yahashi Honcho, Akita City, Akita Prefecture Koyodai Mansion 203 F-term (Reference) 4B017 LC03 LK06 4B018 MD08 ME14 4C083 AA112 AA122 AB032 AB232 AB242 AB282 AB352 AB432 AB442 AC012 AC022 AC072 AC102 AC122 AC132 AC182 AC242 AC352 AC392 AC422 AC432 AC442 AC532 AC542 AC622 AC792 AD042 AD092 AD112 AD152 AD162 AD332 AD491 CC CC05 CC07 CC12 DD22 DD23 DD27 DD31 DD38 DD41 EE16 FF05 4C086 AA01 AA02 DA11 MA01 MA04 NA14 ZA89 ZC20 ZC41 4C091 AA01 BB10 BB20 CC01 DD01 EE04 FF02 FF06 GG01 HH01 JJ03 KK01 LL03 NN06 03

Claims (17)

[Claims] 1. A following formula (1) ## STR1 ## The melanin production inhibitor which consists of ganoderol B represented by these. 2. A whitening agent comprising ganoderol B represented by the following chemical formula 1. 3. A melanin production inhibitor containing ganoderol B represented by the following chemical formula 1. 4. A whitening agent containing ganoderol B represented by the following chemical formula 1. 5. A composition for suppressing melanin production, comprising ganoderol B represented by the following chemical formula 1. 6. A whitening composition containing ganoderol B represented by the following chemical formula 1. 7. A cosmetic containing the Ganoderoru B shown in Chemical formula 1. 8. The cosmetic according to claim 7, which is used for suppressing melanin production. 9. The cosmetic according to claim 7, which is for whitening. 10. A medicament containing ganoderol B represented by the following chemical formula 1. 11. The method according to claim 1, which is for suppressing melanin production.
0. The medicament according to 0. 12. The medicament according to claim 10, which is for whitening. 13. An external preparation for skin containing ganoderol B represented by the following chemical formula 1. 14. The method according to claim 1, which is for suppressing melanin production.
3. The external preparation for skin according to 3. 15. The external preparation for skin according to claim 13, which is for whitening. 16. A food for suppressing melanin production, comprising ganoderol B represented by the following chemical formula 1. 17. A whitening food containing ganoderol B represented by the following chemical formula 1.