JP2002128654A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation which is effectively used for the prevention and symptom improvement of the pigmentation, especially flecks and freckles, of skin and has high safety. SOLUTION: This skin care preparation is produced by formulating the extract of a plant belonging to the genus Bletilla in the family Orchidaceae, and one or more bleaching agents selected from kojic acid and its derivatives, arbutin, ascorbic acid and its derivatives, ellagic acid, resorcinol derivatives, placenta extract, Mulberry bark extract, and rice bran extract hydrolyzate.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin which has an excellent whitening effect and is effective for preventing skin pigmentation such as spots and freckles and improving symptoms.

[0002]

2. Description of the Related Art Various whitening agents such as kojic acid, ascorbic acid derivatives and hydroquinone derivatives have been proposed for the purpose of preventing pigmentation caused by sunburn or aging, particularly spots and freckles, and improving symptoms. An external preparation for skin containing is marketed. However,
In addition to the fact that the whitening effect itself is not always satisfactory, those conventional whitening agents may cause problems such as skin irritation when the amount is increased to maximize the whitening effect. There are still many points to be improved in terms of sex.

[0003] In view of the problems of the prior art, the present inventors have conducted intensive studies to provide a skin external preparation having an excellent whitening effect and high safety. When a combination of a whitening agent and an extract of a plant belonging to the genus Silane belongs to the synergistic action, the whitening effect is remarkably improved, thereby providing a skin external preparation with a further improved whitening / skinning effect. To be
Further, as a result of the improvement of the whitening effect, an excellent whitening effect can be expected even at a low blending amount. Therefore, the present inventors have found that it is possible to provide a highly safe skin external preparation with little fear of skin irritation, and completed the present invention.

That is, the present invention relates to an extract of a plant belonging to the genus Silane of the orchid family and kojic acid and its derivatives, arbutin, ascorbic acid and its derivatives, ellagic acid, resorcinol derivatives, placenta extract, soybean extract and rice bran extract It is an external preparation for skin prepared by blending one or more whitening agents selected from hydrolysates.

Hereinafter, the present invention will be described in detail. The extract of the orchid silane plant used in the present invention is a silane (B
letilla striata), Bretira Hormosana (B. form
osana), Bretilla okiracea (B. ochracea), Bretilla tsuzechuanica (B. szetschuanica), etc., whole plants, leaves, corms, roots, etc. And obtained by extraction with an appropriate solvent. In the present invention, among these silane plants, the use of silane (Bletilla striata) is particularly preferred, and a corm is most preferred as a site to be extracted.

Examples of the solvent used for the extraction include water; lower alcohols such as methanol and ethanol; polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,2-pentanediol and glycerin; Esters such as ethyl, butyl acetate and methyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; hydrocarbon solvents such as hexane, toluene and chloroform;
It is used without any adjustment or after adjusting the pH with an acid or alkali. Among them, in the present invention, it is most preferable to use an aqueous medium such as water, a mixed solution of water and lower alcohols or a mixed solution of water and polyhydric alcohols.

[0007] The extraction conditions vary depending on the type of solvent used, the properties of the extract, and the like.
When the above aqueous medium is used, it is preferable to perform extraction at 20 to 60 ° C. for 4 to 24 hours.

The orchid family silane plant extract solution obtained here is generally adjusted to pH 4 to 8, and used as it is or after adjusting to an appropriate concentration. Powdered and used according to a conventional method such as a drying method.

In the present invention, the kojic acid derivative in the whitening agent used in combination with the above-mentioned silane plant extract of the family Orchidaceae includes, for example, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid dibutyrate. Esters or kojic acid ethers such as citrate; ascorbic acid derivatives include, for example, L
-Ascorbic acid ester salts such as ascorbic acid-2-phosphate ester salt, L-ascorbic acid-2-sulfate salt (the salt is sodium salt, magnesium salt and the like), L-ascorbic acid-2-glucoside (2-O −
α-D-glucopyranosyl-L-ascorbic acid), L
-Ascorbic acid-5-glucoside (5-O-α-D-
Ascorbic acid sugar derivatives such as glucopyranosyl-L-ascorbic acid); examples of resorcinol derivatives include 4-n-butyl resorcinol and 4-isoamyl resorcinol. Further, as the placenta extract, those of cosmetic compounding grades listed in the official cosmetics of cosmetics, and as the rice bran extract hydrolyzate, the method described in JP-A-5-221844, particularly a method using enzyme treatment The hydrolyzate obtained by the above can be suitably used.

In the present invention, among the whitening agents used in combination with the plant extract of the genus Silane in the family Orchidaceae, in particular, kojic acid, arbutin, L-ascorbic acid-2-phosphate magnesium salt, L-ascorbic acid-2. -Glucoside is preferred in view of the whitening effect obtained.

The compounding ratio of the orchid silane plant extract and the whitening agent is in the range of 10: 1 to 1: 100, preferably 5: 1 to 1:50, more preferably 5: 1 to 1: 100 in terms of solids weight ratio. The range is from 2: 1 to 1:40. When the compounding ratio of the whitening agent to the orchid silane plant extract is more than 1: 100 or less than 10: 1, the synergistic effect is hardly exhibited,
The merit of the combination decreases.

The amount of the orchid silane plant extract and the whitening agent in the skin external preparation of the present invention is generally within the range of the above-mentioned compounding ratio. 0.002 to 1.0% by weight, preferably 0.02 to 0.5% by weight, and in the case of whitening agents generally 0.1 to 10% by weight, preferably
It is in the range of 0.5-5% by weight. If the amount is less than the above range, it is difficult to obtain a sufficient whitening / skinning effect. On the other hand, if the amount is more than the above range, further improvement of the whitening effect is not expected, and disadvantageous in cost. All are not preferred.

The external preparation for skin of the present invention can be used as any of cosmetics, quasi-drugs, medicaments and the like, and its dosage form is, for example, cream, emulsion, lotion, ointment, pack, haptic Various things can be adopted according to the use, the application object, etc.

The external preparation for skin of the present invention includes, in addition to the essential components, an extract of a plant belonging to the genus Orchidaceae and a whitening agent, components commonly used in external preparations for skin, such as oily components and surfactants.
A humectant, a thickener, a preservative / disinfectant, a powder component, an ultraviolet absorber, an antioxidant, a dye, a fragrance, and the like can be appropriately compounded as needed.

[0015] Here, as the oily component, for example, plant-derived fats and oils such as olive oil, jojoba oil, castor oil, soybean oil, coconut oil, palm oil, cacao oil and meadowfoam oil; mink oil and turtle oil Animal-derived fats and oils; waxes such as beeswax, carnauba wax and lanolin; hydrocarbons such as liquid paraffin, vaseline, paraffin wax and squalane; fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid; Higher alcohols such as lauryl alcohol, cetanol and stearyl alcohol; synthetic esters such as isopropyl myristate, butyl oleate, and 2-ethylhexyl glyceride; and synthetic triglycerides.

Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, and polyoxyethylene cured castor. Non-ionic surfactants such as oils and polyoxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkyl benzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkyl phenyl ethers Sulfate, polyoxyethylene alkyl ether phosphate, α-sulfonated fatty acid alkyl ester salt, polyoxyethylene alkyl phenyl ether phosphate Quaternary ammonium salts, primary to tertiary fatty amine salts, trialkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salts , N, N-dialkylmorphonium salts, cationic surfactants such as polyethylene polyamine fatty acid amide salts; N, N-dimethyl-N-alkyl-N-carboxymethylammonio betaine;
N, N-trialkyl-N-alkyleneammoniocarboxybetaine, N-acylamidopropyl-N ',
And amphoteric surfactants such as N'-dimethyl-N'-β-hydroxypropylammoniosulfobetaine.

Examples of humectants include glycerin, propylene glycol, dipropylene glycol, 1,3-
Examples include butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, and further include saccharides, hyaluronic acid, lactic acid, urea, higher fatty acid octyldodecyl, various amino acids, and derivatives thereof.

Examples of the thickener include polysaccharides such as carrageenan, alginic acid, pectin and locust bean gum; gums such as xanthan gum, tragacanth gum and guar gum; cellulose derivatives such as carboxymethyl cellulose and hydroxyethyl cellulose; polyvinyl alcohol, polyvinyl pyrrolidone; Synthetic polymers such as carboxyvinyl polymer and acrylic acid / methacrylic acid copolymer; hyaluronic acid and its derivatives;

Examples of the preservative disinfectant include urea; paraoxybenzoic acid esters such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate and butyl paraoxybenzoate; phenoxyethanol, dichlorophen, hexachlorophen, chlorhexidine hydrochloride, Examples include benzalkonium chloride, salicylic acid, ethanol, undecylenic acid, phenols, and jamal (imidazodeinyl urea).

Examples of the powder component include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, and nylon powder.

Examples of the ultraviolet absorber include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and derivatives thereof, ethylhexyl paramethoxycinnamate, octyl cinnamate, 2,4-dihydroxybenzophenone, 2-hydroxy-4- Methoxybenzophenone-5-sulfonate, 2- (2-hydroxy-5-methylphenyl) benzotriazole,
There are urocanic acid, ethyl urocanate and the like.

Examples of the antioxidant include butylhydroxyanisole, butylhydroxytoluene, propyl gallate, vitamin E and derivatives thereof. Further, as other components, lecithins, silk-related substances and the like can be blended.

The external preparation for skin of the present invention may further contain other physiologically active ingredients as long as the effectiveness of the combination component of the present invention is not impaired. Such substances include, for example, collagen, nicotinic acid and its derivatives (eg, nicotinamide, benzyl nicotinate, etc.), vitamin E and its derivatives (eg, vitamin E nicotinate, vitamin E linoleate, etc.), α-hydroxy acids (eg, lactic acid,
Citric acid, α-hydroxyoctanoic acid, etc.), diisopropylamine dichloroacetate, γ-amino-β-hydroxybutyric acid, etc., components for preventing skin aging and improving skin roughness; extracts of crude drugs such as gentian extract.

Next, the present invention will be described more specifically with reference to Production Examples, Examples (formulation examples) and Test Examples, but the invention is not limited thereto. In the following, all parts are parts by weight, and all parts are by weight.

Production Example 1 Preparation of silane plant extract solution (1) Dried slices of corm of silane (Bletilla striata)
900 g of purified water was added to 100 g and extracted at 50 ° C. for 15 hours. The obtained extract was filtered to obtain 300 ml of a pale yellow transparent extract solution (solid content: about 3.3%).

Production Example 2 Preparation of Silane Plant Extract Solution (2) 900 g of purified water per 100 g of dry sliced corm of silane silane
And extracted at 60 ° C. for 4 hours. The obtained extract was filtered to give a pale yellow transparent extract solution (solid content: about 2.6
%) 350 ml were obtained.

Production Example 3 Preparation of Silane Plant Extract Solution (3) 900 g of a 50% aqueous ethanol solution was added to 100 g of dried and finely cut corms of silane silane, and extracted at room temperature (25 ° C.) for 15 hours. The obtained extract was filtered to obtain 600 ml of a pale yellow transparent extract solution (solid content: about 0.9%).

Production Example 4 Preparation of silane plant extract solution (4) Dried slices of corm of silane (Bletilla striata)
900 g of a 5% 1,2-pentanediol aqueous solution was added to 100 g, and the mixture was extracted at room temperature (25 ° C.) for 15 hours. The obtained extract was filtered to give a pale yellow transparent extract solution (solid content: about 1.
2%) 500 ml were obtained.

Production Example 5 Preparation of silane plant extract solution (5) In the same manner as in Production Example 1, except that the corm of silane genus Bmosilla (Bletilla formosana) was used instead of the corm of silane of silane genus in Production Example 1, 300 ml of a clear extract solution (solid content: about 3.0%) were obtained.

Production Example 6 Preparation of Silane Plant Extract Powder The extract solution obtained in the same manner as in Production Example 1 was concentrated to 30 ml and freeze-dried to obtain 9.9 g of extract powder.

Production Example 7 Preparation of rice bran extract hydrolyzate solution 200 g of rice bran, 800 ml of 0.1 N sodium hydroxide aqueous solution
For 24 hours at room temperature. Next, insoluble matter is removed by filtration,
The filtrate was sequentially treated with actinase, pepsin and trypsin. The enzyme treatment was carried out by using 10 mg of each enzyme and maintaining each at the optimum pH of each enzyme at 40 ° C. for 2 hours. The obtained enzyme-treated solution was filtered to obtain 300 ml of a yellow and transparent rice bran extract hydrolyzate solution (solid content: about 1.0%).

Embodiment 1 Cream [A component] part Liquid paraffin 5.0 hexalane (note) 4.0 paraffin 5.0 glyceryl monostearate 2.0 polyoxyethylene (20) sorbitan monostearate 6.0 butyl paraben 0.1 (note) Glyceryl trioctanoate manufactured by Technoble Co., Ltd. [Component B] Extract solution of Production Example 1 5.0 Kojic acid 1.0 Glycerin 5.0 Carboxymethyl monostearate 0.1 Methyl paraben 0.1 Moiston C (Note) 1 0.0 Purified water An amount that makes the total amount 100 parts. (Note) NMF component manufactured by Technoble Co., Ltd. [Component C] Fragrance Appropriate amount The above components A and B were each heated to 80 ° C. or higher, and then stirred and mixed. After cooling to 50 ° C., the C component was added and further stirred and mixed to prepare a cream.

Example 2 Emulsion [Component A] Part Liquid paraffin 6.0 Hexaran 4.0 Jojoba oil 1.0 Polyoxyethylene (20) sorbitan monostearate 2.0 Soybean lecithin 1.5 Methylparaben 0.15 Ethylparaben 0.03 [Component B] Extract solution of Production Example 2 5.0 L-ascorbic acid-2-glucoside 1.0 glycerin 3.0 1,3-butylene glycol 2.0 carboxymethylcellulose 0.3 Sodium hyaluronate 0 .01 Amount of purified water to make the total amount 100 parts [Component C] Perfume Appropriate amount After heating each of the above components A and B to 80 ° C. or higher, they were mixed by stirring. After cooling to 50 ° C., the C component was added and further stirred and mixed to prepare an emulsion.

Example 3 Lotion [Components] Part Extract Solution of Production Example 1 5.0 Arbutin 1.0 Ethanol 10.0 Glycerin 3.0 1, 3-butylene glycol 2.0 Methylparaben 0.2 Citric acid 1 Sodium citrate 0.3 Carboxyvinyl polymer 0.1 Perfume Appropriate amount Purified water Amount to make the total amount 100 parts The above components were mixed to prepare a lotion.

Example 4 Pack [Components] Part Polyvinyl alcohol 15.0 Hydroxymethylcellulose 5.0 Propylene glycol 5.0 Ethanol 10.0 Methylparaben 0.2 Extract solution of Production Example 3 5.0 L-ascorbic acid-2 -Magnesium phosphate ester 1.0 Appropriate amount of fragrance Purified water An amount that gives a total amount of 100 parts The above components were mixed to prepare a pack.

Example 5 Press Powder [Component A] Part Bengala 0.5 Yellow Iron Oxide 1.5 Black Iron Oxide 0.1 Titanium Oxide 10.0 Nylon Powder 4.0 Sericite Amount of 100 parts of Mica 23 2.0 Talc 25.0 Extract powder of Production Example 5 0.2 Kojic acid 1.0 [Component B] squalane 1.0 Methylpolysiloxane 4.0 Propylparaben 0.1 Dehydroacetic acid 0.1 Liquid paraffin 2.0 Appropriate amount of fragrance The above components A and B were mixed and stirred, respectively, and then sieved with a 200-mesh Tyler mesh sieve. The obtained mixed powder was pressed into a mold to prepare a uniform press powder.

Example 6 Cream A cream was prepared in the same manner as in Example 1 except that 1.0 part of kojic acid was used instead of 1.0 part of arbutin.

Example 7 Cream In Example 1, the magnesium salt of L-ascorbic acid-2-phosphate was replaced with 1.0 part of kojic acid.
A cream was prepared in the same manner as in Example 1 except that 0 part was used.

Example 8 Cream A cream was prepared in the same manner as in Example 1 except that 1.0 part of L-ascorbic acid-2-glucoside was used instead of 1.0 part of kojic acid. .

Example 9 Cream In Example 1, 4-n was used in place of 1.0 part of kojic acid.
A cream was prepared in the same manner as in Example 1 except that 1.0 part of -butylresorcinol was used.

Example 10 Cream A cream was prepared in the same manner as in Example 1 except that 1.0 part of ellagic acid was used instead of 1.0 part of kojic acid.

Example 11 Cream A cream was prepared in the same manner as in Example 1 except that 2.0 parts of the rice bran extract hydrolyzate solution of Preparation Example 7 was used instead of 1.0 part of kojic acid. Was prepared.

Example 12 Cream The procedure of Example 1 was repeated, except that 5.0 parts of the extract solution of Preparation Example 1 was replaced with 5.0 parts of the extract solution of Preparation Example 5. A cream was prepared.

Comparative Example 1 Cream The procedure of Example 1 was repeated except that 5.0 parts of the extract solution of Production Example 1 and 1.0 part of kojic acid were used instead of 1.0 part of kojic acid. A cream was prepared in the same manner.

Comparative Example 2 Cream The procedure of Example 6 was repeated, except that 1.0 part of arbutin was used instead of 5.0 parts of the extract solution of Preparation Example 1 and 1.0 part of arbutin. To prepare a cream.

Comparative Example 3 Cream In Example 7, 5.0 parts of the extract solution of Production Example 1 and L
Example 1 except that 1.0 part of L-ascorbic acid-2-phosphate magnesium salt was used instead of 1.0 part of ascorbic acid-2-phosphate magnesium salt
A cream was prepared in the same manner as described above.

Comparative Example 4 Cream In Example 8, 5.0 parts of the extract solution of Production Example 1 and L
-In place of 1.0 part of ascorbic acid-2-glucoside,
A cream was prepared in the same manner as in Example 1 except that 1.0 part of L-ascorbic acid-2-glucoside was used.

Comparative Example 5 Cream In Example 9, 5.0 parts of the extract solution of Production Example 1 and 4
4-n-butyl resorcinol instead of 1.0 part
A cream was prepared in the same manner as in Example 9 except that 1.0 part of -butylresorcinol was used.

Comparative Example 6 Cream The procedure of Example 10 was repeated except that 5.0 parts of the extract solution of Preparation Example 1 and 1.0 part of ellagic acid were used instead of 1.0 part of ellagic acid. A cream was prepared in the same manner.

Comparative Example 7 Cream In Example 11, the rice bran of Production Example 7 was replaced with 5.0 parts of the extract solution of Production Example 1 and 2.0 parts of the rice bran extract hydrolyzate solution of Production Example 7. A cream was prepared in the same manner as in Example 1 except that 2.0 parts of the extract hydrolyzate solution was used.

Test Example 1 Pigmentation Inhibition Test The synergistic effect of a combination of a plant extract of the genus Orchidaceae with a whitening agent was examined by a pigmentation inhibition test using a colored guinea pig.

[Sample] An aqueous solution containing each component at the solid content (%) shown in Table 1 was used as a sample.

[Table 1]

In Table 1, BS, KA, AL, AP
M, AG, EA, BR and RH mean the following, respectively. BS: silane extract of Production Example 1, KA: kojic acid, A
L: arbutin, APM: L-ascorbic acid-2-phosphate magnesium salt, AG: L-ascorbic acid-2-glucoside, EA: ellagic acid, BR: 4-n-
Butyl resorcinol, RH: hydrolyzate of rice bran extract

[Test Method] The hair of a colored guinea pig (male, 8 weeks old) of 60 mm length × 30 mm width at the center of the back was shaved, and this part was divided into four parts: front, rear, left and right. The sample of the present invention was placed in one of the sections, and any of Comparative Samples A, B, and C to F was placed in the remaining three sections, once each in the morning and evening.
In addition to the application, the applied site was irradiated with UV-B of 500 mJ / cm ² once daily immediately before application in the morning, and the state of pigmentation at the irradiated site was visually observed on the evening of the sixth day. Was evaluated according to the following criteria.

[Evaluation Criteria for Pigmentation]-: No pigmentation observed ±: Minor pigmentation observed +: Mild pigmentation observed 2+: Moderate pigmentation observed 3+: Severe pigmentation observed

[Results] The results are shown in Table 2.

[Table 2]

From the results shown in Table 2, it can be seen that the combined use of the orchidaceae silane plant extract of the present invention and an existing whitening agent significantly improves the effect of inhibiting pigmentation as compared with the case where each of these components is used alone. It can be seen that the whitening effect is synergistically enhanced by the above combination. .

Test Example 2 Monitor Test For each of the creams of Examples 1, 6 to 11 and Comparative Examples 1 to 7, the effect of suppressing erythema and pigmentation upon irradiation with ultraviolet rays was examined by a monitor test.

[Test Method] Age 18-
Seventy-five 55-year-old women were set as subjects, and two 1 cm × 1 cm ultraviolet irradiation parts were set on the left and right inner forearms of each subject. UV-B lamp (FL20, manufactured by Toshiba Corporation)
-SE), the subject was irradiated with ultraviolet rays in an amount corresponding to the minimum erythema dose (MED) of each subject once measured once a day (morning) for three consecutive days. Consecutively for one month from the UV irradiation start date, during the UV irradiation period (first three days), immediately after UV irradiation and twice a day in the evening, and after the UV irradiation period (after the fourth day), in the morning and evening. The cream was applied to the ultraviolet irradiation part twice a day. Seventy subjects were divided into seven groups, and the creams of Examples 1, 6 to 11 and Comparative Examples 1 to 7 were applied to 10 groups.
Table 3 shows the types of applied creams for each group.

[0060]

[Table 3]

After application for one month, the occurrence of erythema and the state of pigmentation in the ultraviolet-irradiated part of each subject were visually observed, and evaluated based on the following evaluation criteria.

[Evaluation Criteria] A: No erythema and no pigmentation B: Erythema and pigmentation clearly reduced C: Erythema and pigmentation decreased D: Erythema generation and The state of pigmentation was almost the same as before the use of the cream E: The occurrence of erythema and pigmentation increased rather than before the use of the cream

[Results] The results are shown in Table 4.

[0064]

[Table 4]

As shown in Table 4, when the orchid silane plant extract and the existing whitening agent were used in combination, the effect of inhibiting erythema and pigmentation due to ultraviolet irradiation was significantly enhanced as compared with the whitening agent alone. You.

[0066]

According to the external preparation for skin of the present invention obtained by combining an existing whitening agent with an extract of a plant belonging to the genus Orchidaceae, the whitening effect is remarkably enhanced by the synergistic effect of the components. Erythema development and pigmentation of the skin are more remarkably suppressed as compared with a single combination, and an excellent effect for preventing spots and freckles and improving symptoms is exhibited. In addition, by enhancing the whitening effect, the amount of the whitening agent required to obtain the desired effect can be reduced, and the safety without side effects such as skin irritation often observed when the whitening agent is highly incorporated. It is possible to provide a high skin external preparation.

 ────────────────────────────────────────────────── ─── Continuing from the front page (72) Inventor Takako Ogura 1-6-8 Kitahorie, Nishi-ku, Osaka Kyoei Chemical Industry Co., Ltd. F-term (reference) 4C083 AA071 AA072 AA111 AA112 AA122 AB232 AB242 AB432 AB442 AC012 AC022 AC102 AC122 AC302 AC422 AC442 AC471 AC472 AC482 AC841 AC842 AD072 AD092 AD112 AD152 AD272 AD332 AD391 AD392 AD572 AD641 AD642 CC02 CC04 CC05 CC07 DD17 DD23 DD31 EE10 EE16

Claims (2)

[Claims] 1. An extract of a plant belonging to the genus Silane of the family Orchidaceae, and hydrolysis of kojic acid and its derivatives, arbutin, ascorbic acid and its derivatives, ellagic acid, resorcinol derivatives, placenta extract, soybean sap extract and rice bran extract An external preparation for skin comprising one or more whitening agents selected from products. 2. A whitening agent comprising kojic acid, arbutin, L-
Magnesium ascorbic acid-2-phosphate ester,
L-ascorbic acid-2-glucoside, ellagic acid, 4-
The external preparation for skin according to claim 1, wherein the external preparation is selected from n-butyl resorcinol, a soybean extract, and a rice bran extract hydrolyzate.