JP2002003362A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin care preparation capable of not only protecting the damage to the skin based on ultraviolet rays, or the like, but also exhibiting an excellent improving effect on symptoms and making the skin quickly recover to a sound and healthy state. SOLUTION: This skin care preparation is obtained by formulating a rice extract hydrolyzate with an extract of a marine phonerogram plant and ascorbic acid and/or its derivative.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention has an excellent effect of improving skin roughness, an effect of preventing skin aging, and a lightening effect, and not only prevents skin damage due to ultraviolet rays and the like, but also has a particularly excellent recovery effect. And a skin external preparation capable of exhibiting

[0002]

2. Description of the Related Art Various whitening agents such as kojic acid, ascorbic acid derivatives and hydroquinone derivatives have been proposed for the purpose of preventing and improving the symptoms of pigmentation, especially spots and freckles caused by aging or exposure to ultraviolet rays. Skin external preparations containing these are commercially available. However, the effects of ultraviolet rays not only have an adverse effect on pigmentation but also on skin tissue, causing rough skin and desquamation. In the long term, it leads to the generation of wrinkles and so-called sagging called photoaging. Protecting the skin from the effects of such ultraviolet rays, preventing pigmentation or improving symptoms, as well as those that contribute to the overall soundness and health of the skin are required. It is difficult to cope with the whitening agent.

[0003]

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned problems of the prior art, and has as its object to protect against skin damage due to ultraviolet rays and the like. In addition, it is an object of the present invention to provide an external preparation for skin which exhibits a particularly excellent symptom ameliorating effect and can promptly restore skin to a healthy and healthy state.

[0004]

That is, the present invention is an external preparation for skin comprising a hydrolyzate of a rice extract, an extract of a marine flowering plant, and ascorbic acid and / or a derivative thereof.

[0005] When the skin external preparation of the present invention having the above-mentioned composition is applied to skin exposed to ultraviolet rays, a synergistic action of these components exerts a remarkable effect of improving rough skin, and the skin is promptly healthy. , While restoring to a healthy state, it also has the effect of preventing pigmentation and improving symptoms
A comprehensive cosmetic effect is imparted to the skin.

Hereinafter, the present invention will be described in detail. The hydrolyzate of the rice extract used in the present invention is obtained by hydrolyzing an extract obtained by extracting rice with a solvent such as water or alcohol with an acid, alkali, enzyme or the like.

The rice used here is not particularly limited, and any of brown rice, polished rice, processed rice and the like can be used. Preferably, polished rice or processed rice is used. As the type of rice, both non-glutinous rice and glutinous rice can be used. Examples of the processed rice include antiallergic rice, low protein rice (for example, low glycerin rice), and enriched rice (for example, γ-aminobutyric acid rice). It is preferable that the rice is directly extracted without being crushed or powdered, because the amount of starch mixed into the extract is small.

The solvent used for the extraction is water; lower alcohols such as methanol, ethanol and propanol; ethylene glycol, propylene glycol,
Polyhydric alcohols such as 3-butylene glycol and glycerin; esters such as ethyl acetate, butyl acetate and methyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; n-hexane and toluene And hydrocarbon solvents such as chloroform, which are used without pH adjustment or after pH adjustment with an acid or alkali. Among them, it is preferable to use water or a mixed solution of water and lower alcohols or a mixed solution of water and polyhydric alcohols, and particularly to use them with an alkali such as sodium hydroxide, potassium hydroxide, and sodium carbonate. The use of an alkaline aqueous medium adjusted to a pH of 7.5 to 14, especially pH 9 to 12 is most preferred.

The extraction conditions vary depending on the type and particle size of the rice to be used, the extraction solvent and the like.
And the range is 6 hours to 7 days. When the above-mentioned alkaline aqueous medium is used, the temperature is preferably 4 to 30 ° C. and 12 to 36 hours.

[0010] The hydrolysis treatment of the rice extract obtained here is carried out using an acid, an alkali or an enzyme.
Above all, decomposition by an enzyme is preferred from the viewpoint of uniformity of the quality of the product, ease of process control, and the like. In the case of acid hydrolysis, hydrochloric acid, sulfuric acid, or the like is used as an acid, and p of the extract solution is used.
H is usually adjusted to 5 or less, particularly 4 or less, and then heat-treated at 60 to 90 ° C. for 1 to 6 hours. In the case of alkaline hydrolysis, the pH of the extract solution is adjusted to 9 to 1 using caustic soda, caustic potash, sodium carbonate, or the like.
In general, the heat treatment is performed at 60 to 90 ° C. for 1 to 6 hours.

In the case of hydrolysis by an enzyme, the enzymes used include actinases; pepsins such as pepsin;
Trypsins such as trypsin; papains such as papain and chymopapain; glycylglycine peptidase;
There are peptidases such as carboxypeptidase and aminopeptidase or bromelain, and these are usually used in combination of two or more. When enzymes are used in combination, the combination of actinase and pepsin or trypsin is most preferred.

[0012] In the hydrolysis treatment with these enzymes, the enzyme is usually added to 100 parts by weight of rice extract (solid content) at 0.0
The reaction is carried out by using 1 to 10 parts by weight, preferably 0.05 to 2.0 parts by weight, for 1 to 24 hours under conditions near the optimum pH and the optimum temperature of the enzyme used.

The obtained rice extract hydrolyzate solution is generally adjusted to a pH of 4 to 8, and then used as it is or at an appropriate concentration by concentration under reduced pressure or the like. In some cases, the powder may be used after being pulverized according to a conventional method such as a spray drying method or a freeze drying method.

The marine flowering plants used for preparing the marine flowering plant extract of the present invention include, for example, eelgrass, koagumo, sugamo, shrimp eel, sea urchin, pine bamboo fever, boba eelgrass, ryukyuusugamo, veneer, ryukyuamamo, sea urchin, etc. Is mentioned. Among them, eelgrass, eelgrass, suga, sea hirumi,
The use of sea urchin, especially eelgrass or eelgrass, is preferred from the standpoint of achieving the effects of the present invention.

Preparation of an extract of a marine flowering plant is generally carried out by using whole plants, washing them with water, drying, shredding them, and immersing them in an appropriate solvent. Examples of the extraction solvent include water; lower alcohols such as methanol, ethanol, and propanol; polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, and glycerin; ethyl acetate, butyl acetate;
Esters such as methyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; hydrocarbon solvents such as n-hexane, toluene, and chloroform; Alternatively, it is preferable to use a mixed solution of water and lower alcohols or a mixed solution of water and polyhydric alcohols.

The extraction temperature and time depend on the type of marine flowering plant,
Although the degree of shredding varies depending on the solvent used, etc., it is generally 40 to 90 ° C for 1 to 24 hours, particularly 60 to 80 ° C for
It is preferable to perform the extraction for 5 hours. The extract of the marine flowering plant obtained here is usually adjusted to pH 4 to 8,
It is used as it is or as an appropriate concentration by concentration under reduced pressure. In some cases, the powder may be used in the form of powder according to a conventional method such as a spray drying method and a freeze drying method.

Ascorbic acid and its derivatives (hereinafter referred to as ascorbic acids) as another component used in the present invention include ascorbic acid; L-ascorbic acid-2-phosphate ester salt, L-ascorbic acid-2-phosphate. Ascorbic acid ester salts such as sulfates (sodium salts, magnesium salts and the like), L-ascorbic acid-2-glucoside (2-O-α-D-glucopyranosyl-L-ascorbic acid), L-ascorbic acid- 5
-Glucoside (5-O-α-D-glucopyranosyl-L
-Ascorbic acid) and the like, and among them, L-ascorbic acid-2-
Glucosides are preferably used.

The external preparation for skin of the present invention is obtained by combining and mixing the above three components. The mixing ratio of these components is 100 parts by weight of the hydrolyzate of rice extract in terms of solid content. In contrast, marine flowering plant extracts are generally 10-50
0 parts by weight, preferably 20 to 300 parts by weight, and ascorbic acids generally range from 500 to 20,000 parts by weight, preferably from 1,000 to 10,000 parts by weight. Also,
The usage ratio between the marine flowering plant extract and the ascorbic acids is within the above range, and the solid content ratio is 1:10 to 1:20.
It is preferably 0, especially 1:20 to 1: 100.

The hydrolyzate of the rice extract, the marine flowering plant extract and the solid content of ascorbic acids in the skin preparation for external use of the present invention are as follows. In the case of a marine flowering plant extract, it is generally 0.005 to 0.5% by weight, preferably 0.1 to 1.0% by weight, preferably 0.03 to 0.15% by weight. 01-0.1% by weight, and in the case of ascorbic acid,
Generally 0.1 to 10% by weight, preferably 1.0 to 5.0%.
% By weight.

The external preparation for skin of the present invention can be used as any of cosmetics, quasi-drugs and medicaments, and its dosage form is, for example, cream, milky lotion, lotion, ointment, paq, haptic For example, an appropriate one can be adopted according to the use, the application target, and the like.

The external preparation for skin of the present invention includes, in addition to the essential components, hydrolyzate of rice extract, extract of marine flowering plant and ascorbic acid, components usually used in external preparation for skin, such as oily component and surfactant. An agent, a humectant, a thickener, an antiseptic, a powder component, an ultraviolet absorber, an antioxidant, a pigment, a fragrance, and the like are appropriately compounded as necessary.

The oily component includes, for example, plant-derived fats and oils such as olive oil, jojoba oil, castor oil, soybean oil, coconut oil, palm oil and cocoa oil; and animal-derived fats and oils such as mink oil and turtle oil. Waxes such as beeswax, carnauba wax and lanolin; hydrocarbons such as liquid paraffin, vaseline, paraffin wax and squalane; fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid; lauryl alcohol, cetanol And higher esters such as stearyl alcohol; synthetic esters such as isopropyl myristate, isopropyl palmitate, butyl oleate, and 2-ethylhexyl glyceride; and synthetic triglycerides.

Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, and polyoxyethylene cured castor. Non-ionic surfactants such as oils and polyoxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkyl benzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkyl phenyl ethers Sulfate, polyoxyethylene alkyl ether phosphate, α-sulfonated fatty acid alkyl ester salt, polyoxyethylene alkyl phenyl ether phosphate Quaternary ammonium salts, primary to tertiary fatty amine salts, trialkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salts Cationic surfactants such as N, N, N-dialkylmorphonium salt and polyethylenepolyamine fatty acid amide salt; N, N-dimethyl-N-alkyl-N-carboxymethylammonio betaine;
N, N-trialkyl-N-alkyleneammoniocarboxybetaine, N-acylamidopropyl-N ',
And amphoteric surfactants such as N'-dimethyl-N'-β-hydroxypropylammoniosulfobetaine.

Examples of the humectant include glycerin, propylene glycol, dipropylene glycol, 1,3-
Examples include butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, and further include saccharides, hyaluronic acid, lactic acid, urea, higher fatty acid octyldodecyl, various amino acids, and derivatives thereof.

Examples of the thickener include polysaccharides such as carrageenan, alginic acid, pectin, and locust bean gum; gums such as xanthan gum, tragacanth gum and guar gum; cellulose derivatives such as carboxymethyl cellulose and hydroxyethyl cellulose; polyvinyl alcohol, polyvinyl pyrrolidone; Synthetic polymers such as carboxyvinyl polymer and acrylic acid / methacrylic acid copolymer; hyaluronic acid and its derivatives;

Examples of the preservative disinfectant include urea; paraoxybenzoic acid esters such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate and butyl paraoxybenzoate; phenoxyethanol, dichlorophen, hexachlorophen, chlorhexidine hydrochloride, Examples include benzalkonium chloride, salicylic acid, ethanol, undecylenic acid, phenols, and jamal (imidazodinyl urea).

Examples of the powder component include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder and the like.

Examples of the ultraviolet absorber include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and derivatives thereof, ethylhexyl paramethoxycinnamate, octyl cinnamate, 2,4-dihydroxybenzophenone, 2-hydroxy-4- Methoxybenzophenone-5-sulfonate, 2- (2-hydroxy-5-methylphenyl) benzotriazole,
There are urocanic acid, ethyl urocanate and the like.

Examples of the antioxidant include butylhydroxyanisole, butylhydroxytoluene, propyl gallate, vitamin E and derivatives thereof. Further, as other components, lecithins, silk-related substances and the like can be blended.

The external preparation for skin of the present invention may further contain other physiologically active ingredients as long as the effectiveness of the combination component of the present invention is not impaired. Such substances include, for example, kojic acid, arbutin, ellagic acid, resorcinol derivatives (for example, 4-n-butyl resorcinol, 4-isoamyl resorcinol, etc.), soybean sap extract, saxifrage extract, rice bran extract, 2,5-dihydroxybenzoate Whitening ingredients such as acid derivatives (eg, 2,5-diacetoxybenzoic acid); placental extracts, collagen, nicotinic acid and its derivatives (eg, nicotinamide, benzyl nicotinate, etc.), vitamin E and its derivatives (eg, vitamin E) Nicotine, vitamin E linoleate, etc.), α-hydroxy acids (eg, lactic acid, citric acid, α-hydroxyoctanoic acid, etc.), diisopropylamine dichloroacetate, γ-amino-β-hydroxybutyric acid, etc .; Gentian extract There is a drug extract, or the like.

Next, the present invention will be described more specifically with reference to Production Examples, Examples (formulation examples) and Test Examples, but the invention is not limited thereto. In the following, all parts mean parts by weight.

Production Example 1 Preparation of Rice Extract Hydrolyzate Solution (1) 100 g of polished rice was immersed in 400 ml of a 0.25 N aqueous sodium hydroxide solution at room temperature for 24 hours with gentle stirring. Next, insoluble materials were removed by filtration, and the filtrate was subjected to enzyme treatment with actinase, pepsin and trypsin in this order. The enzymatic treatment was carried out by using 5 mg of each enzyme and maintaining each at the optimum pH of each enzyme at 40 ° C. for 2 hours. The obtained enzyme-treated solution was filtered to obtain 270 ml of a pale yellow and transparent rice extract hydrolyzate solution (solid content: 1.5% by weight).

Preparation Example 2 Preparation of Rice Extract Hydrolyzate Solution (2) A rice extract hydrolyzate solution 250 was prepared in the same manner as in Preparation Example 1 except that papain was used instead of pepsin as an enzyme.
ml (solid content: 1.5% by weight).

Production Example 3 Preparation of Rice Extract Hydrolyzate Solution (3) 100 g of polished rice was immersed in 400 ml of 0.25 N aqueous sodium hydroxide at room temperature for 24 hours with gentle stirring. Next, the insoluble matter was removed by filtration, and the filtrate was adjusted to pH 10 with a 2N aqueous sodium hydroxide solution.
Hold for hours. The treatment liquid obtained here was filtered to obtain 250 ml of a pale yellow transparent rice extract hydrolyzate solution (solid content: 1.4% by weight).

Production Example 4 Preparation of Marine Flowering Plant Extract Solution (1) The whole grass of eelgrass was washed with water to remove foreign substances, and then dried in the sun.
The pieces were cut into about 30 mm. The whole grass of the eelgrass was washed with water to remove foreign substances, dried in the sun, and cut into about 30 mm. 20 g of the cut pieces were immersed in 400 ml of water and extracted at 80 ° C. for 2 hours. This extract was filtered and purified to obtain 250 g of a pale green-brown extract solution (solid content: 0.75% by weight).

Preparation Example 5 Preparation of Marine Flowering Plant Extract Solution (2) 240 g of a pale green-brown extract solution was obtained in the same manner as in Preparation Example 4 except that the eelgrass was used in place of the eelgrass (solid content). : 0.75% by weight).

Example 1 Cream [Component A] Part Liquid Paraffin 5.0 Hexalan Co., Ltd. Technoble Co., Ltd., glyceryl trioctanoate) 4.0 Paraffin 5.0 Glyceryl monostearate 2.0 Polyoxyethylene (20) sorbitan Monostearate 6.0 Butylparaben 0.1 [Component B] Rice extract hydrolyzate solution of Production Example 1 5.0 Marine flowering plant extract solution of Production Example 4 5.0 L-ascorbic acid-2- Glucoside 2.0 Glycerin 5.0 Carboxymethyl monostearate 0.1 Methyl paraben 0.1 Moiston C (manufactured by Technoble Co., Ltd., NMF component) 1.0 Purified water Amount that the total amount becomes 100 parts [Component C] Fragrance Appropriate amounts The above components A and B were each heated to 80 ° C. or higher, and then stirred and mixed. After cooling to 50 ° C., the C component was added and further stirred and mixed to prepare a cream.

Example 2 Emulsion [Component A] Part Liquid Paraffin 6.0 Hexalane 4.0 Jojoba Oil 1.0 Polyoxyethylene (20) Sorbitan Monostearate 2.0 Soybean Lecithin 1.5 Methylparaben 0.15 Ethylparaben 0.03 [Component B] Hydrolyzate solution of rice extract in Production Example 1 5.0 Solution of marine flowering plant extract in Production Example 5.0 5.0 L-ascorbic acid-2-glucoside 2.0 Glycerin 3.0 1,3-butylene glycol 2.0 carboxymethylcellulose 0.3 Sodium hyaluronate 0.01 Purified water Amount to make the total amount 100 parts [Component C] Perfume Appropriate amount The above components A and B were each heated to 80 ° C. or higher. Thereafter, the mixture was stirred and mixed. After cooling to 50 ° C., the C component was added and further stirred and mixed to prepare an emulsion.

Example 3 Lotion [Ingredients] Part Rice Extract Hydrolyzate Solution of Production Example 2 2.0 Marine Flowering Plant Extract Solution of Production Example 4 10.0 L-Ascorbic acid-2-glucoside 2.0 Ethanol 10.0 Glycerin 3.0 1,3-butylene glycol 2.0 Methyl paraben 0.2 Citric acid 0.1 Sodium citrate 0.3 Carboxyvinyl polymer 0.1 Perfume Appropriate amount Purified water The amount that the total amount becomes 100 parts Was mixed to prepare a lotion.

Example 4 Pack [Components] Part Polyvinyl alcohol 15.0 Hydroxymethylcellulose 5.0 Propylene glycol 5.0 Ethanol 10.0 Methylparaben 0.2 Rice extract hydrolyzate solution of Example 3 2.0 Example Marine flowering plant extract solution of No. 4 10.0 L-Ascorbic acid-2-glucoside 2.0 Perfume Appropriate amount Purified water An amount that gives a total amount of 100 parts The above components were mixed to prepare a pack.

Example 5 Cream A cream was prepared in the same manner as in Example 1 except that magnesium L-ascorbic acid-2-phosphate was used in place of L-ascorbic acid-2-glucoside. Prepared.

Example 6 Cream A cream was prepared in the same manner as in Example 1 except that sodium L-ascorbic acid-2-sulfate was used in place of L-ascorbic acid-2-glucoside. did.

Test Example 1 Sunburn Recovery Test The effect of the external preparation for skin of the present invention on the recovery of the function of the skin damaged by ultraviolet irradiation was evaluated by examining the condition of pigmentation,
The evaluation was based on the degree of exfoliation of the stratum corneum and the change over time in the amount of water on the skin surface.

[Test Method] Two 3 cm square holes were inserted into 10 mm
Are attached to the upper arms of five subjects (male, ages 25 to 52), and irradiated with ultraviolet rays equivalent to 1 MED separately obtained (UV-Toshiba-made).
B lamp FL-20SE was used), and 24 hours later, another 1 MED ultraviolet irradiation was performed on the same portion. 2
Immediately after the second UV irradiation, twice a day (morning and evening) for 4 weeks, the lotion of the present invention or the comparative lotion having the composition shown in Table 1 was applied to each of the two irradiated portions, and the pigmentation status of the skin was determined. The degree of exfoliation of the stratum corneum and the amount of water on the skin surface were measured immediately after UV irradiation (first and second times), 3, 6, 10, 14, 21 after the second UV irradiation.
On the 28th and 28th days, measurement and evaluation were performed by the methods described below, respectively.

[0045]

[Table 1]

(1) Pigmentation Situation A color standard paper of five levels of density was prepared by a computer with a color tone (reddish brown) close to tanned skin, and the color tone number of the closest color tone was selected by comparing it with the color tone of the tanned part. And In this case, the darkest reddish brown color was set to 5, and the pale reddish brown color close to flesh color was set to 1.

(2) Degree of exfoliation of stratum corneum A transparent double-sided tape was adhered to a support (slide glass), strongly pressed against a site to which ultraviolet light was applied / lotion applied, and then peeled off. It was immersed in brilliant green-containing 0.5% gentian violet solution for 15 minutes, washed with running water to remove the staining solution, and then air-dried. Next, the horny layer transferred from the skin to the double-sided tape and stained,
Observed under a microscope. That is, 10 places in the visual field of the microscope were randomly taken, and the proportion of the overlapping and peeling parts (layer peeling) in the entire stratum corneum in the visual field was visually evaluated based on the following criteria. The results were shown as the average value of 10 visual fields.

[Evaluation Criteria] 5: Almost not found 4: Slightly seen 3: Somewhat seen 2: Fairly seen 1: Very often seen

(3) Moisture Content on the Skin Surface Two places of ultraviolet irradiation / lotion application and a normal part adjacent thereto were measured with an impedance meter.

[Results] The test results are shown in Table 2 (state of pigmentation), Table 3 (degree of exfoliation of stratum corneum), and Table 4 (moisture amount on skin surface).

[0051]

[Table 2]

[0052]

[Table 3]

[0053]

[Table 4]

From the results shown in Table 2, the pigmentation gradually progressed at the application site of any lotion by the irradiation of ultraviolet rays.
It reaches a peak on the sixth day, and it can be seen that the site where the lotion of the present invention is applied has a lower degree of pigmentation than the site where the comparative lotion is applied, and then returns to a color tone close to the normal site immediately thereafter.

Further, as shown in Table 3, the application of the comparative lotion containing no active ingredient of the present invention showed strong multilayer peeling 3 to 14 days after the irradiation with ultraviolet rays, whereas the comparative lotion did not contain the active ingredient of the present invention. In the lotion-applied site, the delamination was observed at the same time, but was much lighter than the comparative lotion, and the degree of delamination was close to the normal portion throughout the entire period. In addition, the lotion application site of the present invention recovers quickly from damage due to ultraviolet irradiation.

Further, from the results shown in Table 4, although the moisture content on the skin surface is reduced by the irradiation of the ultraviolet rays, the lotion-applied portion of the present invention has a smaller amount than the comparative lotion-applied portion.
It can be seen that the degree of the decrease is remarkably small and the recovery to the normal site is quick.

The tanned skin shows an unhealthy state as compared with normal skin, such as pigmentation, which causes bulkiness and peeling of the epidermis. As is clear from the above test results, the tanned skin preparation of the present invention has According to this, the degree of their skin damage due to sunburn is reduced, and the restoration to normal skin is promoted.

[0058]

The external preparation for skin of the present invention comprising a combination of a hydrolyzate of rice extract, a marine flowering plant extract and ascorbic acids is effective for skin pigmentation based on sunburn and the like.
It has an excellent defense and ameliorating effect on skin aging or damage phenomena such as exfoliation of the stratum corneum, and when applied to the skin, the skin damage due to sunburn etc. is reduced and the skin Recover to a healthy and healthy state.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 N 35/78 35/78 W A61P 17/16 A61P 17/16 (72) Inventor Yutaka Osawa 1-6-8 Kitahorie, Nishi-ku, Osaka-shi Kyoei Chemical Industry Co., Ltd. (72) Inventor Takako Ogura 1-6-8 Kitahorie, Nishi-ku, Osaka City F-term in Kyoei Chemical Industry Co., Ltd. (Reference) 4C083 AA111 AA112 AA122 AC012 AC022 AC102 AC122 AC302 AC352 AC422 AC442 AC482 AD092 AD112 AD282 AD332 AD572 AD661 AD662 CC04 CC05 CC07 DD12 DD23 DD31 EE06 EE12 EE16 4C088 AB71 AB74 AC01 AC04 BA08 CA25 MA07 MA08 MA16 MA28 MA32 MA63 ZA89

Claims (6)

[Claims] An external preparation for skin comprising a hydrolyzate of a rice extract, an extract of a marine flowering plant, and ascorbic acid and / or a derivative thereof. 2. The external preparation for skin according to claim 1, wherein the hydrolyzate of the rice extract is obtained by treating an alkaline medium extract of rice with two or more proteases. 3. The proteolytic enzyme comprises a combination of (a) an actinase and (b) one or more selected from the group consisting of pepsins, trypsins, papains, peptidases and bromelain. The external preparation for skin according to claim 2. 4. The external preparation for skin according to claim 1, wherein the extract of the marine flowering plant is an extract of an eelgrass plant. 5. The external preparation for skin according to claim 4, wherein the eelgrass plant is eelgrass or eelgrass. 6. The ascorbic acid derivative is 2-O-α-
The external preparation for skin according to claim 1, which is D-glucopyranosyl-L-ascorbic acid.