JP2001288035A - External preparation for skin for acne - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an external preparation for skin for acne obtained by compounding a newly found agent having preventive or treating effect on acne superior to those of conventional antiinflammatory agents or sterilizers. SOLUTION: An external preparation for skin for acne containing a singlet oxygen eraser in such an amount that its function for erasing singlet oxygen becomes >=50 s-1. An external preparation for skin for acne containing the singlet oxygen eraser, and an ultraviolet preventing agent and/or an agent selected from a beautifying agent, an antiinflammatory agent, a sterilizer and a cell activator.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for acne and, more particularly, to a method for preventing acne by containing an amount of a singlet oxygen scavenger having a certain amount of singlet oxygen scavenging ability. The present invention relates to a skin external preparation for acne which is effective for improvement.

[0002]

2. Description of the Related Art Acne is also called acne vulgaris, and refers to a phenomenon in which papules or pustules occur in accordance with pores. Since acne occurs particularly on the face of men and women during adolescence and adolescence, prevention and improvement of acne are strongly demanded.
For this reason, skin external preparations for preventing and improving acne,
For example, many emulsions, creams, lotions, packs, detergents, dispersions, ointments, external preparations, and the like are provided.

[0003] In these skin external preparations, anti-inflammatory agents such as glycyrrhizic acid, glycyrrhetinic acid and derivatives thereof, and bactericides such as sulfur and resorcinol have been conventionally used as components for preventing or improving acne. Was.

[0004]

However, these anti-inflammatory agents and bactericides do not have sufficient acne prevention or amelioration effects, or have the desired medicinal effects due to deterioration in the preparation. Often not. Therefore, it has been desired to find a drug excellent in the effect of preventing and improving acne, and to provide a skin external preparation for acne containing the drug.

[0005]

Means for Solving the Problems The present inventors have searched for various factors related to acne, and have found that singlet oxygen is greatly involved in the development of acne.
If the amount of the singlet oxygen scavenger having the predetermined or higher singlet oxygen scavenging ability is added to the external preparation for skin, the acne prevention and improvement effects can be significantly improved, and furthermore, the singlet oxygen scavenger can be added to this singlet oxygen scavenger. The present inventors have found that higher acne prevention and improvement effects can be obtained by combining agents such as an ultraviolet ray inhibitor, a whitening agent, an anti-inflammatory agent, a bactericide, and a cell activator, and completed the present invention.

That is, the present invention provides an external preparation for acne characterized in that it contains an amount of a singlet oxygen scavenger having a singlet oxygen scavenging ability of 50 s ^-1 or more.

The present invention also relates to the following components (A) and (B): (A) a singlet oxygen scavenger having a singlet oxygen scavenging capacity of 50 s ^-1 or more; It is intended to provide a skin external preparation for acne characterized by containing at least one species.

[0008] The present invention further provides a composition for acne, wherein the external preparation for acne contains one or more components selected from the group consisting of component (C) (C) a whitening agent, an anti-inflammatory agent, a bactericide and a cell activator. A skin external preparation is provided.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The singlet oxygen scavenger used in the present invention contains a compound which can effectively scavenge singlet oxygen and does not cause any particular problem when added to an external preparation for skin. If it is, it can be used without particular limitation. The compound acting as a singlet oxygen scavenger may be screened by any measurement method. For example, a singlet oxygen detector (JP-A-7-15)
9325) can be easily screened.

In the present invention, specific examples of the compound used as an active ingredient of the singlet oxygen scavenger include rutin and derivatives thereof, quercetin, β-carotene, astaxanthin, zeaxanthin, vitamin E and derivatives thereof, and salts thereof. , Erythorbic acid, histidine,
Examples include tryptophan, tyrosine, methionine, cystine, hypotaurine, thiotaurine, carrot extract, squid extract, sampens extract, melissa extract, yasajitsu extract, arhat extract, tea extract, and phospholipid.

[0011] The content of the singlet oxygen scavenger in the external preparation for acne of the present invention must be 50 s- ¹ or more as its singlet oxygen scavenging ability.
That is, the compound which is the active ingredient of the singlet oxygen scavenger has a reaction rate constant per weight or mole, and the singlet oxygen scavenging ability obtained by multiplying the reaction rate constant and the compounding concentration is 50 s ^−. it is important to ¹ or more. Particularly when this value is 1000 s ⁻¹ or more, more excellent acne prevention and improvement effects can be obtained.

The above singlet oxygen scavenger is used as a component for preventing or ameliorating acne, and is mixed with various types of bases used in ordinary skin external preparations in accordance with a conventional method to prepare acne. An external preparation for skin can be obtained, but by further combining it with an ultraviolet ray inhibitor and other medicinal ingredients, a skin external preparation for acne having more excellent effects can be obtained.

In the present invention, the UV inhibitor (component (B)) used in combination with the singlet oxygen scavenger (component (A)) includes paramethoxycinnamic acid-2-.
Ethylhexyl, oxybenzone, 4-tert-butyl-4′-methoxydibenzoylmethane, titanium oxide,
Fine particle titanium oxide, zinc oxide and the like can be mentioned. Of these UV inhibitors, particularly preferred are 2-ethylhexyl paramethoxycinnamate, titanium oxide,
Fine particle titanium oxide and zinc oxide are exemplified.

On the other hand, the other medicinal component (component (C)) is selected from a whitening agent, an anti-inflammatory agent, a bactericide and a cell activator. The following are mentioned.

(Whitening Agents) As whitening agents, vitamin C and its derivatives and salts thereof, placenta extract, licorice extract, yokunin extract, gongo extract, seaweed extract, syllable extract, sempukuka extract, Grape extract, wheat extract, tomato extract and the like.

Among these whitening agents, particularly preferred are vitamin C and its derivatives, salts thereof, and placental extracts.

(Anti-inflammatory agent) As the anti-inflammatory agent, glycyrrhizic acid, glycyrrhetinic acid and their derivatives and their salts, aloe extract, perilla extract, mugwort extract, chamomile extract, comfrey extract, diuretic extract Extract,
Watercress extract, oak extract and the like.

Of these anti-inflammatory agents, particularly preferred are glycyrrhizic acid, glycyrrhetinic acid and their derivatives and salts thereof.

(Disinfectant) Disinfectants include sulfur, resorcin, salicylic acid, isopropylmethylphenol, benzalkonium chloride, hinokitiol, dokudami extract, Clara extract and the like.

Of these fungicides, particularly preferred are sulfur, salicylic acid, and isopropylmethylphenol.

(Cell activator) Cell activators include vitamin A and its derivatives, citric acid, lactic acid, tartaric acid, malic acid, glycolic acid, succinic acid, serine, glutamic acid, hydroxyproline, theanine, pyrrolidone carboxylic acid, yeast , Lactic acid bacteria and bifidobacteria.

Among these cell activators, particularly preferred are vitamin A and its derivatives, citric acid,
Malic acid, lactic acid, serine, and pyrrolidone carboxylic acid are included.

The amounts of the ultraviolet ray preventive component (B) and the efficacious agent (C) in the external preparation for skin of the present invention vary depending on the type of the agent, but are preferably in the following ranges. Within this range, when combined with the singlet oxygen scavenger of the component (A), the stability over time of the preparation and the singlet oxygen scavenger of the component (A) in the preparation is not affected and is higher. Acne prevention and improvement effects can be exerted.

That is, the compounding amount of the component (B) in the present invention is preferably 0.001 to 20% by mass (hereinafter simply referred to as "%"), and more preferably 0.01 to 1% by mass.
The range is 0%. Within this range, a skin external preparation that exhibits a more excellent ultraviolet ray preventing effect and also has an excellent acne prevention and improvement effect can be obtained.

On the other hand, the blending amount of the whitening agent in the component (C) of the present invention is preferably 0.0001 to 10%,
More preferably, it is in the range of 0.0001 to 5%. When the placenta extract and the plant extract are used as they are, there is no problem as long as the dry solid content is within this range. Within this range, an external preparation for skin exhibiting more excellent acne prevention and improvement effects can be obtained.

In addition, the amount of the anti-inflammatory agent in the component (C) of the present invention is preferably in the range of 0.0001 to 5%,
More preferably, it is in the range of 0.001 to 3%. When the plant extract is used as it is, there is no problem as long as the dry solid content is within this range. Within this range, an external preparation for skin that exhibits excellent anti-inflammatory effects and excellent acne prevention and improvement effects can be obtained.

Further, among the component (C) of the present invention, the amount of the bactericide is preferably in the range of 0.0001 to 5%, more preferably in the range of 0.001 to 3%. When the plant extract is used as it is, there is no problem as long as the dry solid content is within this range. Within this range, an external preparation for skin which exhibits excellent bactericidal effects and excellent acne prevention and improvement effects can be obtained.

Furthermore, the compounding amount of the cell activator (C) of the present invention is preferably 0.0001 to 5%,
More preferably, it is in the range of 0.001 to 3%. Within this range, a skin external preparation that exhibits a more excellent effect of improving skin roughness and that exhibits an excellent effect of preventing and improving acne can be obtained.

In producing the external acne preparation for acne of the present invention, the ultraviolet ray preventive agent as the component (B) and the medicinal agents (whitening agent, anti-inflammatory agent, bactericide and cell activator) as the component (C) are used. , Can be used in combination,
A plurality of compounds or medicinal agents can be blended in each component. Further, a plurality of compounds may be selected from each of the whitening agents, anti-inflammatory agents, bactericides, and cell activators which are the active ingredients of the component (C), and two or more compounds may be used in combination.

The external preparation for skin obtained by combining the component (A) with the component (B) and / or the component (C) according to the present invention can be prepared by various methods known in the art according to a conventional method. Can be prepared by blending in the base.
In this case, the compounding amount of the component (A) also needs to be such that the singlet oxygen scavenging ability is 50 s ⁻¹ or more as described above.

The formulation of the external preparation for acne skin thus obtained is not particularly limited, and examples thereof include emulsions, creams,
It can be used as cosmetics such as lotions, packs, cleaning agents, makeup cosmetics, dispersions, ointments, and external medicines.

Depending on the form of the above-mentioned external preparation for skin, other than the above-mentioned essential components, components usually used in external preparations for skin such as cosmetics and pharmaceuticals, for example, purified water, lower alcohols, polyhydric alcohols, oily components, powders , Surfactants, thickeners,
Coloring materials, preservatives, humectants, fragrances and the like can be used.

[0033]

The present invention is based on a novel finding that singlet oxygen is greatly involved in the onset of acne. That is, acne bacteria ( Propioniobacterium acnes ) inhabit sebaceous glands, which are organs that produce sebum, and acne bacteria produce porphyrins as metabolites and excrete them outside the cells. Our studies have revealed that this porphyrin is excreted on the skin surface together with the secretion of sebum. When a porphyrin discharged on the skin surface is irradiated with ultraviolet rays, singlet oxygen, which is a kind of active oxygen and is highly reactive, is generated. No. 159325).

In addition, epidermal lipids on the skin surface are unexpectedly not peroxidized at all by ultraviolet irradiation alone, but are peroxidized rapidly and only by the presence of singlet oxygen generated by the porphyrin. Was revealed. The lipid peroxide promoted hyperkeratosis of the epidermis, and the stratum corneum near the pores became firm and thick, so that it was found for the first time that pores were easily clogged and caused acne.

By the way, since squalene is a typical epidermal lipid component which is peroxidized by singlet oxygen, in order to prevent peroxidation of squalene which causes acne, it reacts more with singlet oxygen than squalene. The easy ingredient may be applied to the skin. Since the ease with which single compound reacts with singlet oxygen is determined by the reaction rate constant and the compounding concentration, the singlet oxygen scavenging ability in an actual external preparation for skin is required in consideration of both.

Based on these findings, the present invention provides a singlet oxygen scavenger having a certain number or more of singlet oxygen scavenging ability, which suppresses the peroxidation of squalene on the skin and is effective in preventing and improving acne. It is completed as it is.

Since the source of singlet oxygen is porphyrin excitation by ultraviolet light in the first place, it is effective to protect the ultraviolet light which is the cause thereof from the damage of singlet oxygen, and to prevent and improve acne. Was found to be very effective.

[0038]

EXAMPLES The present invention will be described in more detail with reference to the following Examples and Test Examples, which should not be construed as limiting the invention thereto.

Test Example 1 Measurement of Singlet Oxygen Scavenging Ability: Using the singlet oxygen detecting device disclosed in Japanese Patent Application Laid-Open No. 7-159325, singlet oxygen scavenging was performed for test drugs ^* shown in Table 1 as follows. The rate constant was measured. That is, a 100 μM solution of Rose Bengal was used as a control sample, and this was added to a flow cell in 20 mL
/ Min. The cell was irradiated with UVA wavelength laser light. Since the emission spectrum generated by this irradiation has a peak derived from singlet oxygen at 1268 nm, the emission intensity of this control sample is defined as Io. Next, the same operation was performed by adding the test agent to the control sample, and the obtained luminescence intensity was defined as Is. The ratio Io / Is of the luminescence intensity to the compound concentration (Cs) of the test agent is plotted, and the following Stern-Volmer equation (1), Io / Is = 1 + kq · τ · Cs (1) τ: singlet oxygen Lifetime (constant depending on the solvent) Cs: The singlet oxygen elimination rate constant (kq) was determined from the compounding concentration of the test drug. The actual singlet oxygen scavenging ability is expressed by the following equation (2): Singlet oxygen scavenging ability (s ⁻¹ ) = kq (g− ¹ · L · s ⁻¹ ) × Cs (g · L ⁻¹ ) (2) Is calculated by multiplying the singlet oxygen elimination rate constant by the actual compounding concentration. In addition, the concentration (Cs) of the test drug was adjusted to a solid concentration (g · L ⁻¹ ).

* Among the test drugs, a plant extract was prepared as follows. First, each crude drug is dried and cut into small pieces. 100 parts by weight of a 50% aqueous solution of ethyl alcohol is added to 10 parts by weight of the cut crude drug, and 3
After extraction for days, each extract was obtained by filtration.

Table 1 shows the results of evaluating the singlet oxygen scavenging ability of each test drug. The singlet oxygen scavenging ability was evaluated on the following three levels.

(Evaluation Criteria) Evaluation: Evaluation contents ◎: Singlet oxygen scavenging ability of 1000 s ⁻¹ or more. ：: Singlet oxygen scavenging ability of 50 s ⁻¹ or more and less than 1000 s ⁻¹ . ×: Singlet oxygen scavenging ability of less than 50 s ⁻¹ .

(Result)

[Table 1]

As is clear from the results in Table 1, A1 to A
Each of the 24 test agents was found to have high singlet oxygen scavenging ability, and a skin external preparation containing these compounds had the effect of preventing and improving acne due to singlet oxygen generated from porphyrin produced by P. acnes. It was judged.

Example 1 Emulsion: An emulsion was prepared by the following composition and the following method.
The effects of acne prevention and improvement were investigated. Table 2 shows the results. (Preparation) (%) (1) Polyoxyethylene (10EO) 1.0 Sorbitan monostearate (2) Polyoxyethylene (60EO) 0.5 Sorbit tetraoleate (3) Glyceryl mono Stearate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 5.0 (7) Preservative 0.1 (8) Carboxyvinyl polymer 0.1 (9) Sodium hydroxide 0.05 (10) Ethyl alcohol 5.0 (11) Residual amount of purified water (12) Appropriate amount of perfume (13) Test drugs A1 to A30 (types and amounts described in Table 2)

(Preparation Method) A. Components (1) to (6) are mixed by heating and kept at 70 ° C. B. Heat and mix a part of components (9) and (11),
To keep. C. Add A to B, mix and emulsify uniformly. D. C was dissolved in the remainder of (11) after cooling (7),
(13) dissolved in (8), (12) and (10) were added and mixed uniformly to obtain an emulsion.

(Test Method) An appropriate amount of the test emulsion was applied to the face after washing the face twice daily in the morning and at night, using a panel of 15 women 22 to 40 years old for each test emulsion. 12
Weekly application was performed, and the effectiveness of the acne improvement effect of the application was judged by the following three ranks and evaluated according to the following evaluation criteria.

(Effectiveness rank) Effective ... Acne became difficult to be formed. Acne is no longer noticeable. Somewhat effective…… Acne became somewhat difficult. Acne has become less noticeable. Ineffective ...... No change from before use.

(Evaluation Criteria) Evaluation: Evaluation content ◎: The number of people who combined the effectiveness with the effectiveness was 10 or more. ○: The number of people who combined the validity and the validity was 5 to 9 people. △: The number of people who were effective and slightly effective was 1 to 4 people. ×: The number of people who combined the validity and the validity was 0.

(Result)

[Table 2]

As shown in Table 2, a skin external preparation containing a singlet oxygen scavenger having a singlet oxygen scavenging ability of 50 s ^-1 or more in Table 1 was applied to the skin to obtain acne. It can be prevented and improved, and it is clear that the skin is beautiful. In particular, preferably 1000s
^The external preparation for skin containing a singlet oxygen scavenger so as to be ⁻¹ or more was excellent in its effect.

Example 2 Emulsion: Emulsions having the following basic composition and types and amounts of singlet oxygen scavengers, UV inhibitors, whitening agents, anti-inflammatory agents, bactericides, cell activators, etc. Was added, and an emulsion was prepared by the following method, and the skin effect was examined. This result is also shown in Table 3.
Shown in The basic composition and the amounts shown in Table 3 are the amounts in the emulsion as the final product.

(Basic composition) (%) (1) polyoxyethylene (60E.O.) sorbitan 1.0 monostearate (2) polyoxyethylene (60E.O.) sorbit 0.5 tetraoleate (3) ) Glycerin monostearate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 5.0 (7) Preservative 0.1 (8) Carboxyvinyl polymer 0.1 (9) Sodium hydroxide 0.05 (10) Ethyl alcohol 5.0 (11) Residual amount of purified water (12) Appropriate amount of flavor

(Composition and Results)

[Table 3]

(Preparation Method) A. Components (1) to (6) are mixed by heating and maintained at 70 ° C. B. Heat and mix a part of components (9) and (11),
To keep. C. Add A to B, mix and emulsify uniformly. D. C was dissolved in the remainder of (11) after cooling (7),
(8), (12) and the components (13) to (40) in Table 3 were dissolved in (10) and added, followed by uniform mixing to obtain an emulsion.

(Test Method) The test emulsion was evaluated in the same manner as in Example 1.

As shown in the results in Table 3, a skin external preparation containing a singlet oxygen scavenger so as to have a singlet oxygen scavenging ability of 50 s ^-1 or more was treated with an ultraviolet ray inhibitor, a whitening agent, and an anti-inflammatory agent. When applied to the skin in combination with an agent, a bactericide, and a cell activator, it exerts an even better anti-acne prevention and improvement effect than when an external preparation containing a singlet oxygen scavenger alone is applied, and is transparent. It became clear that the skin had a beautiful feeling.

Example 3 Cosmetic Water: (Preparation) (%) (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20EO) 1 .2 Sorbitan monolaurate (4) Ethyl alcohol 8.0 (5) Green squid extract ^{* 1} 0.5 (6) Licorice extract ^{* 1} 0.1 (7) Perilla extract ^{* 1} 0.1 (8) Serine ^{* 2} 0.01 (9) Preservative appropriate amount (10) Flavor appropriate amount (11) Purified water residue * 1 Prepared by the method of Test Example 1 * 2 Kyowa Hakko Co., Ltd.

(Production method) A. Components (3), (4), (9) and (10) are mixed and dissolved. B. Components (1), (2), (5) to (8) and (11)
Are mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion.

Example 4 Cream: (Preparation) (%) (1) Beeswax 6.0 (2) Cetanol 5.0 (3) Reduced Lanolin 5.0 (4) Squalane 30.0 (5) ) Lipophilic glyceryl monostearate 4.0 (6) Polyoxyethylene sorbitan monolaurate (20EO) 2.0 (7) Sampens extract ^{* 1} 0.5 (8) Aloe extract ^{* 10} .1 (9) Ougon extract ^{* 1} 0.01 (10) Lactic acid bacteria fermentation metabolite ^{* 2} 0.1 (11) Suitable amount of preservative (12) Suitable amount of flavor (13) Residual amount of purified water * 1 Test example 1 * 2 Manufactured by Ichimaru Falcos

(Preparation method) A. Components (1) to (6) and (11) are mixed and heated to 70 ° C. B. Heat component (13) to 70 ° C. C. B was added to A, (7) to (10) and (12) were mixed, and then cooled to obtain a cream.

Both the lotion obtained in Example 3 and the cream obtained in Example 4 have excellent stability over time, and when applied to the skin, can prevent and improve acne and provide clear and beautiful skin. Was something.

Example 5 Ointment: (preparation) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) ) Arhat extract ^{* 1} 1.0 (6) Seaweed extract ^{* 2} 0.5 (7) Chamomile extract ^{* 1} 0.2 (8) Residual water * 1 Prepared by the method of Test Example 1 * 2 Technoble

(Preparation Method) A. A part of the components (3), (4) and (8) is heated and mixed and kept at 75 ° C. B. Components (1) and (2) are mixed by heating and kept at 75 ° C. C. Add A slowly to B. D. Dissolved in the remainder of (8) while cooling C (5)-
(7) was added to obtain an ointment.

The ointment obtained in Example 5 has excellent stability over time,
By applying to the skin, acne was prevented, and the skin was made clear and beautiful.

Example 6 Pack: (Preparation) (%) (1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) ) Tea extract ^{* 1} 0.1 (6) Jiyu extract ^{* 1} 0.2 (7) Wheat extract ^{* 1} 0.1 (8) Preservative 0.2 (9) Flavor 0.1 (10) Purification Water residue * 1 Prepared by the method of Test Example 1.

(Preparation Method) A. Components (1), (3), (4) and (10) are mixed, heated to 70 ° C., and stirred. B. Mix components (2) and (8). C. The above B was added to the above A, mixed, cooled, and (5) to (7) and (9) were uniformly dispersed to obtain a pack.

The pack of Example 6 was excellent in stability over time and, when applied to the skin, prevented acne and gave clear and beautiful skin.

Example 7 Liquid foundation: (Preparation) (%) (1) Lanolin 7.0 (2) Liquid paraffin 5.0 (3) Stearic acid 2.0 (4) Cetanol 1.0 (5) Paramethoxycinnamic acid 3.0-2-ethylhexyl (6) Glycerin 5.0 (7) Triethanolamine 1.0 (8) Carboxymethylcellulose 0.7 (9) Remaining purified water (10) Titanium oxide 8. 0 (11) Fine particle titanium oxide 2.0 (12) Zinc oxide 5.0 (13) Mica 15.0 (14) Talc 6.0 (15) Color pigment 6.0 (16) Melissa extract ^{* 1} 0.0 01 (17) Mackerel extract ^{* 1} 0.5 (18) Artemisia extract ^{* 1} 0.1 (19) Appropriate amount of flavor * 1 Prepared by the method of Test Example 1

(Production Method) A. Components (1) to (5) are mixed and dissolved. B. Add components (10) to (15) to A, mix uniformly, and keep at 70 ° C. C. Components (6) to (9) are uniformly dissolved and kept at 70 ° C. D. Add C to B and emulsify uniformly. After cooling E.D, components (16) to (19) were added to obtain a liquid foundation.

The liquid foundation obtained in Example 7 has excellent stability over time, and can be applied to the skin to
It was to prevent acne.

[0072]

As described above, the external preparation for skin of the present invention containing a singlet oxygen scavenger having a certain amount or more of singlet oxygen scavenging ability is generated from porphyrin produced by acne bacteria due to its singlet oxygen scavenging ability. It is effective in eliminating singlet oxygen and preventing or improving acne.

Further, by combining the above singlet oxygen scavenger with an ultraviolet absorbent, a bactericide, an anti-inflammatory agent, a whitening agent, and a cell activator, it has a high preventive and ameliorating effect on acne and also has acne scars. It can be used as an external preparation for skin which is effective for improving pigmentation. that's all

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme court ゛ (Reference) A61K 31/122 A61K 31/122 31/195 31/195 31/255 31/255 31/352 31/352 31 / 355 31/355 31/405 31/405 31/4172 31/4172 31/662 31/662 31/7004 31/7004 31/7048 31/7048 35/78 35/78 C A61P 17/10 A61P 17/10 39/06 39/06 (72) Inventor Akemi Takayama 48-18 Sakaemachi, Kita-ku, Tokyo F-term in Koseh Research Laboratories (reference) 4C083 AA032 AA082 AA111 AA112 AB032 AB212 AB242 AB442 AC011 AC012 AC022 AC072 AC102 AC122 AC211 AC212 AC242 AC342 AC422 AC542 AC581 AC582 AC791 AC792 AC841 AC842 AC851 AC852 AD092 AD112 AD201 AD202 AD272 AD512 AD661 AD662 CC04 CC05 CC07 CC12 DD23 DD31 EE14 4C086 AA01 AA02 BA08 BA09 BC14 BC38 EA01 EA11 MA01 MA03 MA04 MA05 Z14 ZA89 ZC37 4C2 06 AA01 AA02 BA02 CB25 FA53 JA27 JA62 MA01 MA03 MA04 MA05 MA83 NA14 ZA89 ZC21 ZC37

Claims (4)

[Claims] 1. A skin external preparation for acne, comprising an amount of a singlet oxygen scavenger having a singlet oxygen scavenging ability of 50 s ^-1 or more. 2. The following components (A) and (B): (A) a singlet oxygen scavenger having an amount of 50 s ^-1 or more as a singlet oxygen scavenging ability ^; and (B) one or more kinds of ultraviolet inhibitors. A skin external preparation for acne, characterized by containing. 3. The composition according to claim 1, further comprising (C) (C) one or more drugs selected from whitening agents, anti-inflammatory agents, bactericides and cell activators.
Item 3. An external preparation for acne according to Item 2 or 2. 4. The method according to claim 1, wherein the singlet oxygen scavenger is rutin or a derivative thereof, quercetin, β-carotene, astaxanthin, zeaxanthin, vitamin E or a derivative thereof and a salt thereof, erythorbic acid, histidine, tryptophan, tyrosine, methionine, cystine, hypotaurine. 4. The extract according to claim 1, wherein the extract is selected from the group consisting of thiotaurine, carrot extract, squid extract, sampens extract, melissa extract, yasatsutsu extract, arhat extract, tea extract and phospholipid. The skin external preparation for acne according to the above item.