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ITMI20112329A1 - Nuovi derivati spiro amminici - Google Patents

Nuovi derivati spiro amminici

Info

Publication number
ITMI20112329A1
ITMI20112329A1 IT002329A ITMI20112329A ITMI20112329A1 IT MI20112329 A1 ITMI20112329 A1 IT MI20112329A1 IT 002329 A IT002329 A IT 002329A IT MI20112329 A ITMI20112329 A IT MI20112329A IT MI20112329 A1 ITMI20112329 A1 IT MI20112329A1
Authority
IT
Italy
Prior art keywords
derivatives
expanded
examined
new
new examined
Prior art date
Application number
IT002329A
Other languages
English (en)
Inventor
Roberto Artusi
Fabrizio Colace
Stefano Mandelli
Lorenzo Perugini
Lucio Claudio Rovati
Luigi Piero Stasi
Original Assignee
Rottapharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rottapharm Spa filed Critical Rottapharm Spa
Priority to IT002329A priority Critical patent/ITMI20112329A1/it
Priority to EP12812248.8A priority patent/EP2794593B8/en
Priority to ES12812248.8T priority patent/ES2624209T3/es
Priority to PCT/EP2012/076447 priority patent/WO2013092893A1/en
Priority to US14/366,743 priority patent/US9062033B2/en
Priority to JP2014548027A priority patent/JP6082024B2/ja
Publication of ITMI20112329A1 publication Critical patent/ITMI20112329A1/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT002329A 2011-12-21 2011-12-21 Nuovi derivati spiro amminici ITMI20112329A1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT002329A ITMI20112329A1 (it) 2011-12-21 2011-12-21 Nuovi derivati spiro amminici
EP12812248.8A EP2794593B8 (en) 2011-12-21 2012-12-20 Spiro aminic compounds as orexin antagonists
ES12812248.8T ES2624209T3 (es) 2011-12-21 2012-12-20 Compuestos espiroamínicos como antogonistas de orexina
PCT/EP2012/076447 WO2013092893A1 (en) 2011-12-21 2012-12-20 Chemical compounds
US14/366,743 US9062033B2 (en) 2011-12-21 2012-12-20 Chemical compounds
JP2014548027A JP6082024B2 (ja) 2011-12-21 2012-12-20 化学化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002329A ITMI20112329A1 (it) 2011-12-21 2011-12-21 Nuovi derivati spiro amminici

Publications (1)

Publication Number Publication Date
ITMI20112329A1 true ITMI20112329A1 (it) 2013-06-22

Family

ID=45614926

Family Applications (1)

Application Number Title Priority Date Filing Date
IT002329A ITMI20112329A1 (it) 2011-12-21 2011-12-21 Nuovi derivati spiro amminici

Country Status (6)

Country Link
US (1) US9062033B2 (it)
EP (1) EP2794593B8 (it)
JP (1) JP6082024B2 (it)
ES (1) ES2624209T3 (it)
IT (1) ITMI20112329A1 (it)
WO (1) WO2013092893A1 (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201404738QA (en) 2012-02-07 2014-10-30 Eolas Therapeutics Inc Substituted prolines / piperidines as orexin receptor antagonists
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
ITMI20120424A1 (it) 2012-03-19 2013-09-20 Rottapharm Spa Composti chimici
WO2016025669A1 (en) 2014-08-13 2016-02-18 Eolas Therapeutics, Inc. Difluoropyrrolidines as orexin receptor modulators
MA40858A (fr) 2014-10-31 2021-03-31 Indivior Uk Ltd Composés antagonistes des récepteurs d3 à la dopamine
EP3223803A1 (en) * 2014-11-24 2017-10-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of ox1r antagonists for the treatment of inflammatory bowel diseases
WO2017139603A1 (en) 2016-02-12 2017-08-17 Astrazeneca Ab Halo-substituted piperidines as orexin receptor modulators
CN111004171A (zh) * 2019-12-18 2020-04-14 南开大学 3-氟吡啶-2-甲醇的一种新合成方法
EP3885339A1 (en) * 2020-03-27 2021-09-29 Rottapharm Biotech S.r.l. Process for the preparation of (r)-4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)-cyclopropyl) benzoic acid or a salt thereof
EP4208444A1 (en) 2020-09-03 2023-07-12 Orexia Therapeutics Limited Bicyclic-heterocycle derivatives and their uses as orexin-2 receptor agonists
WO2023167865A1 (en) * 2022-03-01 2023-09-07 Orexia Therapeutics Limited Bicyclic-heterocycle derivatives and related uses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011006960A1 (en) * 2009-07-15 2011-01-20 Rottapharm S.P.A. Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3282927A (en) 1964-05-21 1966-11-01 Bristol Myers Co 5-phenyl-4-thiazolylpenicillins
CL2007003827A1 (es) * 2006-12-28 2008-09-26 Actelion Pharmaceuticals Ltd Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras.
EA200901101A1 (ru) 2007-02-20 2010-04-30 Новартис Аг Макроциклические соединения в качестве ингибиторов протеазы ns3 вгс
EP2152690B1 (en) 2007-05-23 2012-01-11 Merck Sharp & Dohme Corp. Pyridyl piperidine orexin receptor antagonists
GB0806536D0 (en) * 2008-04-10 2008-05-14 Glaxo Group Ltd Novel compounds
US20100144760A1 (en) 2008-12-02 2010-06-10 Giuseppe Alvaro Novel compounds
MX2011011127A (es) * 2009-04-24 2011-11-18 Glaxo Group Ltd 3-azabiciclo[4.1.0] heptanos usados como antagonistas de orexina.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011006960A1 (en) * 2009-07-15 2011-01-20 Rottapharm S.P.A. Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction

Also Published As

Publication number Publication date
US9062033B2 (en) 2015-06-23
ES2624209T3 (es) 2017-07-13
JP2015502385A (ja) 2015-01-22
EP2794593B1 (en) 2017-02-01
EP2794593A1 (en) 2014-10-29
JP6082024B2 (ja) 2017-02-15
WO2013092893A1 (en) 2013-06-27
US20140357653A1 (en) 2014-12-04
EP2794593B8 (en) 2017-05-03

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