ITMI20112329A1 - Nuovi derivati spiro amminici - Google Patents
Nuovi derivati spiro amminiciInfo
- Publication number
- ITMI20112329A1 ITMI20112329A1 IT002329A ITMI20112329A ITMI20112329A1 IT MI20112329 A1 ITMI20112329 A1 IT MI20112329A1 IT 002329 A IT002329 A IT 002329A IT MI20112329 A ITMI20112329 A IT MI20112329A IT MI20112329 A1 ITMI20112329 A1 IT MI20112329A1
- Authority
- IT
- Italy
- Prior art keywords
- derivatives
- expanded
- examined
- new
- new examined
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002329A ITMI20112329A1 (it) | 2011-12-21 | 2011-12-21 | Nuovi derivati spiro amminici |
| EP12812248.8A EP2794593B8 (en) | 2011-12-21 | 2012-12-20 | Spiro aminic compounds as orexin antagonists |
| ES12812248.8T ES2624209T3 (es) | 2011-12-21 | 2012-12-20 | Compuestos espiroamínicos como antogonistas de orexina |
| PCT/EP2012/076447 WO2013092893A1 (en) | 2011-12-21 | 2012-12-20 | Chemical compounds |
| US14/366,743 US9062033B2 (en) | 2011-12-21 | 2012-12-20 | Chemical compounds |
| JP2014548027A JP6082024B2 (ja) | 2011-12-21 | 2012-12-20 | 化学化合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002329A ITMI20112329A1 (it) | 2011-12-21 | 2011-12-21 | Nuovi derivati spiro amminici |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITMI20112329A1 true ITMI20112329A1 (it) | 2013-06-22 |
Family
ID=45614926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT002329A ITMI20112329A1 (it) | 2011-12-21 | 2011-12-21 | Nuovi derivati spiro amminici |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9062033B2 (it) |
| EP (1) | EP2794593B8 (it) |
| JP (1) | JP6082024B2 (it) |
| ES (1) | ES2624209T3 (it) |
| IT (1) | ITMI20112329A1 (it) |
| WO (1) | WO2013092893A1 (it) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201404738QA (en) | 2012-02-07 | 2014-10-30 | Eolas Therapeutics Inc | Substituted prolines / piperidines as orexin receptor antagonists |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| ITMI20120424A1 (it) | 2012-03-19 | 2013-09-20 | Rottapharm Spa | Composti chimici |
| WO2016025669A1 (en) | 2014-08-13 | 2016-02-18 | Eolas Therapeutics, Inc. | Difluoropyrrolidines as orexin receptor modulators |
| MA40858A (fr) | 2014-10-31 | 2021-03-31 | Indivior Uk Ltd | Composés antagonistes des récepteurs d3 à la dopamine |
| EP3223803A1 (en) * | 2014-11-24 | 2017-10-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of ox1r antagonists for the treatment of inflammatory bowel diseases |
| WO2017139603A1 (en) | 2016-02-12 | 2017-08-17 | Astrazeneca Ab | Halo-substituted piperidines as orexin receptor modulators |
| CN111004171A (zh) * | 2019-12-18 | 2020-04-14 | 南开大学 | 3-氟吡啶-2-甲醇的一种新合成方法 |
| EP3885339A1 (en) * | 2020-03-27 | 2021-09-29 | Rottapharm Biotech S.r.l. | Process for the preparation of (r)-4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)-cyclopropyl) benzoic acid or a salt thereof |
| EP4208444A1 (en) | 2020-09-03 | 2023-07-12 | Orexia Therapeutics Limited | Bicyclic-heterocycle derivatives and their uses as orexin-2 receptor agonists |
| WO2023167865A1 (en) * | 2022-03-01 | 2023-09-07 | Orexia Therapeutics Limited | Bicyclic-heterocycle derivatives and related uses |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011006960A1 (en) * | 2009-07-15 | 2011-01-20 | Rottapharm S.P.A. | Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3282927A (en) | 1964-05-21 | 1966-11-01 | Bristol Myers Co | 5-phenyl-4-thiazolylpenicillins |
| CL2007003827A1 (es) * | 2006-12-28 | 2008-09-26 | Actelion Pharmaceuticals Ltd | Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras. |
| EA200901101A1 (ru) | 2007-02-20 | 2010-04-30 | Новартис Аг | Макроциклические соединения в качестве ингибиторов протеазы ns3 вгс |
| EP2152690B1 (en) | 2007-05-23 | 2012-01-11 | Merck Sharp & Dohme Corp. | Pyridyl piperidine orexin receptor antagonists |
| GB0806536D0 (en) * | 2008-04-10 | 2008-05-14 | Glaxo Group Ltd | Novel compounds |
| US20100144760A1 (en) | 2008-12-02 | 2010-06-10 | Giuseppe Alvaro | Novel compounds |
| MX2011011127A (es) * | 2009-04-24 | 2011-11-18 | Glaxo Group Ltd | 3-azabiciclo[4.1.0] heptanos usados como antagonistas de orexina. |
-
2011
- 2011-12-21 IT IT002329A patent/ITMI20112329A1/it unknown
-
2012
- 2012-12-20 EP EP12812248.8A patent/EP2794593B8/en not_active Not-in-force
- 2012-12-20 ES ES12812248.8T patent/ES2624209T3/es active Active
- 2012-12-20 WO PCT/EP2012/076447 patent/WO2013092893A1/en not_active Ceased
- 2012-12-20 JP JP2014548027A patent/JP6082024B2/ja not_active Expired - Fee Related
- 2012-12-20 US US14/366,743 patent/US9062033B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011006960A1 (en) * | 2009-07-15 | 2011-01-20 | Rottapharm S.P.A. | Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction |
Also Published As
| Publication number | Publication date |
|---|---|
| US9062033B2 (en) | 2015-06-23 |
| ES2624209T3 (es) | 2017-07-13 |
| JP2015502385A (ja) | 2015-01-22 |
| EP2794593B1 (en) | 2017-02-01 |
| EP2794593A1 (en) | 2014-10-29 |
| JP6082024B2 (ja) | 2017-02-15 |
| WO2013092893A1 (en) | 2013-06-27 |
| US20140357653A1 (en) | 2014-12-04 |
| EP2794593B8 (en) | 2017-05-03 |
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