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CO6890099A2 - Nuevos derivados dihidroquinolina-2-ona - Google Patents

Nuevos derivados dihidroquinolina-2-ona

Info

Publication number
CO6890099A2
CO6890099A2 CO14040934A CO14040934A CO6890099A2 CO 6890099 A2 CO6890099 A2 CO 6890099A2 CO 14040934 A CO14040934 A CO 14040934A CO 14040934 A CO14040934 A CO 14040934A CO 6890099 A2 CO6890099 A2 CO 6890099A2
Authority
CO
Colombia
Prior art keywords
derivatives
dihydroquinoline
new
new dihydroquinoline
Prior art date
Application number
CO14040934A
Other languages
English (en)
Inventor
Johannes Aebi
Kurt Amrein
Benoit Hornsperger
Henner Knust
Bernd Kuhn
Yongfu Liu
Hans Peter Maerki
Alexander Mayweg
Peter Mohr
Xuefei Tan
Mingwei Zhou
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO6890099A2 publication Critical patent/CO6890099A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CO14040934A 2011-09-15 2014-02-26 Nuevos derivados dihidroquinolina-2-ona CO6890099A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2011079673 2011-09-15

Publications (1)

Publication Number Publication Date
CO6890099A2 true CO6890099A2 (es) 2014-03-10

Family

ID=46829775

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14040934A CO6890099A2 (es) 2011-09-15 2014-02-26 Nuevos derivados dihidroquinolina-2-ona

Country Status (33)

Country Link
US (1) US9260408B2 (es)
EP (2) EP3653618B1 (es)
JP (1) JP6012735B2 (es)
KR (1) KR101785143B1 (es)
CN (1) CN103814021B (es)
AR (1) AR087901A1 (es)
AU (1) AU2012307509B2 (es)
BR (1) BR112014006283B1 (es)
CA (1) CA2846785C (es)
CL (1) CL2014000604A1 (es)
CO (1) CO6890099A2 (es)
CR (1) CR20140091A (es)
DK (1) DK2755963T3 (es)
EA (1) EA035757B1 (es)
EC (1) ECSP14013245A (es)
ES (2) ES2763332T3 (es)
HR (1) HRP20192323T1 (es)
HU (1) HUE047771T2 (es)
IL (1) IL231229A0 (es)
LT (1) LT2755963T (es)
MX (1) MX358376B (es)
MY (1) MY169043A (es)
PE (1) PE20141372A1 (es)
PH (1) PH12014500434A1 (es)
PL (1) PL2755963T3 (es)
PT (1) PT2755963T (es)
RS (1) RS59737B1 (es)
SG (1) SG11201400679WA (es)
SI (1) SI2755963T1 (es)
TW (1) TWI462914B (es)
UA (1) UA111626C2 (es)
WO (1) WO2013037779A1 (es)
ZA (1) ZA201401884B (es)

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* Cited by examiner, † Cited by third party
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MX2015010611A (es) * 2013-03-08 2015-12-16 Hoffmann La Roche Nuevos derivados de dihidroquinolin-2-ona como inhibidores de la aldosterona-sintasa (citocromo p450, familia 11, subfamilia b, polipeptido 2 (cyp11b2) o citocromo p450, familia 11, subfamilia b, polipeptido 1 (cyp11b1)).
BR112015023280A2 (pt) 2013-03-14 2017-07-18 Hoffmann La Roche derivados de dihidroquinolin-2-ona para utilização como inibidores da aldosterona sintase
US9682983B2 (en) 2013-03-14 2017-06-20 The Brigham And Women's Hospital, Inc. BMP inhibitors and methods of use thereof
CN105073732B (zh) * 2013-03-14 2017-07-21 豪夫迈·罗氏有限公司 用作醛固酮合酶抑制剂的二氢喹啉‑2‑酮衍生物
EP2991985B1 (en) * 2013-04-30 2018-06-13 Boehringer Ingelheim International GmbH Aldosterone synthase inhibitors
CN105143205B (zh) * 2013-05-27 2018-02-02 豪夫迈·罗氏有限公司 新的3,4‑二氢‑2h‑异喹啉‑1‑酮和2,3‑二氢‑异吲哚‑1‑酮化合物
RS59663B1 (sr) * 2013-05-27 2020-01-31 Hoffmann La Roche Nova jedinjenja 3,4-dihidro-2h-izokinolin-1-on i 2,3-dihidro-izoindol-1-on
CN105308045B (zh) * 2013-05-27 2017-05-17 豪夫迈·罗氏有限公司 新的3,4‑二氢‑2h‑异喹啉‑1‑酮和2,3‑二氢‑异吲哚‑1‑酮化合物
PT3004077T (pt) * 2013-05-27 2019-12-19 Hoffmann La Roche Novos compostos 3,4-di-hidro-2h-isoquinolin-1-ona e 2,3-di-hidro-isoindol-1-ona
WO2015125858A1 (ja) * 2014-02-24 2015-08-27 日本曹達株式会社 ヘテロアリール化合物およびその用途
EP3122355A4 (en) * 2014-03-26 2017-08-09 The Brigham and Women's Hospital, Inc. Compositions and methods for inhibiting bmp
MY176401A (en) * 2014-04-24 2020-08-05 Mitsubishi Tanabe Pharma Corp Novel disubstituted 1,2,4-triazine compound
US10513521B2 (en) 2014-07-15 2019-12-24 The Brigham And Women's Hospital, Inc. Compositions and methods for inhibiting BMP
WO2016055394A1 (en) * 2014-10-08 2016-04-14 F. Hoffmann-La Roche Ag Spirodiamine derivatives as aldosterone synthase inhibitors
WO2016066597A1 (en) * 2014-10-31 2016-05-06 F. Hoffmann-La Roche Ag New dihydroquinoline pyrazolyl compounds
JP6670832B2 (ja) * 2014-10-31 2020-03-25 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft アルドステロン合成酵素阻害剤としての新規ジヒドロキノリンピラゾリル化合物
EP3212631B1 (en) * 2014-10-31 2020-02-12 F.Hoffmann-La Roche Ag Pyrazolyl-3,4-dihydroquinolin-2-one aldosterone synthase inhibitors
MY199607A (en) 2015-08-31 2023-11-09 Dong A Socio Holdings Co Ltd Heteroaryl compounds and their use as therapeutic drugs
JP6314196B2 (ja) * 2015-10-22 2018-04-18 田辺三菱製薬株式会社 医薬組成物
WO2017069226A1 (ja) 2015-10-23 2017-04-27 田辺三菱製薬株式会社 新規含窒素芳香族複素環化合物
ES2903528T3 (es) 2016-10-10 2022-04-04 Dong A Socio Holdings Co Ltd Compuestos de heteroarilo y su uso como inhibidores de MER
PH12019500664B1 (en) * 2016-12-08 2023-08-11 Hoffmann La Roche New isoxazolyl ether derivatives as gaba a alpha5 pam
EP3962903A1 (en) 2019-05-01 2022-03-09 Boehringer Ingelheim International GmbH (r)-(2-methyloxiran-2-yl)methyl 4-bromobenzenesulfonate
WO2023063851A1 (en) * 2021-10-13 2023-04-20 «Target Medicals» Limited Liability Company Inhibitors of human aldosterone synthase (cyp11b2)
KR20240122521A (ko) 2021-12-14 2024-08-12 베링거 인겔하임 인터내셔날 게엠베하 만성 신장 질환 치료용 알도스테론 신타아제 억제제
WO2024102026A1 (en) * 2022-11-10 2024-05-16 «Target Medicals» Limited Liability Company Inhibitors of human aldosterone synthase (cyp11b2)
WO2024109885A1 (zh) * 2022-11-23 2024-05-30 上海翰森生物医药科技有限公司 吡啶多环类化合物抑制剂、及其制备方法和应用
AU2024271467A1 (en) * 2023-05-12 2026-01-15 JIANGSU DEYUAN PHARMACEUTICAL Co.,Ltd. Nitrogen-containing heterocyclic compound and use thereof
WO2025131022A1 (zh) * 2023-12-22 2025-06-26 上海翊石医药科技有限公司 一类芳杂环化合物及其制备方法和应用
CN120289471B (zh) * 2024-03-01 2025-10-17 浙江扬厉医药技术有限公司 吡喃并吡啶类化合物、其制备方法、药物组合物及应用

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GB8334282D0 (en) * 1983-12-22 1984-02-01 Pfizer Ltd Quinolone inotropic agents
PT79699B (en) * 1983-12-22 1986-12-10 Pfizer Process for preparing quinolone inotropic agents
CN85100796A (zh) * 1985-04-01 1986-10-01 辉瑞公司 喹啉酮衍生物的制备方法
FR2580646A1 (fr) * 1985-04-19 1986-10-24 Synthelabo Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique
EP1874753A2 (en) 2005-04-14 2008-01-09 Smithkline Beecham Corporation Compounds, compositions and methods
DE102008022221A1 (de) * 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
SG175925A1 (en) 2009-05-15 2011-12-29 Novartis Ag Aryl pyridine as aldosterone synthase inhibitors
EA201101621A1 (ru) 2009-05-15 2012-05-30 Новартис Аг Производные бензоксазолона в качестве ингибиторов альдостеронсинтазы
US8541404B2 (en) * 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2

Also Published As

Publication number Publication date
CA2846785A1 (en) 2013-03-21
PL2755963T3 (pl) 2020-07-27
SI2755963T1 (sl) 2020-01-31
PH12014500434A1 (en) 2017-04-19
CR20140091A (es) 2014-06-03
RS59737B1 (sr) 2020-02-28
BR112014006283A2 (pt) 2017-04-11
EP2755963A1 (en) 2014-07-23
WO2013037779A1 (en) 2013-03-21
DK2755963T3 (da) 2020-01-13
EP3653618B1 (en) 2025-01-08
US9260408B2 (en) 2016-02-16
CA2846785C (en) 2020-09-22
PE20141372A1 (es) 2014-10-13
TW201315724A (zh) 2013-04-16
MX358376B (es) 2018-08-16
AU2012307509B2 (en) 2017-06-29
HRP20192323T1 (hr) 2020-03-20
UA111626C2 (uk) 2016-05-25
AU2012307509A1 (en) 2014-03-13
KR101785143B1 (ko) 2017-10-12
HUE047771T2 (hu) 2020-05-28
NZ621599A (en) 2016-07-29
ECSP14013245A (es) 2014-07-31
ZA201401884B (en) 2019-11-27
EA201490596A1 (ru) 2014-07-30
IL231229A0 (en) 2014-04-30
MY169043A (en) 2019-02-07
EP3653618A1 (en) 2020-05-20
LT2755963T (lt) 2020-01-27
CN103814021B (zh) 2016-12-21
BR112014006283B1 (pt) 2021-11-03
SG11201400679WA (en) 2014-04-28
EP2755963B1 (en) 2019-10-30
EA035757B1 (ru) 2020-08-05
PT2755963T (pt) 2020-01-10
JP6012735B2 (ja) 2016-10-25
CN103814021A (zh) 2014-05-21
ES2763332T3 (es) 2020-05-28
TWI462914B (zh) 2014-12-01
JP2014527077A (ja) 2014-10-09
CL2014000604A1 (es) 2014-10-17
AR087901A1 (es) 2014-04-23
MX2014002770A (es) 2014-06-05
ES3016782T3 (en) 2025-05-09
US20130072679A1 (en) 2013-03-21
KR20140067121A (ko) 2014-06-03

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