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ITMI20110480A1 - Procedimento per la preparazione di lapatinib e suoi sali - Google Patents

Procedimento per la preparazione di lapatinib e suoi sali

Info

Publication number
ITMI20110480A1
ITMI20110480A1 IT000480A ITMI20110480A ITMI20110480A1 IT MI20110480 A1 ITMI20110480 A1 IT MI20110480A1 IT 000480 A IT000480 A IT 000480A IT MI20110480 A ITMI20110480 A IT MI20110480A IT MI20110480 A1 ITMI20110480 A1 IT MI20110480A1
Authority
IT
Italy
Prior art keywords
lapatinib
salts
procedure
preparation
Prior art date
Application number
IT000480A
Other languages
English (en)
Inventor
Francesco Fontana
Original Assignee
F I S Fabbrica Italiana Sint P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F I S Fabbrica Italiana Sint P A filed Critical F I S Fabbrica Italiana Sint P A
Priority to IT000480A priority Critical patent/ITMI20110480A1/it
Priority to ES12158120T priority patent/ES2418629T3/es
Priority to EP12158120.1A priority patent/EP2468745B1/en
Priority to US13/414,752 priority patent/US8853396B2/en
Priority to CN201210082780.XA priority patent/CN102702178B/zh
Publication of ITMI20110480A1 publication Critical patent/ITMI20110480A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT000480A 2011-03-25 2011-03-25 Procedimento per la preparazione di lapatinib e suoi sali ITMI20110480A1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT000480A ITMI20110480A1 (it) 2011-03-25 2011-03-25 Procedimento per la preparazione di lapatinib e suoi sali
ES12158120T ES2418629T3 (es) 2011-03-25 2012-03-05 Proceso para la preparación de lapatinib y las sales del mismo
EP12158120.1A EP2468745B1 (en) 2011-03-25 2012-03-05 Process for the preparation of lapatinib and the salts thereof
US13/414,752 US8853396B2 (en) 2011-03-25 2012-03-08 Methods for the preparation of lapatinib and the salts thereof
CN201210082780.XA CN102702178B (zh) 2011-03-25 2012-03-26 拉帕替尼及其盐的制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000480A ITMI20110480A1 (it) 2011-03-25 2011-03-25 Procedimento per la preparazione di lapatinib e suoi sali

Publications (1)

Publication Number Publication Date
ITMI20110480A1 true ITMI20110480A1 (it) 2012-09-26

Family

ID=43977145

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000480A ITMI20110480A1 (it) 2011-03-25 2011-03-25 Procedimento per la preparazione di lapatinib e suoi sali

Country Status (5)

Country Link
US (1) US8853396B2 (it)
EP (1) EP2468745B1 (it)
CN (1) CN102702178B (it)
ES (1) ES2418629T3 (it)
IT (1) ITMI20110480A1 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102964339A (zh) * 2012-11-19 2013-03-13 北京阜康仁生物制药科技有限公司 拉帕替尼的新药用盐
ITVI20130003A1 (it) * 2013-01-14 2014-07-14 F I S Fabbrica Italiana Sint I S P A Procedimento per la preparazione di lapatinib e suoi sali mediante nuovi intermedi.
US9024023B2 (en) 2013-01-14 2015-05-05 F.I.S.—Fabbrica Italiana Sintetici S.p.A. Efficient process for the preparation of lapatinib and salts thereof by means of new intermediates
WO2014170910A1 (en) 2013-04-04 2014-10-23 Natco Pharma Limited Process for the preparation of lapatinib
HU231012B1 (hu) 2013-05-24 2019-11-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Lapatinib sók
EP2937346A1 (en) * 2014-04-24 2015-10-28 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Co-crystals of lapatinib
KR20200091954A (ko) 2014-12-15 2020-07-31 더 리젠츠 오브 더 유니버시티 오브 미시간 Egfr 및 pi3k의 소분자 억제제
CN108473435A (zh) 2015-10-05 2018-08-31 纽约市哥伦比亚大学理事会 自噬潮和磷脂酶d的活化剂以及包括tau的蛋白聚集体的清除和蛋白质病的治疗
CN106946861A (zh) * 2017-03-21 2017-07-14 上海普凯姆化学科技有限公司 一种拉帕替尼结构片段的合成优化方法
JP2024501995A (ja) 2020-12-22 2024-01-17 メカニスティク・セラピューティクス・エルエルシー Ｅｇｆｒ及び／又はｐｉ３ｋ阻害剤としての置換アミノベンジルヘテロアリール化合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220354A1 (en) * 2000-06-30 2003-11-27 Mcclure Michael Scott Quinazoline ditosylate salt compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011116634A1 (en) * 2010-03-23 2011-09-29 Scinopharm Taiwan Ltd. Process and intermediates for preparing lapatinib

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220354A1 (en) * 2000-06-30 2003-11-27 Mcclure Michael Scott Quinazoline ditosylate salt compounds

Also Published As

Publication number Publication date
US8853396B2 (en) 2014-10-07
CN102702178B (zh) 2015-03-04
ES2418629T3 (es) 2013-08-14
EP2468745B1 (en) 2013-04-24
US20120245350A1 (en) 2012-09-27
EP2468745A1 (en) 2012-06-27
CN102702178A (zh) 2012-10-03

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