ITMI20040019A1 - Derivati isossazolici e loro impiego come inibitori della ciclossigenasi - Google Patents
Derivati isossazolici e loro impiego come inibitori della ciclossigenasiInfo
- Publication number
- ITMI20040019A1 ITMI20040019A1 IT000019A ITMI20040019A ITMI20040019A1 IT MI20040019 A1 ITMI20040019 A1 IT MI20040019A1 IT 000019 A IT000019 A IT 000019A IT MI20040019 A ITMI20040019 A IT MI20040019A IT MI20040019 A1 ITMI20040019 A1 IT MI20040019A1
- Authority
- IT
- Italy
- Prior art keywords
- inhibitors
- isossazolic
- cyclosxygenase
- derivatives
- cyclooxygenase
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102100038277 Prostaglandin G/H synthase 1 Human genes 0.000 abstract 2
- MXTWADCRLRQMDW-UHFFFAOYSA-N 5-ethyl-3,4-diphenyl-1,2-oxazole Chemical compound CCC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=CC=C1 MXTWADCRLRQMDW-UHFFFAOYSA-N 0.000 abstract 1
- ZXIRUKJWLADSJS-UHFFFAOYSA-N 5-methyl-3,4-diphenyl-1,2-oxazole Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=CC=C1 ZXIRUKJWLADSJS-UHFFFAOYSA-N 0.000 abstract 1
- 108010037464 Cyclooxygenase 1 Proteins 0.000 abstract 1
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 1
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 abstract 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000019A ITMI20040019A1 (it) | 2004-01-12 | 2004-01-12 | Derivati isossazolici e loro impiego come inibitori della ciclossigenasi |
| EP10005150A EP2246337B1 (en) | 2004-01-12 | 2005-01-12 | Isoxazole derivatives for use as cyclooxygenase inhibitors |
| AT05702217T ATE468329T1 (de) | 2004-01-12 | 2005-01-12 | Isoxazolderivate und deren verwendung als cyclooxygenaseinhibitoren |
| PCT/IB2005/000047 WO2005068442A2 (en) | 2004-01-12 | 2005-01-12 | Isoxazole derivatives and their use as cyclooxygenase inhibitors |
| DE602005021309T DE602005021309D1 (de) | 2004-01-12 | 2005-01-12 | Isoxazolderivate und deren verwendung als cyclooxygenaseinhibitoren |
| AT10005150T ATE538107T1 (de) | 2004-01-12 | 2005-01-12 | Isoxazol-derivate zur anwendung als cyclooxygenase-inhibitoren |
| EP05702217A EP1706390B1 (en) | 2004-01-12 | 2005-01-12 | Isoxazole derivatives and their use as cyclooxygenase inhibitors |
| DK05702217.0T DK1706390T3 (da) | 2004-01-12 | 2005-01-12 | Isoxazolderivater og deres anvendelse som cyclo-oxygenase inhibitorer |
| ES05702217T ES2344738T3 (es) | 2004-01-12 | 2005-01-12 | Derivados de isoxazol y su uso como inhibidores de la ciclooxigenasa. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000019A ITMI20040019A1 (it) | 2004-01-12 | 2004-01-12 | Derivati isossazolici e loro impiego come inibitori della ciclossigenasi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITMI20040019A1 true ITMI20040019A1 (it) | 2004-04-12 |
Family
ID=34779432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT000019A ITMI20040019A1 (it) | 2004-01-12 | 2004-01-12 | Derivati isossazolici e loro impiego come inibitori della ciclossigenasi |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP1706390B1 (it) |
| AT (2) | ATE538107T1 (it) |
| DE (1) | DE602005021309D1 (it) |
| DK (1) | DK1706390T3 (it) |
| ES (1) | ES2344738T3 (it) |
| IT (1) | ITMI20040019A1 (it) |
| WO (1) | WO2005068442A2 (it) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7943588B2 (en) | 2006-03-28 | 2011-05-17 | Trustees Of Dartmouth College | Method for preventing or treating neuropathic pain |
| US7989450B2 (en) | 2008-01-11 | 2011-08-02 | Universita' Degli Studi Di Bari | Functionalized diarylisoxazoles inhibitors of ciclooxygenase |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1128526A (en) * | 1979-10-05 | 1982-07-27 | Cdc Life Sciences Inc. | 3,4-diarylisoxazol-5-acetic acids |
| JPH04134077A (ja) * | 1990-09-21 | 1992-05-07 | Taiho Yakuhin Kogyo Kk | イソオキサゾール化合物 |
| AU658629B2 (en) * | 1991-05-01 | 1995-04-27 | Taiho Pharmaceutical Co., Ltd. | Novel isoxazole derivative and salt thereof |
| BR9607035A (pt) * | 1995-02-13 | 1997-11-04 | Searle & Co | Isoxazois substituidos para o tratamento de inflamação |
| WO1998047880A1 (en) * | 1997-04-21 | 1998-10-29 | Sumitomo Pharmaceuticals Company, Limited | Isoxazole derivatives |
| WO2001081333A2 (en) * | 2000-04-25 | 2001-11-01 | Pharmacia Corporation | Regioselective synthesis of 3,4-di(carbocyclyl or heterocyclyl)thiophenes |
| US20030105144A1 (en) * | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
| US6673818B2 (en) * | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
| BR0213027A (pt) * | 2001-10-02 | 2004-10-05 | Pharmacia Corp | Método para preparar compostos benzenosulfonila |
| JP2005510479A (ja) * | 2001-10-12 | 2005-04-21 | オンコノバ・セラピューティックス・インコーポレーテッド | 置換イソオキサゾールおよび置換２−イソオキサゾリンを調製する方法 |
| RU2300529C2 (ru) * | 2002-03-15 | 2007-06-10 | Фармация Корпорейшн | Кристаллическая натриевая соль парекоксиба |
| AU2003238667B2 (en) * | 2002-04-05 | 2006-07-20 | Cadila Healthcare Limited | 4-(heterocyclyl)-benzenesulfoximine compounds for the treatment of inflammation |
| DE10237883A1 (de) * | 2002-08-19 | 2004-03-04 | Merckle Gmbh Chem.-Pharm. Fabrik | Substituierte Isoxazolderivate und ihre Verwendung in der Pharmazie |
| CA2503063A1 (en) * | 2002-10-22 | 2004-05-06 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | Nitric oxide releasing selective cyclooxygenase-2 inhibitors |
| HUP0302219A2 (hu) * | 2003-07-16 | 2005-03-29 | Richter Gedeon Vegyészeti Gyár Rt. | N-hidroxi-4-(3-fenil-5-metil-izoxazol-4-il)-benzolszulfonamid-szolvátok, eljárás előállításukra és alkalmazásuk |
-
2004
- 2004-01-12 IT IT000019A patent/ITMI20040019A1/it unknown
-
2005
- 2005-01-12 ES ES05702217T patent/ES2344738T3/es not_active Expired - Lifetime
- 2005-01-12 EP EP05702217A patent/EP1706390B1/en not_active Expired - Lifetime
- 2005-01-12 AT AT10005150T patent/ATE538107T1/de active
- 2005-01-12 DK DK05702217.0T patent/DK1706390T3/da active
- 2005-01-12 DE DE602005021309T patent/DE602005021309D1/de not_active Expired - Lifetime
- 2005-01-12 EP EP10005150A patent/EP2246337B1/en not_active Expired - Lifetime
- 2005-01-12 AT AT05702217T patent/ATE468329T1/de not_active IP Right Cessation
- 2005-01-12 WO PCT/IB2005/000047 patent/WO2005068442A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005068442A2 (en) | 2005-07-28 |
| EP1706390A2 (en) | 2006-10-04 |
| DE602005021309D1 (de) | 2010-07-01 |
| ES2344738T3 (es) | 2010-09-06 |
| EP2246337A1 (en) | 2010-11-03 |
| WO2005068442A3 (en) | 2006-04-06 |
| EP1706390B1 (en) | 2010-05-19 |
| EP2246337B1 (en) | 2011-12-21 |
| ATE468329T1 (de) | 2010-06-15 |
| ATE538107T1 (de) | 2012-01-15 |
| DK1706390T3 (da) | 2010-08-23 |
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| ITMI20040019A1 (it) | Derivati isossazolici e loro impiego come inibitori della ciclossigenasi |