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IT1229765B - New immunogenic cpds. for synthetic vaccines for Plasmodium malariae - Google Patents

New immunogenic cpds. for synthetic vaccines for Plasmodium malariae

Info

Publication number
IT1229765B
IT1229765B IT8920553A IT2055389A IT1229765B IT 1229765 B IT1229765 B IT 1229765B IT 8920553 A IT8920553 A IT 8920553A IT 2055389 A IT2055389 A IT 2055389A IT 1229765 B IT1229765 B IT 1229765B
Authority
IT
Italy
Prior art keywords
lysine
cpds
immunogenic
contg
pref
Prior art date
Application number
IT8920553A
Other languages
Italian (it)
Other versions
IT8920553A0 (en
Inventor
Antonello Pessi
Fabio Bonelli
Lorella Chiappinelli
Original Assignee
Eniricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche Spa filed Critical Eniricerche Spa
Priority to IT8920553A priority Critical patent/IT1229765B/en
Publication of IT8920553A0 publication Critical patent/IT8920553A0/en
Priority to DK90201244.2T priority patent/DK0398443T3/en
Priority to DE69014150T priority patent/DE69014150T2/en
Priority to AT90201244T priority patent/ATE114158T1/en
Priority to ES90201244T priority patent/ES2063901T3/en
Priority to EP90201244A priority patent/EP0398443B1/en
Application granted granted Critical
Publication of IT1229765B publication Critical patent/IT1229765B/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Immunogenic cpds. of formula (I), and acid or basic addn. salts are new. D is L-lysine or branched poly (L-lysine) with a number n of L-lysine aminoacid residues of alpha and epsilon amide linkages; n is odd integer from 1-15 (pref. 3-7); m is integer from 3-40 (pref. 6-15); R1 is side chain of aminoacid residue from L-Asp, L-His, L-Cys, L-Gln, L-Thr, L-Ala, L-Leu, L-Met, L-Phe, L-Glu, L-Arg, L-Tyr, L-Asn, L-Ser, L-Gly, L-Val, L-Ile, L-Pro, and L-Trp; R2 is OH or NH2; R is H or acyl radical. An immunogenic cpd. (I) is claimed contg. hapten(s) specifically (NNAP)r or (DRAD(AGQPAG)r (r = 3-40). (I) may also be used for determining Plasmodium malariae antibodies in human blood, specifically by ELISA. A vaccine is also claimed against Plasmodium vivax contg. (I) and an appropriate hapten.
IT8920553A 1989-05-19 1989-05-19 New immunogenic cpds. for synthetic vaccines for Plasmodium malariae IT1229765B (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT8920553A IT1229765B (en) 1989-05-19 1989-05-19 New immunogenic cpds. for synthetic vaccines for Plasmodium malariae
DK90201244.2T DK0398443T3 (en) 1989-05-19 1990-05-16 Immunogenic compounds and their use in the preparation of genetically unrestricted synthetic vaccines and for the immunoenzymatic determination of antisporozoite antibodies against Plasmodium malariae
DE69014150T DE69014150T2 (en) 1989-05-19 1990-05-16 Immunogen compounds and their use in the production of genetically unrestricted synthetic vaccines and in the immunoenzymatic determination of antisporozoid antibodies from Plasmodium malariae.
AT90201244T ATE114158T1 (en) 1989-05-19 1990-05-16 IMMUNOGEN COMPOUNDS AND THEIR USE IN THE PRODUCTION OF GENETICALLY UNRESTRICTED SYNTHETIC VACCINES AND IN THE IMMUNOENZYMATIC DETERMINATION OF ANTISPOROZOID ANTIBODIES OF PLASMODIUM MALARIAE.
ES90201244T ES2063901T3 (en) 1989-05-19 1990-05-16 IMMUNOGENOUS COMPOUNDS AND THEIR USE IN THE PREPARATION OF GENETICALLY RESTRICTED SYNTHETIC VACCINES AND IN THE IMMUNOENZYMATIC DETERMINATION OF ANTIESPOROZOITE ANTIBODIES OF PLASMODIUM MALARIAE.
EP90201244A EP0398443B1 (en) 1989-05-19 1990-05-16 Immunogenic compounds and their use in the preparation of genetically unrestricted synthetic vaccines and in the immunoenzymatic determination of antisporozoite antibodies of plasmodium malariae

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8920553A IT1229765B (en) 1989-05-19 1989-05-19 New immunogenic cpds. for synthetic vaccines for Plasmodium malariae

Publications (2)

Publication Number Publication Date
IT8920553A0 IT8920553A0 (en) 1989-05-19
IT1229765B true IT1229765B (en) 1991-09-10

Family

ID=11168684

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8920553A IT1229765B (en) 1989-05-19 1989-05-19 New immunogenic cpds. for synthetic vaccines for Plasmodium malariae

Country Status (1)

Country Link
IT (1) IT1229765B (en)

Also Published As

Publication number Publication date
IT8920553A0 (en) 1989-05-19

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