IT1296985B1 - Derivati benzazinici inibitori della fosfodiesterasi 4 - Google Patents
Derivati benzazinici inibitori della fosfodiesterasi 4Info
- Publication number
- IT1296985B1 IT1296985B1 IT97MI002807A ITMI972807A IT1296985B1 IT 1296985 B1 IT1296985 B1 IT 1296985B1 IT 97MI002807 A IT97MI002807 A IT 97MI002807A IT MI972807 A ITMI972807 A IT MI972807A IT 1296985 B1 IT1296985 B1 IT 1296985B1
- Authority
- IT
- Italy
- Prior art keywords
- benzazinic
- phosphodiesterase
- derivatives inhibitors
- inhibitors
- derivatives
- Prior art date
Links
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 title 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI002807A IT1296985B1 (it) | 1997-12-19 | 1997-12-19 | Derivati benzazinici inibitori della fosfodiesterasi 4 |
| PCT/EP1998/008292 WO1999032449A2 (en) | 1997-12-19 | 1998-12-17 | Benzazine derivatives as phosphodiesterase 4 inhibitors |
| AU22742/99A AU2274299A (en) | 1997-12-19 | 1998-12-17 | Benzazine derivatives phosphodiesterase 4 inhibitors |
| US09/581,505 US6297257B1 (en) | 1997-12-19 | 1998-12-17 | Benzazine derivatives phosphodiesterase 4 inhibitors |
| EP98966359A EP1060173A2 (en) | 1997-12-19 | 1998-12-17 | Benzazine derivatives phosphodiesterase 4 inhibitors |
| JP2000525386A JP2001526264A (ja) | 1997-12-19 | 1998-12-17 | ベンゾアジン誘導体ホスホジエステラーゼ４阻害剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI002807A IT1296985B1 (it) | 1997-12-19 | 1997-12-19 | Derivati benzazinici inibitori della fosfodiesterasi 4 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI972807A1 ITMI972807A1 (it) | 1999-06-19 |
| IT1296985B1 true IT1296985B1 (it) | 1999-08-03 |
Family
ID=11378397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT97MI002807A IT1296985B1 (it) | 1997-12-19 | 1997-12-19 | Derivati benzazinici inibitori della fosfodiesterasi 4 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6297257B1 (it) |
| EP (1) | EP1060173A2 (it) |
| JP (1) | JP2001526264A (it) |
| AU (1) | AU2274299A (it) |
| IT (1) | IT1296985B1 (it) |
| WO (1) | WO1999032449A2 (it) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI981671A1 (it) | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodisterasi 4 |
| IT1302677B1 (it) | 1998-10-15 | 2000-09-29 | Zambon Spa | Derivati benzazinici inibitori della fosfodiesterasi 4 |
| ITMI20000261A1 (it) * | 2000-02-16 | 2001-08-16 | Zambon Group | Processo per la preparazione di piridiniliden-ftalidi |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| JP2009513672A (ja) | 2005-10-31 | 2009-04-02 | ブレインセルス，インコーポレイティド | 神経発生のｇａｂａ受容体媒介調節 |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| JP5341526B2 (ja) * | 2006-03-09 | 2013-11-13 | オーエム ファーマ | 免疫調節化合物、及び炎症性サイトカインの過剰産生に関連する疾患の治療 |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US8138205B2 (en) | 2006-07-07 | 2012-03-20 | Kalypsys, Inc. | Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 |
| CA2657093A1 (en) | 2006-07-07 | 2008-01-10 | Steven P. Govek | Bicyclic heteroaryl inhibitors of pde4 |
| MX2009002496A (es) | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| EP2155656A2 (en) * | 2007-04-16 | 2010-02-24 | Cipla Limited | Process for the preparation of gefitinib |
| TWI366565B (en) * | 2007-06-06 | 2012-06-21 | Otsuka Pharma Co Ltd | Quinolone compound and pharmaceutical composition |
| TWI492943B (zh) | 2008-12-05 | 2015-07-21 | 大塚製藥股份有限公司 | 喹啉酮化合物及藥學組成物（二） |
| CN102238951A (zh) * | 2008-12-05 | 2011-11-09 | 大塚制药株式会社 | 含有喹诺酮化合物的药剂 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| CN111961045A (zh) * | 2020-08-07 | 2020-11-20 | 南京纳丁菲医药科技有限公司 | 1,6-萘啶-4(1h)-酮化合物的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0351399A1 (en) * | 1987-03-12 | 1990-01-24 | Huhtamäki Oy | Isoquinoline derivatives, their manufacture and use |
| GB8800397D0 (en) * | 1988-01-08 | 1988-02-10 | Sandoz Ltd | Improvements in/relating to organic compounds |
| GB9027055D0 (en) * | 1990-12-13 | 1991-02-06 | Sandoz Ltd | Organic compounds |
| JP3276762B2 (ja) * | 1993-12-28 | 2002-04-22 | 日本臓器製薬株式会社 | イソキノリン誘導体を含有する医薬組成物 |
| ATE239477T1 (de) | 1995-08-02 | 2003-05-15 | Darwin Discovery Ltd | Chinolone und deren therapeutische verwendung |
| AU718752B2 (en) | 1996-03-26 | 2000-04-20 | Altana Pharma Ag | Novel phenanthridines substituted in the 6 position |
-
1997
- 1997-12-19 IT IT97MI002807A patent/IT1296985B1/it active IP Right Grant
-
1998
- 1998-12-17 AU AU22742/99A patent/AU2274299A/en not_active Abandoned
- 1998-12-17 JP JP2000525386A patent/JP2001526264A/ja active Pending
- 1998-12-17 EP EP98966359A patent/EP1060173A2/en not_active Withdrawn
- 1998-12-17 US US09/581,505 patent/US6297257B1/en not_active Expired - Fee Related
- 1998-12-17 WO PCT/EP1998/008292 patent/WO1999032449A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US6297257B1 (en) | 2001-10-02 |
| AU2274299A (en) | 1999-07-12 |
| EP1060173A2 (en) | 2000-12-20 |
| ITMI972807A1 (it) | 1999-06-19 |
| WO1999032449A3 (en) | 1999-09-30 |
| WO1999032449A2 (en) | 1999-07-01 |
| JP2001526264A (ja) | 2001-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |