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IT1277405B1 - Derivati di lattami biciclici come inibitori della trombina - Google Patents

Derivati di lattami biciclici come inibitori della trombina

Info

Publication number
IT1277405B1
IT1277405B1 IT95MI001688A ITMI951688A IT1277405B1 IT 1277405 B1 IT1277405 B1 IT 1277405B1 IT 95MI001688 A IT95MI001688 A IT 95MI001688A IT MI951688 A ITMI951688 A IT MI951688A IT 1277405 B1 IT1277405 B1 IT 1277405B1
Authority
IT
Italy
Prior art keywords
thrombin inhibitors
lactam derivatives
bicyclic lactam
bicyclic
derivatives
Prior art date
Application number
IT95MI001688A
Other languages
English (en)
Inventor
Aldo Salimbeni
Fabio Paleari
Carlo Scolastico
Marco Criscuoli
Original Assignee
Menarini Farma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Farma Ind filed Critical Menarini Farma Ind
Priority to IT95MI001688A priority Critical patent/IT1277405B1/it
Publication of ITMI951688A0 publication Critical patent/ITMI951688A0/it
Priority to PCT/EP1996/003167 priority patent/WO1997005160A1/en
Priority to AU67342/96A priority patent/AU6734296A/en
Publication of ITMI951688A1 publication Critical patent/ITMI951688A1/it
Application granted granted Critical
Publication of IT1277405B1 publication Critical patent/IT1277405B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT95MI001688A 1995-08-01 1995-08-01 Derivati di lattami biciclici come inibitori della trombina IT1277405B1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT95MI001688A IT1277405B1 (it) 1995-08-01 1995-08-01 Derivati di lattami biciclici come inibitori della trombina
PCT/EP1996/003167 WO1997005160A1 (en) 1995-08-01 1996-07-18 Bicyclic lactam derivatives as thrombin inhibitors
AU67342/96A AU6734296A (en) 1995-08-01 1996-07-18 Bicyclic lactam derivatives as thrombin inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001688A IT1277405B1 (it) 1995-08-01 1995-08-01 Derivati di lattami biciclici come inibitori della trombina

Publications (3)

Publication Number Publication Date
ITMI951688A0 ITMI951688A0 (it) 1995-08-01
ITMI951688A1 ITMI951688A1 (it) 1997-02-01
IT1277405B1 true IT1277405B1 (it) 1997-11-10

Family

ID=11372107

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI001688A IT1277405B1 (it) 1995-08-01 1995-08-01 Derivati di lattami biciclici come inibitori della trombina

Country Status (3)

Country Link
AU (1) AU6734296A (it)
IT (1) IT1277405B1 (it)
WO (1) WO1997005160A1 (it)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
JP2001524931A (ja) * 1996-08-05 2001-12-04 モレキュメティクス リミテッド プロテアーゼおよびキナーゼのインヒビターとしてならびに転写因子のインヒビターとしてのβシート模倣物の使用
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
WO1998046626A1 (en) 1997-04-14 1998-10-22 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
WO1998046628A1 (en) * 1997-04-14 1998-10-22 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
EP0977773A1 (en) 1997-04-14 2000-02-09 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
JP2002513412A (ja) 1997-04-14 2002-05-08 シーオーアール セラピューティクス インコーポレイテッド 選択的Ｘａ因子阻害剤
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
NZ502803A (en) * 1997-08-11 2001-11-30 Cor Therapeutics Inc Selective factor Xa inhibitors for treating diseases such as angina, myocardial infarction, transient ischemic attacks or diseases associated with undesired thrombosis
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
CA2319766A1 (en) * 1998-02-12 1999-08-19 Molecumetics Ltd. .beta.-sheet mimetics and methods relating to the use thereof
US6235877B1 (en) * 1999-08-04 2001-05-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
WO2000038683A1 (en) * 1998-12-23 2000-07-06 Du Pont Pharmaceuticals Company THROMBIN OR FACTOR Xa INHIBITORS
ITMI20031476A1 (it) * 2003-07-18 2005-01-19 Univ Degli Studi Milano Composti peptido-mimetici a struttura azabicicloalcanica comprendenti la sequenza rgd
CN1960728A (zh) 2004-01-16 2007-05-09 密歇根大学董事会 构象受限的smac模拟物及其应用
KR100887045B1 (ko) 2004-01-16 2009-03-04 더 리젠츠 오브 더 유니버시티 오브 미시간 구조적으로 강제된 ｓｍａｃ 유사물 및 이들의 용도
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
KR102525392B1 (ko) * 2014-12-10 2023-04-24 오노 야꾸힝 고교 가부시키가이샤 디히드로인돌리지논 유도체

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121947A1 (de) * 1991-07-03 1993-01-07 Basf Ag 2-(3-(4-amidino-phenyl))-propionsaeurederivate, ihre herstellung und verwendung
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
HUT77651A (hu) * 1994-12-22 1998-07-28 Biochem Pharma Inc. Oxazolo- és tiazolo[3,2-a]piridin-, pirrolo[1,2-a]pirazin- és pirido[2,1-c][1,4]tiazin-karboxamido-arginin-származékok, eljárás ezek előállítására és az ezeket tartalmazó gyógyszerkészítmények

Also Published As

Publication number Publication date
AU6734296A (en) 1997-02-26
ITMI951688A0 (it) 1995-08-01
WO1997005160A1 (en) 1997-02-13
ITMI951688A1 (it) 1997-02-01

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