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IT1270261B - Derivati peptidici ad attivita' inibitrice delle metallopeptidasi - Google Patents

Derivati peptidici ad attivita' inibitrice delle metallopeptidasi

Info

Publication number
IT1270261B
IT1270261B ITMI941292A ITMI941292A IT1270261B IT 1270261 B IT1270261 B IT 1270261B IT MI941292 A ITMI941292 A IT MI941292A IT MI941292 A ITMI941292 A IT MI941292A IT 1270261 B IT1270261 B IT 1270261B
Authority
IT
Italy
Prior art keywords
peptidal
metallopeptidases
derivatives
inhibitive activity
formula
Prior art date
Application number
ITMI941292A
Other languages
English (en)
Inventor
Franco Pellacini
Gabriele Norcini
Daniela Botta
Stefano Romagnano
Francesco Santangelo
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Priority to ITMI941292A priority Critical patent/IT1270261B/it
Publication of ITMI941292A0 publication Critical patent/ITMI941292A0/it
Priority to AT95921816T priority patent/ATE169303T1/de
Priority to EP95921816A priority patent/EP0766694B1/en
Priority to DE69503905T priority patent/DE69503905T2/de
Priority to ES95921816T priority patent/ES2122627T3/es
Priority to PCT/EP1995/002100 priority patent/WO1995035307A1/en
Priority to AU26737/95A priority patent/AU2673795A/en
Publication of ITMI941292A1 publication Critical patent/ITMI941292A1/it
Application granted granted Critical
Publication of IT1270261B publication Critical patent/IT1270261B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Vengono descritti composti di formula (FORMULA I) in cui R, R1 R21 ed X hanno i significati riportati nella descrizione.I composti di formula I sono dotati di attività mista ACE - inibitrice e NEP - inibitrice e sono utili nel trattamento di disturbi cardiovascolari.
ITMI941292A 1994-06-21 1994-06-21 Derivati peptidici ad attivita' inibitrice delle metallopeptidasi IT1270261B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITMI941292A IT1270261B (it) 1994-06-21 1994-06-21 Derivati peptidici ad attivita' inibitrice delle metallopeptidasi
AT95921816T ATE169303T1 (de) 1994-06-21 1995-06-02 Peptidderivate mit metallopeptidasehemmender aktivität
EP95921816A EP0766694B1 (en) 1994-06-21 1995-06-02 Peptide derivatives with metallopeptidase inhibitory activity
DE69503905T DE69503905T2 (de) 1994-06-21 1995-06-02 Peptidderivate mit metallopeptidasehemmender aktivität
ES95921816T ES2122627T3 (es) 1994-06-21 1995-06-02 Derivados peptidicos que poseen una actividad inhibidora de metalopeptidasas.
PCT/EP1995/002100 WO1995035307A1 (en) 1994-06-21 1995-06-02 Peptide derivatives with metallopeptidase inhibitory activity
AU26737/95A AU2673795A (en) 1994-06-21 1995-06-02 Peptide derivatives with metallopeptidase inhibitory activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941292A IT1270261B (it) 1994-06-21 1994-06-21 Derivati peptidici ad attivita' inibitrice delle metallopeptidasi

Publications (3)

Publication Number Publication Date
ITMI941292A0 ITMI941292A0 (it) 1994-06-21
ITMI941292A1 ITMI941292A1 (it) 1995-12-21
IT1270261B true IT1270261B (it) 1997-04-29

Family

ID=11369147

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941292A IT1270261B (it) 1994-06-21 1994-06-21 Derivati peptidici ad attivita' inibitrice delle metallopeptidasi

Country Status (7)

Country Link
EP (1) EP0766694B1 (it)
AT (1) ATE169303T1 (it)
AU (1) AU2673795A (it)
DE (1) DE69503905T2 (it)
ES (1) ES2122627T3 (it)
IT (1) IT1270261B (it)
WO (1) WO1995035307A1 (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2435409T1 (sl) 2009-05-28 2014-12-31 Novartis Ag Substituirani aminopropionski derivati kot inhibitorji neprilizina
EA201101672A1 (ru) 2009-05-28 2012-06-29 Новартис Аг Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
AU2014216417B2 (en) 2013-02-14 2016-05-12 Novartis Ag Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
JP6295277B2 (ja) 2013-02-14 2018-03-14 ノバルティス アーゲー Ｎｅｐ（中性エンドペプチダーゼ）阻害剤としての置換ビスフェニルブタン酸ホスホン酸誘導体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives

Also Published As

Publication number Publication date
DE69503905D1 (de) 1998-09-10
AU2673795A (en) 1996-01-15
EP0766694A1 (en) 1997-04-09
DE69503905T2 (de) 1999-04-22
ITMI941292A1 (it) 1995-12-21
ES2122627T3 (es) 1998-12-16
WO1995035307A1 (en) 1995-12-28
ATE169303T1 (de) 1998-08-15
ITMI941292A0 (it) 1994-06-21
EP0766694B1 (en) 1998-08-05

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970825