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IT1270260B - Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi - Google Patents

Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi

Info

Publication number
IT1270260B
IT1270260B ITMI941291A ITMI941291A IT1270260B IT 1270260 B IT1270260 B IT 1270260B IT MI941291 A ITMI941291 A IT MI941291A IT MI941291 A ITMI941291 A IT MI941291A IT 1270260 B IT1270260 B IT 1270260B
Authority
IT
Italy
Prior art keywords
metallopeptidase
acid derivatives
phosphonic acid
inhibitive
activities
Prior art date
Application number
ITMI941291A
Other languages
English (en)
Inventor
Gabriele Norcini
Daniela Botta
Francesco Santangelo
Gabriele Morazzoni
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of ITMI941291A0 publication Critical patent/ITMI941291A0/it
Priority to ITMI941291A priority Critical patent/IT1270260B/it
Priority to DE69503904T priority patent/DE69503904T2/de
Priority to AT95924260T priority patent/ATE169301T1/de
Priority to AU28842/95A priority patent/AU2884295A/en
Priority to PCT/EP1995/002343 priority patent/WO1995035302A1/en
Priority to ES95924260T priority patent/ES2122646T3/es
Priority to SI9520067A priority patent/SI9520067A/sl
Priority to US08/750,035 priority patent/US5739123A/en
Priority to EP95924260A priority patent/EP0766687B1/en
Priority to JP8501655A priority patent/JPH10501546A/ja
Publication of ITMI941291A1 publication Critical patent/ITMI941291A1/it
Application granted granted Critical
Publication of IT1270260B publication Critical patent/IT1270260B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Vengono descritti composti di formula (FORMULA I) in cui R. R1, R2, m ed X hamo i significati riportati nella descrizione.I composti di formula I sono dotati di attività mista ACE - inibitrice e NEP - inibitrice e sono utili nel trattamento di disturbi cardiovascolari.
ITMI941291A 1994-06-21 1994-06-21 Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi IT1270260B (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
ITMI941291A IT1270260B (it) 1994-06-21 1994-06-21 Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
PCT/EP1995/002343 WO1995035302A1 (en) 1994-06-21 1995-06-16 Phosphinic acid derivatives with metallopeptidase inhibitory activity
AT95924260T ATE169301T1 (de) 1994-06-21 1995-06-16 Phosphinsaeurederivate mit metallopeptidase inhibtorischer wirkung
AU28842/95A AU2884295A (en) 1994-06-21 1995-06-16 Phosphinic acid derivatives with metallopeptidase inhibitory activity
DE69503904T DE69503904T2 (de) 1994-06-21 1995-06-16 Phosphinsaeurederivate mit metallopeptidase inhibtorischer wirkung
ES95924260T ES2122646T3 (es) 1994-06-21 1995-06-16 Derivados de acido fosfinico con actividad inhibidora de la metalopeptidasa.
SI9520067A SI9520067A (en) 1994-06-21 1995-06-16 Phosphinic acid derivates with metallopeptidase inhibitory activity.
US08/750,035 US5739123A (en) 1994-06-21 1995-06-16 Phosphinic acid derivatives with metallopeptidase inhibitory activity
EP95924260A EP0766687B1 (en) 1994-06-21 1995-06-16 Phosphinic acid derivatives with metallopeptidase inhibitory activity
JP8501655A JPH10501546A (ja) 1994-06-21 1995-06-16 メタロペプチダーゼ阻害作用を有するホスフィン酸誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941291A IT1270260B (it) 1994-06-21 1994-06-21 Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi

Publications (3)

Publication Number Publication Date
ITMI941291A0 ITMI941291A0 (it) 1994-06-21
ITMI941291A1 ITMI941291A1 (it) 1995-12-21
IT1270260B true IT1270260B (it) 1997-04-29

Family

ID=11369146

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941291A IT1270260B (it) 1994-06-21 1994-06-21 Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi

Country Status (10)

Country Link
US (1) US5739123A (it)
EP (1) EP0766687B1 (it)
JP (1) JPH10501546A (it)
AT (1) ATE169301T1 (it)
AU (1) AU2884295A (it)
DE (1) DE69503904T2 (it)
ES (1) ES2122646T3 (it)
IT (1) IT1270260B (it)
SI (1) SI9520067A (it)
WO (1) WO1995035302A1 (it)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1276710B1 (it) * 1995-06-14 1997-11-03 Zambon Spa Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi
FR2755135B1 (fr) 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent
FR2777780B1 (fr) 1998-04-22 2001-05-04 Inst Nat Sante Rech Med Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent
US6528499B1 (en) * 2000-04-27 2003-03-04 Georgetown University Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
ES2547481T3 (es) 2006-11-08 2015-10-06 Molecular Insight Pharmaceuticals, Inc. Heterodímeros de ácido glutámico
FR2934267B1 (fr) * 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
WO2010051883A1 (de) * 2008-11-05 2010-05-14 Clariant International Ltd Verfahren zur herstellung von dialkylphosphinsäuren, -estern und -salzen mittels allylalkoholen/acroleinen und ihre verwendung
DE102008055914A1 (de) * 2008-11-05 2010-05-06 Clariant International Limited Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acroleinen und ihre Verwendung
DE102008055916A1 (de) * 2008-11-05 2010-05-06 Clariant International Limited Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Allylalkoholen und ihre Verwendung
DE102008056341A1 (de) * 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung
DE102008056342A1 (de) * 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung
ES2525550T3 (es) * 2008-11-07 2014-12-26 Clariant Finance (Bvi) Limited Procedimiento para la preparación de ácidos, ésteres y sales dialquilfosfínicos mediante derivados del ácido acrílico y su uso
DE102008056339A1 (de) * 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von mono-aminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
CN102171226B (zh) 2008-11-11 2015-02-11 科莱恩金融(Bvi)有限公司 利用烯丙基化合物制备单烯丙基官能化的二烷基次膦酸、其盐或酯的方法以及它们的用途
DE102008060035A1 (de) * 2008-12-02 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung
DE102008060036A1 (de) * 2008-12-02 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung
DE102008060535A1 (de) * 2008-12-04 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylether und ihre Verwendung
WO2010065899A2 (en) 2008-12-05 2010-06-10 Molecular Insight Pharmaceuticals, Inc. Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof
DE102008063627A1 (de) 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von monohydroxyfunktionalisierten Dialkylphosphinsäuren,-estern und -salzen mittels Ethylenoxid und ihre Verwendung
KR101697948B1 (ko) 2008-12-18 2017-01-19 클라리언트 파이넌스 (비브이아이)리미티드 아세틸렌을 사용하는 에틸렌디알킬포스핀산, 에틸렌디알킬포스핀산 에스테르 및 에틸렌디알킬포스핀산 염의 제조방법 및 이의 용도
DE102008063642A1 (de) 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von monocarboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Alkylenoxiden und ihre Verwendung
DE102008063668A1 (de) 2008-12-18 2010-07-01 Clariant International Limited Verfahren zur Herstellung von Alkylphosponsäuren, -estern und -salzen mittels Oxidation von Alkylphosphonigsäuren und ihre Verwendung
DE102008064012A1 (de) 2008-12-19 2010-06-24 Clariant International Limited Halogenfreie Addukte von Alkylphosphonigsäurederivaten und diesterbildenden Olefinen, halogenfreie Verfahren zu deren Herstellung und ihre Verwendung
DE102008064003A1 (de) 2008-12-19 2010-06-24 Clariant International Limited Verfahren zur Herstellung von mono-funktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
BR112012000210A2 (pt) 2009-06-15 2019-09-24 Molecular Insight Pharm Inc processo para a produção de heterodímeoros de ácido glutâmico.
US9120837B2 (en) 2012-01-06 2015-09-01 Molecular Insight Pharmaceuticals Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX
CN105025933B (zh) 2013-01-14 2019-03-26 分子制药洞察公司 三嗪类放射性药物和放射性显影剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4379146A (en) * 1981-02-17 1983-04-05 Merck & Co., Inc. Substituted phosphonamides as antihypertensives
US4432972A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
US4396772A (en) * 1981-11-23 1983-08-02 F. R. Squibb & Sons, Inc. Phosphinylalkanoyl amino acids
DE3600365A1 (de) * 1986-01-09 1987-07-16 Hoechst Ag Neue thyroninderivate
IT1224405B (it) * 1987-12-23 1990-10-04 Simes Composti attivi sul sistema cardiovascolare
US5155100A (en) * 1991-05-01 1992-10-13 Ciba-Geigy Corporation Phosphono/biaryl substituted dipeptide derivatives
US5250522A (en) * 1992-10-09 1993-10-05 Ciba-Geigy Corporation Phosphono/biaryl substituted amino acid derivatives
CA2126687A1 (en) * 1992-01-15 1993-07-22 Charles G. Caldwell Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents
IT1254521B (it) * 1992-03-17 1995-09-25 Zambon Spa Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare

Also Published As

Publication number Publication date
ITMI941291A1 (it) 1995-12-21
DE69503904D1 (de) 1998-09-10
SI9520067A (en) 1997-10-31
EP0766687A1 (en) 1997-04-09
US5739123A (en) 1998-04-14
AU2884295A (en) 1996-01-15
WO1995035302A1 (en) 1995-12-28
JPH10501546A (ja) 1998-02-10
ATE169301T1 (de) 1998-08-15
ES2122646T3 (es) 1998-12-16
ITMI941291A0 (it) 1994-06-21
DE69503904T2 (de) 1999-04-22
EP0766687B1 (en) 1998-08-05

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970825