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IT1269301B - PROCEDURE FOR THE CONVERSION OF CEPHALOSPORIN C INTO GLUTARIL ACID - 7 AMINOCEPHALOSPORANIC - Google Patents

PROCEDURE FOR THE CONVERSION OF CEPHALOSPORIN C INTO GLUTARIL ACID - 7 AMINOCEPHALOSPORANIC

Info

Publication number
IT1269301B
IT1269301B ITMI940418A ITMI940418A IT1269301B IT 1269301 B IT1269301 B IT 1269301B IT MI940418 A ITMI940418 A IT MI940418A IT MI940418 A ITMI940418 A IT MI940418A IT 1269301 B IT1269301 B IT 1269301B
Authority
IT
Italy
Prior art keywords
cephalosporin
glutaryl
acid
present
glutaril
Prior art date
Application number
ITMI940418A
Other languages
Italian (it)
Inventor
Kenji Matsuyama
Satoshi Soga
Original Assignee
Asahi Chemical Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Ind filed Critical Asahi Chemical Ind
Publication of ITMI940418A0 publication Critical patent/ITMI940418A0/en
Publication of ITMI940418A1 publication Critical patent/ITMI940418A1/en
Application granted granted Critical
Publication of IT1269301B publication Critical patent/IT1269301B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

La presente invenzione riguarda un migliorato procedimento di ossidazione enzimatica per convertire la cefalosporina C in acido glutaril-7-amminocefalosporanico (glutaril-7-ACA) che prevede l'uso di una miscela contenente D-amminoacido-ossidasi, la cui attività esterasica è del 5% o meno dell'attività della DAO.Secondo il procedimento della presente invenzione, la resa eccellente del glutaril-7-ACA può essere ottenuta in termini di qualità.Inoltre, il procedimento della presente invenzione prevede tappe semplici e sicure ed è perciò applicabile su scala industriale.The present invention relates to an improved enzymatic oxidation process for converting cephalosporin C to glutaryl-7-amino-cephalosporanic acid (glutaryl-7-ACA) which provides for the use of a mixture containing D-amino acid oxidase, the ester activity of which is 5% or less of the DAO activity. According to the process of the present invention, the excellent yield of glutaryl-7-ACA can be obtained in terms of quality. Furthermore, the process of the present invention provides simple and safe steps and is therefore applicable on an industrial scale.

ITMI940418A 1993-03-08 1994-03-08 PROCEDURE FOR THE CONVERSION OF CEPHALOSPORIN C INTO GLUTARIL ACID - 7 AMINOCEPHALOSPORANIC IT1269301B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7072793 1993-03-08

Publications (3)

Publication Number Publication Date
ITMI940418A0 ITMI940418A0 (en) 1994-03-08
ITMI940418A1 ITMI940418A1 (en) 1995-09-08
IT1269301B true IT1269301B (en) 1997-03-26

Family

ID=13439867

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI940418A IT1269301B (en) 1993-03-08 1994-03-08 PROCEDURE FOR THE CONVERSION OF CEPHALOSPORIN C INTO GLUTARIL ACID - 7 AMINOCEPHALOSPORANIC

Country Status (7)

Country Link
JP (1) JPH06315396A (en)
AT (1) AT401269B (en)
DE (1) DE4407699C2 (en)
ES (1) ES2097080B1 (en)
FR (1) FR2702493B1 (en)
GB (1) GB2275925B (en)
IT (1) IT1269301B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0991752A2 (en) * 1997-09-09 2000-04-12 Biochemie Gesellschaft M.B.H. Esterase free enzymes
KR102642620B1 (en) 2019-01-15 2024-03-05 더 프록터 앤드 갬블 캄파니 Multilayer dissolvable solid article with apertures or holes
WO2020147010A1 (en) 2019-01-15 2020-07-23 The Procter & Gamble Company Multilayer dissolvable solid article with specific aspect ratio
WO2020147008A1 (en) 2019-01-15 2020-07-23 The Procter & Gamble Company Flexible and dissolvable solid sheet article

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1272769A (en) * 1968-08-02 1972-05-03 Glaxo Lab Ltd Improvements in or relating to cephalosporin derivatives
GB1385685A (en) * 1971-04-21 1975-02-26 Glaxo Lab Ltd Cephalosporin derivatives
CA2049958A1 (en) * 1989-04-04 1990-10-05 Bing L. Wong Enzymatic production of 7-amino cephalosporanic acid
ATE129012T1 (en) * 1989-07-19 1995-10-15 Lilly Co Eli ENZYMATIC OXIDATION OF CEPH C TO GLUTARYL-7-AMINOOCEPHALOSPORANIC ACID.
DE4028119C1 (en) * 1990-09-05 1991-12-05 Hoechst Ag, 6230 Frankfurt, De
IT1252308B (en) * 1990-12-21 1995-06-08 Antibioticos Spa ENZYMATIC PROCEDURE FOR THE PRODUCTION OF 7- AMINOCEPHALOSPORANIC ACID AND DERIVATIVES
CA2100987C (en) * 1992-07-27 1999-06-15 Kaoru Furuya A transformant capable of producing d-amino acid oxidase

Also Published As

Publication number Publication date
GB2275925B (en) 1996-08-14
ES2097080B1 (en) 1997-11-16
JPH06315396A (en) 1994-11-15
ITMI940418A1 (en) 1995-09-08
ITMI940418A0 (en) 1994-03-08
FR2702493A1 (en) 1994-09-16
FR2702493B1 (en) 1996-02-02
DE4407699C2 (en) 2003-12-18
GB2275925A (en) 1994-09-14
ES2097080A1 (en) 1997-03-16
DE4407699A1 (en) 1994-09-15
ATA47694A (en) 1995-12-15
AT401269B (en) 1996-07-25
GB9404103D0 (en) 1994-04-20

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19961021