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IT1256705B - Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione. - Google Patents

Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.

Info

Publication number
IT1256705B
IT1256705B ITRM920915A ITRM920915A IT1256705B IT 1256705 B IT1256705 B IT 1256705B IT RM920915 A ITRM920915 A IT RM920915A IT RM920915 A ITRM920915 A IT RM920915A IT 1256705 B IT1256705 B IT 1256705B
Authority
IT
Italy
Prior art keywords
carnitine
procedure
preparation
waste product
opposite configuration
Prior art date
Application number
ITRM920915A
Other languages
English (en)
Inventor
Fabio Giannessi
Maria Ornella Tinti
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ITRM920915A0 publication Critical patent/ITRM920915A0/it
Priority to ITRM920915A priority Critical patent/IT1256705B/it
Priority to ZA939444A priority patent/ZA939444B/xx
Priority to AT93830506T priority patent/ATE140694T1/de
Priority to EP93830506A priority patent/EP0609643B1/en
Priority to DK93830506.7T priority patent/DK0609643T3/da
Priority to ES93830506T priority patent/ES2090945T3/es
Priority to DE69303807T priority patent/DE69303807T2/de
Priority to KR1019930028618A priority patent/KR100294780B1/ko
Priority to JP31979293A priority patent/JP3502649B2/ja
Priority to CA002111898A priority patent/CA2111898C/en
Priority to US08/170,764 priority patent/US5412113A/en
Publication of ITRM920915A1 publication Critical patent/ITRM920915A1/it
Priority to US08/367,863 priority patent/US5599978A/en
Application granted granted Critical
Publication of IT1256705B publication Critical patent/IT1256705B/it
Priority to GR960401768T priority patent/GR3020617T3/el
Priority to HK98104936A priority patent/HK1005861A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Processing Of Solid Wastes (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procedimento per produrre L-(-)-carnitina dal composto di scarto D-(+)-carnitinammide, consistente nel convertire la D-(+)-carnitinammide in D-(+)-carnitina, questa in un estere che viene acilato con un agente acilante che introduce un gruppo uscente fornendo un estere di acil D-(+)-carnitina che, una volta ripristinata la funzione carbossilica, per trattamento in ambiente basico dà L-(-)carnitina.
ITRM920915A 1992-12-21 1992-12-21 Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione. IT1256705B (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ITRM920915A IT1256705B (it) 1992-12-21 1992-12-21 Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
ZA939444A ZA939444B (en) 1992-12-21 1993-03-28 Process for manfacturing L-(-) carnitine from a waste product having opposite configuration.
DE69303807T DE69303807T2 (de) 1992-12-21 1993-12-15 Verfahren zur Herstellung einer L-(-)Carnitin aus einem Abfallprodukt mit der gegengesetzter Konfiguration
EP93830506A EP0609643B1 (en) 1992-12-21 1993-12-15 Process for manufacturing L-(-)-carnitine from a waste product having opposite configuration
DK93830506.7T DK0609643T3 (da) 1992-12-21 1993-12-15 Fremgangsmåde til fremstilling af L-(-)carnitin ud fra et spildprodukt med modsat konfiguration
ES93830506T ES2090945T3 (es) 1992-12-21 1993-12-15 Procedimiento para la preparacion de l-(-)-carnitina a partir de un producto de desecho que tiene configuracion opuesta.
AT93830506T ATE140694T1 (de) 1992-12-21 1993-12-15 Verfahren zur herstellung einer l-(-)carnitin aus einem abfallprodukt mit der gegengesetzter konfiguration
CA002111898A CA2111898C (en) 1992-12-21 1993-12-20 Process for manufacturing l-(-)-carnitine from a waste product having opposite configuration
JP31979293A JP3502649B2 (ja) 1992-12-21 1993-12-20 配置異性体副産物からのｌ−（−）−カルニチンの製造方法
KR1019930028618A KR100294780B1 (ko) 1992-12-21 1993-12-20 반대배치를갖는폐물질로부터l-(-)-카르니틴의제조방법
US08/170,764 US5412113A (en) 1992-12-21 1993-12-21 Process for manufacturing L-(-)-carnitine from a waste product having opposite configuration
US08/367,863 US5599978A (en) 1992-12-21 1995-01-03 Process for manufacturing L-(-)-carnitine from a waste product having opposite configuration
GR960401768T GR3020617T3 (en) 1992-12-21 1996-07-25 Process for manufacturing L-(-)-carnitine from a waste product having opposite configuration.
HK98104936A HK1005861A1 (en) 1992-12-21 1998-06-05 Process for manufacturing l-(-)-carnitine from a waste product having opposite configuration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM920915A IT1256705B (it) 1992-12-21 1992-12-21 Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.

Publications (3)

Publication Number Publication Date
ITRM920915A0 ITRM920915A0 (it) 1992-12-21
ITRM920915A1 ITRM920915A1 (it) 1994-06-21
IT1256705B true IT1256705B (it) 1995-12-12

Family

ID=11401346

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM920915A IT1256705B (it) 1992-12-21 1992-12-21 Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.

Country Status (13)

Country Link
US (2) US5412113A (it)
EP (1) EP0609643B1 (it)
JP (1) JP3502649B2 (it)
KR (1) KR100294780B1 (it)
AT (1) ATE140694T1 (it)
CA (1) CA2111898C (it)
DE (1) DE69303807T2 (it)
DK (1) DK0609643T3 (it)
ES (1) ES2090945T3 (it)
GR (1) GR3020617T3 (it)
HK (1) HK1005861A1 (it)
IT (1) IT1256705B (it)
ZA (1) ZA939444B (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1240760B (it) * 1990-02-12 1993-12-17 Sigma Tau Ind Farmaceuti Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1261230B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
IT1261828B (it) 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1276207B1 (it) * 1995-09-29 1997-10-27 Sigma Tau Ind Farmaceuti Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattone
IT1277953B1 (it) * 1995-12-21 1997-11-12 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per
IT1297120B1 (it) * 1997-12-16 1999-08-03 Sigma Tau Ind Farmaceuti Procedimento per la produzione di (r)-3-idrossi-4-butirrolattone utile nella preparazione della (r)-carnitina
IT1299182B1 (it) 1998-05-29 2000-02-29 Sigma Tau Ind Farmaceuti Procedimento chimico per la sintesi stereoselettiva della r-(-)- carnitina.
IT1301977B1 (it) * 1998-07-31 2000-07-20 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di r-(-)-carnitina
IT1307303B1 (it) 1999-12-23 2001-10-30 Sigma Tau Ind Farmaceuti Idrolisi stereospecifica di esteri otticamente attivi.
IT1306184B1 (it) 1999-08-05 2001-05-30 Sigma Tau Ind Farmaceuti Nitrilossi derivati della (r) e (s)-carnitina.
CA2383814C (en) * 1999-09-03 2010-08-17 Sigma-Tau Healthscience S.P.A. Ultrafine l-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same
DE10027393B4 (de) * 2000-06-02 2007-05-16 Wella Ag Poly- und Oligoester kationischer Hydroxysäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
CN103003257B (zh) * 2010-07-21 2016-03-16 隆萨有限公司 用于由β-内酯生产肉碱的方法
HRP20231572T1 (hr) 2014-07-03 2024-03-15 Silti Ag Postupci i pripravci za liječenje pretilosti, sprečavanje dobivanja na težini, promicanje gubitka težine, promicanje mršavljenja, ili liječenje ili prevenciju razvoja dijabetesa
CN115057789B (zh) * 2022-06-30 2024-04-02 中科萱嘉医养(珠海)健康科技有限公司 一种左旋肉碱离子液体及其制备方法与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3830931A (en) 1972-11-06 1974-08-20 Felice S De Carnitine and its use in the treatment of arrhythmia and impaired cardiac function
IT1156852B (it) * 1978-07-10 1987-02-04 Sigma Tau Ind Farmaceuti Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni
IT1136945B (it) * 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
US5200526A (en) * 1987-04-27 1993-04-06 The Governors Of The University Of Alberta Syntheses of optically pure α-amino acids from 3-amino-2-oxetanone salts

Also Published As

Publication number Publication date
ZA939444B (en) 1994-08-09
GR3020617T3 (en) 1996-10-31
DK0609643T3 (da) 1996-11-11
JP3502649B2 (ja) 2004-03-02
US5599978A (en) 1997-02-04
ITRM920915A0 (it) 1992-12-21
KR940014303A (ko) 1994-07-18
DE69303807D1 (de) 1996-08-29
ATE140694T1 (de) 1996-08-15
HK1005861A1 (en) 1999-01-29
ES2090945T3 (es) 1996-10-16
ITRM920915A1 (it) 1994-06-21
JPH06199751A (ja) 1994-07-19
DE69303807T2 (de) 1996-11-28
EP0609643B1 (en) 1996-07-24
EP0609643A1 (en) 1994-08-10
KR100294780B1 (ko) 2001-09-17
CA2111898A1 (en) 1994-06-22
US5412113A (en) 1995-05-02
CA2111898C (en) 2004-04-27

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19951113