IT1240760B - Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma. - Google Patents
Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.Info
- Publication number
- IT1240760B IT1240760B IT47618A IT4761890A IT1240760B IT 1240760 B IT1240760 B IT 1240760B IT 47618 A IT47618 A IT 47618A IT 4761890 A IT4761890 A IT 4761890A IT 1240760 B IT1240760 B IT 1240760B
- Authority
- IT
- Italy
- Prior art keywords
- acid
- coma
- gamma
- acyl
- treatment
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 8
- 206010010071 Coma Diseases 0.000 title abstract 2
- 230000004770 neurodegeneration Effects 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 acyl L-carnitines Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 2
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 229940009098 aspartate Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT47618A IT1240760B (it) | 1990-02-12 | 1990-02-12 | Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma. |
| EP91830024A EP0442850B1 (en) | 1990-02-12 | 1991-01-28 | Esters of acyl L-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma |
| DE69103037T DE69103037T2 (de) | 1990-02-12 | 1991-01-28 | Ester von Acyl L-Carnitin mit Gamma-Hydroxybuttersäure und diese enthaltende pharmazeutische Zusammensetzungen zur Inhibierung von neuronaler Degeneration und zur Behandlung von Koma. |
| ES91830024T ES2057837T3 (es) | 1990-02-12 | 1991-01-28 | Esteres de acil l-carnitinas con acido gamma-hidroxibutirico y composiciones farmaceuticas que los contienen para inhibir degeneracion neuronal y para el tratamiento de coma. |
| AT91830024T ATE109128T1 (de) | 1990-02-12 | 1991-01-28 | Ester von acyl l-carnitin mit gamma- hydroxybuttersäure und diese enthaltende pharmazeutische zusammensetzungen zur inhibierung von neuronaler degeneration und zur behandlung von koma. |
| DK91830024.5T DK0442850T3 (da) | 1990-02-12 | 1991-01-28 | Estere af acyl L-carnitiner med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende disse til hæmning af neurondegeneration og til behandling af coma |
| JP3039174A JP2930749B2 (ja) | 1990-02-12 | 1991-02-08 | アシル−Ｌ−カルニチンとγ−ヒドロキシ酪酸とのエステル |
| US08/317,750 US5543556A (en) | 1990-02-12 | 1994-10-04 | Esters of acyl l-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma |
| US08/395,914 US5534549A (en) | 1990-02-12 | 1995-02-28 | Easters of acyl L-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma |
| HK98104934.4A HK1005859B (en) | 1990-02-12 | 1998-06-05 | Esters of acyl l-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT47618A IT1240760B (it) | 1990-02-12 | 1990-02-12 | Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT9047618A0 IT9047618A0 (it) | 1990-02-12 |
| IT9047618A1 IT9047618A1 (it) | 1991-08-13 |
| IT1240760B true IT1240760B (it) | 1993-12-17 |
Family
ID=11261466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT47618A IT1240760B (it) | 1990-02-12 | 1990-02-12 | Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5543556A (it) |
| EP (1) | EP0442850B1 (it) |
| JP (1) | JP2930749B2 (it) |
| AT (1) | ATE109128T1 (it) |
| DE (1) | DE69103037T2 (it) |
| DK (1) | DK0442850T3 (it) |
| ES (1) | ES2057837T3 (it) |
| IT (1) | IT1240760B (it) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1242020B (it) * | 1990-11-20 | 1994-02-02 | Sigma Tau Ind Farmaceuti | Ftalidilidene derivati della carnitina e di alcanoil carnitine e composizioni farmaceutiche che li contengono. |
| IT1244636B (it) * | 1991-01-04 | 1994-08-08 | Sigma Tau Ind Farmaceuti | Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento. |
| IT1248321B (it) * | 1991-05-15 | 1995-01-05 | Sigma Tau Ind Farmaceuti | Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie |
| IT1263013B (it) * | 1992-10-20 | 1996-07-23 | Avantgarde Spa | Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee. |
| IT1261432B (it) * | 1993-03-26 | 1996-05-23 | Sigma Tau Ind Farmaceuti | Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo. |
| IT1261984B (it) * | 1993-06-22 | 1996-06-11 | Avantgarde Spa | Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee. |
| IT1261828B (it) | 1993-07-14 | 1996-06-03 | Sigma Tau Ind Farmaceuti | Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico. |
| IT1276225B1 (it) * | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
| IT1276253B1 (it) | 1995-12-15 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi |
| IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
| US6090848A (en) * | 1997-12-01 | 2000-07-18 | Sigma-Tau Healthscience S.P.A. | Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans |
| US5863940A (en) | 1997-12-01 | 1999-01-26 | Sigma-Tau Healthscience S.P.A. | Medicament and therapeutical method for treating idiopathic asthenozoospermia |
| ATE254923T1 (de) | 1998-03-19 | 2003-12-15 | Sigma Tau Ind Farmaceuti | Kombinierte zusammensetzung bestehend aus l- karnitin oder l-alkanoylkarnitin, einem glycosaminoglycan und/oder einem seiner bestandteile |
| ES2383673T3 (es) | 2000-09-22 | 2012-06-25 | Jpi Commercial, Llc | Composiciones de gamma-hidroxibutirato que contienen portadores de hidrato de carbonos |
| WO2012069221A1 (en) | 2010-11-22 | 2012-05-31 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Therapeutical method for the treatment of the leber optic |
| CN103458892A (zh) | 2010-12-09 | 2013-12-18 | 希格马托制药工业公司 | 治疗皮肤疾病的局部用组合物 |
| EP2783695A1 (en) | 2013-03-28 | 2014-10-01 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Physiological supplement or medicament for ophthalmic use containing L-carnitine or alkanoyl L-carnitines in combination with eledoisin |
| CN114292190B (zh) | 2016-06-07 | 2025-04-11 | J大卫格莱斯顿研究机构 | 丁二醇的中链脂肪酸酯，其组合物、口服制剂及其应用方法 |
| IL272173B2 (en) | 2017-07-21 | 2025-06-01 | Buck Inst Res Aging | S-enantiomers of beta-hydroxybutyrate and butanediol and methods for using same |
| US12037317B2 (en) | 2018-01-25 | 2024-07-16 | Buck Institute For Research On Aging | Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4032641A (en) * | 1976-06-09 | 1977-06-28 | Tanabe Seiyaku Co., Ltd. | Nicotinoyl carnitine derivatives |
| AU518617B2 (en) * | 1977-04-29 | 1981-10-08 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Therapeutic application of acetyl-d, 1-carnitine |
| IT1116037B (it) * | 1979-04-23 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico |
| IT1177874B (it) * | 1984-07-04 | 1987-08-26 | Sigma Tau Ind Farmaceuti | Estere della acetil carnitina,procedimenti per la sua preparazione e composizioni farmaceutiche che lo contengono |
| IT1231751B (it) * | 1989-04-12 | 1991-12-21 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina |
| IT1256705B (it) * | 1992-12-21 | 1995-12-12 | Sigma Tau Ind Farmaceuti | Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione. |
-
1990
- 1990-02-12 IT IT47618A patent/IT1240760B/it active IP Right Grant
-
1991
- 1991-01-28 DK DK91830024.5T patent/DK0442850T3/da active
- 1991-01-28 EP EP91830024A patent/EP0442850B1/en not_active Expired - Lifetime
- 1991-01-28 AT AT91830024T patent/ATE109128T1/de not_active IP Right Cessation
- 1991-01-28 ES ES91830024T patent/ES2057837T3/es not_active Expired - Lifetime
- 1991-01-28 DE DE69103037T patent/DE69103037T2/de not_active Expired - Fee Related
- 1991-02-08 JP JP3039174A patent/JP2930749B2/ja not_active Expired - Fee Related
-
1994
- 1994-10-04 US US08/317,750 patent/US5543556A/en not_active Expired - Fee Related
-
1995
- 1995-02-28 US US08/395,914 patent/US5534549A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0442850B1 (en) | 1994-07-27 |
| HK1005859A1 (en) | 1999-01-29 |
| DE69103037T2 (de) | 1994-11-17 |
| US5534549A (en) | 1996-07-09 |
| JP2930749B2 (ja) | 1999-08-03 |
| JPH06179642A (ja) | 1994-06-28 |
| IT9047618A1 (it) | 1991-08-13 |
| IT9047618A0 (it) | 1990-02-12 |
| ES2057837T3 (es) | 1994-10-16 |
| US5543556A (en) | 1996-08-06 |
| ATE109128T1 (de) | 1994-08-15 |
| DK0442850T3 (da) | 1994-09-05 |
| DE69103037D1 (de) | 1994-09-01 |
| EP0442850A1 (en) | 1991-08-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IT1240760B (it) | Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma. | |
| IT1240775B (it) | Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma. | |
| IT1238344B (it) | Estere della l-carnitina con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che lo contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma | |
| CA1252098A (en) | Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same | |
| ZA93162B (en) | Esters of acyl carnitines with long-chain aliphatic alcohols and pharmaceutical compositions containing same having antibacterial activity. | |
| EP0514359A3 (en) | Alkanoyl l-carnitine amides with aminoacids and pharmaceutical compositions containing same, for promoting regeneration of the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory, and for the treatment of coma | |
| DE69207479T2 (de) | Verwendung der Ester von Acyl-L-Carnitin mit Gamma-Hydroxy-Buttersäure zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Lebererkrankungen | |
| HK1005848B (en) | Use of esters of acyl l-carnitines with gamma-hydroxybutyric acid for producing pharmaceutical compositions for the treatment of hepatopathies | |
| KR940006576A (ko) | 에이즈 및 에이즈 관련 증후군 환자 및 무증후성 hiv혈청양성 환자치료를 위한 l-카르니틴 및 아실 l-카르니틴의 용도 | |
| ATE167056T1 (de) | Verwendung von ester von acyl-l-carnitin mit gammahydroxybuttersäure zur behandlung von alkoholismus | |
| HK1005859B (en) | Esters of acyl l-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19940113 |