IS5918A - 13-membered azalides and their use as antibiotics - Google Patents

13-membered azalides and their use as antibiotics

Info

Publication number: IS5918A
Authority: IS; Iceland
Prior art keywords: antibiotics; membered azalides; azalides; membered
Prior art date: 1998-11-20

Application number

IS5918A

Other languages

Icelandic (is)

Other versions

IS2350B (en

Inventor

John Rafka Robert

James Morton Barry

Brendan Ragan Colman

Bertinato Peter

Philip Dirlam John

Elwood Blize Alan

Bernard Ziegler Carl

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-20

Filing date

2001-04-17

Publication date

2001-04-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22327457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS5918(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-04-17 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2001-04-17 Publication of IS5918A publication Critical patent/IS5918A/en

2008-04-15 Publication of IS2350B publication Critical patent/IS2350B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Pyrane Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyridine Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)

IS5918A 1998-11-20 2001-04-17 13-membered azalides and their use as antibiotics IS2350B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10939998P	1998-11-20	1998-11-20
PCT/IB1999/001803 WO2000031097A1 (en)	1998-11-20	1999-11-09	13-membered azalides and their use as antibiotic agents

Publications (2)

Publication Number	Publication Date
IS5918A true IS5918A (en)	2001-04-17
IS2350B IS2350B (en)	2008-04-15

Family

ID=22327457

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS5918A IS2350B (en)	1998-11-20	2001-04-17	13-membered azalides and their use as antibiotics

Country Status (46)

Country	Link
US (1)	US6329345B1 (en)
EP (1)	EP1131331B1 (en)
JP (1)	JP3842973B2 (en)
KR (1)	KR100477774B1 (en)
CN (2)	CN1326460A (en)
AP (1)	AP2001002142A0 (en)
AR (3)	AR019496A1 (en)
AT (1)	ATE260927T1 (en)
AU (1)	AU766106B2 (en)
BG (1)	BG65107B1 (en)
BR (2)	BRPI9915480B8 (en)
CA (1)	CA2351429C (en)
CO (1)	CO5380019A1 (en)
CZ (1)	CZ303099B6 (en)
DE (1)	DE69915336T2 (en)
DK (1)	DK1131331T3 (en)
DZ (1)	DZ2944A1 (en)
EA (2)	EA009729B1 (en)
EG (1)	EG23823A (en)
ES (1)	ES2216581T3 (en)
GT (1)	GT199900198A (en)
HK (1)	HK1041269A1 (en)
HR (1)	HRP20010374B1 (en)
HU (1)	HU229008B1 (en)
ID (1)	ID28548A (en)
IL (3)	IL142631A0 (en)
IS (1)	IS2350B (en)
MA (1)	MA26707A1 (en)
ME (1)	ME00467B (en)
MY (1)	MY122353A (en)
NO (3)	NO319796B1 (en)
NZ (1)	NZ511199A (en)
OA (1)	OA11713A (en)
PA (1)	PA8485601A1 (en)
PE (1)	PE20001378A1 (en)
PL (1)	PL198580B1 (en)
PT (1)	PT1131331E (en)
RS (1)	RS50302B (en)
SI (1)	SI1131331T1 (en)
SK (1)	SK284607B6 (en)
TN (1)	TNSN99214A1 (en)
TW (2)	TWI243825B (en)
UA (1)	UA70972C2 (en)
UY (1)	UY25805A1 (en)
WO (1)	WO2000031097A1 (en)
ZA (1)	ZA200104019B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HN1998000086A (en)	1997-06-11	1999-03-08	Pfizer Prod Inc	DERIVATIVES OF 9 - DESOFO - 9 AZA - 9A - HOMOERITROMICINA A - C - 4 SUBSTITUTED.
AP9801420A0 (en) *	1998-01-02	1998-12-31	Pfizer Prod Inc	Novel macrolides.
UA70972C2 (en) *	1998-11-20	2004-11-15	Пфайзер Продактс Інк.	13-membered azalides and use thereof as antibiotics
CA2373117C (en) *	1999-05-24	2006-02-28	Pfizer Products Inc.	13-methyl-erythromycin derivatives
US6465437B1 (en) *	1999-06-30	2002-10-15	Pfizer Inc.	Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
EA200200995A1 (en) *	2000-04-27	2003-04-24	Пфайзер Продактс Инк.	APPLICATION OF AZALIDE ANTIBIOTIC COMPOSITIONS FOR THE TREATMENT OR PREVENTION OF BACTERIAL OR PROTOSOIC INFECTIONS IN MAMMALS
RU2263117C2 (en) *	2001-04-27	2005-10-27	Пфайзер Продактс Инк.	Method for preparing 4''-substituted derivatives of 9-deoxo-9a-aza-9a-homoerythromycin a
WO2003014136A1 (en) *	2001-08-08	2003-02-20	Taisho Pharmaceutical Co., Ltd.	11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
EP3738591A3 (en) *	2003-03-10	2021-03-24	Merck Sharp & Dohme Corp.	Novel antibacterial agents
WO2004108744A2 (en) *	2003-05-19	2004-12-16	Prasad K Deshpande	Azalides and azaketolides having antimicrobial activity
KR100785601B1 (en) *	2003-11-21	2007-12-14	화이자 프로덕츠 인크.	The use of antibiotics as vaccine adjuvants
US8097708B2 (en) *	2006-02-07	2012-01-17	Taisho Pharmaceutical Co., Ltd.	10a-Azalide compound
US8293715B2 (en)	2007-08-06	2012-10-23	Taisho Pharmaceutical Co., Ltd.	10a-Azalide compound crosslinked at 10a- and 12-positions
EP2287173A4 (en) *	2008-05-15	2013-06-19	Taisho Pharmaceutical Co Ltd	10A-AZALIDE COMPOUND HAVING 4 CHAIN CYCLE STRUCTURE
US8940880B2 (en)	2010-09-20	2015-01-27	Novartis Ag	Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4″ of the cladinose ring by an epoxide group
CN102295672B (en) *	2011-07-13	2014-06-04	武汉回盛生物科技有限公司	Synthetic method for tylosin
EP2736915A1 (en)	2011-07-27	2014-06-04	Farma GRS, d.o.o.	New crystalline forms of tulathromycin
CN102786569B (en) *	2012-09-07	2016-12-07	安徽中升药业有限公司	The preparation method of Tulathromycin intermediate and preparation method thereof and Tulathromycin
SI3027634T1 (en) *	2013-07-31	2018-10-30	Farma Grs, D.O.O.	Process for preparation of tulathromycin
CN109748942A (en) *	2014-05-16	2019-05-14	普莱柯生物工程股份有限公司	A kind of macrolides compound
CN104725446B (en) *	2015-03-26	2017-10-27	宁夏泰瑞制药股份有限公司	A kind of method that Tulathromycin A and Tulathromycin B is separated in the crude product from Tulathromycin
AU2019385383B2 (en) *	2018-11-19	2023-06-15	President And Fellows Of Harvard College	C10-Cyclic Substituted 13-Membered Macrolides and Uses Thereof
CN113573779A (en) *	2018-11-19	2021-10-29	齐卡尼治疗股份有限公司	C10-alkylene substituted 13-membered macrolides and their use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI7910768A8 (en)	1979-04-02	1996-06-30	Pliva Pharm & Chem Works	Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
SI8110592A8 (en) *	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
YU44599B (en) *	1986-09-12	1990-10-31	Pliva Pharm & Chem Works	Process for preparing complex of n-methyl-11-aza-10-deoxo-10-dihydroeritromicine a and 11-aza-10-deoxo-10-dihydroeritromicine a with metals
US5106961A (en)	1987-05-26	1992-04-21	Eli Lilly And Company	Erythromycin ring-contracted derivatives
SI9011409A (en)	1990-07-18	1995-10-31	Pliva Pharm & Chem Works	O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
HRP931480B1 (en) *	1993-12-08	1997-08-31	Sour Pliva	9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
GB2327084A (en) *	1997-07-08	1999-01-13	Merck & Co Inc	9a-Aza-3-ketolide antibiotics
UA70972C2 (en) *	1998-11-20	2004-11-15	Пфайзер Продактс Інк.	13-membered azalides and use thereof as antibiotics

1999
- 1999-09-11 UA UA2001053376A patent/UA70972C2/en unknown
- 1999-11-09 WO PCT/IB1999/001803 patent/WO2000031097A1/en not_active Ceased
- 1999-11-09 CN CN99813464A patent/CN1326460A/en active Pending
- 1999-11-09 OA OA1200100120A patent/OA11713A/en unknown
- 1999-11-09 BR BRPI9915480A patent/BRPI9915480B8/en not_active IP Right Cessation
- 1999-11-09 ES ES99954277T patent/ES2216581T3/en not_active Expired - Lifetime
- 1999-11-09 PL PL347784A patent/PL198580B1/en unknown
- 1999-11-09 BR BRPI9915480A patent/BRPI9915480B1/en not_active IP Right Cessation
- 1999-11-09 CA CA002351429A patent/CA2351429C/en not_active Expired - Lifetime
- 1999-11-09 KR KR10-2001-7006301A patent/KR100477774B1/en not_active Expired - Lifetime
- 1999-11-09 AT AT99954277T patent/ATE260927T1/en active
- 1999-11-09 PT PT99954277T patent/PT1131331E/en unknown
- 1999-11-09 EP EP99954277A patent/EP1131331B1/en not_active Expired - Lifetime
- 1999-11-09 NZ NZ511199A patent/NZ511199A/en not_active IP Right Cessation
- 1999-11-09 AP APAP/P/2001/002142A patent/AP2001002142A0/en unknown
- 1999-11-09 HU HU0104313A patent/HU229008B1/en active Protection Beyond IP Right Term
- 1999-11-09 AU AU10686/00A patent/AU766106B2/en not_active Expired
- 1999-11-09 EA EA200400701A patent/EA009729B1/en not_active IP Right Cessation
- 1999-11-09 CN CNA2008100813586A patent/CN101367853A/en active Pending
- 1999-11-09 ME MEP-2008-719A patent/ME00467B/en unknown
- 1999-11-09 HK HK02102807.7A patent/HK1041269A1/en unknown
- 1999-11-09 HR HR20010374A patent/HRP20010374B1/en not_active IP Right Cessation
- 1999-11-09 RS YUP-334/01A patent/RS50302B/en unknown
- 1999-11-09 NO NO20012464A patent/NO319796B1/en not_active IP Right Cessation
- 1999-11-09 SI SI9930572T patent/SI1131331T1/en unknown
- 1999-11-09 EA EA200100416A patent/EA005156B1/en not_active IP Right Cessation
- 1999-11-09 SK SK663-2001A patent/SK284607B6/en not_active IP Right Cessation
- 1999-11-09 DK DK99954277T patent/DK1131331T3/en active
- 1999-11-09 CZ CZ20011754A patent/CZ303099B6/en not_active IP Right Cessation
- 1999-11-09 ID IDW00200101093A patent/ID28548A/en unknown
- 1999-11-09 JP JP2000583925A patent/JP3842973B2/en not_active Expired - Lifetime
- 1999-11-09 DE DE1999615336 patent/DE69915336T2/en not_active Expired - Lifetime
- 1999-11-09 IL IL14263199A patent/IL142631A0/en unknown
- 1999-11-15 TW TW092131563A patent/TWI243825B/en not_active IP Right Cessation
- 1999-11-15 TW TW088119885A patent/TWI243824B/en not_active IP Right Cessation
- 1999-11-17 EG EG147699A patent/EG23823A/en active
- 1999-11-17 PA PA19998485601A patent/PA8485601A1/en unknown
- 1999-11-17 TN TNTNSN99214A patent/TNSN99214A1/en unknown
- 1999-11-17 DZ DZ990244A patent/DZ2944A1/en active
- 1999-11-17 UY UY25805A patent/UY25805A1/en not_active Application Discontinuation
- 1999-11-17 MA MA25850A patent/MA26707A1/en unknown
- 1999-11-18 MY MYPI99005021A patent/MY122353A/en unknown
- 1999-11-18 AR ARP990105876A patent/AR019496A1/en active IP Right Grant
- 1999-11-18 CO CO99072704A patent/CO5380019A1/en active IP Right Grant
- 1999-11-18 US US09/442,530 patent/US6329345B1/en not_active Expired - Lifetime
- 1999-11-18 GT GT199900198A patent/GT199900198A/en unknown
- 1999-11-18 PE PE1999001166A patent/PE20001378A1/en not_active Application Discontinuation
2001
- 2001-04-16 IL IL142631A patent/IL142631A/en not_active IP Right Cessation
- 2001-04-17 IS IS5918A patent/IS2350B/en unknown
- 2001-05-17 ZA ZA200104019A patent/ZA200104019B/en unknown
- 2001-06-14 BG BG105600A patent/BG65107B1/en unknown
2005
- 2005-02-18 NO NO20050904A patent/NO329629B1/en not_active IP Right Cessation
- 2005-02-18 NO NO20050893A patent/NO330249B1/en not_active IP Right Cessation
2007
- 2007-02-15 AR ARP070100662A patent/AR059523A2/en active IP Right Grant
- 2007-02-15 AR ARP070100663A patent/AR059524A2/en active IP Right Grant
2008
- 2008-02-11 IL IL189430A patent/IL189430A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL142631A0 (en)	2002-03-10
BRPI9915480B1 (en)	2015-12-29
JP3842973B2 (en)	2006-11-08
NZ511199A (en)	2003-08-29
SI1131331T1 (en)	2004-08-31
NO20012464D0 (en)	2001-05-18
KR20010086043A (en)	2001-09-07
ME00467B (en)	2011-10-10
NO329629B1 (en)	2010-11-22
TW200404077A (en)	2004-03-16
IL189430A (en)	2010-05-31
TWI243824B (en)	2005-11-21
CN101367853A (en)	2009-02-18
EA005156B1 (en)	2004-12-30
NO330249B1 (en)	2011-03-14
DK1131331T3 (en)	2004-06-14
AP2001002142A0 (en)	2001-05-09
HUP0104313A2 (en)	2002-02-28
CN1326460A (en)	2001-12-12
OA11713A (en)	2005-01-25
BG65107B1 (en)	2007-02-28
JP2002530422A (en)	2002-09-17
EA200100416A1 (en)	2001-10-22
EP1131331A1 (en)	2001-09-12
GT199900198A (en)	2001-05-11
PA8485601A1 (en)	2000-09-29
BRPI9915480B8 (en)	2022-05-10
AR059523A2 (en)	2008-04-09
EA200400701A1 (en)	2004-12-30
NO20012464L (en)	2001-07-17
PL347784A1 (en)	2002-04-22
UY25805A1 (en)	2001-08-27
CA2351429A1 (en)	2000-06-02
BG105600A (en)	2001-12-29
CZ303099B6 (en)	2012-04-04
CZ20011754A3 (en)	2002-03-13
EG23823A (en)	2007-09-19
HUP0104313A3 (en)	2003-12-29
HU229008B1 (en)	2013-07-29
PT1131331E (en)	2004-06-30
RS50302B (en)	2009-09-08
DZ2944A1 (en)	2004-03-15
NO20050893L (en)	2001-07-17
TWI243825B (en)	2005-11-21
AU766106B2 (en)	2003-10-09
AR059524A2 (en)	2008-04-09
PE20001378A1 (en)	2000-12-14
IL189430A0 (en)	2008-06-05
PL198580B1 (en)	2008-06-30
ES2216581T3 (en)	2004-10-16
WO2000031097A1 (en)	2000-06-02
HRP20010374B1 (en)	2006-09-30
AR019496A1 (en)	2002-02-20
IL142631A (en)	2010-05-31
US6329345B1 (en)	2001-12-11
UA70972C2 (en)	2004-11-15
ATE260927T1 (en)	2004-03-15
KR100477774B1 (en)	2005-03-21
BR9915480A (en)	2001-07-31
SK284607B6 (en)	2005-07-01
YU33401A (en)	2004-05-12
NO20050904L (en)	2001-07-17
EP1131331B1 (en)	2004-03-03
ID28548A (en)	2001-05-31
TNSN99214A1 (en)	2005-11-10
CA2351429C (en)	2005-07-12
DE69915336T2 (en)	2005-01-13
NO319796B1 (en)	2005-09-19
SK6632001A3 (en)	2002-07-02
ZA200104019B (en)	2002-06-17
MY122353A (en)	2006-04-29
AU1068600A (en)	2000-06-13
EA009729B1 (en)	2008-02-28
CO5380019A1 (en)	2004-03-31
HK1041269A1 (en)	2002-07-05
MA26707A1 (en)	2004-12-20
IS2350B (en)	2008-04-15
DE69915336D1 (en)	2004-04-08
HRP20010374A2 (en)	2002-06-30

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IS2350B (en)	2008-04-15	13-membered azalides and their use as antibiotics
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