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WO2003014136A1 - 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME - Google Patents

11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME Download PDF

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Publication number
WO2003014136A1
WO2003014136A1 PCT/JP2002/008081 JP0208081W WO03014136A1 WO 2003014136 A1 WO2003014136 A1 WO 2003014136A1 JP 0208081 W JP0208081 W JP 0208081W WO 03014136 A1 WO03014136 A1 WO 03014136A1
Authority
WO
WIPO (PCT)
Prior art keywords
represents hydrogen
hydrogen
alkyl
same
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/008081
Other languages
French (fr)
Japanese (ja)
Inventor
Toshifumi Asaka
Akira Manaka
Tetsuya Tanikawa
Tomohiro Sugimoto
Youichi Shimazaki
Masakazu Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Priority to JP2003519085A priority Critical patent/JP4311203B2/en
Publication of WO2003014136A1 publication Critical patent/WO2003014136A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

11a-Azalide compounds represented by the following general formula (1) or pharmaceutically acceptable salts thereof: (1) wherein R1 represents hydrogen, C1-10 alkyl, etc.; R2represents hydrogen, hydroxy, etc.; R3 represents hydrogen, acetyl, etc.; R4 and R5 represent each hydrogen, C1-10 alkyl, etc.; R6 represents hydrogen, hydroxy, etc.; R7 represents hydrogen, or R6 and R7 form together carbonyl, etc.; R8 represents hydrogen, halogeno, etc.; X represents carbonyl, etc.; Y represents a group of the following general formula (14): (14) (wherein k is an integer of 2 to 4; and R24 and R25 are the same or different and each represents hydrogen, C1-10 alkyl, etc.); and Z represents oxygen, etc. These compounds are useful as novel antibiotics showing an antibacterial effect not only on the existing erythromycin-sensitive strains but also on erythromycin-tolerant strains (for example, tolerant pneumococci and streptococci).
PCT/JP2002/008081 2001-08-08 2002-08-07 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME Ceased WO2003014136A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2003519085A JP4311203B2 (en) 2001-08-08 2002-08-07 11a-azalide compound and method for producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-240263 2001-08-08
JP2001240263 2001-08-08

Publications (1)

Publication Number Publication Date
WO2003014136A1 true WO2003014136A1 (en) 2003-02-20

Family

ID=19070904

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008081 Ceased WO2003014136A1 (en) 2001-08-08 2002-08-07 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME

Country Status (2)

Country Link
JP (1) JP4311203B2 (en)
WO (1) WO2003014136A1 (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005019238A1 (en) * 2003-08-22 2005-03-03 Meiji Seika Kaisha, Ltd. Novel azalide and azalactam derivatives and process for the production of the same
WO2004108744A3 (en) * 2003-05-19 2005-03-24 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
US7015203B2 (en) 1998-01-02 2006-03-21 Pfizer Inc. Macrolides
JP2006528667A (en) * 2003-05-13 2006-12-21 グラクソ　グループ　リミテッド Novel 14- and 15-membered ring compounds
JP2006528947A (en) * 2003-05-13 2006-12-28 グラクソ　グループ　リミテッド 4 "-substituted macrolide
JP2007500193A (en) * 2003-05-13 2007-01-11 グラクソ　グループ　リミテッド Novel 14- and 15-membered ring compounds
JP2007502313A (en) * 2003-05-13 2007-02-08 グラクソ　グループ　リミテッド New 14- and 15-membered ring compounds
WO2009019868A1 (en) 2007-08-06 2009-02-12 Taisho Pharmaceutical Co., Ltd. 10a-azalide compound crosslinked at position-10a and position-12
WO2009139181A1 (en) 2008-05-15 2009-11-19 大正製薬株式会社 10a-azalide compound having 4-membered ring structure
US8097708B2 (en) 2006-02-07 2012-01-17 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound
WO2017194452A1 (en) * 2016-05-11 2017-11-16 Fidelta D.O.O. Seco macrolide compounds
JP2022507776A (en) * 2018-11-19 2022-01-18 ジカニ セラピューティクス， インコーポレイテッド C10-alkylene substituted 13-membered macrolides and their use
JP2022507795A (en) * 2018-11-19 2022-01-18 ジカニ セラピューティクス， インコーポレイテッド C10 cyclic substitution 13-member macrolides and their use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06247996A (en) * 1993-02-25 1994-09-06 Taisho Pharmaceut Co Ltd 6-O-methylerythromycin A derivative
EP0895999A1 (en) * 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
WO2000031097A1 (en) * 1998-11-20 2000-06-02 Pfizer Products Inc. 13-membered azalides and their use as antibiotic agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06247996A (en) * 1993-02-25 1994-09-06 Taisho Pharmaceut Co Ltd 6-O-methylerythromycin A derivative
EP0895999A1 (en) * 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
WO2000031097A1 (en) * 1998-11-20 2000-06-02 Pfizer Products Inc. 13-membered azalides and their use as antibiotic agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WADDELL SHERMAN T. ET AL.: "Chimeric azalides with simplified western portions", TETRAHEDRON LETTERS, vol. 34, no. 34, 20 August 1993 (1993-08-20), pages 5385 - 5388, XP002959892 *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7015203B2 (en) 1998-01-02 2006-03-21 Pfizer Inc. Macrolides
JP2006528667A (en) * 2003-05-13 2006-12-21 グラクソ　グループ　リミテッド Novel 14- and 15-membered ring compounds
JP2006528947A (en) * 2003-05-13 2006-12-28 グラクソ　グループ　リミテッド 4 "-substituted macrolide
JP2007500193A (en) * 2003-05-13 2007-01-11 グラクソ　グループ　リミテッド Novel 14- and 15-membered ring compounds
JP2007502313A (en) * 2003-05-13 2007-02-08 グラクソ　グループ　リミテッド New 14- and 15-membered ring compounds
WO2004108744A3 (en) * 2003-05-19 2005-03-24 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
WO2005019238A1 (en) * 2003-08-22 2005-03-03 Meiji Seika Kaisha, Ltd. Novel azalide and azalactam derivatives and process for the production of the same
US7365174B2 (en) 2003-08-22 2008-04-29 Meiji Seika Kaisha, Ltd. Azalide and azalactam derivatives and method for producing the same
JP5015016B2 (en) * 2006-02-07 2012-08-29 大正製薬株式会社 10a-azalide compounds
US8097708B2 (en) 2006-02-07 2012-01-17 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound
EP1985620A4 (en) * 2006-02-07 2012-08-15 Taisho Pharmaceutical Co Ltd 10a-azalide compound
WO2009019868A1 (en) 2007-08-06 2009-02-12 Taisho Pharmaceutical Co., Ltd. 10a-azalide compound crosslinked at position-10a and position-12
US8293715B2 (en) 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
WO2009139181A1 (en) 2008-05-15 2009-11-19 大正製薬株式会社 10a-azalide compound having 4-membered ring structure
US8299035B2 (en) 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
WO2017194452A1 (en) * 2016-05-11 2017-11-16 Fidelta D.O.O. Seco macrolide compounds
CN109311929A (en) * 2016-05-11 2019-02-05 菲德尔塔公司 SECO macrolide compounds
US10919910B2 (en) 2016-05-11 2021-02-16 Fidelta D.O.O. Seco macrolide compounds
CN109311929B (en) * 2016-05-11 2022-10-04 塞尔维塔公司 SECO macrolide compounds
US11512096B2 (en) 2016-05-11 2022-11-29 Selvita D.O.O. Seco macrolide compounds
JP2022507776A (en) * 2018-11-19 2022-01-18 ジカニ セラピューティクス， インコーポレイテッド C10-alkylene substituted 13-membered macrolides and their use
JP2022507795A (en) * 2018-11-19 2022-01-18 ジカニ セラピューティクス， インコーポレイテッド C10 cyclic substitution 13-member macrolides and their use
JP7551610B2 (en) 2018-11-19 2024-09-17 ジカニ セラピューティクス， インコーポレイテッド C10-alkylene-substituted 13-membered macrolides and uses thereof
JP2025000636A (en) * 2018-11-19 2025-01-07 ジカニ セラピューティクス， インコーポレイテッド C10-alkylene substituted 13-membered macrolides and uses thereof

Also Published As

Publication number Publication date
JPWO2003014136A1 (en) 2004-11-25
JP4311203B2 (en) 2009-08-12

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