IS5667A - 4-bensýlpíperidínalkýlsúlfoxíð-heteróhringir og not þeirra sem undirtegunda-valbundin nmda-þega-mótlyf - Google Patents

4-bensýlpíperidínalkýlsúlfoxíð-heteróhringir og not þeirra sem undirtegunda-valbundin nmda-þega-mótlyf

Info

Publication number: IS5667A
Authority: IS; Iceland
Prior art keywords: benzylpiperidine; antagonists; sub; selective nmda; alkylsulfoxide
Prior art date: 1998-06-26

Application number

IS5667A

Other languages

English (en)

Inventor

Ross Kesten Susanne

C. Lan Nancy

B. Upasani Ravindra

L. Wright Jonathan

Original Assignee

Warner-Lambert Company, , Delaware Corporation

Cocensys, Inc., , U.S. Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-26

Filing date

2000-10-16

Publication date

2000-10-16

2000-10-16 Application filed by Warner-Lambert Company, , Delaware Corporation, Cocensys, Inc., , U.S. Corporation filed Critical Warner-Lambert Company, , Delaware Corporation

2000-10-16 Publication of IS5667A publication Critical patent/IS5667A/is

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IS5667A 1998-06-26 2000-10-16 4-bensýlpíperidínalkýlsúlfoxíð-heteróhringir og not þeirra sem undirtegunda-valbundin nmda-þega-mótlyf IS5667A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9091498P	1998-06-26	1998-06-26
PCT/US1999/014291 WO2000000197A1 (en)	1998-06-26	1999-06-25	4-benzyl piperidine alkylsulfoxide heterocycles and their use as subtype-selective nmda receptor antagonists

Publications (1)

Publication Number	Publication Date
IS5667A true IS5667A (is)	2000-10-16

Family

ID=22224939

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS5667A IS5667A (is)	1998-06-26	2000-10-16	4-bensýlpíperidínalkýlsúlfoxíð-heteróhringir og not þeirra sem undirtegunda-valbundin nmda-þega-mótlyf

Country Status (28)

Country	Link
US (1)	US6284774B1 (is)
EP (1)	EP1089735B1 (is)
JP (1)	JP2002519322A (is)
KR (1)	KR20010053170A (is)
CN (1)	CN1304307A (is)
AP (1)	AP2000001949A0 (is)
AT (1)	ATE297207T1 (is)
AU (1)	AU769650B2 (is)
BG (1)	BG105082A (is)
BR (1)	BR9911575A (is)
CA (1)	CA2327888A1 (is)
DE (1)	DE69925730T2 (is)
EA (1)	EA200100058A1 (is)
EE (1)	EE200000778A (is)
ES (1)	ES2244201T3 (is)
HU (1)	HUP0102471A2 (is)
ID (1)	ID28005A (is)
IL (1)	IL138949A0 (is)
IS (1)	IS5667A (is)
NO (1)	NO20006482D0 (is)
NZ (1)	NZ508808A (is)
OA (1)	OA11570A (is)
PE (1)	PE20000728A1 (is)
PL (1)	PL345024A1 (is)
SK (1)	SK19512000A3 (is)
TR (1)	TR200003888T2 (is)
WO (1)	WO2000000197A1 (is)
ZA (1)	ZA200005848B (is)

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KR20020093950A (ko)	2000-04-26	2002-12-16	워너-램버트 캄파니	아형 선택적인 ｎｍｄａ 수용체 길항제로서의시클로헥실아민 유도체
MXPA02010863A (es) *	2000-06-01	2003-03-27	Warner Lambert Co	Derivados de ciclohexilamina como subtipo de antagonistas del receptor nmda selectivo.
JP5079202B2 (ja) *	2000-07-18	2012-11-21	大日本住友製薬株式会社	セロトニン再取り込み阻害剤
IL145584A0 (en) *	2000-10-02	2002-06-30	Pfizer Prod Inc	Nmda nr2b antagonists for treatment
HU227197B1 (en)	2000-10-24	2010-10-28	Richter Gedeon Nyrt	Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
SI1379520T1 (sl)	2001-02-23	2006-08-31	Merck & Co Inc	N-substituirani nonaril-heterociklicni NMDA/NR2B antagonisti
WO2002072542A2 (en)	2001-03-08	2002-09-19	Emory University	Ph-dependent nmda receptor antagonists
CA2443108A1 (en)	2001-04-03	2002-10-17	Merck & Co. Inc.	N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
CA2381630A1 (en) *	2001-04-23	2002-10-23	Leonard Theodore Meltzer	Method for preventing dyskinesias
DK1409477T3 (da)	2001-07-24	2008-12-08	Richter Gedeon Nyrt	Piperdinderivater som NMDA receptorantagonister
KR20040066788A (ko)	2001-08-31	2004-07-27	더 락커펠러 유니버시티	프스포다이에스터레이즈 활성 및 뇌에서프스포다이에스터레이즈 1ｂ 매개되는 신호의 조절
HUP0500001A3 (en) *	2001-12-11	2005-11-28	Univ Virginia	Use of pramipexole to treat amyotrophic lateral sclerosis
US20060281797A1 (en) *	2001-12-11	2006-12-14	University Of Virginia Patent Foundation	Neurorestoration with R(+) Pramipexole
US20040082543A1 (en) *	2002-10-29	2004-04-29	Pharmacia Corporation	Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US8389578B2 (en) *	2004-11-24	2013-03-05	Adamas Pharmaceuticals, Inc	Composition and method for treating neurological disease
JP2008525439A (ja) *	2004-12-23	2008-07-17	ボイジャー・ファーマシューティカル・コーポレーション	アルツハイマー病の治療のための酢酸ロイプロリド及びアセチルコリンエステラーゼインヒビターまたはｎｍｄａレセプターアゴニスト
EP1917014B1 (en) *	2005-08-15	2009-10-07	University Of Virginia Patent Foundation	Neurorestoration with r(+) pramipexole
US8518926B2 (en)	2006-04-10	2013-08-27	Knopp Neurosciences, Inc.	Compositions and methods of using (R)-pramipexole
DK2026803T3 (da)	2006-05-16	2012-04-16	Knopp Neurosciences Inc	Sammensætninger af R(+) og S(-) pramipexol og fremgangsmåder til anvendelse heraf
JP5379692B2 (ja)	2006-11-09	2013-12-25	プロビオドルグエージー	潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2091948B1 (en)	2006-11-30	2012-04-18	Probiodrug AG	Novel inhibitors of glutaminyl cyclase
US8524695B2 (en)	2006-12-14	2013-09-03	Knopp Neurosciences, Inc.	Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
EP2117540A1 (en)	2007-03-01	2009-11-18	Probiodrug AG	New use of glutaminyl cyclase inhibitors
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WO2008128985A1 (en)	2007-04-18	2008-10-30	Probiodrug Ag	Thiourea derivatives as glutaminyl cyclase inhibitors
CN101815518B (zh)	2007-06-29	2013-01-09	埃莫里大学	用于神经保护的nmda受体拮抗剂
DE102007047737A1 (de)	2007-10-05	2009-04-30	Merck Patent Gmbh	Piperidin- und Piperazinderivate
TWI410420B (zh) *	2008-02-05	2013-10-01	Dainippon Sumitomo Pharma Co	苄基哌啶化合物
WO2009129497A2 (en) *	2008-04-18	2009-10-22	Arizona Board Of Regents, A Body Corp. Of The State Of Arizona, Acting For And On Behalf Of The University Of Arizona	Methods and compositions for treating and identifying compounds to treat age-related macular degeneration
CA2734491A1 (en)	2008-08-19	2010-02-25	Knopp Neurosciences, Inc.	Compositions and methods of using (r)-pramipexole
HUP0900130A3 (en)	2009-03-03	2012-02-28	Richter Gedeon Nyrt	Novel crystalline hydrate, amorphous and polymorphic forms of dihydro-benzoxazole-6-yl-acetamide derivative and processes for their preparation
WO2011016468A1 (ja)	2009-08-04	2011-02-10	大日本住友製薬株式会社	ベンジルピペリジン化合物
SG178279A1 (en)	2009-08-05	2012-03-29	Intra Cellular Therapies Inc	Novel regulatory proteins and inhibitors
WO2011029920A1 (en)	2009-09-11	2011-03-17	Probiodrug Ag	Heterocylcic derivatives as inhibitors of glutaminyl cyclase
BR112012013487A2 (pt)	2009-12-02	2017-10-03	Adamas Pharmaceuticals Inc	Composições de amantadina e métodos de uso
WO2011107530A2 (en)	2010-03-03	2011-09-09	Probiodrug Ag	Novel inhibitors
ES2481823T3 (es)	2010-03-10	2014-07-31	Probiodrug Ag	Inhibidores heterocíclicos de glutaminil ciclasa (QC, EC 2.3.2.5)
EP2560953B1 (en)	2010-04-21	2016-01-06	Probiodrug AG	Inhibitors of glutaminyl cyclase
ES2570167T3 (es)	2011-03-16	2016-05-17	Probiodrug Ag	Derivados de benzimidazol como inhibidores de glutaminil ciclasa
JP6411215B2 (ja)	2011-11-22	2018-10-24	ザリージェンツオブザユニバーシティオブカリフォルニア	虚血傷害を治療するためのシステアミンおよび／またはシスタミン
WO2013096816A1 (en)	2011-12-22	2013-06-27	Biogen Idec Ma Inc.	Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en)	2013-02-28	2017-05-30	Knopp Biosciences Llc	Compositions and methods for treating amyotrophic lateral sclerosis in responders
WO2014204933A1 (en)	2013-06-17	2014-12-24	Adamas Pharmaceuticals, Inc.	Amantadine compositions and methods of use
ES3043076T3 (en)	2013-07-12	2025-11-24	Areteia Therapeutics Inc	Treating elevated levels of eosinophils and/or basophils
US9468630B2 (en)	2013-07-12	2016-10-18	Knopp Biosciences Llc	Compositions and methods for treating conditions related to increased eosinophils
EP3033081B1 (en)	2013-08-13	2021-05-12	Knopp Biosciences LLC	Compositions and methods for treating chronic urticaria
AU2014306683B2 (en)	2013-08-13	2017-10-12	Knopp Biosciences Llc	Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
EP3233799B1 (en)	2014-12-19	2021-05-19	The Broad Institute, Inc.	Dopamine d2 receptor ligands
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1999
- 1999-06-24 PE PE1999000567A patent/PE20000728A1/es not_active Application Discontinuation
- 1999-06-25 TR TR2000/03888T patent/TR200003888T2/xx unknown
- 1999-06-25 ID IDW20002514A patent/ID28005A/id unknown
- 1999-06-25 AU AU48303/99A patent/AU769650B2/en not_active Ceased
- 1999-06-25 WO PCT/US1999/014291 patent/WO2000000197A1/en not_active Ceased
- 1999-06-25 US US09/674,298 patent/US6284774B1/en not_active Expired - Fee Related
- 1999-06-25 AT AT99931887T patent/ATE297207T1/de not_active IP Right Cessation
- 1999-06-25 AP APAP/P/2000/001949A patent/AP2000001949A0/en unknown
- 1999-06-25 JP JP2000556782A patent/JP2002519322A/ja active Pending
- 1999-06-25 EA EA200100058A patent/EA200100058A1/ru unknown
- 1999-06-25 DE DE69925730T patent/DE69925730T2/de not_active Expired - Fee Related
- 1999-06-25 CN CN99807087A patent/CN1304307A/zh active Pending
- 1999-06-25 IL IL13894999A patent/IL138949A0/xx unknown
- 1999-06-25 EE EEP200000778A patent/EE200000778A/xx unknown
- 1999-06-25 CA CA002327888A patent/CA2327888A1/en not_active Abandoned
- 1999-06-25 SK SK1951-2000A patent/SK19512000A3/sk unknown
- 1999-06-25 HU HU0102471A patent/HUP0102471A2/hu unknown
- 1999-06-25 EP EP99931887A patent/EP1089735B1/en not_active Expired - Lifetime
- 1999-06-25 NZ NZ508808A patent/NZ508808A/xx unknown
- 1999-06-25 BR BR9911575-1A patent/BR9911575A/pt not_active Application Discontinuation
- 1999-06-25 ES ES99931887T patent/ES2244201T3/es not_active Expired - Lifetime
- 1999-06-25 KR KR1020007014745A patent/KR20010053170A/ko not_active Withdrawn
- 1999-06-25 OA OA1200000347A patent/OA11570A/en unknown
- 1999-06-25 PL PL99345024A patent/PL345024A1/xx unknown
2000
- 2000-10-16 IS IS5667A patent/IS5667A/is unknown
- 2000-10-19 ZA ZA200005848A patent/ZA200005848B/en unknown
- 2000-12-19 NO NO20006482A patent/NO20006482D0/no not_active Application Discontinuation
- 2000-12-21 BG BG105082A patent/BG105082A/xx unknown

Also Published As

Publication number	Publication date
DE69925730D1 (de)	2005-07-14
AP2000001949A0 (en)	2000-12-31
PL345024A1 (en)	2001-11-19
HUP0102471A2 (hu)	2002-05-29
AU769650B2 (en)	2004-01-29
KR20010053170A (ko)	2001-06-25
NO20006482L (no)	2000-12-19
AU4830399A (en)	2000-01-17
ES2244201T3 (es)	2005-12-01
ATE297207T1 (de)	2005-06-15
BG105082A (en)	2001-09-28
US6284774B1 (en)	2001-09-04
EE200000778A (et)	2002-04-15
CA2327888A1 (en)	2000-01-06
CN1304307A (zh)	2001-07-18
ZA200005848B (en)	2001-12-18
TR200003888T2 (tr)	2001-06-21
PE20000728A1 (es)	2000-08-21
BR9911575A (pt)	2001-03-20
EP1089735A1 (en)	2001-04-11
EP1089735B1 (en)	2005-06-08
DE69925730T2 (de)	2006-03-23
JP2002519322A (ja)	2002-07-02
IL138949A0 (en)	2001-11-25
OA11570A (en)	2004-07-01
NO20006482D0 (no)	2000-12-19
WO2000000197A1 (en)	2000-01-06
EA200100058A1 (ru)	2001-08-27
ID28005A (id)	2001-05-03
SK19512000A3 (sk)	2001-08-06
EP1089735A4 (en)	2002-12-18
NZ508808A (en)	2002-12-20

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