[go: up one dir, main page]

IS2483B - 3-Heteróarýl-3,5-díhýdró-4-oxó-4H-pýridasínó[4,5-b]indól-1-asetamíð afleiður, framleiðsla og notkunþeirra í lyfjum - Google Patents

3-Heteróarýl-3,5-díhýdró-4-oxó-4H-pýridasínó[4,5-b]indól-1-asetamíð afleiður, framleiðsla og notkunþeirra í lyfjum

Info

Publication number
IS2483B
IS2483B IS7478A IS7478A IS2483B IS 2483 B IS2483 B IS 2483B IS 7478 A IS7478 A IS 7478A IS 7478 A IS7478 A IS 7478A IS 2483 B IS2483 B IS 2483B
Authority
IS
Iceland
Prior art keywords
sub
pyridazino
indole
pharmaceuticals
dihydro
Prior art date
Application number
IS7478A
Other languages
English (en)
Other versions
IS7478A (is
Inventor
Froissant Jacques
Marabout Benoit
Marguet Frank
Puech Frédéric
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of IS7478A publication Critical patent/IS7478A/is
Publication of IS2483B publication Critical patent/IS2483B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
IS7478A 2002-04-03 2004-09-30 3-Heteróarýl-3,5-díhýdró-4-oxó-4H-pýridasínó[4,5-b]indól-1-asetamíð afleiður, framleiðsla og notkunþeirra í lyfjum IS2483B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0204158A FR2838124B1 (fr) 2002-04-03 2002-04-03 Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
PCT/FR2003/001027 WO2003082874A2 (fr) 2002-04-03 2003-04-02 DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-b]INDOLE-1-ACETAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (2)

Publication Number Publication Date
IS7478A IS7478A (is) 2004-09-30
IS2483B true IS2483B (is) 2008-12-15

Family

ID=28052083

Family Applications (1)

Application Number Title Priority Date Filing Date
IS7478A IS2483B (is) 2002-04-03 2004-09-30 3-Heteróarýl-3,5-díhýdró-4-oxó-4H-pýridasínó[4,5-b]indól-1-asetamíð afleiður, framleiðsla og notkunþeirra í lyfjum

Country Status (28)

Country Link
US (4) US7235554B2 (is)
EP (1) EP1492792B1 (is)
JP (2) JP4575670B2 (is)
KR (1) KR100975999B1 (is)
CN (2) CN100543016C (is)
AT (1) ATE321763T1 (is)
AU (1) AU2003240930B2 (is)
BR (1) BR0309018A (is)
CA (1) CA2481460C (is)
CY (1) CY1104998T1 (is)
DE (1) DE60304327T2 (is)
DK (1) DK1492792T3 (is)
EA (1) EA007219B1 (is)
ES (1) ES2261940T3 (is)
FR (1) FR2838124B1 (is)
HR (1) HRP20040911B1 (is)
IL (2) IL164257A0 (is)
IS (1) IS2483B (is)
ME (2) MEP23708A (is)
MX (1) MXPA04009635A (is)
NO (1) NO329426B1 (is)
NZ (1) NZ535741A (is)
PL (1) PL372617A1 (is)
PT (1) PT1492792E (is)
RS (1) RS51244B (is)
UA (1) UA77273C2 (is)
WO (1) WO2003082874A2 (is)
ZA (1) ZA200407945B (is)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080255065A1 (en) * 2004-08-18 2008-10-16 Genesense Technologies, Inc. Small Interfering Rna Molecules Against Ribonucleotide Reductase and Uses Thereof
MX2008002366A (es) * 2005-08-19 2008-03-18 Schering Corp Antagonistas triciclicos fusionados de mglur1 como agentes terapeuticos.
EP2391607A1 (en) * 2009-01-30 2011-12-07 AstraZeneca AB Novel process for preparing carboxy-containing pyrazoleamido compounds 597
CN105330665B (zh) * 2015-11-04 2017-10-03 衡阳师范学院 一种抑制激肽释放酶klk7的化合物、制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
FR2766823B1 (fr) 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2833953B1 (fr) * 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Also Published As

Publication number Publication date
PL372617A1 (en) 2005-07-25
US20080255129A1 (en) 2008-10-16
JP4575670B2 (ja) 2010-11-04
IL164257A (en) 2009-11-18
IS7478A (is) 2004-09-30
CN100543016C (zh) 2009-09-23
AU2003240930B2 (en) 2009-07-30
DE60304327D1 (de) 2006-05-18
US20050124615A1 (en) 2005-06-09
DE60304327T2 (de) 2006-12-28
CN1970538A (zh) 2007-05-30
US20070219202A1 (en) 2007-09-20
US7235554B2 (en) 2007-06-26
EA007219B1 (ru) 2006-08-25
JP2010248221A (ja) 2010-11-04
JP2005527566A (ja) 2005-09-15
US7405306B2 (en) 2008-07-29
UA77273C2 (en) 2006-11-15
NO20044153L (no) 2004-12-27
KR100975999B1 (ko) 2010-08-17
RS51244B (sr) 2010-12-31
EP1492792A2 (fr) 2005-01-05
MXPA04009635A (es) 2005-07-13
WO2003082874A2 (fr) 2003-10-09
MEP23708A (en) 2010-06-10
JP5277208B2 (ja) 2013-08-28
AU2003240930A1 (en) 2003-10-13
NO329426B1 (no) 2010-10-18
PT1492792E (pt) 2006-08-31
EA200401146A1 (ru) 2005-06-30
FR2838124A1 (fr) 2003-10-10
CN100406459C (zh) 2008-07-30
HK1074632A1 (zh) 2005-11-18
KR20040094904A (ko) 2004-11-10
CA2481460A1 (en) 2003-10-09
EP1492792B1 (fr) 2006-03-29
CN1656099A (zh) 2005-08-17
CA2481460C (en) 2011-02-15
ATE321763T1 (de) 2006-04-15
HRP20040911B1 (en) 2012-11-30
IL164257A0 (en) 2005-12-18
DK1492792T3 (da) 2006-08-14
US20080076775A1 (en) 2008-03-27
RS86904A (sr) 2006-12-15
FR2838124B1 (fr) 2004-05-28
HRP20040911A2 (en) 2004-12-31
HK1102371A1 (en) 2007-11-16
WO2003082874A3 (fr) 2004-04-01
ES2261940T3 (es) 2006-11-16
NZ535741A (en) 2007-03-30
ME00081B (me) 2010-10-10
BR0309018A (pt) 2005-02-01
CY1104998T1 (el) 2009-11-04
ZA200407945B (en) 2005-11-30
US7323467B2 (en) 2008-01-29

Similar Documents

Publication Publication Date Title
HRP20020712B1 (hr) Farmaceutske strukture koje sadrže derivate azetidina, novi derivati azetidina i njihovo pripremanje
HUP0303398A2 (hu) 1,2-Dihidropiridin-származékok, eljárás előállításukra és alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények
TR200102490T2 (tr) Fenil ve piridinil türevleri
IL156873A0 (en) Pharmaceutically active piperidine derivatives
CY1111822T1 (el) Παραγωγα σπειροϊνδολινοπιπεριδινης ονες
ATE296826T1 (de) Pyrazolo(1,5)pyridinderivate
WO1999061444A3 (en) Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
MY140873A (en) Novel pyridine derivative and pyrimidine derivative (3)
GB0124933D0 (en) Chemical compounds
MXPA03008754A (es) Derivados de piridina fundidos para utilizarse como agonistas receptores vaniloide para tratar dolor.
TW200504061A (en) Pyrazolopyridine derivatives
DK0968206T3 (da) N-heterocykliske derivater som NOS-inhibitorer
CY1106343T1 (el) Παραγωγα νικοτιναμιδιου χρησιμα σαν pde4 αναστολεις
IL159554A0 (en) Tricyclic imidazopyridine derivatives and pharmaceutical compositions containing the same
DK393486A (da) Dihydropyridin-derivater og fremgangsmaade til fremstilling deraf
YU49902A (sh) Supstituisani derivati piperazina kao mtp inhibitori
IS2483B (is) 3-Heteróarýl-3,5-díhýdró-4-oxó-4H-pýridasínó[4,5-b]indól-1-asetamíð afleiður, framleiðsla og notkunþeirra í lyfjum
CY1106029T1 (el) Παραγωγα 3-ετepοαρυλιο-3,5-διυδρο-4-οξο-4η-πυριδαζινο[4,5-β]ινδολη-1-καρβοξαμιδο, η παρασκευη τους και η εφαρμογη τους στη θepαπευτικη
TW200607808A (en) Pyrido-pyrimidine derivatives, preparation thereof and application thereof
DE69414112D1 (de) Pyridazinon derivate mit pharmazeutischer wirkung
NO20041704L (no) Substituerte alkylaminopyridazinonderivater, fremgangsmater for deres fremstilling og farmasoytiske sammensetninger som inneholder disse
HK1042288A1 (zh) 6-[[(芳基和雜芳基)氧]甲基]-萘基-2-甲亞胺酸酰胺衍生物，其製備方法及其在治療方面的應用
DK0982308T3 (da) Derivater af 8H-[2,3-b]pyrrolizin-8-on, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger, som indeholder disse
CO5631444A2 (es) Derivados 3-heteroaril-3,5-dihidro-4-oxo-4h-piridazino [4,5- b] indol-1-ecetamida