IN2014DN10144A - - Google Patents
Download PDFInfo
- Publication number
- IN2014DN10144A IN2014DN10144A IN10144DEN2014A IN2014DN10144A IN 2014DN10144 A IN2014DN10144 A IN 2014DN10144A IN 10144DEN2014 A IN10144DEN2014 A IN 10144DEN2014A IN 2014DN10144 A IN2014DN10144 A IN 2014DN10144A
- Authority
- IN
- India
- Prior art keywords
- hydrophobic
- nucleoside
- group
- complex compound
- bound
- Prior art date
Links
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 6
- 239000002777 nucleoside Substances 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 2
- -1 nucleoside phosphoramidite compound Chemical class 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000006482 condensation reaction Methods 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 125000001165 hydrophobic group Chemical group 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 239000012454 non-polar solvent Substances 0.000 abstract 1
- 238000001668 nucleic acid synthesis Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
- C07H1/04—Introducing polyphosphoric acid radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2012/063921 WO2013179412A1 (fr) | 2012-05-30 | 2012-05-30 | Procédé de synthèse d'oligonucléotide utilisant un support en phase liquide hautement dispersible |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN10144A true IN2014DN10144A (fr) | 2015-08-21 |
Family
ID=49672666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN10144DEN2014 IN2014DN10144A (fr) | 2012-05-30 | 2012-05-30 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9284344B2 (fr) |
| EP (1) | EP2857412B1 (fr) |
| DK (1) | DK2857412T3 (fr) |
| IL (1) | IL235978B (fr) |
| IN (1) | IN2014DN10144A (fr) |
| SG (1) | SG11201407967TA (fr) |
| WO (1) | WO2013179412A1 (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2616051T3 (es) | 2008-12-02 | 2017-06-09 | Wave Life Sciences Japan, Inc. | Método para la síntesis de ácidos nucleicos modificados en el átomo de fósforo |
| KR101885383B1 (ko) | 2009-07-06 | 2018-08-03 | 웨이브 라이프 사이언시스 리미티드 | 신규한 핵산 프로드러그 및 그의 사용 방법 |
| US10428019B2 (en) | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
| CN107365339A (zh) | 2011-07-19 | 2017-11-21 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| US8846885B2 (en) | 2012-02-17 | 2014-09-30 | Ajinomoto Co., Inc. | Oligonucleotide with protected base |
| EP2816053B1 (fr) * | 2012-02-17 | 2021-03-24 | Ajinomoto Co., Inc. | Oligonucléotide ayant une base protégée |
| RU2693381C2 (ru) | 2012-07-13 | 2019-07-02 | Уэйв Лайф Сайенсес Лтд. | Асимметричная вспомогательная группа |
| BR112015000723A2 (pt) | 2012-07-13 | 2017-06-27 | Shin Nippon Biomedical Laboratories Ltd | adjuvante de ácido nucléico quiral |
| WO2014012081A2 (fr) | 2012-07-13 | 2014-01-16 | Ontorii, Inc. | Contrôle chiral |
| EP3095460A4 (fr) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Adjuvant d'acide nucléique chiral ayant une activité anti-allergique, et agent anti-allergique |
| EP3095461A4 (fr) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Adjuvant d'acide nucléique chiral possédant une activité d'induction d'immunité, et activateur d'induction d'immunité |
| WO2015108048A1 (fr) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | Adjuvant d'acide nucléique chiral ayant un effet antitumoral et agent antitumoral |
| PT3094728T (pt) | 2014-01-16 | 2022-05-19 | Wave Life Sciences Ltd | Desenho quiral |
| WO2017086397A1 (fr) | 2015-11-17 | 2017-05-26 | 日産化学工業株式会社 | Procédé de production d'oligonucléotide |
| CN116063365A (zh) * | 2015-12-16 | 2023-05-05 | 味之素株式会社 | 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸 |
| WO2017111137A1 (fr) * | 2015-12-22 | 2017-06-29 | 味の素株式会社 | Procédé de production d'oligonucléotides |
| JP7567483B2 (ja) | 2019-02-15 | 2024-10-16 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| EP3932899A4 (fr) | 2019-02-28 | 2022-04-20 | FUJIFILM Corporation | Procédé de production d'un composé peptidique, réactif formant un groupe protecteur et composé hydrocarboné aromatique polycyclique fusionné |
| CN113490679A (zh) | 2019-02-28 | 2021-10-08 | 富士胶片株式会社 | 肽化合物的制造方法、保护基形成用试药及芳香族杂环化合物 |
| WO2020196890A1 (fr) | 2019-03-28 | 2020-10-01 | 味の素株式会社 | Procédé de production d'un oligonucléotide ayant un site de phosphorothioate |
| IL319933A (en) * | 2019-05-08 | 2025-05-01 | Biogen Ma Inc | Convergent Syntheses of Oligonucleotides in Liquid Phase |
| WO2021039935A1 (fr) * | 2019-08-29 | 2021-03-04 | 富士フイルム株式会社 | Procédé de fabrication de composé d'acide nucléique et composé d'acide nucléique |
| BR112022019752A2 (pt) | 2020-03-31 | 2022-11-16 | Janssen Biopharma Inc | Síntese de oligonucleotídeos e compostos relacionados |
| FR3111896A1 (fr) * | 2020-06-24 | 2021-12-31 | Strainchem | Procédés de synthèses en solution de macromolécules à partir d’unités de dérivés de glucides |
| CN113583069B (zh) * | 2021-09-09 | 2023-06-06 | 北京大学 | 核苷磷脂类化合物及其化学合成方法和在核酸递送中的应用 |
| WO2024083746A1 (fr) | 2022-10-17 | 2024-04-25 | Bachem Holding Ag | Procédé et composition pour la synthèse d'oligonucléotides |
| US12180140B2 (en) | 2022-12-23 | 2024-12-31 | Hongene Biotech Corporation | Compounds and methods for liquid phase oligonucleotide synthesis |
| CN120813558A (zh) | 2023-03-06 | 2025-10-17 | 斯佩拉制药株式会社 | 长链烯氧基取代的苯甲酰衍生物及使用该衍生物的寡核苷酸合成方法 |
| WO2025082632A1 (fr) | 2023-10-16 | 2025-04-24 | Bachem Holding Ag | Procédé et composition pour la synthèse d'oligonucléotides |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7094943B2 (en) | 1998-04-27 | 2006-08-22 | Hubert Köster | Solution phase biopolymer synthesis |
| JP2003002895A (ja) | 2001-05-30 | 2003-01-08 | Tokyo Inst Of Technol | 核酸の合成法 |
| JP4963665B2 (ja) | 2007-11-27 | 2012-06-27 | 株式会社ミツバ | 扁平型コミュテータ及びその製造方法 |
| JP5548852B2 (ja) | 2009-05-29 | 2014-07-16 | 国立大学法人東京農工大学 | 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法 |
| CN103476784B (zh) | 2011-05-17 | 2017-05-24 | 味之素株式会社 | 制备寡核苷酸的方法 |
| EP2816053B1 (fr) * | 2012-02-17 | 2021-03-24 | Ajinomoto Co., Inc. | Oligonucléotide ayant une base protégée |
-
2012
- 2012-05-30 IN IN10144DEN2014 patent/IN2014DN10144A/en unknown
- 2012-05-30 SG SG11201407967TA patent/SG11201407967TA/en unknown
- 2012-05-30 EP EP12877844.6A patent/EP2857412B1/fr active Active
- 2012-05-30 DK DK12877844.6T patent/DK2857412T3/en active
- 2012-05-30 WO PCT/JP2012/063921 patent/WO2013179412A1/fr not_active Ceased
- 2012-05-30 US US14/404,562 patent/US9284344B2/en active Active
-
2014
- 2014-11-27 IL IL235978A patent/IL235978B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP2857412A4 (fr) | 2015-10-21 |
| IL235978B (en) | 2018-02-28 |
| US20150112053A1 (en) | 2015-04-23 |
| WO2013179412A1 (fr) | 2013-12-05 |
| SG11201407967TA (en) | 2015-01-29 |
| EP2857412A1 (fr) | 2015-04-08 |
| DK2857412T3 (en) | 2017-04-03 |
| US9284344B2 (en) | 2016-03-15 |
| EP2857412B1 (fr) | 2017-01-11 |
| IL235978A0 (en) | 2015-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2014DN10144A (fr) | ||
| Singh et al. | Progress in 1, 3-dipolar cycloadditions in the recent decade: an update to strategic development towards the arsenal of organic synthesis | |
| Müller et al. | Diazo Compounds in Continuous‐Flow Technology | |
| Liu et al. | Metal-free direct difunctionalization of alkenes with I 2 O 5 and P (O)–H compounds leading to β-iodophosphates | |
| WO2011132977A3 (fr) | Dispositif de pcr comprenant deux blocs de colonne | |
| WO2014162307A3 (fr) | Procédés et appareil utilisables en vue de la synthèse d'acides nucléiques | |
| EA201100292A1 (ru) | Способ сжижения углеродсодержащего материала с получением жидкого углеводорода | |
| WO2011106368A3 (fr) | Procédés d'amplification destinés à minimiser le biais spécifique de séquence | |
| EP2647711A3 (fr) | Voies d'export alternatives pour l'interférence d'ARN exprimée par vecteur | |
| WO2012104399A3 (fr) | Dispositif et procédé de génération de micro-réseaux moléculaires | |
| BR112013004444A2 (pt) | método para a extração de compostos orgânicos a partir de misturas aquosas | |
| EA201290550A1 (ru) | Способ получения акриловой и метакриловой кислоты | |
| WO2012149182A3 (fr) | Synthèse automatisée de petites molécules à l'aide de boronates non racémiques, chiraux | |
| WO2012104886A3 (fr) | Système et procédé de production d'oxirane | |
| MX2018000196A (es) | Procedimiento para la preparacion de un derivado de furfural. | |
| WO2012164242A8 (fr) | Procédé pour la préparation de palipéridone | |
| ES2600037T3 (es) | Procedimiento para la preparación de 2,2-difluoroetilamina a partir de 2,2-difluoro-1-cloroetano y amoniaco | |
| GB201019701D0 (en) | Reaction process | |
| MX2018000198A (es) | Procedimiento para la preparacion de un derivado de furfural que comprende neutralizar una mezcla de reaccion acida. | |
| WO2013048163A3 (fr) | Procédé de purification pratique et efficace d'acides nucléiques marqués chimiquement | |
| CN104193695A (zh) | 一种吗啡啉类化合物的合成方法 | |
| FR2974087B1 (fr) | Preparation d'alkyltetrazenes | |
| Wohlfarth | Viscosity of the mixture (1) methacrylic acid;(2) ethyl 3-ethoxypropionate: Data extract from Landolt-Börnstein IV/25: Viscosity of Pure Organic Liquids and Binary Liquid Mixtures | |
| TH87277A (th) | กระบวนการสำหรับการสังเคราะห์สารประกอบอินทรีย์ | |
| Bešlo et al. | Comparative modeling of biological activities of alcohols by enthalpy parameters and molecular connectivity descriptors |