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IL97119A0 - Process for the enzymatic cleavage of recombinant proteins using iga proteases - Google Patents

Process for the enzymatic cleavage of recombinant proteins using iga proteases

Info

Publication number
IL97119A0
IL97119A0 IL97119A IL9711991A IL97119A0 IL 97119 A0 IL97119 A0 IL 97119A0 IL 97119 A IL97119 A IL 97119A IL 9711991 A IL9711991 A IL 9711991A IL 97119 A0 IL97119 A0 IL 97119A0
Authority
IL
Israel
Prior art keywords
enzymatic cleavage
recombinant proteins
fused
fused protein
iga proteases
Prior art date
Application number
IL97119A
Other languages
English (en)
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4015922A external-priority patent/DE4015922A1/de
Priority claimed from DE4039415A external-priority patent/DE4039415A1/de
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Publication of IL97119A0 publication Critical patent/IL97119A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5409—IL-5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL97119A 1990-02-03 1991-01-31 Process for the enzymatic cleavage of recombinant proteins using iga proteases IL97119A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4003149 1990-02-03
DE4015922A DE4015922A1 (de) 1990-05-17 1990-05-17 Verfahren zur enzymatischen prozessierung von proteinen unter verwendung von iga-proteasen (igase)
DE4015921 1990-05-17
DE4039415A DE4039415A1 (de) 1990-02-03 1990-12-10 Verfahren zur herstellung rekombinanter proteine ohne n-terminalen methioninrest

Publications (1)

Publication Number Publication Date
IL97119A0 true IL97119A0 (en) 1992-03-29

Family

ID=27434868

Family Applications (1)

Application Number Title Priority Date Filing Date
IL97119A IL97119A0 (en) 1990-02-03 1991-01-31 Process for the enzymatic cleavage of recombinant proteins using iga proteases

Country Status (19)

Country Link
US (1) US5427927A (xx)
EP (2) EP0513073B1 (xx)
JP (2) JPH0789952B2 (xx)
KR (1) KR960011919B1 (xx)
AT (2) ATE219518T1 (xx)
AU (1) AU638309B2 (xx)
CA (1) CA2074943C (xx)
CZ (1) CZ284774B6 (xx)
DK (1) DK0513073T3 (xx)
ES (2) ES2177536T3 (xx)
FI (1) FI109810B (xx)
HU (1) HU217103B (xx)
IE (1) IE64938B1 (xx)
IL (1) IL97119A0 (xx)
LV (1) LV10309B (xx)
NO (1) NO311142B1 (xx)
NZ (1) NZ236819A (xx)
PT (1) PT96658B (xx)
WO (1) WO1991011520A1 (xx)

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US5536495A (en) * 1994-04-15 1996-07-16 Foster; Preston F. Use of G-CSF to reduce acute rejection
WO1996009395A2 (de) * 1994-09-21 1996-03-28 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Arzneimittel zur prophylaxe und behandlung von und diagnostika zur erkennung von autoimmunkrankheiten und viralen erkrankungen
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DE19549232C2 (de) * 1995-12-20 1998-05-20 Boehringer Mannheim Gmbh Verwendung von G-CSF in Kombination mit einem Chemotherapeutikum bei der Behandlung von Erkrankungen, die eine periphere Stammzelltransplantation erfordern
GB9618960D0 (en) 1996-09-11 1996-10-23 Medical Science Sys Inc Proteases
US6444202B1 (en) 1996-11-25 2002-09-03 Bundesrepublic Deutschland, Vertreten Durch Den Bundesminister Fur Gesundheit Processed polypeptides with IL-16 activity, processes for their production and their use
EP1121425B1 (en) * 1998-10-13 2005-06-29 The University Of Georgia Research Foundation, Inc. Stabilized bioactive peptides and methods of identification, synthesis and use
US20030190740A1 (en) * 1998-10-13 2003-10-09 The University Of Georgia Research Foundation, Inc Stabilized bioactive peptides and methods of identification, synthesis, and use
KR100356140B1 (ko) * 1999-07-08 2002-10-19 한미약품공업 주식회사 인간 과립구 콜로니 자극인자 변이체 및 이의 생산 방법
US7668658B2 (en) * 1999-10-13 2010-02-23 Sequenom, Inc. Methods for generating databases and databases for identifying polymorphic genetic markers
AU2003298733B2 (en) * 2002-11-27 2009-06-18 Agena Bioscience, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
EP2308901B1 (en) * 2003-04-23 2017-11-08 F. Hoffmann-La Roche AG Cleavage of fusion proteins using Granzyme B protease
AU2004235331B2 (en) * 2003-04-25 2008-12-18 Sequenom, Inc. Fragmentation-based methods and systems for De Novo sequencing
US9394565B2 (en) * 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
EP2305798A3 (en) 2003-10-23 2011-04-20 Illumigen Biosciences, Inc. Detection of mutations in a gene associated with resistance to viral infection, OAS1
US7220407B2 (en) 2003-10-27 2007-05-22 Amgen Inc. G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction
SI21639A (sl) * 2003-12-23 2005-06-30 LEK farmacevtska dru�ba d.d. Farmacevtski pripravek, ki vsebuje nemicelarne sulfobetaine
CN101233240A (zh) * 2004-03-26 2008-07-30 斯昆诺有限公司 与质量分析结合的甲基化特异性扩增产物的碱基特异性切割
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
AU2005284980A1 (en) * 2004-09-10 2006-03-23 Sequenom, Inc. Methods for long-range sequence analysis of nucleic acids
EP1817047B1 (en) 2004-11-05 2012-02-08 Northwestern University Use of scf and g-csf in the treatment of cerebral ischemia and neurological disorders
UA95446C2 (xx) 2005-05-04 2011-08-10 Іллюміджен Байосайєнсіз, Інк. Мутації в генах oas1$мутаци в генах oas1
CL2007002502A1 (es) * 2006-08-31 2008-05-30 Hoffmann La Roche Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer.
MX2009001691A (es) * 2006-08-31 2009-02-25 Hoffmann La Roche Metodo para produccion del factor de crecimiento i tipo insulina.
AU2008240143B2 (en) * 2007-04-13 2013-10-03 Agena Bioscience, Inc. Comparative sequence analysis processes and systems
US8562967B2 (en) 2007-08-27 2013-10-22 Biogenerix Ag Stable liquid formulations of G-CSF
DE102007040932A1 (de) 2007-08-27 2009-03-05 Biogenerix Ag Flüssigformulierung von G-CSF
US8501449B2 (en) * 2007-12-04 2013-08-06 Proteon Therapeutics, Inc. Recombinant elastase proteins and methods of manufacturing and use thereof
KR20100119899A (ko) * 2008-04-03 2010-11-11 에프. 호프만-라 로슈 아게 폴리에틸렌글리콜화된 인슐린 유사 성장 인자 분석법
ES2388827T3 (es) * 2008-04-03 2012-10-19 F. Hoffmann-La Roche Ag Uso de variantes de IGF-I PEGiladas para el tratamiento de trastornos neuromusculares
US8053222B2 (en) * 2009-02-12 2011-11-08 Academia Sinica, Taiwan Protein expression system involving mutated severe respiratory syndrome-associated coronavirus 3C-like protease
US20110152188A1 (en) * 2009-12-23 2011-06-23 Hanns-Christian Mahler Pharmaceutical compositions of igf/i proteins
CN102740840A (zh) 2010-01-19 2012-10-17 韩美科学株式会社 长效g-csf缀合物的液体制剂
CA2807431A1 (en) * 2010-08-30 2012-03-08 F. Hoffmann-La Roche Ag Prokaryotic expression construct
WO2014187974A1 (en) * 2013-05-24 2014-11-27 Novo Nordisk A/S Fusion protease
KR20160098277A (ko) * 2013-12-20 2016-08-18 에프. 호프만-라 로슈 아게 개선된 재조합 폴리펩티드 제조 방법
DK3313879T3 (da) 2015-06-24 2022-03-14 Hoffmann La Roche Anti-transferrinreceptor-antistoffer med tilpasset affinitet
EP3356406A1 (en) 2015-10-02 2018-08-08 H. Hoffnabb-La Roche Ag Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
JP6456579B1 (ja) * 2017-06-09 2019-01-23 三菱電機株式会社 フェーズドアレイアンテナ
JP7736395B1 (ja) * 2024-02-29 2025-09-09 積水メディカル株式会社 免疫学的測定方法、免疫学的測定用試薬、免疫学的測定用検体前処理液、免疫学的測定用試薬キット、及び非特異反応抑制剤

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Also Published As

Publication number Publication date
LV10309A (lv) 1994-10-20
CA2074943A1 (en) 1991-08-04
NO923010D0 (no) 1992-07-30
HUT63195A (en) 1993-07-28
IE64938B1 (en) 1995-09-20
WO1991011520A1 (de) 1991-08-08
FI923463L (fi) 1992-07-31
IE910358A1 (en) 1991-08-14
ATE219518T1 (de) 2002-07-15
CA2074943C (en) 1999-12-07
NZ236819A (en) 1993-07-27
ATE124456T1 (de) 1995-07-15
NO311142B1 (no) 2001-10-15
FI109810B (fi) 2002-10-15
NO923010L (no) 1992-09-14
DK0513073T3 (da) 1995-10-30
PT96658B (pt) 1998-09-30
HU217103B (hu) 1999-11-29
EP0602688B1 (de) 2002-06-19
EP0602688A1 (en) 1994-06-22
HU9202511D0 (en) 1992-10-28
JPH07278195A (ja) 1995-10-24
AU7149691A (en) 1991-08-21
LV10309B (en) 1995-12-20
FI923463A0 (fi) 1992-07-31
JPH0789952B2 (ja) 1995-10-04
AU638309B2 (en) 1993-06-24
CZ284774B6 (cs) 1999-02-17
CS9100241A2 (en) 1991-08-13
JP2766621B2 (ja) 1998-06-18
ES2177536T3 (es) 2002-12-16
JPH05501360A (ja) 1993-03-18
US5427927A (en) 1995-06-27
ES2076521T3 (es) 1995-11-01
KR960011919B1 (ko) 1996-09-04
EP0513073A1 (de) 1992-11-19
PT96658A (pt) 1991-10-31
EP0513073B1 (de) 1995-06-28

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