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IL97617A - Preparation of 2, 4, 5-trihalo-beta-ketobenzene (and pyridine) propanoic acid esters for use in preparing quinolone antibiotics - Google Patents

Preparation of 2, 4, 5-trihalo-beta-ketobenzene (and pyridine) propanoic acid esters for use in preparing quinolone antibiotics

Info

Publication number
IL97617A
IL97617A IL9761791A IL9761791A IL97617A IL 97617 A IL97617 A IL 97617A IL 9761791 A IL9761791 A IL 9761791A IL 9761791 A IL9761791 A IL 9761791A IL 97617 A IL97617 A IL 97617A
Authority
IL
Israel
Prior art keywords
formula
chloro
compound
alkyl
imidazolyl
Prior art date
Application number
IL9761791A
Other languages
English (en)
Other versions
IL97617A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL97617A0 publication Critical patent/IL97617A0/xx
Publication of IL97617A publication Critical patent/IL97617A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL9761791A 1990-03-27 1991-03-20 Preparation of 2, 4, 5-trihalo-beta-ketobenzene (and pyridine) propanoic acid esters for use in preparing quinolone antibiotics IL97617A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50015590A 1990-03-27 1990-03-27

Publications (2)

Publication Number Publication Date
IL97617A0 IL97617A0 (en) 1992-06-21
IL97617A true IL97617A (en) 1998-08-16

Family

ID=23988274

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9761791A IL97617A (en) 1990-03-27 1991-03-20 Preparation of 2, 4, 5-trihalo-beta-ketobenzene (and pyridine) propanoic acid esters for use in preparing quinolone antibiotics

Country Status (22)

Country Link
US (1) US5380860A (no)
EP (1) EP0449445A3 (no)
JP (1) JPH0648990A (no)
KR (1) KR930005059B1 (no)
CN (1) CN1041083C (no)
AU (1) AU617066B1 (no)
BR (1) BR9101188A (no)
CA (1) CA2039306C (no)
EG (1) EG19607A (no)
FI (1) FI911465A7 (no)
HU (1) HUT56826A (no)
IE (1) IE910991A1 (no)
IL (1) IL97617A (no)
MY (1) MY108069A (no)
NO (1) NO911229L (no)
NZ (1) NZ237555A (no)
PH (1) PH30994A (no)
PL (1) PL289582A1 (no)
PT (1) PT97130B (no)
RU (1) RU2058977C1 (no)
YU (1) YU53991A (no)
ZA (1) ZA912263B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043092A (en) * 1996-03-18 2000-03-28 University Of Pittsburgh Cell culture media for mammalian cells
KR100372563B1 (ko) * 1996-12-16 2003-11-20 주식회사 엘지생명과학 퀴놀론계항생제중간체인베타-케토에스테르유도체의제조방법
BR9915208A (pt) * 1998-11-10 2001-07-31 Bayer Ag Preparado farmacêutico de moxifloxacina
KR100484386B1 (ko) * 2000-10-04 2005-04-22 경동제약 주식회사 알킬2-[2,3,5-트리플루오로-4-(4-메틸-1-피페라지닐)]벤조일-3(ｓ)-(1-히드록시프로피-2-닐아미노)아크릴레이트의 제조방법
EP1436263B1 (en) * 2001-10-15 2007-09-19 LG Life Sciences Ltd. A process for preparing beta-ketoester compound
US7642356B2 (en) * 2005-09-16 2010-01-05 Lg Life Sciences Ltd. Process for preparing beta-ketoester compounds
KR100843125B1 (ko) * 2005-09-16 2008-07-02 주식회사 엘지생명과학 베타-케토에스테르 화합물의 제조방법
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
RU2558932C1 (ru) * 2014-05-22 2015-08-10 Открытое Акционерное Общество "Татхимфармпрепараты" Фармацевтическая композиция моксифлоксацина и способ ее приготовления
CN116120173A (zh) * 2023-02-22 2023-05-16 金浦新材料股份有限公司 一种长链烷基-β-酮酸酯类化合物的合成方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4014919A (en) * 1974-03-01 1977-03-29 The Dow Chemical Company Process for preparing methyl jasmonate and related compounds
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
DE3426482A1 (de) * 1984-07-18 1986-01-30 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von halogenierten aroylessigestern
DE3508816A1 (de) * 1985-01-10 1986-07-10 Bayer Ag, 5090 Leverkusen 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
AT392789B (de) * 1985-01-23 1991-06-10 Toyama Chemical Co Ltd Verfahren zur herstellung von 1-substituierten aryl-1,4-dihydro-4-oxonaphthyridinderivaten
JPH0629246B2 (ja) * 1985-02-18 1994-04-20 富山化学工業株式会社 ２−（５−フルオロニコチノイル）酢酸誘導体およびその塩
JP2581556B2 (ja) * 1986-05-06 1997-02-12 メレルダウファーマスーティカルズ インコーポレーテッド 新規なドパミンベ−タヒドロキシラ−ゼ抑制剤
EP0251308B1 (de) * 1986-07-04 1990-11-22 Chemie Linz Gesellschaft m.b.H. 4-Chinolon-3-carbonsäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE3641343A1 (de) * 1986-12-03 1988-06-16 Hoechst Ag Carbamoylimidazol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
ES2074047T3 (es) * 1987-08-14 1995-09-01 Asahi Glass Co Ltd Compuestos de benzoilo fluorados.
US4833270A (en) * 1987-12-21 1989-05-23 American Cyanamid Company Process for preparing 2-chloro-4,5-difluorobenzoic acid
JPH0228178A (ja) * 1988-04-23 1990-01-30 Toyama Chem Co Ltd 新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法
EP0342849A3 (en) * 1988-05-19 1990-03-14 Pfizer Inc. Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters
JPH0225462A (ja) * 1988-06-06 1990-01-26 Eli Lilly & Co β―ラクタム抗生物質の製造法およびその中間体
US4883270A (en) * 1989-02-09 1989-11-28 Maag Henry H Four-bar variable-resistance frontal calf developing machine
IE66202B1 (en) * 1989-08-16 1995-12-13 Pfizer Azabicyclo quinolone carboxylic acids

Also Published As

Publication number Publication date
PT97130A (pt) 1991-11-29
NZ237555A (en) 1993-08-26
CN1055177A (zh) 1991-10-09
BR9101188A (pt) 1991-11-05
CA2039306C (en) 1999-01-26
FI911465A0 (fi) 1991-03-26
EG19607A (en) 1995-07-27
YU53991A (sh) 1993-11-16
CA2039306A1 (en) 1991-09-28
IL97617A0 (en) 1992-06-21
EP0449445A3 (en) 1993-08-25
NO911229L (no) 1991-09-30
PH30994A (en) 1997-12-23
HUT56826A (en) 1991-10-28
EP0449445A2 (en) 1991-10-02
US5380860A (en) 1995-01-10
PL289582A1 (en) 1992-06-01
AU617066B1 (en) 1991-11-14
IE910991A1 (en) 1991-10-09
MY108069A (en) 1996-08-15
RU2058977C1 (ru) 1996-04-27
KR930005059B1 (ko) 1993-06-15
CN1041083C (zh) 1998-12-09
NO911229D0 (no) 1991-03-26
FI911465A7 (fi) 1991-09-28
ZA912263B (en) 1992-11-25
PT97130B (pt) 1999-02-26
JPH0648990A (ja) 1994-02-22
KR920018007A (ko) 1992-10-21

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Legal Events

Date Code Title Description
FF Patent granted
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KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees