IL85069A0 - Tricyclic benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents
Tricyclic benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing themInfo
- Publication number
- IL85069A0 IL85069A0 IL85069A IL8506988A IL85069A0 IL 85069 A0 IL85069 A0 IL 85069A0 IL 85069 A IL85069 A IL 85069A IL 8506988 A IL8506988 A IL 8506988A IL 85069 A0 IL85069 A0 IL 85069A0
- Authority
- IL
- Israel
- Prior art keywords
- groups
- group
- heteroatoms
- hydroxyl
- alkyl
- Prior art date
Links
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- -1 nitro, amino Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
- 125000005094 alkyl carbonyl amino alkyl group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Amplifiers (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873701277 DE3701277A1 (de) | 1987-01-17 | 1987-01-17 | Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL85069A0 true IL85069A0 (en) | 1988-06-30 |
Family
ID=6319010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL85069A IL85069A0 (en) | 1987-01-17 | 1988-01-11 | Tricyclic benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing them |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US4954498A (xx) |
| EP (1) | EP0275888B1 (xx) |
| JP (1) | JPS63192773A (xx) |
| KR (1) | KR880009019A (xx) |
| AT (1) | ATE103915T1 (xx) |
| DD (1) | DD272649A5 (xx) |
| DE (2) | DE3701277A1 (xx) |
| DK (1) | DK14688A (xx) |
| FI (1) | FI880182A7 (xx) |
| HU (1) | HU205354B (xx) |
| IL (1) | IL85069A0 (xx) |
| MX (1) | MX10126A (xx) |
| PT (1) | PT86561B (xx) |
| ZA (1) | ZA88263B (xx) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4027592A1 (de) * | 1990-08-31 | 1992-03-05 | Beiersdorf Ag | Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
| JPH07509215A (ja) * | 1990-11-14 | 1995-10-12 | カイロン コーポレイション | ジヒドロ葉酸還元酵素の特異的阻害およびそのための化合物 |
| CA2148082A1 (en) * | 1993-09-03 | 1995-03-09 | Daisuke Machii | Imidazoquinazoline derivatives |
| US5476851A (en) * | 1994-09-08 | 1995-12-19 | Rhone-Poulenc Rorer Pharmaceuticals, Inc. | Pyrazolo[3,4-g]quinoxaline compounds which inhibit PDGF receptor protein tyrosine kinase |
| WO1999007701A1 (en) * | 1997-08-05 | 1999-02-18 | Sugen, Inc. | Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors |
| US5932580A (en) * | 1997-12-01 | 1999-08-03 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | PDGF receptor kinase inhibitory compounds their preparation and compositions |
| WO1999040072A1 (de) * | 1998-02-03 | 1999-08-12 | Boehringer Ingelheim Pharma Kg | 5-gliedrige benzokondensierte heterocyclen als antithrombotika |
| US6114532A (en) * | 1998-02-03 | 2000-09-05 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals |
| US6087368A (en) * | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
| CA2333643A1 (en) * | 1998-06-30 | 2000-01-06 | James D. Rodgers | Substituted quinolin-2(1h)-ones useful as hiv reverse transcriptase inhibitors |
| US6358954B1 (en) * | 1999-11-09 | 2002-03-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same |
| US6423844B1 (en) | 2001-06-06 | 2002-07-23 | The United States Of America As Represented By The Secretary Of The Navy | Process for making 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine |
| ATE416168T1 (de) * | 2002-02-15 | 2008-12-15 | Glaxo Group Ltd | Modulatoren des vanilloidrezeptors |
| US7470712B2 (en) * | 2004-01-21 | 2008-12-30 | Bristol-Myers Squibb Company | Amino-benzazoles as P2Y1 receptor inhibitors |
| US7285569B2 (en) | 2004-09-24 | 2007-10-23 | Hoff Hoffmann-La Roche Inc. | Tricycles, their manufacture and use as pharmaceutical agents |
| US20060142247A1 (en) * | 2004-12-17 | 2006-06-29 | Guy Georges | Tricyclic heterocycles |
| US20060235013A1 (en) * | 2005-04-14 | 2006-10-19 | Guy Georges | Tricyclic azole derivatives |
| KR20070113286A (ko) * | 2005-04-14 | 2007-11-28 | 에프. 호프만-라 로슈 아게 | 아미노피라졸 유도체, 이의 제조 및 약학 제제로서의 용도 |
| JP2009519279A (ja) * | 2005-12-15 | 2009-05-14 | エフ．ホフマン−ラ ロシュ アーゲー | 三員環ラクタム誘導体、それらの製造方法、及び医薬剤としての使用 |
| BRPI0709082A2 (pt) * | 2006-03-23 | 2011-06-28 | Hoffmann La Roche | derivados de indazol substituìdos, sua fabricação e uso como agentes farmacêuticos |
| US20140309257A1 (en) * | 2011-11-11 | 2014-10-16 | The Regents Of The University Of Colorado, A Body Corporate | Topoisomerase inhibitors and methods of making and use as therapeutic agents |
| EP3363800A1 (en) | 2013-10-03 | 2018-08-22 | Kura Oncology, Inc. | Heterocyclic inhibitors of erk and methods of use |
| WO2019043208A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROQUINOLINONES |
| CA3107120A1 (en) | 2018-07-31 | 2020-02-06 | The Trustees Of Princeton University | Tetrahydroquinolino derivatives for the treatment of metastatic and chemoresistant cancers |
| AU2021209962A1 (en) * | 2020-01-24 | 2022-09-15 | Kayothera Inc. | Heterocyclic compounds and uses thereof |
| WO2022226383A1 (en) * | 2021-04-22 | 2022-10-27 | Kayothera Inc. | Heterocyclic compounds and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN148930B (xx) * | 1977-09-19 | 1981-07-25 | Hoffmann La Roche | |
| US4352931A (en) * | 1980-05-22 | 1982-10-05 | Siegfried Aktiengesellschaft | Lin-benzoaminopurinols |
| CH644116A5 (de) * | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | Imidazolderivate. |
| DE3410168A1 (de) * | 1984-03-20 | 1985-09-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue isochinolin-dione, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| DE3445669A1 (de) * | 1984-12-14 | 1986-06-19 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3501497A1 (de) * | 1985-01-18 | 1986-07-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| DE3524067A1 (de) * | 1985-07-05 | 1987-01-08 | Boehringer Mannheim Gmbh | Neue benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
-
1987
- 1987-01-17 DE DE19873701277 patent/DE3701277A1/de not_active Withdrawn
-
1988
- 1988-01-11 DE DE88100223T patent/DE3888854D1/de not_active Expired - Fee Related
- 1988-01-11 EP EP88100223A patent/EP0275888B1/de not_active Expired - Lifetime
- 1988-01-11 IL IL85069A patent/IL85069A0/xx unknown
- 1988-01-11 AT AT88100223T patent/ATE103915T1/de not_active IP Right Cessation
- 1988-01-13 DK DK014688A patent/DK14688A/da not_active Application Discontinuation
- 1988-01-15 US US07/144,514 patent/US4954498A/en not_active Expired - Fee Related
- 1988-01-15 MX MX1012688A patent/MX10126A/es unknown
- 1988-01-15 DD DD88312252A patent/DD272649A5/de unknown
- 1988-01-15 PT PT86561A patent/PT86561B/pt not_active IP Right Cessation
- 1988-01-15 HU HU88161A patent/HU205354B/hu unknown
- 1988-01-15 ZA ZA880263A patent/ZA88263B/xx unknown
- 1988-01-15 FI FI880182A patent/FI880182A7/fi not_active Application Discontinuation
- 1988-01-16 KR KR1019880000316A patent/KR880009019A/ko not_active Withdrawn
- 1988-01-18 JP JP63007108A patent/JPS63192773A/ja active Pending
-
1990
- 1990-06-25 US US07/543,350 patent/US5116843A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU605822B2 (en) | 1991-01-24 |
| DD272649A5 (de) | 1989-10-18 |
| EP0275888A3 (en) | 1989-09-27 |
| DE3701277A1 (de) | 1988-07-28 |
| HUT46915A (en) | 1988-12-28 |
| US5116843A (en) | 1992-05-26 |
| AU1031688A (en) | 1988-07-21 |
| HU205354B (en) | 1992-04-28 |
| KR880009019A (ko) | 1988-09-13 |
| JPS63192773A (ja) | 1988-08-10 |
| PT86561A (de) | 1988-02-01 |
| US4954498A (en) | 1990-09-04 |
| MX10126A (es) | 1993-11-01 |
| DK14688A (da) | 1988-07-18 |
| DK14688D0 (da) | 1988-01-13 |
| DE3888854D1 (de) | 1994-05-11 |
| PT86561B (pt) | 1991-12-31 |
| EP0275888A2 (de) | 1988-07-27 |
| FI880182A0 (fi) | 1988-01-15 |
| FI880182A7 (fi) | 1988-07-18 |
| ZA88263B (en) | 1988-06-29 |
| ATE103915T1 (de) | 1994-04-15 |
| EP0275888B1 (de) | 1994-04-06 |
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