IL83236A0 - Preparation of functional human urokinase proteins - Google Patents

Preparation of functional human urokinase proteins

Info

Publication number: IL83236A0
Authority: IL; Israel
Prior art keywords: preparation; functional human; human urokinase; proteins; urokinase proteins
Prior art date: 1982-04-15

Application number

IL83236A

Other languages

English (en)

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-04-15

Filing date

1987-07-17

Publication date

1987-12-31

1987-07-17 Application filed by Genentech Inc filed Critical Genentech Inc

1987-07-17 Priority to IL83236A priority Critical patent/IL83236A0/xx

1987-12-31 Publication of IL83236A0 publication Critical patent/IL83236A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Diabetes (AREA)
Biotechnology (AREA)
Hematology (AREA)
Microbiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Heart & Thoracic Surgery (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)

IL83236A 1982-04-15 1987-07-17 Preparation of functional human urokinase proteins IL83236A0 (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
IL83236A IL83236A0 (en)	1982-04-15	1987-07-17	Preparation of functional human urokinase proteins

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US36877382A	1982-04-15	1982-04-15
US47493083A	1983-03-14	1983-03-14
IL68366A IL68366A (en)	1982-04-15	1983-04-12	Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
IL83236A IL83236A0 (en)	1982-04-15	1987-07-17	Preparation of functional human urokinase proteins

Publications (1)

Publication Number	Publication Date
IL83236A0 true IL83236A0 (en)	1987-12-31

Family

ID=27004326

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL68366A IL68366A (en)	1982-04-15	1983-04-12	Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
IL83236A IL83236A0 (en)	1982-04-15	1987-07-17	Preparation of functional human urokinase proteins

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
IL68366A IL68366A (en)	1982-04-15	1983-04-12	Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture

Country Status (20)

Country	Link
EP (2)	EP0620279B1 (xx)
JP (3)	JPH0655145B2 (xx)
AT (2)	ATE232237T1 (xx)
AU (1)	AU573523B2 (xx)
BR (1)	BR8301918A (xx)
CA (1)	CA1341301C (xx)
DE (2)	DE3382837T2 (xx)
DK (1)	DK173910B1 (xx)
ES (3)	ES8500325A1 (xx)
FI (1)	FI88932C (xx)
GR (1)	GR78180B (xx)
HK (1)	HK38297A (xx)
IE (1)	IE64536B1 (xx)
IL (2)	IL68366A (xx)
MY (1)	MY102472A (xx)
NO (1)	NO831317L (xx)
NZ (1)	NZ203869A (xx)
PH (4)	PH24783A (xx)
PT (1)	PT76546B (xx)
YU (1)	YU45128B (xx)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4370417A (en) *	1980-04-03	1983-01-25	Abbott Laboratories	Recombinant deoxyribonucleic acid which codes for plasminogen activator
NZ208612A (en) *	1983-06-24	1991-09-25	Genentech Inc	Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations
AU587960B2 (en) *	1983-06-24	1989-09-07	Genentech Inc.	Procaryotic carbonyl hydrolases
DE3486023T2 (de) *	1983-09-13	1993-06-24	Green Cross Corp	Verfahren zur herstellung von urokinase zymogen.
JPS61177987A (ja) *	1985-01-31	1986-08-09	Green Cross Corp:The	ヒトウロキナ−ゼの製造方法
JPS60180591A (ja) *	1984-02-27	1985-09-14	Green Cross Corp:The	ヒトウロキナ−ゼのｄνａ配列，プラスミド，宿主
EP0154272B1 (en) *	1984-02-27	1992-01-08	Green Cross Corporation	Production of human urokinase
EP0210279B1 (en) *	1985-01-25	1991-08-14	Sagami Chemical Research Center	Stabilized human prourokinase
JPS61181377A (ja) *	1985-01-25	1986-08-14	Sagami Chem Res Center	ヒトウロキナ−ゼ遺伝子
US5219569A (en) *	1985-04-22	1993-06-15	Genentech, Inc.	Protease resistant urokinase
US4916071A (en) *	1985-08-14	1990-04-10	American Home Products Corporation	Poly-kringle plasminogen activator
US4997766A (en) *	1986-07-11	1991-03-05	American Home Products Corporation	Poly-kringle plasminogen activator
JPS62149625A (ja) *	1985-12-25	1987-07-03	Green Cross Corp:The	生理活性物質の製造方法
DE3613401A1 (de) *	1986-04-21	1987-12-17	Boehringer Mannheim Gmbh	Verfahren zur herstellung von plasminogen-aktivatoren in prokaryonten
NL8601240A (nl) *	1986-05-15	1987-12-01	Leuven Res & Dev Vzw	Plasminogeenactivator en trombolytisch geneesmiddel.
GB8623823D0 (en) *	1986-10-03	1986-11-05	Sandoz Ltd	Therapeutic lysis of fibrin blood clots
JPS63105675A (ja) *	1986-10-23	1988-05-10	Green Cross Corp:The	ヒトウロキナ−ゼの製造方法
ZA879286B (en)	1986-12-16	1988-10-26	Smith Kline Rit	New plasminogen activators
AU1295088A (en) *	1987-01-30	1988-08-24	American Home Products Corporation	Des-epidermal growth factor plasminogen activators
MY103358A (en) *	1987-04-15	1993-06-30	Novartis Ag	Process for the production of protiens.
DE3886517T2 (de) *	1987-08-19	1994-04-21	Central Glass Co Ltd	Menschlicher Prourokinase ähnliches Polypeptid.
FI96121C (fi) *	1987-10-02	1996-05-10	Zymogenetics Inc	DNA-rakenne ja menetelmä heterologisen proteiinin tuottamiseksi
AU2354588A (en) *	1987-10-09	1989-04-20	Collaborative Research Inc.	Modified low molecular weight plasminogen activator and method of preparation
US4999194A (en) *	1988-01-14	1991-03-12	Collaborative Research, Inc.	Two-chain urokinase plasminogen activators for treatment of thrombotic disease
US4920051A (en) *	1988-02-03	1990-04-24	Damon Biotech, Inc.	Recovery of urokinase compounds
IE901849A1 (en) *	1989-07-19	1991-06-19	Gruenenthal Gmbh	Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
CA2027936C (en)	1989-10-23	2001-07-24	Smithkline Beecham Corporation	Cyclic anti-aggregatory peptides
ATE212672T1 (de) *	1989-10-24	2002-02-15	Chiron Corp	System zur freisetzung von infektiösen proteinen
DE4101736A1 (de) *	1991-01-22	1992-07-23	Gruenenthal Gmbh	Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
US5888814A (en) *	1994-06-06	1999-03-30	Chiron Corporation	Recombinant host cells encoding TNF proteins
DE69924110D1 (de) *	1998-06-26	2005-04-14	Croptech Dev Corp	Herstellung von urokinase in pflanzlichen expressionssystemen
WO2001097752A2 (en) *	2000-06-20	2001-12-27	The Trustees Of The University Of Pennsylvania	Compositions comprising urokinase for modulating muscle contractility and angiogenisis
US20030040095A1 (en) *	2001-03-16	2003-02-27	Achille Arini	Method for the production of pharmaceutically active recombinant proteins
CA2626356C (en) *	2005-10-21	2017-08-22	Catalyst Biosciences, Inc.	Modified proteases that inhibit complement activation
TW201139677A (en)	2006-07-05	2011-11-16	Catalyst Biosciences Inc	Protease screening methods and proteases identified thereby

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0040238B1 (en) *	1979-11-13	1984-07-11	HUSAIN, Syed Shaukat	Plasminogen activators useful as therapeutic and diagnostic agents and their isolation
US4321363A (en) *	1980-02-21	1982-03-23	Nippon Soda Company Limited	Adsorbent for urokinase containing agarose
US4370417A (en) *	1980-04-03	1983-01-25	Abbott Laboratories	Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4506013A (en) *	1980-10-03	1985-03-19	Eli Lilly And Company	Stabilizing and selecting recombinant DNA host cells
PH22337A (en) *	1983-11-21	1988-08-12	Ciba Geigy Ag	Synthesis of fibrinolytic agents by yeast

1983
- 1983-04-12 IL IL68366A patent/IL68366A/xx not_active IP Right Cessation
- 1983-04-12 FI FI831228A patent/FI88932C/fi not_active IP Right Cessation
- 1983-04-12 GR GR71061A patent/GR78180B/el unknown
- 1983-04-13 PH PH28772A patent/PH24783A/en unknown
- 1983-04-13 ES ES521418A patent/ES8500325A1/es not_active Expired
- 1983-04-13 PT PT76546A patent/PT76546B/pt unknown
- 1983-04-13 NZ NZ203869A patent/NZ203869A/en unknown
- 1983-04-14 NO NO831317A patent/NO831317L/no unknown
- 1983-04-14 BR BR8301918A patent/BR8301918A/pt unknown
- 1983-04-14 DK DK198301636A patent/DK173910B1/da not_active IP Right Cessation
- 1983-04-14 JP JP58066284A patent/JPH0655145B2/ja not_active Expired - Lifetime
- 1983-04-14 DE DE3382837T patent/DE3382837T2/de not_active Expired - Lifetime
- 1983-04-14 EP EP94104777A patent/EP0620279B1/en not_active Expired - Lifetime
- 1983-04-14 AT AT94104777T patent/ATE232237T1/de not_active IP Right Cessation
- 1983-04-14 IE IE85083A patent/IE64536B1/en not_active IP Right Cessation
- 1983-04-14 DE DE3382760T patent/DE3382760T2/de not_active Expired - Lifetime
- 1983-04-14 AU AU13524/83A patent/AU573523B2/en not_active Expired
- 1983-04-14 CA CA000425894A patent/CA1341301C/en not_active Expired - Lifetime
- 1983-04-14 AT AT83103629T patent/ATE112802T1/de not_active IP Right Cessation
- 1983-04-14 EP EP83103629A patent/EP0092182B1/en not_active Expired - Lifetime
- 1983-04-15 YU YU868/83A patent/YU45128B/xx unknown
1984
- 1984-07-02 ES ES533925A patent/ES8602121A1/es not_active Expired
- 1984-07-02 ES ES533924A patent/ES8506087A1/es not_active Expired
- 1984-07-24 PH PH31022A patent/PH22461A/en unknown
- 1984-07-24 PH PH31024A patent/PH25312A/en unknown
- 1984-07-24 PH PH31025A patent/PH25120A/en unknown
1987
- 1987-07-17 IL IL83236A patent/IL83236A0/xx unknown
- 1987-09-28 MY MYPI87002076A patent/MY102472A/en unknown
1992
- 1992-01-09 JP JP4002252A patent/JPH0824579B2/ja not_active Expired - Lifetime
1994
- 1994-02-08 JP JP6014310A patent/JP2584192B2/ja not_active Expired - Lifetime
1997
- 1997-03-27 HK HK38297A patent/HK38297A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL68366A (en)	1990-08-31
FI88932B (fi)	1993-04-15
FI831228L (fi)	1983-10-16
IL68366A0 (en)	1983-07-31
DE3382837T2 (de)	2004-01-15
GR78180B (xx)	1984-09-26
FI88932C (fi)	1993-07-26
NZ203869A (en)	1987-04-30
EP0620279B1 (en)	2003-02-05
AU573523B2 (en)	1988-06-16
ES521418A0 (es)	1984-11-01
EP0620279A1 (en)	1994-10-19
DE3382760T2 (de)	1995-03-02
EP0092182B1 (en)	1994-10-12
IE950235L (en)	1983-10-15
ES533925A0 (es)	1985-12-01
NO831317L (no)	1983-10-17
EP0092182A3 (en)	1984-07-18
BR8301918A (pt)	1983-12-20
JPH0530970A (ja)	1993-02-09
PT76546A (en)	1983-05-01
EP0092182A2 (en)	1983-10-26
PH25312A (en)	1991-04-30
JP2584192B2 (ja)	1997-02-19
HK38297A (en)	1997-04-04
YU86883A (en)	1988-10-31
DK163683A (da)	1983-11-28
JPH07186A (ja)	1995-01-06
ATE232237T1 (de)	2003-02-15
DK163683D0 (da)	1983-04-14
ES8602121A1 (es)	1985-12-01
ES533924A0 (es)	1985-07-01
JPS5951300A (ja)	1984-03-24
DE3382837D1 (de)	2003-03-13
YU45128B (en)	1992-03-10
PH24783A (en)	1990-10-30
DE3382760D1 (de)	1994-11-17
AU1352483A (en)	1983-10-20
MY102472A (en)	1992-06-30
FI831228A0 (fi)	1983-04-12
JPH0824579B2 (ja)	1996-03-13
IE830850L (en)	1983-10-15
PT76546B (en)	1986-03-20
JPH0655145B2 (ja)	1994-07-27
DK173910B1 (da)	2002-02-11
CA1341301C (en)	2001-10-09
PH22461A (en)	1988-09-12
ES8506087A1 (es)	1985-07-01
PH25120A (en)	1991-02-19
ATE112802T1 (de)	1994-10-15
IE64536B1 (en)	1995-08-09
ES8500325A1 (es)	1984-11-01

Publication	Publication Date	Title
EP0092182A3 (en)	1984-07-18	Preparation of functional human urokinase proteins
IL80678A0 (en)	1987-02-27	Mammalian interleukin-4
FI91160B (fi)	1994-02-15	Menetelmä modifioidun ihmisen t-PA-proteiinin valmistamiseksi
EP0383837A4 (en)	1991-09-11	Alveolar surfactant proteins
IL80562A0 (en)	1987-02-27	Recombinant human lysozyme,its preparation by recombinant dna technology and pharmaceutical compositions containing it
GB2068970B (en)	1983-06-22	Recombinant dna technique for the preparation of a protein resembling human interferon
GB2171703B (en)	1989-11-15	Expression-secretion vector for gene expression and protein secretion, recombinant dna including the vector, and method of producing proteins by use of the re
EP0149241A3 (en)	1987-05-27	Dna base sequence containing regions involved in the production and secretion of a protein, recombinant dna including the whole or a part of the dna base sequence, and method of producing proteins by use of the recombinant dna
AU545758B2 (en)	1985-08-01	Recombinant dna technique for the preparation of a protein resembling human interferon
PT86162A (en)	1987-12-01	Recombinant protein expression
GB8310142D0 (en)	1983-05-18	Functional human urokinase proteins
IE873131L (en)	1988-05-21	Recombinant protein expression.
ZA832587B (en)	1984-06-27	Preparation of functional human urokinase proteins
AU630070B2 (en)	1992-10-22	Preparation of fused proteins, antibodies and processes therefore
AU630070C (en)	1993-09-23	Preparation of fused proteins, antibodies and processes therefore