IL83994A - Method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives - Google Patents
Method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivativesInfo
- Publication number
- IL83994A IL83994A IL83994A IL8399487A IL83994A IL 83994 A IL83994 A IL 83994A IL 83994 A IL83994 A IL 83994A IL 8399487 A IL8399487 A IL 8399487A IL 83994 A IL83994 A IL 83994A
- Authority
- IL
- Israel
- Prior art keywords
- acetals
- preparation
- controlling
- hydrocarbon solvent
- epimeric distribution
- Prior art date
Links
- 150000003126 pregnane derivatives Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 150000008282 halocarbons Chemical class 0.000 abstract 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000003607 modifier Substances 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8604059A SE8604059D0 (sv) | 1986-09-25 | 1986-09-25 | A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL83994A0 IL83994A0 (en) | 1988-02-29 |
| IL83994A true IL83994A (en) | 1992-02-16 |
Family
ID=20365704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL83994A IL83994A (en) | 1986-09-25 | 1987-09-23 | Method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4925933A (xx) |
| EP (1) | EP0262108B1 (xx) |
| JP (1) | JP2668000B2 (xx) |
| KR (1) | KR950014460B1 (xx) |
| AT (1) | ATE70066T1 (xx) |
| CY (1) | CY1791A (xx) |
| DE (1) | DE3774987D1 (xx) |
| ES (1) | ES2026576T3 (xx) |
| FI (1) | FI90345C (xx) |
| GR (1) | GR3003332T3 (xx) |
| HK (1) | HK46194A (xx) |
| IL (1) | IL83994A (xx) |
| SE (1) | SE8604059D0 (xx) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8903219D0 (sv) * | 1989-10-02 | 1989-10-02 | Astra Ab | Process for the manufacture of budesonide |
| GR1001529B (el) * | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
| SE9100341D0 (sv) * | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroids |
| FR2675146A1 (fr) * | 1991-04-10 | 1992-10-16 | Roussel Uclaf | Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires. |
| GB9423919D0 (en) * | 1994-11-26 | 1995-01-11 | Rhone Poulenc Rorer Ltd | Chemical process |
| DE19635498A1 (de) * | 1996-09-03 | 1998-03-26 | Byk Gulden Lomberg Chem Fab | Verfahren zur Epimerenanreicherung |
| IT1291288B1 (it) * | 1997-04-30 | 1999-01-07 | Farmabios Srl | Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22. |
| US6266556B1 (en) | 1998-04-27 | 2001-07-24 | Beth Israel Deaconess Medical Center, Inc. | Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation |
| IT1302657B1 (it) * | 1998-10-13 | 2000-09-29 | Farmabios Srl | Processo stereoselettivo per la preparazione di budesonide nella formadi epimero 22-r. |
| KR20070116185A (ko) * | 2000-11-10 | 2007-12-06 | 니코메드 게엠베하 | 트랜스케탈화 반응에 의한16,17-[(시클로헥실메틸렌)비스(옥시)]-11,21-디히드록시-프레그나-1,4-디엔-3,20-디온 또는 이의 21-이소부티라트의제조방법 |
| WO2003027134A1 (en) * | 2001-09-25 | 2003-04-03 | Pharmacia & Upjohn Company | Stereoselective transacetalization of steroidal c-22 acetonide |
| AU2003291634A1 (en) * | 2002-10-08 | 2004-05-04 | Sepracor Inc. | Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory |
| JP2009512733A (ja) * | 2005-11-02 | 2009-03-26 | シコール インコーポレイティド | シクレソニドの改良された製造法 |
| US20070232578A1 (en) * | 2006-02-15 | 2007-10-04 | Pierluigi Rossetto | Crystalline forms of ciclesonide |
| US10233210B2 (en) | 2015-01-30 | 2019-03-19 | Coral Drugs Pvt. Ltd. | Process for preparation of glucocorticoid steroids |
| EP4659809A2 (en) | 2016-11-08 | 2025-12-10 | Regeneron Pharmaceuticals, Inc. | Steroids and protein-conjugates thereof |
| US11491237B2 (en) | 2017-05-18 | 2022-11-08 | Regeneron Pharmaceuticals, Inc. | Cyclodextrin protein drug conjugates |
| MX2020004691A (es) | 2017-11-07 | 2020-08-20 | Regeneron Pharma | Enlazadores hidrofilicos para conjugados anticuerpo-farmaco. |
| CN112004557B (zh) | 2018-01-08 | 2024-07-30 | 里珍纳龙药品有限公司 | 类固醇类化合物及其抗体偶联物 |
| KR20210008008A (ko) | 2018-05-09 | 2021-01-20 | 리제너론 파마슈티칼스 인코포레이티드 | 항-msr1 항체 및 이의 사용 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE378109B (xx) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| SE378110B (xx) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| SE8008524L (sv) * | 1980-12-04 | 1982-06-05 | Draco Ab | 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand |
| IT1196142B (it) * | 1984-06-11 | 1988-11-10 | Sicor Spa | Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti |
-
1986
- 1986-09-25 SE SE8604059A patent/SE8604059D0/xx unknown
-
1987
- 1987-09-11 US US07/096,598 patent/US4925933A/en not_active Expired - Lifetime
- 1987-09-18 ES ES198787850282T patent/ES2026576T3/es not_active Expired - Lifetime
- 1987-09-18 EP EP87850282A patent/EP0262108B1/en not_active Expired - Lifetime
- 1987-09-18 AT AT87850282T patent/ATE70066T1/de not_active IP Right Cessation
- 1987-09-18 DE DE8787850282T patent/DE3774987D1/de not_active Expired - Fee Related
- 1987-09-23 IL IL83994A patent/IL83994A/xx unknown
- 1987-09-24 KR KR1019870010561A patent/KR950014460B1/ko not_active Expired - Fee Related
- 1987-09-24 FI FI874189A patent/FI90345C/fi not_active IP Right Cessation
- 1987-09-24 JP JP62237588A patent/JP2668000B2/ja not_active Expired - Fee Related
-
1991
- 1991-12-12 GR GR91401949T patent/GR3003332T3/el unknown
-
1994
- 1994-05-12 HK HK46194A patent/HK46194A/en not_active IP Right Cessation
-
1995
- 1995-10-20 CY CY179195A patent/CY1791A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4925933A (en) | 1990-05-15 |
| FI90345C (fi) | 1994-01-25 |
| CY1791A (en) | 1995-10-20 |
| EP0262108B1 (en) | 1991-12-04 |
| JP2668000B2 (ja) | 1997-10-27 |
| EP0262108A1 (en) | 1988-03-30 |
| KR880003969A (ko) | 1988-06-01 |
| FI90345B (fi) | 1993-10-15 |
| IL83994A0 (en) | 1988-02-29 |
| SE8604059D0 (sv) | 1986-09-25 |
| GR3003332T3 (en) | 1993-02-17 |
| FI874189L (fi) | 1988-03-26 |
| HK46194A (en) | 1994-05-20 |
| DE3774987D1 (de) | 1992-01-16 |
| KR950014460B1 (ko) | 1995-11-28 |
| ATE70066T1 (de) | 1991-12-15 |
| JPS6393795A (ja) | 1988-04-25 |
| ES2026576T3 (es) | 1992-05-01 |
| FI874189A0 (fi) | 1987-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed |