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IL163828A0 - Process for making chiral 1,4-disubstituted piperazines - Google Patents

Process for making chiral 1,4-disubstituted piperazines

Info

Publication number
IL163828A0
IL163828A0 IL16382803A IL16382803A IL163828A0 IL 163828 A0 IL163828 A0 IL 163828A0 IL 16382803 A IL16382803 A IL 16382803A IL 16382803 A IL16382803 A IL 16382803A IL 163828 A0 IL163828 A0 IL 163828A0
Authority
IL
Israel
Prior art keywords
making chiral
disubstituted piperazines
piperazines
disubstituted
chiral
Prior art date
Application number
IL16382803A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of IL163828A0 publication Critical patent/IL163828A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/06Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing halogen atoms, or nitro or nitroso groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18Ethylenedioxybenzenes, not substituted on the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
IL16382803A 2002-03-12 2003-03-10 Process for making chiral 1,4-disubstituted piperazines IL163828A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36345802P 2002-03-12 2002-03-12
PCT/US2003/007176 WO2003078420A2 (en) 2002-03-12 2003-03-10 Process for making chiral 1,4-disubstituted piperazines

Publications (1)

Publication Number Publication Date
IL163828A0 true IL163828A0 (en) 2005-12-18

Family

ID=28041772

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16382803A IL163828A0 (en) 2002-03-12 2003-03-10 Process for making chiral 1,4-disubstituted piperazines

Country Status (20)

Country Link
US (3) US7019137B2 (es)
EP (1) EP1483256A2 (es)
JP (1) JP2005527530A (es)
KR (1) KR20040091119A (es)
CN (2) CN100451014C (es)
AR (1) AR038931A1 (es)
AU (1) AU2003220110B2 (es)
BR (1) BR0308347A (es)
CA (1) CA2477906A1 (es)
CR (1) CR7428A (es)
EC (1) ECSP045292A (es)
IL (1) IL163828A0 (es)
MX (1) MXPA04008730A (es)
NO (1) NO20043988L (es)
NZ (1) NZ535169A (es)
RU (2) RU2315044C2 (es)
TW (1) TW200304825A (es)
UA (1) UA79774C2 (es)
WO (1) WO2003078420A2 (es)
ZA (1) ZA200408205B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5080716B2 (ja) * 2001-07-20 2012-11-21 サイコジェニックス・インコーポレーテッド 注意欠陥・多動性障害の治療
US7361773B2 (en) * 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
CN100451014C (zh) * 2002-03-12 2009-01-14 惠氏公司 制备手性1,4-二取代哌嗪的方法
US20050215561A1 (en) * 2004-03-19 2005-09-29 Krishnendu Ghosh Pharmaceutical dosage forms and compositions
PA8626301A1 (es) * 2004-03-19 2006-12-07 Wyeth Wyeth Proceso para preparar derivados de n-aril-piperazina
US20070099931A1 (en) * 2004-03-19 2007-05-03 Wyeth Pharmaceutical dosage forms and compositions
EP2896624B1 (en) 2007-03-28 2016-07-13 Atir Holding S.A. Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof
CN108627380B (zh) * 2017-03-15 2020-10-20 中国人民解放军军事医学科学院毒物药物研究所 去除或减少有毒物质的方法以及检测有毒物质的方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE960203C (de) * 1953-12-25 1957-03-21 Yoshitomi Pharmaceutical Verfahren zur Herstellung von N-substituierten Aminocarbonsaeureestern
ZA848005B (en) * 1983-10-17 1985-05-29 Duphar Int Res Blood-pressure lowering piperazine derivatives
DE3586794T2 (de) 1984-12-21 1993-05-27 Duphar Int Res Arzneimittel mit psychotroper wirkung.
JPH01125357A (ja) 1987-11-06 1989-05-17 Dainippon Pharmaceut Co Ltd トリペプチドの誘導体
MX9201991A (es) 1991-05-02 1992-11-01 Jonh Wyeth & Brother Limited Derivados de piperazina y procedimiento para su preparacion.
GB9125900D0 (en) * 1991-12-05 1992-02-05 Wyeth John & Brother Ltd Piperazine derivatives
EP0636133A1 (en) * 1992-04-13 1995-02-01 Fujisawa Pharmaceutical Co., Ltd. Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents
GB9208740D0 (en) * 1992-04-23 1992-06-10 Glaxo Group Ltd Chemical compounds
JP3077047B2 (ja) 1993-04-16 2000-08-14 参天製薬株式会社 新規ピペラジン誘導体
ATE222238T1 (de) 1994-06-03 2002-08-15 Wyeth John & Brother Ltd Verfahren und zwischenprodukte zur herstellung von piperazinderivaten
GB9411099D0 (en) 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives
GB9413772D0 (en) 1994-07-08 1994-08-24 Wyeth John & Brother Ltd 5-HT1A ligands
ES2201105T3 (es) * 1994-08-05 2004-03-16 Pfizer Inc. Derivados del bencimidazol con actividad dopaminergica.
US5681958A (en) * 1995-06-07 1997-10-28 Shaman Pharmaceuticals, Inc. Cryptolepine analogs with hypoglycemic activity
US5889010A (en) * 1995-05-18 1999-03-30 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity
GB9514901D0 (en) 1995-07-20 1995-09-20 American Home Prod Piperazine derivatives
WO1997037655A1 (en) 1996-04-10 1997-10-16 Merck & Co., Inc. αvβ3 ANTAGONISTS
US6271234B1 (en) 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
JPH11106381A (ja) * 1997-09-30 1999-04-20 Ss Pharmaceut Co Ltd クロメン誘導体及びその塩並びにこれを含有する医薬
US6469007B2 (en) 2000-11-28 2002-10-22 Wyeth Serotonergic agents
MXPA04005158A (es) * 2001-11-30 2004-08-11 Schering Corp Antagonistas receptores de adenosina a2a biciclica de (1.2.4]- triazol.
ES2334836T3 (es) 2002-03-12 2010-03-16 Wyeth Preparacion de 2-((2,3-dihidro-benzo(1,4)dioxin-5-il)-(2-hidroxietil)-amino)-etanol y productos intermedios correspondientes.
CN100451014C (zh) 2002-03-12 2009-01-14 惠氏公司 制备手性1,4-二取代哌嗪的方法
US7361773B2 (en) * 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
JP4391241B2 (ja) * 2002-03-12 2009-12-24 ワイス キラルn−アリールピペラジンの合成方法
US7091349B2 (en) * 2002-03-12 2006-08-15 Wyeth Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution

Also Published As

Publication number Publication date
MXPA04008730A (es) 2004-12-06
NO20043988L (no) 2004-09-23
WO2003078420A2 (en) 2003-09-25
ECSP045292A (es) 2004-10-26
TW200304825A (en) 2003-10-16
NZ535169A (en) 2006-03-31
JP2005527530A (ja) 2005-09-15
EP1483256A2 (en) 2004-12-08
ZA200408205B (en) 2007-03-28
US7256289B2 (en) 2007-08-14
RU2007125687A (ru) 2009-01-20
US20050228181A1 (en) 2005-10-13
US20080058543A1 (en) 2008-03-06
CN1642937A (zh) 2005-07-20
WO2003078420A3 (en) 2004-03-11
RU2315044C2 (ru) 2008-01-20
CN101492383A (zh) 2009-07-29
BR0308347A (pt) 2005-01-25
US7019137B2 (en) 2006-03-28
CR7428A (es) 2008-09-23
CN100451014C (zh) 2009-01-14
UA79774C2 (en) 2007-07-25
AR038931A1 (es) 2005-02-02
KR20040091119A (ko) 2004-10-27
RU2004130313A (ru) 2005-04-10
US20030208075A1 (en) 2003-11-06
AU2003220110B2 (en) 2009-04-09
CA2477906A1 (en) 2003-09-25
AU2003220110A1 (en) 2003-09-29

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