IL163828A0 - Process for making chiral 1,4-disubstituted piperazines - Google Patents
Process for making chiral 1,4-disubstituted piperazinesInfo
- Publication number
- IL163828A0 IL163828A0 IL16382803A IL16382803A IL163828A0 IL 163828 A0 IL163828 A0 IL 163828A0 IL 16382803 A IL16382803 A IL 16382803A IL 16382803 A IL16382803 A IL 16382803A IL 163828 A0 IL163828 A0 IL 163828A0
- Authority
- IL
- Israel
- Prior art keywords
- making chiral
- disubstituted piperazines
- piperazines
- disubstituted
- chiral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/06—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing halogen atoms, or nitro or nitroso groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36345802P | 2002-03-12 | 2002-03-12 | |
| PCT/US2003/007176 WO2003078420A2 (en) | 2002-03-12 | 2003-03-10 | Process for making chiral 1,4-disubstituted piperazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL163828A0 true IL163828A0 (en) | 2005-12-18 |
Family
ID=28041772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16382803A IL163828A0 (en) | 2002-03-12 | 2003-03-10 | Process for making chiral 1,4-disubstituted piperazines |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7019137B2 (es) |
| EP (1) | EP1483256A2 (es) |
| JP (1) | JP2005527530A (es) |
| KR (1) | KR20040091119A (es) |
| CN (2) | CN100451014C (es) |
| AR (1) | AR038931A1 (es) |
| AU (1) | AU2003220110B2 (es) |
| BR (1) | BR0308347A (es) |
| CA (1) | CA2477906A1 (es) |
| CR (1) | CR7428A (es) |
| EC (1) | ECSP045292A (es) |
| IL (1) | IL163828A0 (es) |
| MX (1) | MXPA04008730A (es) |
| NO (1) | NO20043988L (es) |
| NZ (1) | NZ535169A (es) |
| RU (2) | RU2315044C2 (es) |
| TW (1) | TW200304825A (es) |
| UA (1) | UA79774C2 (es) |
| WO (1) | WO2003078420A2 (es) |
| ZA (1) | ZA200408205B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5080716B2 (ja) * | 2001-07-20 | 2012-11-21 | サイコジェニックス・インコーポレーテッド | 注意欠陥・多動性障害の治療 |
| US7361773B2 (en) * | 2002-03-12 | 2008-04-22 | Wyeth | Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines |
| CN100451014C (zh) * | 2002-03-12 | 2009-01-14 | 惠氏公司 | 制备手性1,4-二取代哌嗪的方法 |
| US20050215561A1 (en) * | 2004-03-19 | 2005-09-29 | Krishnendu Ghosh | Pharmaceutical dosage forms and compositions |
| PA8626301A1 (es) * | 2004-03-19 | 2006-12-07 | Wyeth Wyeth | Proceso para preparar derivados de n-aril-piperazina |
| US20070099931A1 (en) * | 2004-03-19 | 2007-05-03 | Wyeth | Pharmaceutical dosage forms and compositions |
| EP2896624B1 (en) | 2007-03-28 | 2016-07-13 | Atir Holding S.A. | Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof |
| CN108627380B (zh) * | 2017-03-15 | 2020-10-20 | 中国人民解放军军事医学科学院毒物药物研究所 | 去除或减少有毒物质的方法以及检测有毒物质的方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE960203C (de) * | 1953-12-25 | 1957-03-21 | Yoshitomi Pharmaceutical | Verfahren zur Herstellung von N-substituierten Aminocarbonsaeureestern |
| ZA848005B (en) * | 1983-10-17 | 1985-05-29 | Duphar Int Res | Blood-pressure lowering piperazine derivatives |
| DE3586794T2 (de) | 1984-12-21 | 1993-05-27 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
| JPH01125357A (ja) | 1987-11-06 | 1989-05-17 | Dainippon Pharmaceut Co Ltd | トリペプチドの誘導体 |
| MX9201991A (es) | 1991-05-02 | 1992-11-01 | Jonh Wyeth & Brother Limited | Derivados de piperazina y procedimiento para su preparacion. |
| GB9125900D0 (en) * | 1991-12-05 | 1992-02-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
| EP0636133A1 (en) * | 1992-04-13 | 1995-02-01 | Fujisawa Pharmaceutical Co., Ltd. | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents |
| GB9208740D0 (en) * | 1992-04-23 | 1992-06-10 | Glaxo Group Ltd | Chemical compounds |
| JP3077047B2 (ja) | 1993-04-16 | 2000-08-14 | 参天製薬株式会社 | 新規ピペラジン誘導体 |
| ATE222238T1 (de) | 1994-06-03 | 2002-08-15 | Wyeth John & Brother Ltd | Verfahren und zwischenprodukte zur herstellung von piperazinderivaten |
| GB9411099D0 (en) | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
| GB9413772D0 (en) | 1994-07-08 | 1994-08-24 | Wyeth John & Brother Ltd | 5-HT1A ligands |
| ES2201105T3 (es) * | 1994-08-05 | 2004-03-16 | Pfizer Inc. | Derivados del bencimidazol con actividad dopaminergica. |
| US5681958A (en) * | 1995-06-07 | 1997-10-28 | Shaman Pharmaceuticals, Inc. | Cryptolepine analogs with hypoglycemic activity |
| US5889010A (en) * | 1995-05-18 | 1999-03-30 | Pfizer Inc. | Benzimidazole derivatives having dopaminergic activity |
| GB9514901D0 (en) | 1995-07-20 | 1995-09-20 | American Home Prod | Piperazine derivatives |
| WO1997037655A1 (en) | 1996-04-10 | 1997-10-16 | Merck & Co., Inc. | αvβ3 ANTAGONISTS |
| US6271234B1 (en) | 1997-08-01 | 2001-08-07 | Recordati S.A., Chemical And Pharmaceutical Company | 1,4-disubstituted piperazines |
| JPH11106381A (ja) * | 1997-09-30 | 1999-04-20 | Ss Pharmaceut Co Ltd | クロメン誘導体及びその塩並びにこれを含有する医薬 |
| US6469007B2 (en) | 2000-11-28 | 2002-10-22 | Wyeth | Serotonergic agents |
| MXPA04005158A (es) * | 2001-11-30 | 2004-08-11 | Schering Corp | Antagonistas receptores de adenosina a2a biciclica de (1.2.4]- triazol. |
| ES2334836T3 (es) | 2002-03-12 | 2010-03-16 | Wyeth | Preparacion de 2-((2,3-dihidro-benzo(1,4)dioxin-5-il)-(2-hidroxietil)-amino)-etanol y productos intermedios correspondientes. |
| CN100451014C (zh) | 2002-03-12 | 2009-01-14 | 惠氏公司 | 制备手性1,4-二取代哌嗪的方法 |
| US7361773B2 (en) * | 2002-03-12 | 2008-04-22 | Wyeth | Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines |
| JP4391241B2 (ja) * | 2002-03-12 | 2009-12-24 | ワイス | キラルn−アリールピペラジンの合成方法 |
| US7091349B2 (en) * | 2002-03-12 | 2006-08-15 | Wyeth | Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution |
-
2003
- 2003-03-10 CN CNB038059169A patent/CN100451014C/zh not_active Expired - Fee Related
- 2003-03-10 CN CNA2008101786904A patent/CN101492383A/zh not_active Withdrawn
- 2003-03-10 BR BR0308347-0A patent/BR0308347A/pt not_active IP Right Cessation
- 2003-03-10 AU AU2003220110A patent/AU2003220110B2/en not_active Expired - Fee Related
- 2003-03-10 CA CA002477906A patent/CA2477906A1/en not_active Withdrawn
- 2003-03-10 NZ NZ535169A patent/NZ535169A/xx unknown
- 2003-03-10 KR KR10-2004-7014163A patent/KR20040091119A/ko not_active Ceased
- 2003-03-10 EP EP03716403A patent/EP1483256A2/en not_active Withdrawn
- 2003-03-10 TW TW092105096A patent/TW200304825A/zh unknown
- 2003-03-10 IL IL16382803A patent/IL163828A0/xx unknown
- 2003-03-10 RU RU2004130313/04A patent/RU2315044C2/ru not_active IP Right Cessation
- 2003-03-10 WO PCT/US2003/007176 patent/WO2003078420A2/en not_active Ceased
- 2003-03-10 JP JP2003576425A patent/JP2005527530A/ja active Pending
- 2003-03-10 US US10/384,837 patent/US7019137B2/en not_active Expired - Fee Related
- 2003-03-10 MX MXPA04008730A patent/MXPA04008730A/es active IP Right Grant
- 2003-03-11 AR ARP030100832A patent/AR038931A1/es unknown
- 2003-10-03 UA UA20041008215A patent/UA79774C2/uk unknown
-
2004
- 2004-08-24 CR CR7428A patent/CR7428A/es not_active Application Discontinuation
- 2004-09-10 EC EC2004005292A patent/ECSP045292A/es unknown
- 2004-09-23 NO NO20043988A patent/NO20043988L/no not_active Application Discontinuation
- 2004-10-11 ZA ZA200408205A patent/ZA200408205B/en unknown
-
2005
- 2005-06-07 US US11/147,055 patent/US7256289B2/en not_active Expired - Fee Related
-
2007
- 2007-07-06 RU RU2007125687/04A patent/RU2007125687A/ru not_active Application Discontinuation
- 2007-08-08 US US11/891,062 patent/US20080058543A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04008730A (es) | 2004-12-06 |
| NO20043988L (no) | 2004-09-23 |
| WO2003078420A2 (en) | 2003-09-25 |
| ECSP045292A (es) | 2004-10-26 |
| TW200304825A (en) | 2003-10-16 |
| NZ535169A (en) | 2006-03-31 |
| JP2005527530A (ja) | 2005-09-15 |
| EP1483256A2 (en) | 2004-12-08 |
| ZA200408205B (en) | 2007-03-28 |
| US7256289B2 (en) | 2007-08-14 |
| RU2007125687A (ru) | 2009-01-20 |
| US20050228181A1 (en) | 2005-10-13 |
| US20080058543A1 (en) | 2008-03-06 |
| CN1642937A (zh) | 2005-07-20 |
| WO2003078420A3 (en) | 2004-03-11 |
| RU2315044C2 (ru) | 2008-01-20 |
| CN101492383A (zh) | 2009-07-29 |
| BR0308347A (pt) | 2005-01-25 |
| US7019137B2 (en) | 2006-03-28 |
| CR7428A (es) | 2008-09-23 |
| CN100451014C (zh) | 2009-01-14 |
| UA79774C2 (en) | 2007-07-25 |
| AR038931A1 (es) | 2005-02-02 |
| KR20040091119A (ko) | 2004-10-27 |
| RU2004130313A (ru) | 2005-04-10 |
| US20030208075A1 (en) | 2003-11-06 |
| AU2003220110B2 (en) | 2009-04-09 |
| CA2477906A1 (en) | 2003-09-25 |
| AU2003220110A1 (en) | 2003-09-29 |
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